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The Diagnosis of Bovine Tuberculosis

  • Nicolaas P. J. Kriek
  • Demelash B. Areda
  • Asseged B. DibabaEmail author
Chapter

Abstract

To successfully deal with any specific disease, it is critical to make a correct diagnosis and then to institute the necessary measures to control, and, if possible, to eradicate it. For some diseases this is not a complicated matter, but for Mycobacterium bovis that infects a wide range of mammals, including humans, there is not a single test or procedure by which to reliably confirm the diagnosis in all infected and diseased animals, mostly because of the lack of sensitivity and specificity of all the currently available tests. The various species that can be infected react immunologically different to the infection, respond differently to the various immune-mediated diagnostic tests, show a marked variation in the macro- and microscopical appearance of the lesions caused by the infection and change their appearance as the disease progresses. It is critical to understand that the diagnostic criteria for the different tests in a specific species cannot be used in species in which they have not been validated, and that extrapolation between species cannot be done as the test results cannot then be interpreted correctly. This chapter provides an overview of the currently available diagnostic tests, their deficiencies, and the way in which they can be applied in resource-poor countries to aid efforts to control bovine tuberculosis.

Keywords

Tuberculosis Bovine tuberculosis Diagnosis Africa Cattle Livestock Wildlife Tuberculin skin test Pathology Serology Molecular diagnostic techniques 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nicolaas P. J. Kriek
    • 1
  • Demelash B. Areda
    • 2
  • Asseged B. Dibaba
    • 3
    Email author
  1. 1.Department of Paraclinical Sciences, Faculty of Veterinary ScienceUniversity of PretoriaOnderstepoortSouth Africa
  2. 2.Department of Biological SciencesMinnesota State University, MankatoMankatoUSA
  3. 3.Department of Pathobiology, College of Veterinary MedicineTuskegee UniversityTuskegeeUSA

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