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Liver Flukes: Clonorchis and Opisthorchis

  • Weerachai Saijuntha
  • Paiboon SithithawornEmail author
  • Nadda Kiatsopit
  • Ross H. Andrews
  • Trevor N. Petney
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1154)

Abstract

Clonorchis sinensis, Opisthorchis viverrini, and O. felineus are liver flukes of human and animal pathogens occurring across much of Europe and Asia. Nevertheless, they are often underestimated compared to other, better known neglected diseases in spite of the fact that many millions of people are infected and hundreds of millions are at risk. This is possibly because of the chronic nature of the infection and disease and that it takes several decades prior to a life-threatening pathology to develop. Several studies in the past decade have provided more information on the molecular biology of the liver flukes which clearly lead to better understanding of parasite biology, systematics, and population genetics. Clonorchiasis and opisthorchiasis are characterized by a chronic infection that induces hepatobiliary inflammation, especially periductal fibrosis, which can be detected by ultrasonography. These chronic inflammations eventually lead to cholangiocarcinoma (CCA), a usually fatal bile duct cancer that develops in some infected individuals. In Thailand alone, opisthorchiasis-associated CCA kills up to 20,000 people every year and is therefore of substantial public health importance. Its socioeconomic impacts on impoverished families and communities are considerable. To reduce hepatobiliary morbidity and CCA, the primary intervention measures focus on control and elimination of the liver fluke. Accurate diagnosis of liver fluke infections in both human and other mammalian, snail and fish intermediate hosts, are important for achieving these goals. While the short-term goal of liver fluke control can be achieved by praziquantel chemotherapy, a comprehensive health education package targeting school children is believed to be more beneficial for a long-term goal/solution. It is recommended that a transdisciplinary research or multisectoral control approach including one health and/or eco health intervention strategy should be applied to combat the liver flukes, and hence contribute to reduction of cholangiocarcinoma in endemic areas.

Keywords

Liver flukes Opisthorchis viverrini Clonorchis sinensis Opisthorchis felineus Fish-borne trematodes 

References

  1. Adam R, Arnold H, Pipitgool V, Sithithaworn P, Hinz E, Storch V (1993) Studies on lophocercous cercariae from Bithynia siamensis goniomphalos (Prosobranchia: Bithyniidae). Southeast Asian J Trop Med Public Health 24:697–700PubMedPubMedCentralGoogle Scholar
  2. Akai PS, Pungpak S, Chaicumpa W, Kitikoon V, Ruangkunaporn Y, Bunnag D, Befus AD (1995) Serum antibody responses in opisthorchiasis. Int J Parasitol 25:971–973PubMedCrossRefPubMedCentralGoogle Scholar
  3. Ando K, Sithithaworn P, Nuchjungreed C, Tesana S, Srisawangwong T, Limviroj W, Chinzei Y (2001) Nucleotide sequence of mitochondrial CO I and ribosomal ITS II genes of Opisthorchis viverrini in northeast Thailand. Southeast Asian J Trop Med Public Health 32(Suppl 2):17–22PubMedPubMedCentralGoogle Scholar
  4. Andrews RH, Sithithaworn P, Petney TN (2008) Opisthorchis viverrini: an underestimated parasite in world health. Trends Parasitol 24:497–501PubMedPubMedCentralCrossRefGoogle Scholar
  5. Araki H, Ong KIC, Lorphachan L, Soundala P, Iwagami M, Shibanuma A, Hongvanthong B, Brey PT, Kano S, Jimba M (2018) Mothers’ Opisthorchis viverrini infection status and raw fish dish consumption in Lao People’s Democratic Republic: determinants of child infection status. Trop Med Health 46:29PubMedPubMedCentralCrossRefGoogle Scholar
  6. Arimatsu Y, Kaewkes S, Laha T, Hong SJ, Sripa B (2012) Rapid detection of Opisthorchis viverrini copro-DNA using loop-mediated isothermal amplification (LAMP). Parasitol Int 61:178–182PubMedCrossRefPubMedCentralGoogle Scholar
  7. Armignacco O, Caterini L, Marucci G, Ferri F, Bernardini G, Natalini Raponi G, Ludovisi A, Bossu T, Gomez Morales MA, Pozio E (2008) Human illnesses caused by Opisthorchis felineus flukes, Italy. Emerg Infect Dis 14:1902–1905PubMedPubMedCentralCrossRefGoogle Scholar
  8. Armignacco O, Ferri F, Gomez-Morales MA, Caterini L, Pozio E (2013) Cryptic and asymptomatic Opisthorchis felineus infections. Am J Trop Med Hyg 88:364–366PubMedPubMedCentralCrossRefGoogle Scholar
  9. Attwood HD, Chou ST (1978) The longevity of Clonorchis sinensis. Pathology 10:153–156PubMedCrossRefPubMedCentralGoogle Scholar
  10. Aung WPP, Htoon TT, Tina HH, Thinn KK, Sanpool O, Jongthawin J, Sadaow L, Phosuk I, Rodpai R, Intapan PM, Maleewong W (2017) First report and molecular identification of Opisthorchis viverrini infection in human communities from Lower Myanmar. PLoS One 12:e0177130PubMedPubMedCentralCrossRefGoogle Scholar
  11. Aunpromma S, Tangkawattana P, Papirom P, Kanjampa P, Tesana S, Sripa B, Tangkawattana S (2012) High prevalence of Opisthorchis viverrini infection in reservoir hosts in four districts of Khon Kaen Province, an opisthorchiasis endemic area of Thailand. Parasitol Int 61:60–64PubMedCrossRefGoogle Scholar
  12. Aunpromma S, Kanjampa P, Papirom P, Tangkawattana S, Tangkawattana P, Tesana S, Boonmars T, Suwannatrai A, Uopsai S, Sukon P, Sripa B (2016) Prevalence and risk factors for Opisthorchis viverrini infection among cats and dogs in six districts surrounding the Ubolratana Dam, an endemic area for human opisthorchiasis in Northeastern Thailand. Southeast Asian J Trop Med Public Health 47:1153–1159PubMedGoogle Scholar
  13. Awiruttapanich M (2004) Epidemiology of liver fluke (Opisthorchis viverrini) in pla kao na (Cyclocheilichthys armatus). Dissertation, Khon Kaen UniversityGoogle Scholar
  14. Bae YA, Kong Y (2003) Evolutionary course of CsRn1 long-terminal-repeat retrotransposon and its heterogeneous integrations into the genome of the liver fluke, Clonorchis sinensis. Korean J Parasitol 41:209–219PubMedCrossRefGoogle Scholar
  15. Bae YA, Moon SY, Kong Y, Cho SY, Rhyu MG (2001) CsRn1, a novel active retrotransposon in a parasitic trematode, Clonorchis sinensis, discloses a new phylogenetic clade of Ty3/gypsy-like LTR retrotransposons. Mol Biol Evol 18:1474–1483PubMedCrossRefGoogle Scholar
  16. Bedier E, Chesneau P (1929) Distomatose hepatique a Opisthorchis au Laos (a Vientiane et Thakhek). Bull Soc Pathol Exot 22:331–334Google Scholar
  17. Behr MA, Gyorkos TW, Kokoskin E, Ward BJ, MacLean JD (1998) North American liver fluke (Metorchis conjunctus) in a Canadian aboriginal population: a submerging human pathogen? Can J Public Health 89:258–259PubMedPubMedCentralGoogle Scholar
  18. Bensted-Smith R, Anderson RM, Butterworth AE, Dalton PR, Kariuki CH, Koech D, Mugambi M, Ouma JH, Arap Siongok TK, Sturrock RF (1987) Evidence for predisposition of individual patients to reinfections with Schistosoma mansoni after treatment. Trans R Soc Trop Med Hyg 81:651–656PubMedCrossRefGoogle Scholar
  19. Bhamarapravati N, Thammavit W, Vajrasthira S (1978) Liver changes in hamsters infected with a liver fluke of man, Opisthorchis viverrini. Am J Trop Med Hyg 27:787–794PubMedCrossRefGoogle Scholar
  20. Blechacz BR, Gores GJ (2008) Cholangiocarcinoma. Clin Liver Dis 12:131–150PubMedCrossRefPubMedCentralGoogle Scholar
  21. Boonmee S, Imtawil K, Wongkham C, Wongkham S (2003) Comparative proteomic analysis of juvenile and adult liver fluke, Opisthorchis viverrini. Acta Trop 88:233–238PubMedCrossRefPubMedCentralGoogle Scholar
  22. Brockelman WY, Upatham ES, Viyanant V, Ardsungnoen S, Chantanawat R (1986) Field studies on the transmission of the human liver fluke, Opisthorchis viverrini, in northeast Thailand: population changes of the snail intermediate host. Int J Parasitol 16:545–552PubMedCrossRefPubMedCentralGoogle Scholar
