Dynamics of Basal Ganglia and Thalamus in Parkinsonian Tremor
Although beta-range oscillation is observed in the basal ganglia (BG) of Parkinson’s disease (PD) patients, its causal role in Parkinson’s tremor has been controversial because the PD tremor is in much lower frequency range. In order to explore the dynamic interaction between the BG and their downstream, we built a spiking neuron model of the BG-thalamocortical (TC) network at the scale of a rat brain. The model of the BG-TC circuit reproduced normal, asynchronous firing state and Parkinson-like state with 15 Hz beta-range oscillation in the BG and 4–8 Hz oscillation in the thalamus and the cortex, which is consistent with the PD tremor frequency. Simulation results show that hyperpolarizing current in the thalamic neurons and synchronous burst input from the BG are essential for subharmonic resonant response of the thalamic network in generating Parkinsonian tremor.
KeywordsParkinson’s disease Tremor Beta-range oscillation Sub-harmonic resonance Basal ganglia Thalamus Spiking neural network Computational modeling
- 6.Igarashi J, Shouno O, Moren J, Yoshimoto J, Doya K (2015) A spiking neural network model of the basal ganglia-thalamo-cortical circuit toward understanding of motor symptoms of parkinson disease. Brain Neural Netw 22(3):103–111. https://doi.org/10.3902/jnns.22.103. (in Japanese)CrossRefGoogle Scholar
- 7.Miller WC, DeLong MR (1987) Altered tonic activity of neurons in the globus pallidus and subthalamic nucleus in the primate MPTP model of Parkinsonism. Springer US, Boston, pp 415–427Google Scholar
- 8.Moren J, Igarashi J, Yoshimoto J, Doya K (2015) A full rat-scale model of the basal ganglia and thalamocortical network to reproduce parkinsonian tremor. BMC Neurosci 16(Suppl 1). https://doi.org/10.1186/1471-2202-16-s1-p64
- 11.Shouno O, Takeuchi J, Tsujino H (2009) A spiking neuron model of the basal ganglia circuitry that can generate behavioral variability. In: The basal ganglia IX. Springer, pp 191–200Google Scholar