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What Makes Evolution Tick?

  • Robert Jack
  • Louis Du Pasquier
Chapter

Abstract

In this book we will be looking at some of the evolutionary forces that shaped, and are shaping, immune defence systems. However, before doing that it makes sense to look at some of the basic features of the evolutionary process. Perhaps the best place to start is with an essay written by Ernst Mayr, at that time professor of Zoology at Harvard, which was published in Science in 1961 [1]. In this essay Mayr considered the case of a little bird that fluttered around outside his office window all summer and then, as autumn approached, took off and flew south. Mayr pointed out that there are two types of question one might ask about all this. The first is what he called the “how” question. How does the little bird know that the year is nearly over? How does it organise its flight south? Clearly the bird must be able to detect some feature of approaching autumn—perhaps by using some appropriate receptor system to detect the shortening of the day or the gradual fall in average daily temperature. Then it must convert this signal into electrical impulses that can be interpreted by its brain, after which an output signal must be generated, which encourages the little bird to fly off in the correct direction. Finding the answers to the “how” questions would involve a lifetime or two of fascinating research, and the results would be expressed in terms of molecules and of biochemical and neural pathways. These things are familiar to all of us, since molecules and pathways are what most scientists spend most of their working lives dealing with.

References

  1. 1.
    Mayr E (1961) Cause and effect in biology. Science 134(3489):1501–1506CrossRefGoogle Scholar
  2. 2.
    Hodgkin J, Barnes TM (1991) More is not better: brood size and population growth in a self-fertilizing nematode. Proc Biol Sci 246(1315):19–24CrossRefGoogle Scholar
  3. 3.
    Doolittle WF (2013) Is junk DNA bunk? A critique of ENCODE. Proc Natl Acad Sci U S A 110(14):5294–5300CrossRefGoogle Scholar
  4. 4.
    Hsu E, Du Pasquier L (2015) Pathogen-host interactions: antigenic variation v. somatic adaptations. In: Richter DJ, Tiedge H (eds) Results and problems in cell differentiation, vol 57. Springer, HeidelbergGoogle Scholar
  5. 5.
    Lek M et al (2016) Analysis of protein-coding genetic variation in 60,706 humans. Nature 536(7616):285–291CrossRefGoogle Scholar
  6. 6.
    Luria SE, Delbruck M (1943) Mutations of bacteria from virus sensitivity to virus resistance. Genetics 28(6):491–511PubMedPubMedCentralGoogle Scholar
  7. 7.
    Rutherford SL, Lindquist S (1998) Hsp90 as a capacitor for morphological evolution. Nature 396(6709):336CrossRefGoogle Scholar
  8. 8.
    Lango Allen H et al (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467(7317):832–838CrossRefGoogle Scholar
  9. 9.
    OMIM (2019) Online Mendelian inheritance in man, OMIM®. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MDGoogle Scholar
  10. 10.
    Jacob F (1977) Evolution and tinkering. Science 196(4295):1161–1166CrossRefGoogle Scholar
  11. 11.
    Fischer MG, Hackl T (2016) Host genome integration and giant virus-induced reactivation of the virophage mavirus. Nature 540(7632):288–291CrossRefGoogle Scholar

Further Reading

  1. Darwin C (1859) On the origin of species. John Murray, LondonGoogle Scholar
  2. Howard J (1982) DARWIN a very short introduction. Oxford University Press. isbn:0-19-285454-2Google Scholar
  3. Jacob F (1977) Evolution and tinkering. Science 196(4295):1161–1166CrossRefGoogle Scholar
  4. Malthus T (1798) An essay on the principle of population. www.esp.org/books/malthus/population/malthus.pdf

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Robert Jack
    • 1
  • Louis Du Pasquier
    • 2
  1. 1.Department of ImmunologyUniversity of GreifswaldGreifswaldGermany
  2. 2.Department of Environmental Sciences, ZoologyUniversity of BaselBasel StadtSwitzerland

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