  23. Brusentsov II, Katokhin AV, Brusentsova IV, Shekhovtsov SV, Borovikov SN, Goncharenko GG, Lider LA, Romashov BV, Rusinek OT, Shibitov SK, Suleymanov MM, Yevtushenko AV, Mordvinov VA (2013) Low genetic diversity in wide-spread Eurasian liver fluke Opisthorchis felineus suggests special demographic history of this trematode species. PLoS One 8:e62453PubMedPubMedCentralCrossRefGoogle Scholar
  24. Buathong S, Leelayoova S, Mungthin M, Ruang-areerate T, Naaglor T, Suwannahitatorn P, Piyaraj P, Taamasri P, Tan-ariya P (2017) Molecular discrimination of Opisthorchis-like eggs from residents in a rural community of central Thailand. PLoS Negl Trop Dis 11:e0006030PubMedPubMedCentralCrossRefGoogle Scholar
  25. Bui TN, Pham TT, Nguyen NT, Nguyen HV, Murrell D, Phan VT (2016) The importance of wild fish in the epidemiology of Clonorchis sinensis in Vietnam. Parasitol Res 115:3401–3408PubMedCrossRefPubMedCentralGoogle Scholar
  26. Bundhamcharoen K, Odton P, Phulkerd S, Tangcharoensathien V (2011) Burden of disease in Thailand: changes in health gap between 1999 and 2004. BMC Public Health 11:53PubMedPubMedCentralCrossRefGoogle Scholar
  27. Bundy DA, Golden MH (1987) The impact of host nutrition on gastrointestinal helminth populations. Parasitology 95(Pt 3):623–635PubMedCrossRefPubMedCentralGoogle Scholar
  28. Bunnag D, Harinasuta T (1981) Studies on the chemotherapy of human opisthorchiasis: III. Minimum effective dose of praziquantel. Southeast Asian J Trop Med Public Health 12:413–417PubMedPubMedCentralGoogle Scholar
  29. Bürli C, Harbrecht H, Odermatt P, Sayasone S, Chitnis N (2018a) Analysis of interventions against the liver fluke, Opisthorchis viverrini. Math Biosci 303:115–125PubMedCrossRefPubMedCentralGoogle Scholar
  30. Bürli C, Harbrecht H, Odermatt P, Sayasone S, Chitnis N (2018b) Mathematical analysis of the transmission dynamics of the liver fluke, Opisthorchis viverrini. J Theor Biol 439:181–194PubMedCrossRefPubMedCentralGoogle Scholar
  31. Cai XQ, Xu MJ, Wang YH, Qiu DY, Liu GX, Lin A, Tang JD, Zhang RL, Zhu XQ (2010) Sensitive and rapid detection of Clonorchis sinensis infection in fish by loop-mediated isothermal amplification (LAMP). Parasitol Res 106:1379–1383PubMedCrossRefPubMedCentralGoogle Scholar
  32. Cai XQ, Liu GH, Song HQ, Wu CY, Zou FC, Yan HK, Yuan ZG, Lin RQ, Zhu XQ (2012) Sequences and gene organization of the mitochondrial genomes of the liver flukes Opisthorchis viverrini and Clonorchis sinensis (Trematoda). Parasitol Res 110:235–243PubMedCrossRefPubMedCentralGoogle Scholar
  33. Calumpang SM, Medina MJ, Tejada AW, Medina JR (1995) Environmental impact of two molluscicides: niclosamide and metaldehyde in a rice paddy ecosystem. Bull Environ Contam Toxicol 55:494–501PubMedCrossRefPubMedCentralGoogle Scholar
  34. Chai JY, Park JH, Han ET, Guk SM, Shin EH, Lin A, Kim JL, Sohn WM, Yong TS, Eom KS, Min DY, Hwang EH, Phommmasack B, Insisiengmay B, Rim HJ (2005) Mixed infections with Opisthorchis viverrini and intestinal flukes in residents of Vientiane Municipality and Saravane Province in Laos. J Helminthol 79:283–289PubMedCrossRefPubMedCentralGoogle Scholar
  35. Chaicumpa W, Ybanez L, Kitikoon V, Pungpak S, Ruangkunaporn Y, Chongsa-nguan M, Sornmani S (1992) Detection of Opisthorchis viverrini antigens in stools using specific monoclonal antibody. Int J Parasitol 22:527–531PubMedCrossRefPubMedCentralGoogle Scholar
  36. Chen D, Chen J, Huang J, Chen X, Feng D, Liang B, Che Y, Liu X, Zhu C, Li X, Shen H (2010) Epidemiological investigation of Clonorchis sinensis infection in freshwater fishes in the Pearl River Delta. Parasitol Res 107:835–839PubMedCrossRefPubMedCentralGoogle Scholar
  37. Chen J, Xu H, Zhang Z, Zeng S, Gan W, Yu X, Hu X (2011) Cloning and expression of 21.1-kDa tegumental protein of Clonorchis sinensis and human antibody response to it as a trematode-nematode pan-specific serodiagnosis antigen. Parasitol Res 108:161–168PubMedCrossRefPubMedCentralGoogle Scholar
  38. Choi BI, Park JH, Kim YI, Yu ES, Kim SH, Kim WH, Kim CY, Han MC (1988) Peripheral cholangiocarcinoma and clonorchiasis: CT findings. Radiology 169:149–153PubMedCrossRefPubMedCentralGoogle Scholar
  39. Choi MH, Ryu JS, Lee M, Li S, Chung BS, Chai JY, Sithithaworn P, Tesana S, Hong ST (2003) Specific and common antigens of Clonorchis sinensis and Opisthorchis viverrini (Opisthorchidae, Trematoda). Korean J Parasitol 41:155–163PubMedPubMedCentralCrossRefGoogle Scholar
  40. Choi CD, Savage J, Stephens DN, O'Donnell M (2005) An integrated semicompliant balloon ultrasound catheter for quantitative feedback and image guidance during stent deployment. IEEE Trans Ultrason Ferroelectr Freq Control 52:1498–1503PubMedCrossRefPubMedCentralGoogle Scholar
  41. Chotigeat W, Ruenwongsa P (1986) Types of collagen in Opisthorchis viverrini infected hamster liver. Mol Biochem Parasitol 18:377–387PubMedCrossRefPubMedCentralGoogle Scholar
  42. Chou ST, Chan CW (1976) Mucin-producing cholangiocarcinoma: an autopsy study in Hong Kong. Pathology 8:321–328PubMedCrossRefPubMedCentralGoogle Scholar
  43. Dao TT, Abatih EN, Nguyen TT, Tran HT, Gabriel S, Smit S, Le PN, Dorny P (2016) Prevalence of Opisthorchis viverrini-like fluke infection in ducks in Binh Dinh Province, central Vietnam. Korean J Parasitol 54:357–361PubMedPubMedCentralCrossRefGoogle Scholar
  44. Dao TTH, Nguyen TTG, Gabriel S, Bui KL, Dorny P, Le TH (2017) Updated molecular phylogenetic data for Opisthorchis spp. (Trematoda: Opisthorchioidea) from ducks in Vietnam. Parasit Vectors 10:575PubMedPubMedCentralCrossRefGoogle Scholar
  45. De NV, Le TH (2011) Human infections of fish-borne trematodes in Vietnam: prevalence and molecular specific identification at an endemic commune in Nam Dinh province. Exp Parasitol 129:355–361PubMedCrossRefPubMedCentralGoogle Scholar
  46. Ditrich O, Scholz T, Giboda M (1990) Occurrence of some medically important flukes (Trematoda: Opisthorchiidae and Heterophyidae) in Nam Ngum water reservoir, Laos. Southeast Asian J Trop Med Public Health 21:482–488PubMedPubMedCentralGoogle Scholar
  47. Doanh PN, Nawa Y (2016) Clonorchis sinensis and Opisthorchis spp. in Vietnam: current status and prospects. Trans R Soc Trop Med Hyg 110:13–20PubMedCrossRefPubMedCentralGoogle Scholar
  48. Donthaisong C, Arunsan P, Suwannatrai K, Prasopdee S, Kulsantiwong J, Wongmaneeprateep S, Suwannatrai A, Tesana S (2014) Experimental infection of Opisthorchis viverrini cercariae to the cyprinid fish, Barbonymus gonionotus. Acta Trop 136:118–122PubMedCrossRefPubMedCentralGoogle Scholar
  49. Duenngai K, Sithithaworn P, Rudrappa UK, Iddya K, Laha T, Stensvold CR, Strandgaard H, Johansen MV (2008) Improvement of PCR for detection of Opisthorchis viverrini DNA in human stool samples. J Clin Microbiol 46:366–368PubMedCrossRefPubMedCentralGoogle Scholar
  50. Duenngai K, Boonmars T, Sithithaworn J, Sithithaworn P (2013) Diagnosis of early infection and post chemotherapeutic treatment by copro-DNA detection in experimental opisthorchiasis. Parasitol Res 112:271–278PubMedCrossRefPubMedCentralGoogle Scholar
  51. Dung VT, Waikagul J, Thanh BN, Vo DT, Nguyen DN, Murrell KD (2014) Endemicity of Opisthorchis viverrini liver flukes, Vietnam, 2011-2012. Emerg Infect Dis 20:152–154CrossRefGoogle Scholar
  52. Elkins DB, Haswell-Elkins M, Anderson RM (1986) The epidemiology and control of intestinal helminths in the Pulicat Lake region of Southern India. I. Study design and pre- and post-treatment observations on Ascaris lumbricoides infection. Trans R Soc Trop Med Hyg 80:774–792PubMedCrossRefPubMedCentralGoogle Scholar
  53. Elkins DB, Haswell-Elkins MR, Mairiang E, Mairiang P, Sithithaworn P, Kaewkes S, Bhudhisawasdi V, Uttaravichien T (1990) A high frequency of hepatobiliary disease and suspected cholangiocarcinoma associated with heavy Opisthorchis viverrini infection in a small community in north-east Thailand. Trans R Soc Trop Med Hyg 84:715–719PubMedCrossRefPubMedCentralGoogle Scholar
