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Neural Synchronization in Parkinson’s Disease on Different Time Scales

  • Sungwoo AhnEmail author
  • Choongseok Park
  • Leonid L. Rubchinsky
Chapter
Part of the Springer Series in Cognitive and Neural Systems book series (SSCNS, volume 13)

Abstract

Parkinson’s disease is marked by an elevated neural synchrony in the cortico-basal ganglia circuits in the beta frequency band. This elevated synchrony has been associated with Parkinsonian hypokinetic symptoms. The application of recently developed synchronization analysis techniques allows us to investigate the temporal dynamics of synchrony on different time scales. The results of this analysis are summarized here, revealing highly variable dynamics of synchronized neural activity on multiple time scales and its association with disease.

Keywords

Parkinson’s disease Neural oscillations Neural synchronization Desynchronization Intermittency Beta-band oscillations 

Notes

Acknowledgments

This paper was supported by the ICTSI/Indiana University Health–IU School of Medicine Strategic Research Initiative, the National Science Foundation Grant DMS 1813819, and National Science Foundation Grant HRD 1700199.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Sungwoo Ahn
    • 1
    Email author
  • Choongseok Park
    • 2
  • Leonid L. Rubchinsky
    • 3
    • 4
  1. 1.Department of MathematicsEast Carolina UniversityGreenvilleUSA
  2. 2.Department of MathematicsNorth Carolina A&T State UniversityGreensboroUSA
  3. 3.Department of Mathematical SciencesIndiana University-Purdue University IndianapolisIndianapolisUSA
  4. 4.Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisUSA

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