Advertisement

Dynamics of Basal Ganglia and Thalamus in Parkinsonian Tremor

  • Jan Morén
  • Jun Igarashi
  • Osamu Shouno
  • Junichiro Yoshimoto
  • Kenji DoyaEmail author
Chapter
Part of the Springer Series in Cognitive and Neural Systems book series (SSCNS, volume 13)

Abstract

Although beta-range oscillation is observed in the basal ganglia (BG) of Parkinson’s disease (PD) patients, its causal role in Parkinson’s tremor has been controversial because the PD tremor is in much lower frequency range. In order to explore the dynamic interaction between the BG and their downstream, we built a spiking neuron model of the BG-thalamocortical (TC) network at the scale of a rat brain. The model of the BG-TC circuit reproduced normal, asynchronous firing state and Parkinson-like state with 15 Hz beta-range oscillation in the BG and 4–8 Hz oscillation in the thalamus and the cortex, which is consistent with the PD tremor frequency. Simulation results show that hyperpolarizing current in the thalamic neurons and synchronous burst input from the BG are essential for subharmonic resonant response of the thalamic network in generating Parkinsonian tremor.

Keywords

Parkinson’s disease Tremor Beta-range oscillation Sub-harmonic resonance Basal ganglia Thalamus Spiking neural network Computational modeling 

References

  1. 1.
    Destexhe A, Bal T, McCormick D, Sejnowski T (1996) Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices. J Neurophysiol 76(3):2049–2070CrossRefGoogle Scholar
  2. 2.
    Djurfeldt M, Hjorth J, Eppler JM, Dudani N, Helias M, Potjans TC, Bhalla US, Diesmann M, Hellgren Kotaleski J, Ekeberg O (2010) Run-time interoperability between neuronal network simulators based on the MUSIC framework. Neuroinformatics 8(1):43–60CrossRefGoogle Scholar
  3. 3.
    Dovzhenok A, Rubchinsky LL (2012) On the origin of tremor in Parkinson’s disease. PLoS ONE 7(7):e41598CrossRefGoogle Scholar
  4. 4.
    Edgerton J, Jaeger D (2014) Optogenetic activation of nigral inhibitory inputs to motor thalamus in the mouse reveals classic inhibition with little potential for rebound activation. Front Cell Neurosci 8:36CrossRefGoogle Scholar
  5. 5.
    Gewaltig MO, Diesmann M (2007) Nest (neural simulation tool). Scholarpedia 2(4):1430CrossRefGoogle Scholar
  6. 6.
    Igarashi J, Shouno O, Moren J, Yoshimoto J, Doya K (2015) A spiking neural network model of the basal ganglia-thalamo-cortical circuit toward understanding of motor symptoms of parkinson disease. Brain Neural Netw 22(3):103–111.  https://doi.org/10.3902/jnns.22.103. (in Japanese)CrossRefGoogle Scholar
  7. 7.
    Miller WC, DeLong MR (1987) Altered tonic activity of neurons in the globus pallidus and subthalamic nucleus in the primate MPTP model of Parkinsonism. Springer US, Boston, pp 415–427Google Scholar
  8. 8.
    Moren J, Igarashi J, Yoshimoto J, Doya K (2015) A full rat-scale model of the basal ganglia and thalamocortical network to reproduce parkinsonian tremor. BMC Neurosci 16(Suppl 1). https://doi.org/10.1186/1471-2202-16-s1-p64
  9. 9.
    Oorschot DE (1996) Total number of neurons in the neostriatal, pallidal, subthalamic, and substantia nigral nuclei of the rat basal ganglia: a stereological study using the cavalieri and optical disector methods. J Comp Neurol 366(4):580–599CrossRefGoogle Scholar
  10. 10.
    Sarnthein J, Jeanmonod D (2007) High thalamocortical theta coherence in patients with Parkinson’s disease. J Neurosci 27(1):124–131CrossRefGoogle Scholar
  11. 11.
    Shouno O, Takeuchi J, Tsujino H (2009) A spiking neuron model of the basal ganglia circuitry that can generate behavioral variability. In: The basal ganglia IX. Springer, pp 191–200Google Scholar
  12. 12.
    Shouno O, Tachibana Y, Nambu A, Doya K (2017) Computational model of recurrent subthalamo-pallidal circuit for generation of Parkinsonian oscillations. Front Neuroanat 11:21CrossRefGoogle Scholar
  13. 13.
    Tachibana Y, Iwamuro H, Kita H, Takada M, Nambu A (2011) Subthalamo-pallidal interactions underlying Parkinsonian neuronal oscillations in the primate basal ganglia. Eur J Neurosci 34(9):1470–1484CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Jan Morén
    • 1
  • Jun Igarashi
    • 2
  • Osamu Shouno
    • 3
  • Junichiro Yoshimoto
    • 4
  • Kenji Doya
    • 5
    Email author
  1. 1.Scientific Computing and Data Analysis SectionOkinawa Institute of Science and Technology Graduate UniversityOkinawaJapan
  2. 2.Computational Engineering Applications UnitRIKENWakoJapan
  3. 3.Honda Research Institute Japan Co., LtdWakoJapan
  4. 4.Mathematical Informatics LaboratoryNara Institute of Science and TechnologyIkomaJapan
  5. 5.Neural Computation UnitOkinawa Institute of Science and Technology Graduate UniversityOkinawaJapan

Personalised recommendations