  54. Elkins DB, Sithithaworn P, Haswell-Elkins M, Kaewkes S, Awacharagan P, Wongratanacheewin S (1991) Opisthorchis viverrini: relationships between egg counts, worms recovered and antibody levels within an endemic community in northeast Thailand. Parasitology 102(Pt 2):283–288PubMedCrossRefPubMedCentralGoogle Scholar
  55. Elkins DB, Mairiang E, Sithithaworn P, Mairiang P, Chaiyakum J, Chamadol N, Loapaiboon V, Haswell-Elkins MR (1996) Cross-sectional patterns of hepatobiliary abnormalities and possible precursor conditions of cholangiocarcinoma associated with Opisthorchis viverrini infection in humans. Am J Trop Med Hyg 55:295–301PubMedCrossRefPubMedCentralGoogle Scholar
  56. Erhardt A, Germer WD, Hörning B (1962) Die Opisthorchiasis hervorgerufen durch den Katzenleberegel Opisthorchis felineus (Riv.). Parasitol Schriftenr 15:1–171Google Scholar
  57. Fang YY, Chen YD, Li XM, Wu J, Zhang QM, Ruan CW (2008) Current prevalence of Clonorchis sinensis infection in endemic areas of China. Chin J Parasitol Parasit Dis 26:99–103Google Scholar
  58. Fedorova OS, Kovshirina YV, Kovshirina AE, Fedotova MM, Deev IA, Petrovskiy FI, Filimonov AV, Dmitrieva AI, Kudyakov LA, Saltykova IV, Odermatt P, Ogorodova LM (2017) Opisthorchis felineus infection and cholangiocarcinoma in the Russian Federation: a review of medical statistics. Parasitol Int 66:365–371PubMedCrossRefPubMedCentralGoogle Scholar
  59. Feldmeier H, Hazay M, Sato M, Tiengkham P, Nishimoto F, Jiang H, Sopraseuth V, Moji K (2016) Morbidity assessment of Opisthorchis viverrini infection in rural Laos: I. Parasitological, clinical, ultrasonographical and biochemical findings. Trop Med Health 44:12PubMedPubMedCentralCrossRefGoogle Scholar
  60. Flavell DJ, Flavell SU, Field GF (1983) Opisthorchis viverrini: the relationship between egg production, worm size and intensity of infection in the hamster. Trans R Soc Trop Med Hyg 77:538–545PubMedCrossRefPubMedCentralGoogle Scholar
  61. Frazer IH, Leggatt GR, Mattarollo SR (2011) Prevention and treatment of papillomavirus-related cancers through immunization. Annu Rev Immunol 29:111–138PubMedCrossRefPubMedCentralGoogle Scholar
  62. Fried B, Abruzzi A (2010) Food-borne trematode infections of humans in the United States of America. Parasitol Res 106:1263–1280PubMedCrossRefPubMedCentralGoogle Scholar
  63. Giboda M, Ditrich O, Scholz T, Viengsay T, Bouaphanh S (1991) Current status of food-borne parasitic zoonoses in Laos. Southeast Asian J Trop Med Public Health 22(Suppl):56–61PubMedPubMedCentralGoogle Scholar
  64. Gozlan RE, Britton JR, Cowx I, Copp GH (2010) Current knowledge on non-native freshwater fish introductions. J Fish Biol 76:751–786CrossRefGoogle Scholar
  65. Grundy-Warr C, Andrews RH, Sithithaworn P, Petney TN, Sripa B, Laithavewat L, Ziegler AD (2012) Raw attitudes, wetland cultures, life-cycles: socio-cultural dynamics relating to Opisthorchis viverrini in the Mekong Basin. Parasitol Int 61:65–70PubMedCrossRefPubMedCentralGoogle Scholar
  66. Haas W, Granzer M, Brockelman CR (1990) Opisthorchis viverrini: finding and recognition of the fish host by the cercariae. Exp Parasitol 71:422–431PubMedCrossRefPubMedCentralGoogle Scholar
  67. Han S, Zhang X, Wen J, Li Y, Shu J, Ling H, Zhang F (2012) A combination of the Kato-Katz methods and ELISA to improve the diagnosis of clonorchiasis in an endemic area, China. PLoS One 7:e46977PubMedPubMedCentralCrossRefGoogle Scholar
  68. Haswell-Elkins MR, Elkins DB, Sithithaworn P, Treesarawat P, Kaewkes S (1991) Distribution patterns of Opisthorchis viverrini within a human community. Parasitology 103(Pt 1):97–101PubMedCrossRefPubMedCentralGoogle Scholar
  69. Haswell-Elkins MR, Mairiang E, Mairiang P, Chaiyakum J, Chamadol N, Loapaiboon V, Sithithaworn P, Elkins DB (1994) Cross-sectional study of Opisthorchis viverrini infection and cholangiocarcinoma in communities within a high-risk area in northeast Thailand. Int J Cancer 59:505–509PubMedCrossRefPubMedCentralGoogle Scholar
  70. Hering-Hagenbeck S, Schuster R (1996) A focus of opisthorchiidosis in Germany. Appl Parasitol 37:260–265PubMedPubMedCentralGoogle Scholar
  71. Hira PR, Al-Enizi AA, Al-Kandari S, Behbehani K (1987) Opisthorchiasis in Kuwait: first report of infections in Thai migrant workers in the Arabian Gulf. Ann Soc Bel Med Trop 67:363–368Google Scholar
  72. Hong ST (1988) Changes of anti-Clonorchis sinensis IgG antibody in serum after praziquantel treatment in human clonorchiasis. Korean J Parasitol 26:1–8CrossRefGoogle Scholar
  73. Hong ST, Fang Y (2012) Clonorchis sinensis and clonorchiasis, an update. Parasitol Int 61:17–24PubMedCrossRefPubMedCentralGoogle Scholar
  74. Hong ST, Kho WG, Kim WH, Chai JY, Lee SH (1993) Turnover of biliary epithelial cells in Clonorchis sinensis infected rats. Korean J Parasitol 31:83–89PubMedCrossRefPubMedCentralGoogle Scholar
  75. Hong SJ, Seong KY, Sohn WM, Song KY (2000) Molecular cloning and immunological characterization of phosphoglycerate kinase from Clonorchis sinensis. Mol Biochem Parasitol 108:207–216PubMedCrossRefPubMedCentralGoogle Scholar
  76. Hong SJ, Yun Kim T, Gan XX, Shen LY, Sukontason K, Sukontason K, Kang SY (2002) Clonorchis sinensis: glutathione S-transferase as a serodiagnostic antigen for detecting IgG and IgE antibodies. Exp Parasitol 101:231–233PubMedCrossRefPubMedCentralGoogle Scholar
  77. Hong SJ, Shin JK, Kang SY, Ryu JR (2003a) Ultrastructural localization of phosphoglycerate kinase in adult Clonorchis sinensis. Parasitol Res 90:369–371PubMedCrossRefPubMedCentralGoogle Scholar
  78. Hong ST, Choi MH, Kim CH, Chung BS, Ji Z (2003b) The Kato-Katz method is reliable for diagnosis of Clonorchis sinensis infection. Diagn Microbiol Infect Dis 47:345–347PubMedCrossRefPubMedCentralGoogle Scholar
  79. Honjo S, Srivatanakul P, Sriplung H, Kikukawa H, Hanai S, Uchida K, Todoroki T, Jedpiyawongse A, Kittiwatanachot P, Sripa B, Deerasamee S, Miwa M (2005) Genetic and environmental determinants of risk for cholangiocarcinoma via Opisthorchis viverrini in a densely infested area in Nakhon Phanom, northeast Thailand. Int J Cancer 117:854–860PubMedCrossRefPubMedCentralGoogle Scholar
  80. Hotez PJ, Alibek K (2011) Central Asia’s hidden burden of neglected tropical diseases. PLoS Negl Trop Dis 5:e1224PubMedPubMedCentralCrossRefGoogle Scholar
  81. Hou PC (1956) The relationship between primary carcinoma of the liver and infestation with Clonorchis sinensis. J Pathol Bacteriol 72:239–246PubMedCrossRefPubMedCentralGoogle Scholar
  82. Hu F, Yu X, Ma C, Zhou H, Zhou Z, Li Y, Lu F, Xu J, Wu Z, Hu X (2007) Clonorchis sinensis: expression, characterization, immunolocalization and serological reactivity of one excretory/secretory antigen-LPAP homologue. Exp Parasitol 117:157–164PubMedCrossRefPubMedCentralGoogle Scholar
  83. Huang Y, Zhou Z, Hu X, Wei Q, Xu J, Wu Z, Yu X (2007) A novel tegumental protein 31.8 kDa of Clonorchis sinensis: sequence analysis, expression, and immunolocalization. Parasitol Res 102:77–81PubMedCrossRefPubMedCentralGoogle Scholar
  84. Huang SY, Zhao GH, Fu BQ, Xu MJ, Wang CR, Wu SM, Zou FC, Zhu XQ (2012) Genomics and molecular genetics of Clonorchis sinensis: current status and perspectives. Parasitol Int 61:71–76PubMedCrossRefPubMedCentralGoogle Scholar
  85. Huang Y, Huang D, Geng Y, Fang S, Yang F, Wu C, Zhang H, Wang M, Zhang R, Wang X, Wu S, Cao J, Zhang R (2017) An integrated control strategy takes Clonorchis sinensis under control in an endemic area in south China. Vector Borne Zoonotic Dis 17:791–798PubMedCrossRefPubMedCentralGoogle Scholar
  86. Hutadilok N, Ruenwongsa P (1983) Liver collagen turnover in hamsters during infection by the human liver fluke, Opisthorchis viverrini. Mol Biochem Parasitol 8:71–77PubMedCrossRefPubMedCentralGoogle Scholar
  87. IARC (2012) Biological agents: a review of human carcinogens. IARC Monogr Eval Carcinog Risks Hum 100B:341–370Google Scholar
  88. Inoue S, Kawanishi S (1995) Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide. FEBS Lett 371:86–88PubMedCrossRefPubMedCentralGoogle Scholar
