Innate Immunity

  • Robert Jack
  • Louis Du Pasquier


All defence systems have much in common. No matter whether we are thinking in terms of defending a mediaeval castle from greedy neighbours or a multicellular eukaryote from attack by pathogens, the basic story is always the same. The defence system employed will consist of three parts. The first part provides information about whether a dangerous situation is developing. In the case of the castle, sentries will provide this necessary information. In the case of an animal’s innate immune system, soluble extracellular receptor molecules, and cell-associated sensors expressed by macrophages and other innate sentinel cells will detect incipient infections or other deviations from the homeostatic norm.


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Further Reading

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  9. Roers A, Hiller B, Hornung V (2016) Recognition of endogenous nucleic acids by the innate immune system. Immunity 44:739–754CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Robert Jack
    • 1
  • Louis Du Pasquier
    • 2
  1. 1.Department of ImmunologyUniversity of GreifswaldGreifswaldGermany
  2. 2.Department of Environmental Sciences, ZoologyUniversity of BaselBasel StadtSwitzerland

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