  89. Itoh M, Pairojkul C, Thamawit W, Sithithaworn P, Tiwawech D, Uttaravicien T, Shirai T, Ito N (1994) Association of antibodies to Opisthorchis viverrini with hepatobiliary disease in northeastern Thailand. Am J Trop Med Hyg 51:424–429PubMedCrossRefPubMedCentralGoogle Scholar
  90. Jeong YI, Shin HE, Lee SE, Cheun HI, Ju JW, Kim JY, Park MY, Cho SH (2016) Prevalence of Clonorchis sinensis infection among residents along 5 major rivers in the Republic of Korea. Korean J Parasitol 54:215–219PubMedPubMedCentralCrossRefGoogle Scholar
  91. Jittimanee J, Sermswan RW, Kaewraemruaen C, Barta JR, Macinnes JI, Maleewong W, Wongratanacheewin S (2012) Protective immunization of hamsters against Opisthorchis viverrini infection is associated with the reduction of TGF-beta expression. Acta Trop 122:189–195PubMedCrossRefPubMedCentralGoogle Scholar
  92. Johansen MV, Sithithaworn P, Bergquist R, Utzinger J (2010) Towards improved diagnosis of zoonotic trematode infections in Southeast Asia. Adv Parasitol 73:171–195PubMedCrossRefPubMedCentralGoogle Scholar
  93. Jones MK, Gobert GN, Zhang L, Sunderland P, McManus DP (2004) The cytoskeleton and motor proteins of human schistosomes and their roles in surface maintenance and host-parasite interactions. Bioessays 26:752–765PubMedCrossRefPubMedCentralGoogle Scholar
  94. Jongsuksuntigul P (2002) Parasitic diseases in Northeast Thailand. In: Seminar in parasitic diseases in Northeast Thailand. Klang Nana Tham, Khon Kaen, pp 3–18Google Scholar
  95. Jongsuksuntigul P, Imsomboon T (2003) Opisthorchiasis control in Thailand. Acta Trop 88:229–232PubMedCrossRefPubMedCentralGoogle Scholar
  96. Jongsuksuntigul P, Chaychumsri W, Techamontrikul P, Cheeradit P, Suratawanich P (1992) Studies on prevalence and intensity of intestinal helminthiasis and liver fluke in Thailand in 1991. J Med Assoc Thai 2:80–95Google Scholar
  97. Joo KR, Bang SJ (2005) A bile based study of Clonorchis sinensis infections in patients with biliary tract diseases in Ulsan, Korea. Yonsei Med J 46:794–798PubMedPubMedCentralCrossRefGoogle Scholar
  98. Joo CY, Chung MS, Kim SJ, Kang CM (1997) Changing patterns of Clonorchis sinensis infections in Kyongbuk, Korea. Korean J Parasitol 35:155–164PubMedCrossRefPubMedCentralGoogle Scholar
  99. Ju JW, Joo HN, Lee MR, Cho SH, Cheun HI, Kim JY, Lee YH, Lee KJ, Sohn WM, Kim DM, Kim IC, Park BC, Kim TS (2009) Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory-secretory products of Clonorchis sinensis adult worms. Proteomics 9:3066–3078PubMedCrossRefPubMedCentralGoogle Scholar
  100. Kaewkes S (2003) Taxonomy and biology of liver flukes. Acta Trop 88:177–186PubMedCrossRefPubMedCentralGoogle Scholar
  101. Kaewkes S, Kaewkes W, Boonmars T, Sripa B (2012a) Effect of light intensity on Opisthorchis viverrini cercarial shedding levels from Bithynia snails—a preliminary study. Parasitol Int 61:46–48PubMedCrossRefPubMedCentralGoogle Scholar
  102. Kaewkes W, Kaewkes S, Tesana S, Laha T, Sripa B (2012b) Fecal bacterial contamination in natural water reservoirs as an indicator of seasonal infection by Opisthorchis viverrini in snail intermediate hosts. Parasitol Int 61:49–51PubMedCrossRefPubMedCentralGoogle Scholar
  103. Kaewkong W, Choochote W, Kanla P, Maleewong W, Intapan PM, Wongkham S, Wongkham C (2012a) Chromosomes and karyotype analysis of a liver fluke, Opisthorchis viverrini, by scanning electron microscopy. Parasitol Int 61:504–507PubMedCrossRefPubMedCentralGoogle Scholar
  104. Kaewkong W, Imtawil K, Maleewong W, Intapan PM, Sri-Aroon P, Wongkham S, Wongkham C (2012b) Genome size estimation of liver fluke Opisthorchis viverrini by real-time polymerase chain reaction based method. Parasitol Int 61:77–80PubMedCrossRefPubMedCentralGoogle Scholar
  105. Kaewpitoon N, Kaewpitoon SJ, Ueng-arporn N, Rujirakul R, Churproong S, Matrakool L, Auiwatanagul S, Sripa B (2012) Carcinogenic human liver fluke: current status of Opisthorchis viverrini metacercariae in Nakhon Ratchasima, Thailand. Asian Pac J Cancer Prev 13:1235–1240PubMedCrossRefPubMedCentralGoogle Scholar
  106. Kaewpitoon N, Kootanavanichpong N, Kompor P, Chavenkun W, Kujapun J, Norkaew J, Ponphimai S, Matrakool L, Tongtawee T, Panpimanmas S, Rujirakul R, Padchasuwan N, Pholsripradit P, Eksanti T, Phatisena T, Loyd RA, Kaewpitoon SJ (2015) Review and current status of Opisthorchis viverrini infection at the community level in Thailand. Asian Pac J Cancer Prev 16:6825–6830PubMedCrossRefPubMedCentralGoogle Scholar
  107. Kang TH, Yun DH, Lee EH, Chung YB, Bae YA, Chung JY, Kang I, Kim J, Cho SY, Kong Y (2004) A cathepsin F of adult Clonorchis sinensis and its phylogenetic conservation in trematodes. Parasitology 128:195–207PubMedCrossRefPubMedCentralGoogle Scholar
  108. Kang S, Sultana T, Loktev VB, Wongratanacheewin S, Sohn WM, Eom KS, Park JK (2008) Molecular identification and phylogenetic analysis of nuclear rDNA sequences among three opisthorchid liver fluke species (Opisthorchiidae: Trematoda). Parasitol Int 57:191–197PubMedCrossRefPubMedCentralGoogle Scholar
  109. Katokhin AV, Shekhovtsov SV, Konkow S, Yurlova NI, Serbina EA, Vodianitskai SN, Fedorov KP, Loktev VB, Muratov IV, Ohyama F, Makhnev TV, Pel'tek SE, Mordvinov VA (2008) Assessment of the genetic distinctions of Opisthorchis felineus from O. viverrini and Clonorchis sinensis by ITS2 and CO1 sequences. Dokl Biochem Biophys 421:214–217PubMedCrossRefPubMedCentralGoogle Scholar
  110. Keiser J, Utzinger J (2005) Emerging foodborne trematodiasis. Emerg Infect Dis 11:1507–1514PubMedCrossRefGoogle Scholar
  111. Kenny PA, Bissell MJ (2003) Tumor reversion: correction of malignant behavior by microenvironmental cues. Int J Cancer 107:688–695PubMedCrossRefGoogle Scholar
  112. Khampoosa P, Jones MK, Lovas EM, Piratae S, Kulsuntiwong J, Prasopdee S, Srisawangwong T, Laha T, Sripanidkulchai B, Thitapakorn V, Tesana S (2018) Egg-hatching mechanism of human liver fluke, Opisthorchis viverrini: a role for leucine aminopeptidases from the snail host, Bithynia siamensis goniomphalos. J Parasitol 104:388–397PubMedCrossRefGoogle Scholar
  113. Khan SA, Miras A, Pelling M, Taylor-Robinson SD (2007) Cholangiocarcinoma and its management. Gut 56:1755–1756PubMedPubMedCentralCrossRefGoogle Scholar
  114. Khuntikeo N, Sithithaworn P, Loilom W, Namwat N, Yongvanit P, Thinkhamrop B, Kiatsopit N, Andrews RH, Petney TN (2016) Changing patterns of prevalence in Opisthorchis viverrini sensu lato infection in children and adolescents in northeast Thailand. Acta Trop 164:469–472PubMedCrossRefGoogle Scholar
  115. Khuntikeo N, Thinkhamrop B, Bundhamcharoen K, Andrews RH, Grundy-Warr C, Yongvanit P, Loilome W, Chamadol N, Kosuwan W, Sithithaworn P, Petney TN (2018) The socioeconomic burden of cholangiocarcinoma associated with Opisthorchis viverrini sensu lato infection in northeast Thailand: a preliminary analysis. Adv Parasitol 102:141–163PubMedCrossRefGoogle Scholar
  116. Kiatsopit N, Sithithaworn P, Sithithaworn J, Boonmars T, Tesana S, Pitaksakulrat O, Saijuntha W, Petney TN, Andrews RH (2011) Genetic relationships within the Opisthorchis viverrini species complex with specific analysis of O. viverrini from Savannakhet, Lao PDR by multilocus enzyme electrophoresis. Parasitol Res 108:211–217PubMedCrossRefGoogle Scholar
  117. Kiatsopit N, Sithithaworn P, Saijuntha W, Boonmars T, Tesana S, Sithithaworn J, Petney TN, Andrews RH (2012) Exceptionally high prevalence of infection of Bithynia siamensis goniomphalos with Opisthorchis viverrini cercariae in different wetlands in Thailand and Lao PDR. Am J Trop Med Hyg 86:464–469PubMedCrossRefPubMedCentralGoogle Scholar
  118. Kiatsopit N, Sithithaworn P, Saijuntha W, Petney TN, Andrews RH (2013) Opisthorchis viverrini: implications of the systematics of first intermediate hosts, Bithynia snail species in Thailand and Lao PDR. Infect Genet Evol 14:313–319PubMedCrossRefGoogle Scholar
  119. Kiatsopit N, Sithithaworn P, Saijuntha W, Pitaksakulrat O, Petney TN, Webster JP, Andrews RH (2014) Analysis of the population genetics of Opisthorchis viverrini sensu lato in the Nam Ngum River wetland, Lao PDR, by multilocus enzyme electrophoresis. Parasitol Res 113:2973–2981PubMedCrossRefGoogle Scholar
  120. Kim YI, Yu ES, Kim ST (1989) Intraductal variant of peripheral cholangiocarcinoma of the liver with Clonorchis sinensis infection. Cancer 63:1562–1566PubMedCrossRefGoogle Scholar
  121. Kim TI, Na BK, Hong SJ (2009a) Functional genes and proteins of Clonorchis sinensis. Korean J Parasitol 47(Suppl):S59–S68PubMedCrossRefGoogle Scholar
  122. Kim TS, Cho SH, Huh S, Kong Y, Sohn WM, Hwang SS, Chai JY, Lee SH, Park YK, Oh DK, Lee JK, Working Groups in National Institute of Health, Korea Association of Health, Promotion (2009b) A nationwide survey on the prevalence of intestinal parasitic infections in the Republic of Korea, 2004. Korean J Parasitol 47:37–47PubMedCrossRefPubMedCentralGoogle Scholar
  123. Kim TY, Lee YS, Yun JH, Kim JJ, Choi WH, Oh IH, Song HO, Chu JP (2010) A case of probable mixed-infection with Clonorchis sinensis and Fasciola sp.: CT and parasitological findings. Korean J Parasitol 48:157–160PubMedCrossRefGoogle Scholar
  124. Kim JH, Choi MH, Bae YM, Oh JK, Lim MK, Hong ST (2011) Correlation between discharged worms and fecal egg counts in human clonorchiasis. PLoS Negl Trop Dis 5:e1339PubMedCrossRefGoogle Scholar
  125. King S, Scholz T (2001) Trematodes of the family Opisthorchiidae: a minireview. Korean J Parasitol 39:209–221PubMedCrossRefGoogle Scholar
  126. Kirby GM, Pelkonen P, Vatanasapt V, Camus AM, Wild CP, Lang MA (1994) Association of liver fluke (Opisthorchis viverrini) infestation with increased expression of cytochrome P450 and carcinogen metabolism in male hamster liver. Mol Carcinog 11:81–89PubMedCrossRefGoogle Scholar
  127. Kobayashi J, Vannachone B, Xeutvongsa A, Manivang K, Ogawa S, Sato Y, Pholsena K (1996) Prevalence of intestinal parasitic infection among children in two villages in Lao PDR. Southeast Asian J Trop Med Public Health 27:562–565PubMedGoogle Scholar
  128. Kobayashi J, Vannachone B, Sato Y, Manivong K, Nambanya S, Inthakone S (2000) An epidemiological study on Opisthorchis viverrini infection in Lao villages. Southeast Asian J Trop Med Public Health 31:128–132PubMedGoogle Scholar
  129. Komalamisra C (1999) Chromosomes and C-banding of Opisthorchis viverrini. Southeast Asian J Trop Med Public Health 30:576–579PubMedGoogle Scholar
  130. Kwon YD, Cho PY, Hong SJ (2005) Clonorchis sinensis: molecular cloning and localization of myosin regulatory light chain. Parasitol Res 97:21–26PubMedCrossRefGoogle Scholar
  131. Laha T, Pinlaor P, Mulvenna J, Sripa B, Sripa M, Smout MJ, Gasser RB, Brindley PJ, Loukas A (2007) Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini. BMC Genomics 8:189PubMedPubMedCentralCrossRefGoogle Scholar
  132. Lai DH, Wang QP, Chen W, Cai LS, Wu ZD, Zhu XQ, Lun ZR (2008) Molecular genetic profiles among individual Clonorchis sinensis adults collected from cats in two geographic regions of China revealed by RAPD and MGE-PCR methods. Acta Trop 107:213–216PubMedCrossRefGoogle Scholar
  133. Lai DH, Hong XK, Su BX, Liang C, Hide G, Zhang X, Yu X, Lun ZR (2016) Current status of Clonorchis sinensis and clonorchiasis in China. Trans R Soc Trop Med Hyg 110:21–27PubMedCrossRefGoogle Scholar
  134. Laithavewat L, Grundy-Warr C, Khuntikeo N, Andrews RH, Petney TN, Yongvanit P, Banchonhattakit P, Sithithaworn P (2018) Analysis of a school-based health education model to prevent opisthorchiasis and cholangiocarcinoma in primary school children in northeast Thailand. Glob Health Promot.  https://doi.org/10.1177/1757975918767622
  135. Lan-Anh NT, Phuong NT, Murrell KD, Johansen MV, Dalsgaard A, Thu LT, Kim-Chi TT, Thamsborg SM (2009) Animal reservoir hosts and fish-borne zoonotic trematode infections on fish farms, Vietnam. Emerg Infect Dis 15:540–546PubMedCrossRefGoogle Scholar
  136. Laoprom N, Saijuntha W, Sithithaworn P, Wongkham S, Laha T, Ando K, Andrews RH, Petney TN (2009) Biological variation within Opisthorchis viverrini sensu lato in Thailand and Lao PDR. J Parasitol 95:1307–1313PubMedCrossRefGoogle Scholar
  137. Laoprom N, Sithithaworn P, Ando K, Sithithaworn J, Wongkham S, Laha T, Klinbunga S, Webster JP, Andrews RH (2010) Microsatellite loci in the carcinogenic liver fluke, Opisthorchis viverrini and their application as population genetic markers. Infect Genet Evol 10:146–153PubMedCrossRefGoogle Scholar
  138. Laoprom N, Sithithaworn P, Andrews RH, Ando K, Laha T, Klinbunga S, Webster JP, Petney TN (2012) Population genetic structuring in Opisthorchis viverrini over various spatial scales in Thailand and Lao PDR. PLoS Negl Trop Dis 6:e1906PubMedPubMedCentralCrossRefGoogle Scholar
  139. Laoprom N, Kiatsopit N, Sithithaworn P, Kopolrat K, Namsanor J, Andrews RH, Petney TN (2016) Cercarial emergence patterns for Opisthorchis viverrini sensu lato infecting Bithynia siamensis goniomphalos from Sakon Nakhon Province, Thailand. Parasitol Res 115:3313–3321PubMedCrossRefGoogle Scholar
  140. Lazutkina EA, Andreyev NI, Andreyeva SI, Gloer P, Vinarski MV (2009) On the taxonomic state of Bithynia troschelii var. sibirica Westerlund, 1886, a Siberian endemic bithyniid snail (Gastropoda: Bithyniidae). Mollusca 27:113–122Google Scholar
  141. Le TH, Van De N, Blair D, Sithithaworn P, McManus DP (2006) Clonorchis sinensis and Opisthorchis viverrini: development of a mitochondrial-based multiplex PCR for their identification and discrimination. Exp Parasitol 112:109–114PubMedCrossRefGoogle Scholar
  142. Le TH, Nguyen NT, Truong NH, De NV (2012) Development of mitochondrial loop-mediated isothermal amplification for detection of the small liver fluke Opisthorchis viverrini (Opisthorchiidae; Trematoda; Platyhelminthes). J Clin Microbiol 50:1178–1184PubMedPubMedCentralCrossRefGoogle Scholar
  143. Lee SU, Huh S (2004) Variation of nuclear and mitochondrial DNAs in Korean and Chinese isolates of Clonorchis sinensis. Korean J Parasitol 42:145–148PubMedPubMedCentralCrossRefGoogle Scholar
  144. Lee JH, Rim HJ, Bak UB (1993) Effect of Clonorchis sinensis infection and dimethylnitrosamine administration on the induction of cholangiocarcinoma in Syrian golden hamsters. Korean J Parasitol 31:21–30PubMedCrossRefGoogle Scholar
  145. Lee JH, Yang HM, Bak UB, Rim HJ (1994) Promoting role of Clonorchis sinensis infection on induction of cholangiocarcinoma during two-step carcinogenesis. Korean J Parasitol 32:13–18PubMedCrossRefGoogle Scholar
  146. Lee JS, Kim IS, Sohn WM, Lee J, Yong TS (2006) Vaccination with DNA encoding cysteine proteinase confers protective immune response to rats infected with Clonorchis sinensis. Vaccine 24:2358–2366PubMedCrossRefGoogle Scholar
  147. Leiper RT (1915) Notes of the occurrence of parasites presumably rare in man. J R Army Med Corps 24:569–575Google Scholar
  148. Li S, Shin JG, Cho PY, Kim TI, Hong ST, Hong SJ (2011) Multiple recombinant antigens of Clonorchis sinensis for serodiagnosis of human clonorchiasis. Parasitol Res 108:1295–1302PubMedCrossRefGoogle Scholar
  149. Li Y, Hu X, Liu X, Huang Y, Xu J, Zhao J, Wu Z, Yu X (2012) Serological diagnosis of clonorchiasis: using a recombinant propeptide of cathepsin L proteinase from Clonorchis sinensis as a candidate antigen. Parasitol Res 110:2197–2203PubMedCrossRefGoogle Scholar
  150. Lin R, Li X, Lan C, Yu S, Kawanaka M (2005) Investigation on the epidemiological factors of Clonorchis sinensis infection in an area of south China. Southeast Asian J Trop Med Public Health 36:1114–1117PubMedGoogle Scholar
  151. Liu WQ, Liu J, Zhang JH, Long XC, Lei JH, Li YL (2007) Comparison of ancient and modern Clonorchis sinensis based on ITS1 and ITS2 sequences. Acta Trop 101:91–94PubMedCrossRefGoogle Scholar
  152. Liu GH, Li B, Li JY, Song HQ, Lin RQ, Cai XQ, Zou FC, Yan HK, Yuan ZG, Zhou DH, Zhu XQ (2012) Genetic variation among Clonorchis sinensis isolates from different geographic regions in China revealed by sequence analyses of four mitochondrial genes. J Helminthol 86:479–484PubMedCrossRefGoogle Scholar
  153. Lohachit C (2004-2005) Ecological studies of Bithynia siamensis goniomphalos, a snail intermediate host of Opisthorchis viverrini, in Khon Kaen Province, Northeast Thailand. Malacol Rev 37(38):1–26Google Scholar
  154. Looss A (1907) On some parasites in the museum of the School of Tropical Medicine, Liverpool. Ann Trop Med Parasitol 1:123–152CrossRefGoogle Scholar
  155. Lovis L, Mak TK, Phongluxa K, Soukhathammavong P, Sayasone S, Akkhavong K, Odermatt P, Keiser J, Felger I (2009) PCR diagnosis of Opisthorchis viverrini and Haplorchis taichui infections in a Lao community in an area of endemicity and comparison of diagnostic methods for parasitological field surveys. J Clin Microbiol 47:1517–1523PubMedPubMedCentralCrossRefGoogle Scholar
  156. Lovis L, Mak TK, Phongluxa K, Aye Soukhathammavong P, Vonghachack Y, Keiser J, Vounatsou P, Tanner M, Hatz C, Utzinger J, Odermatt P, Akkhavong K (2012) Efficacy of praziquantel against Schistosoma mekongi and Opisthorchis viverrini: a randomized, single-blinded dose-comparison trial. PLoS Negl Trop Dis 6:e1726PubMedPubMedCentralCrossRefGoogle Scholar
  157. Lowe S, Browne M, Boudjelas S, De Poorter M (2000) 100 of the World’s Worst Invasive Alien Species A selection from the Global Invasive Species Database. In: The Invasive Species Specialist Group (ISSG) a specialist group of the Species Survival Commission (SSC) of the World Conservation Union (IUCN). Hollands Printing Ltd, AucklandGoogle Scholar
  158. Lun ZR, Gasser RB, Lai DH, Li AX, Zhu XQ, Yu XB, Fang YY (2005) Clonorchiasis: a key foodborne zoonosis in China. Lancet Infect Dis 5:31–41PubMedCrossRefGoogle Scholar
  159. Mairiang E, Elkins DB, Mairiang P, Chaiyakum J, Chamadol N, Loapaiboon V, Posri S, Sithithaworn P, Haswell-Elkins M (1992) Relationship between intensity of Opisthorchis viverrini infection and hepatobiliary disease detected by ultrasonography. J Gastroenterol Hepatol 7:17–21PubMedCrossRefGoogle Scholar
  160. Mairiang E, Laha T, Bethony JM, Thinkhamrop B, Kaewkes S, Sithithaworn P, Tesana S, Loukas A, Brindley PJ, Sripa B (2012) Ultrasonography assessment of hepatobiliary abnormalities in 3359 subjects with Opisthorchis viverrini infection in endemic areas of Thailand. Parasitol Int 61:208–211PubMedCrossRefGoogle Scholar
  161. Manivong K, Komalamisra C, Waikagul J, Radomyos P (2009) Opisthorchis viverrini metacercariae in cyprinoid fish from three rivers in Khammouane Province, Lao PDR. J Trop Med Parasitol 32:23–29Google Scholar
  162. Mas-Coma S, Bargues MD (1997) Human liver flukes: a review. Res Rev Parasitol 57:144–225Google Scholar
  163. Mazidur Rahman SM, Choi MH, Bae YM, Hong ST (2012) Coproantigen capture ELISA for detection of Clonorchis sinensis infection in experimentally infected rats. Parasitol Int 61:203–207PubMedCrossRefPubMedCentralGoogle Scholar
  164. Miyamoto K, Kirinoki M, Matsuda H, Hayashi N, Chigusa Y, Sinuon M, Chuor CM, Kitikoon V (2014) Field survey focused on Opisthorchis viverrini infection in five provinces of Cambodia. Parasitol Int 63:366–373PubMedCrossRefGoogle Scholar
  165. Molina CD, Molina MM, Molina JM (1988) Intestinal parasites in southeast Asian refugees two years after immigration. West J Med 149:422–425PubMedPubMedCentralGoogle Scholar
  166. Mordvinov VA, Yurlova NI, Ogorodova LM, Katokhin AV (2012) Opisthorchis felineus and Metorchis bilis are the main agents of liver fluke infection of humans in Russia. Parasitol Int 61:25–31PubMedCrossRefPubMedCentralGoogle Scholar
  167. Mulvenna J, Sripa B, Brindley PJ, Gorman J, Jones MK, Colgrave ML, Jones A, Nawaratna S, Laha T, Suttiprapa S, Smout MJ, Loukas A (2010) The secreted and surface proteomes of the adult stage of the carcinogenic human liver fluke Opisthorchis viverrini. Proteomics 10:1063–1078PubMedPubMedCentralGoogle Scholar
  168. Nagano I, Pei F, Wu Z, Wu J, Cui H, Boonmars T, Takahashi Y (2004) Molecular expression of a cysteine proteinase of Clonorchis sinensis and its application to an enzyme-linked immunosorbent assay for immunodiagnosis of clonorchiasis. Clin Diagn Lab Immunol 11:411–416PubMedPubMedCentralGoogle Scholar
  169. Nakeeb A, Pitt HA, Sohn TA, Coleman J, Abrams RA, Piantadosi S, Hruban RH, Lillemoe KD, Yeo CJ, Cameron JL (1996) Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumors. Ann Surg 224:463–473PubMedPubMedCentralCrossRefGoogle Scholar
  170. Namsanor J, Sithithaworn P, Kopolrat K, Kiatsopit N, Pitaksakulrat O, Tesana S, Andrews RH, Petney TN (2015) Seasonal transmission of Opisthorchis viverrini sensu lato and a Lecithodendriid trematode species in Bithynia siamensis goniomphalos snails in Northeast Thailand. Am J Trop Med Hyg 93:87–93PubMedPubMedCentralCrossRefGoogle Scholar
  171. Nawa Y, Doanh PN, Thaenkham U (2015) Is Opisthorchis viverrini an avian liver fluke? J Helminthol 89:255–256PubMedCrossRefGoogle Scholar
  172. Naylor RL, Goldburg RJ, Primavera JH, Kautsky N, Beveridge MC, Clay J, Folke C, Lubchenco J, Mooney H, Troell M (2000) Effect of aquaculture on world fish supplies. Nature 405:1017–1024PubMedCrossRefGoogle Scholar
  173. Ngern-klun R, Sukontason KL, Tesana S, Sripakdee D, Irvine KN, Sukontason K (2006) Field investigation of Bithynia funiculata, intermediate host of Opisthorchis viverrini in northern Thailand. Southeast Asian J Trop Med Publ Health 37:662–672Google Scholar
  174. Ngoen-Klan R, Piangjai S, Somwang P, Moophayak K, Sukontason K, Sukontason KL, Sampson M, Irvine K (2010) Emerging helminths infection in snails and cyprinoid fish in sewage treatment wetlands waters in Cambodia. Asian J Water Environ Pollut 7:13–21Google Scholar
  175. Nguyen TT, Arimatsu Y, Hong SJ, Brindley PJ, Blair D, Laha T, Sripa B (2015) Genome-wide characterization of microsatellites and marker development in the carcinogenic liver fluke Clonorchis sinensis. Parasitol Res 114:2263–2272PubMedPubMedCentralCrossRefGoogle Scholar
  176. Ogorodova LM, Freidin MB, Sazonov AE, Fedorova OS, Gerbek IE, Cherevko NA, Lebedeva NY (2007) A pilot screening of prevalence of atopic states and opisthorchosis and their relationship in people of Tomsk Oblast. Parasitol Res 101:1165–1168PubMedCrossRefPubMedCentralGoogle Scholar
  177. Ohshima H, Bartsch H (1994) Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat Res 305:253–264PubMedCrossRefPubMedCentralGoogle Scholar
  178. Onsurathum S, Pinlaor P, Charoensuk L, Haonon O, Chaidee A, Intuyod K, Laummaunwai P, Boonmars T, Kaewkes W, Pinlaor S (2016a) Contamination of Opisthorchis viverrini and Haplorchis taichui metacercariae in fermented fish products in northeastern Thailand markets. Food Control 59:493–498CrossRefGoogle Scholar
  179. Onsurathum S, Pinlaor P, Haonon O, Chaidee A, Charoensuk L, Intuyod K, Boonmars T, Laummaunwai P, Pinlaor S (2016b) Effects of fermentation time and low temperature during the production process of Thai pickled fish (pla-som) on the viability and infectivity of Opisthorchis viverrini metacercariae. Int J Food Microbiol 218:1–5PubMedCrossRefPubMedCentralGoogle Scholar
  180. Park GM (2007) Genetic comparison of liver flukes, Clonorchis sinensis and Opisthorchis viverrini, based on rDNA and mtDNA gene sequences. Parasitol Res 100:351–357PubMedCrossRefPubMedCentralGoogle Scholar
  181. Park GM, Yong TS (2001) Geographical variation of the liver fluke, Clonorchis sinensis, from Korea and China based on the karyotypes, zymodeme and DNA sequences. Southeast Asian J Trop Med Publ Health 32(Suppl 2):12–16Google Scholar
  182. Park GM, Im K, Huh S, Yong TS (2000a) Chromosomes of the liver fluke, Clonorchis sinensis. Korean J Parasitol 38:201–206PubMedPubMedCentralCrossRefGoogle Scholar
  183. Park GM, Yong TS, Im K, Lee KJ (2000b) Isozyme electrophoresis patterns of the liver fluke, Clonorchis sinensis from Kimhae, Korea and from Shenyang, China. Korean J Parasitol 38:45–48PubMedPubMedCentralCrossRefGoogle Scholar
  184. Parkin DM (2006) The global health burden of infection-associated cancers in the year 2002. Int J Cancer 118:3030–3044PubMedCrossRefPubMedCentralGoogle Scholar
  185. Parkin DM, Srivatanakul P, Khlat M, Chenvidhya D, Chotiwan P, Insiripong S, L'Abbe KA, Wild CP (1991) Liver cancer in Thailand. I. A case-control study of cholangiocarcinoma. Int J Cancer 48:323–328PubMedCrossRefPubMedCentralGoogle Scholar
  186. Parkin DM, Ohshima H, Srivatanakul P, Vatanasapt V (1993) Cholangiocarcinoma: epidemiology, mechanisms of carcinogenesis and prevention. Cancer Epidemiol Biomarkers Prev 2:537–544PubMedPubMedCentralGoogle Scholar
  187. Parvathi A, Sanath Kumar H, Kenchanna Prakasha B, Lu J, Xu X, Hu W, Feng Z, Karunasagar I, Karunasagar I (2007) Clonorchis sinensis: development and evaluation of a nested polymerase chain reaction (PCR) assay. Exp Parasitol 115:291–295PubMedCrossRefPubMedCentralGoogle Scholar
  188. Parvathi A, Umesha KR, Kumar S, Sithithaworn P, Karunasagar I, Karunasagar I (2008) Development and evaluation of a polymerase chain reaction (PCR) assay for the detection of Opisthorchis viverrini in fish. Acta Trop 107:13–16PubMedCrossRefPubMedCentralGoogle Scholar
  189. Patz JA, Githeko AK, McCarty JP, Hussein S, Confalonieri U, de Wet N (2003) Climate change and infectious diseases. In: McMichael AJ, Campbell-Lendrum DH, Corvalán CF, Ebi KL, Githeko A, Scheraga JD, Woodward A (eds) Climate change and human health: risks and responses. World Health Organization, Malta, pp 103–132Google Scholar
  190. Patz JA, Daszak P, Tabor GM, Aguirre AA, Pearl M, Epstein J, Wolfe ND, Kilpatrick AM, Foufopoulos J, Molyneux D, Bradley DJ, Members of the Working Group on Land Use Change and Disease Emergence (2004) Unhealthy landscapes: Policy recommendations on land use change and infectious disease emergence. Environ Health Perspect 112:1092–1098PubMedPubMedCentralCrossRefGoogle Scholar
  191. Pauly A, Schuster R, Steuber S (2003) Molecular characterization and differentiation of opisthorchiid trematodes of the species Opisthorchis felineus (Rivolta, 1884) and Metorchis bilis (Braun, 1790) using polymerase chain reaction. Parasitol Res 90:409–414PubMedCrossRefPubMedCentralGoogle Scholar
  192. Petney TN, Andrews RH (1998) Multiparasite communities in animals and humans: frequency, structure and pathogenic significance. Int J Parasitol 28:377–393PubMedCrossRefPubMedCentralGoogle Scholar
  193. Petney T, Sithithaworn P, Andrews R, Kiatsopit N, Tesana S, Grundy-Warr C, Ziegler A (2012) The ecology of the Bithynia first intermediate hosts of Opisthorchis viverrini. Parasitol Int 61:38–45PubMedCrossRefPubMedCentralGoogle Scholar
  194. Petney TN, Andrews RH, Saijuntha W, Wenz-Mucke A, Sithithaworn P (2013) The zoonotic, fish-borne liver flukes Clonorchis sinensis, Opisthorchis felineus and Opisthorchis viverrini. Int J Parasitol 43:1031–1046PubMedCrossRefPubMedCentralGoogle Scholar
  195. Petney TN, Andrews RH, Saijuntha W, Tesana S, Prasopdee S, Kiatsopit N, Sithithaworn P (2018) Taxonomy, ecology and population genetics of Opisthorchis viverrini and its intermediate hosts. Adv Parasitol 101:1–39PubMedCrossRefPubMedCentralGoogle Scholar
  196. Phalee A, Wongsawad C, Chuboon S (2008) Occurrence of Metacercariae in Cyprinoid Fish from Khumtakla District, Sakonnakorn Province. In: 34th Congress on Science and Technology of Thailand. Queen Sirikit National Convention Center, ThailandGoogle Scholar
  197. Phan VT, Ersboll AK, Nguyen KV, Madsen H, Dalsgaard A (2010a) Farm-level risk factors for fish-borne zoonotic trematode infection in integrated small-scale fish farms in northern Vietnam. PLoS Negl Trop Dis 4:e742PubMedPubMedCentralCrossRefGoogle Scholar
  198. Phan VT, Ersboll AK, Nguyen TT, Nguyen KV, Nguyen HT, Murrell D, Dalsgaard A (2010b) Freshwater aquaculture nurseries and infection of fish with zoonotic trematodes, Vietnam. Emerg Infect Dis 16:1905–1909PubMedPubMedCentralCrossRefGoogle Scholar
  199. Phung LT, Loukas A, Brindley PJ, Sripa B, Laha T (2014) Retrotransposon OV-RTE-1 from the carcinogenic liver flukes Opisthorchis viverrini: Potential target for DNA-based diagnosis. Infect Genet Evol 21:443–451PubMedCentralCrossRefGoogle Scholar
  200. Pinlaor S, Prakobwong S, Hiraku Y, Kaewsamut B, Dechakhamphu S, Boonmars T, Sithithaworn P, Pinlaor P, Ma N, Yongvanit P, Kawanishi S (2008) Oxidative and nitrative stress in Opisthorchis viverrini-infected hamsters: an indirect effect after praziquantel treatment. Am J Trop Med Hyg 78:564–573PubMedCrossRefPubMedCentralGoogle Scholar
  201. Pinlaor S, Onsurathum S, Boonmars T, Pinlaor P, Hongsrichan N, Chaidee A, Haonon O, Limviroj W, Tesana S, Kaewkes S, Sithithaworn P (2013) Distribution and abundance of Opisthorchis viverrini metacercariae in cyprinid fish in Northeastern Thailand. Korean J Parasitol 51:703–710PubMedPubMedCentralCrossRefGoogle Scholar
  202. Pitaksakulrat O, Sithithaworn P, Laoprom N, Laha T, Petney TN, Andrews RH (2013) A cross-sectional study on the potential transmission of the carcinogenic liver fluke Opisthorchis viverrini and other fishborne zoonotic trematodes by aquaculture fish. Foodborne Pathog Dis 10:35–41PubMedCrossRefPubMedCentralGoogle Scholar
  203. Pitaksakulrat O, Webster BL, Webster JP, Laha T, Saijuntha W, Lamberton PHL, Kiatsopit N, Andrews RH, Petney TN, Sithithaworn P (2018) Phylogenetic relationships within the Opisthorchis viverrini species complex with specific analysis of O. viverrini sensu lato from Sakon Nakhon, Thailand by mitochondrial and nuclear DNA sequencing. Infect Genet Evol 62:86–94PubMedCrossRefPubMedCentralGoogle Scholar
  204. Poirier MJ (1886) Trematodes nouveaux ou peu connus. Bull Soc Philom 7:20–40Google Scholar
  205. Polyakov AV, Katokhin AV, Bocharova TA, Romanov KV, L'vova MN, Bonina OM, Yurlova NI, Mordvinov VA (2010) Comparative analysis of karyotypes of Opisthorchis felineus from West Siberia. Contemp Probl Ecol 3:1–3CrossRefGoogle Scholar
  206. Poopyruchpong N, Viyanant V, Upatham ES, Srivatanakul P (1990) Diagnosis of opisthorchiasis by enzyme-linked immunosorbent assay using partially purified antigens. Asian Pac J Allergy Immunol 8:27–31PubMedPubMedCentralGoogle Scholar
  207. Pozio E, Armignacco O, Ferri F, Gomez Morales MA (2013) Opisthorchis felineus, an emerging infection in Italy and its implication for the European Union. Acta Trop 126:54–62PubMedCrossRefPubMedCentralGoogle Scholar
  208. Prakobwong S, Suwannatrai A, Sancomerang A, Chaipibool S, Siriwechtumrong N (2017) A large scale study of the epidemiology and risk factors for the carcinogenic liver fluke Opisthorchis viverrini in Udon Thani Province, Thailand. Asian Pac J Cancer Prev 18:2853–2860PubMedPubMedCentralGoogle Scholar
  209. Prasopdee S, Kulsantiwong J, Piratae S, Khampoosa P, Thammasiri C, Suwannatrai A, Laha T, Grams R, Loukas A, Tesana S (2015) Temperature dependence of Opisthorchis viverrini infection in first intermediate host snail, Bithynia siamensis goniomphalos. Acta Trop 141:112–117PubMedCrossRefPubMedCentralGoogle Scholar
  210. Prommas C (1927) Report of a case of Opisthorchis felineus in siam. Ann Trop Med Parasitol 21:9–10CrossRefGoogle Scholar
  211. Pumidonming W, Katahira H, Igarashi M, Salman D, Abdelbaset AE, Sangkaeo K (2018) Potential risk of a liver fluke Opisthorchis viverrini infection brought by immigrants from prevalent areas: a case study in the lower Northern Thailand. Acta Trop 178:213–218PubMedCrossRefPubMedCentralGoogle Scholar
  212. Qian MB, Chen YD, Yan F (2013) Time to tackle clonorchiasis in China. Infect Dis Poverty 2:4PubMedPubMedCentralCrossRefGoogle Scholar
  213. Qiao T, Zheng PM, Ma RH, Luo XB, Luo ZL (2012) Development of a real-time PCR assay for the detection of Clonorchis sinensis DNA in gallbladder bile and stone samples from patients with cholecystolithiasis. Parasitol Res 111:1497–1503PubMedCrossRefGoogle Scholar
  214. Radomyos P, Radomyos B, Tungtrongchitr A (1994) Multi-infection with helminths in adults from northeast Thailand as determined by post-treatment fecal examination of adult worms. Trop Med Parasitol 45:133–135PubMedGoogle Scholar
  215. Rahman SM, Bae YM, Hong ST, Choi MH (2011) Early detection and estimation of infection burden by real-time PCR in rats experimentally infected with Clonorchis sinensis. Parasitol Res 109:297–303PubMedCrossRefGoogle Scholar
  216. Ramsay RJ, Sithithaworn P, Prociv P, Moorhouse DE, Methaphat C (1989) Density-dependent fecundity of Opisthorchis viverrini in humans, based on faecal recovery of flukes. Trans R Soc Trop Med Hyg 83:241–242PubMedCrossRefPubMedCentralGoogle Scholar
  217. Riganti M, Pungpak S, Punpoowong B, Bunnag D, Harinasuta T (1989) Human pathology of Opisthorchis viverrini infection: a comparison of adults and children. Southeast Asian J Trop Med Publ Health 20:95–100Google Scholar
  218. Rim HJ (2005) Clonorchiasis: an update. J Helminthol 79:269–281PubMedCrossRefPubMedCentralGoogle Scholar
  219. Rim HJ, Yoo KS (1979) Chemotherapeutic effect of praziquantel (Embay 8440) in the treatment of Clonorchiasis sinensis. Korea Univ Med J 16:459–470Google Scholar
  220. Rim HJ, Sohn WM, Yong TS, Eom KS, Chai JY, Min DY, Lee SH, Hoang EH, Phommasack B, Insisengmay S (2008) Fishborne trematode metacercariae detected in freshwater fish from Vientiane Municipality and Savannakhet Province, Lao PDR. Korean J Parasitol 46:253–260PubMedPubMedCentralCrossRefGoogle Scholar
  221. Rim HJ, Sohn WM, Yong TS, Eom KS, Chai JY, Min DY, Lee SH, Hoang EH, Phommasack B, Insisiengmay S (2013) Fishborne trematode metacercariae in Luang Prabang, Khammouane, and Saravane Province, Lao PDR. Korean J Parasitol 51:107–114PubMedPubMedCentralCrossRefGoogle Scholar
  222. Rivolta S (1884) Sopra una specie di Distoma nel gatto e nel cane. Giorn Anat Fisiol Patol Anim 16:20–28Google Scholar
  223. Ruangkunaporn Y, Akai PS, Chongsa-nguan M, Sri-Yeythong S, Kitikoon V, Chaicumpa W (1994) Changes in serum antibodies to Opisthorchis viverrini in humans and hamsters following treatment of opisthorchiasis. Asian Pac J Allergy Immunol 12:83–84PubMedPubMedCentralGoogle Scholar
  224. Ruangsittichai J, Viyanant V, Vichasri-Grams S, Sobhon P, Tesana S, Upatham ES, Hofmann A, Korge G, Grams R (2006) Opisthorchis viverrini: identification of a glycine-tyrosine rich eggshell protein and its potential as a diagnostic tool for human opisthorchiasis. Int J Parasitol 36:1329–1339PubMedCrossRefPubMedCentralGoogle Scholar
  225. Sadun EH (1955) Studies on Opisthorchis viverrini in Thailand. Am J Hyg 62:81–115PubMedPubMedCentralGoogle Scholar
  226. Saijuntha W, Sithithaworn P, Wongkham S, Laha T, Pipitgool V, Petney TN, Andrews RH (2006a) Genetic markers for the identification and characterization of Opisthorchis viverrini, a medically important food borne trematode in Southeast Asia. Acta Trop 100:246–251PubMedPubMedCentralCrossRefGoogle Scholar
  227. Saijuntha W, Sithithaworn P, Wongkham S, Laha T, Pipitgool V, Petney TN, Chilton NB, Andrews RH (2006b) Enzyme markers to identify and characterize Opisthorchis viverrini in Thailand and Lao PDR. Southeast Asian J Trop Med Publ Health 37(Suppl 3):43–47Google Scholar
  228. Saijuntha W, Sithithaworn P, Wongkham S, Laha T, Pipitgool V, Tesana S, Chilton NB, Petney TN, Andrews RH (2007) Evidence of a species complex within the food-borne trematode Opisthorchis viverrini and possible co-evolution with their first intermediate hosts. Int J Parasitol 37:695–703PubMedPubMedCentralCrossRefGoogle Scholar
  229. Saijuntha W, Sithithaworn P, Wongkham S, Laha T, Satrawaha R, Chilton NB, Petney TN, Andrews RH (2008) Genetic variation at three enzyme loci within a Thailand population of Opisthorchis viverrini. Parasitol Res 103:1283–1287PubMedPubMedCentralCrossRefGoogle Scholar
  230. Saijuntha W, Sithithaworn P, Chilton NB, Petney TN, Klinbunga S, Satrawaha R, Webster JP, Andrews RH (2009) Impact of temporal changes and host factors on the genetic structure of a population of Opisthorchis viverrini sensu lato in Khon Kaen Province (Thailand). Parasitology 136:1057–1063PubMedCrossRefGoogle Scholar
  231. Saijuntha W, Duenngai K, Tangkawattana S, Petney TN, Andrews RH, Sithithaworn P (2018) Recent advances in the diagnosis and detection of Opisthorchis viverrini sensu lato in human and intermediate hosts for use in control and elimination programs. Adv Parasitol 101:177–214PubMedCrossRefGoogle Scholar
  232. Saksirisampant W, Wiwanitkit V, Akrabovorn P, Nuchprayoon S (2002) Parasitic infections in Thai workers that pursue overseas employment: the need for a screening program. Southeast Asian J Trop Med Publ Health 33(Suppl 3):110–112Google Scholar
  233. Sanpool O, Intapan PM, Thanchomnang T, Janwan P, Lulitanond V, Doanh PN, Van Hien H, Dung do T, Maleewong W, Nawa Y (2012) Rapid detection and differentiation of Clonorchis sinensis and Opisthorchis viverrini eggs in human fecal samples using a duplex real-time fluorescence resonance energy transfer PCR and melting curve analysis. Parasitol Res 111:89–96PubMedCrossRefPubMedCentralGoogle Scholar
  234. Sanpool O, Aung WPP, Rodpai R, Maleewong W, Intapan PM (2018) Human liver fluke Opisthorchis viverrini (Trematoda, Opisthorchiidae) in Central Myanmar: new records of adults and metacercariae identified by morphology and molecular analysis. Acta Trop 185:149–155PubMedCrossRefGoogle Scholar
  235. Saowakontha S, Pipitgool V, Pariyanonda S, Tesana S, Rojsathaporn K, Intarakhao C (1993) Field trials in the control of Opisthorchis viverrini with an integrated programme in endemic areas of northeast Thailand. Parasitology 106(Pt 3):283–288PubMedCrossRefGoogle Scholar
  236. Satarug S, Lang MA, Yongvanit P, Sithithaworn P, Mairiang E, Mairiang P, Pelkonen P, Bartsch H, Haswell-Elkins MR (1996) Induction of cytochrome P450 2A6 expression in humans by the carcinogenic parasite infection, Opisthorchiasis viverrini. Cancer Epidemiol Biomarkers Prev 5:795–800PubMedGoogle Scholar
  237. Satarug S, Haswell-Elkins MR, Sithithaworn P, Bartsch H, Ohshima H, Tsuda M, Mairiang P, Mairiang E, Yongvanit P, Esumi H, Elkins DB (1998) Relationships between the synthesis of N-nitrosodimethylamine and immune responses to chronic infection with the carcinogenic parasite, Opisthorchis viverrini, in men. Carcinogenesis 19:485–491PubMedCrossRefGoogle Scholar
  238. Sato M, Thaenkham U, Dekumyoy P, Waikagul J (2009) Discrimination of O. viverrini, C. sinensis, H. pumilio and H. taichui using nuclear DNA-based PCR targeting ribosomal DNA ITS regions. Acta Trop 109:81–83PubMedCrossRefPubMedCentralGoogle Scholar
  239. Sawangsoda P, Sithithaworn J, Tesana S, Pinlaor S, Boonmars T, Mairiang E, Yongvanit P, Duenngai K, Sithithaworn P (2012) Diagnostic values of parasite-specific antibody detections in saliva and urine in comparison with serum in opisthorchiasis. Parasitol Int 61:196–202PubMedCrossRefPubMedCentralGoogle Scholar
  240. Sayasone S, Odermatt P, Phoumindr N, Vongsaravane X, Sensombath V, Phetsouvanh R, Choulamany X, Strobel M (2007) Epidemiology of Opisthorchis viverrini in a rural district of southern Lao PDR. Trans R Soc Trop Med Hyg 101:40–47PubMedCrossRefPubMedCentralGoogle Scholar
  241. Schad GA, Anderson RM (1985) Predisposition to hookworm infection in humans. Science 228:1537–1540PubMedCrossRefGoogle Scholar
  242. Scholz T (2008) Family Opistorchiidae Looss, 1899. In: Bray RA, Gibson DI, Jones A (eds) Keys to the Trematoda. CAB International and Natural History Museum, London, pp 9–49CrossRefGoogle Scholar
  243. Scholz T, Ditrich O, Giboda M (1991) Differential diagnosis of opisthorchiid and heterophyid metacercariae (Trematoda) infecting flesh of cyprinid fish from Nam Ngum Dam Lake in Laos. Southeast Asian J Trop Med Publ Health 22(Suppl):171–173Google Scholar
  244. Schuster R (2002) Leberegelbefall. Denisia 184:291–315Google Scholar
  245. Shekhovtsov SV, Katokhin AV, Romanov KV, Besprozvannykh VV, Fedorov KP, Yurlova NI, Serbina EA, Sithithaworn P, Kolchanov NA, Mordvinov VA (2009) A novel nuclear marker, Pm-int9, for phylogenetic studies of Opisthorchis felineus, Opisthorchis viverrini, and Clonorchis sinensis (Opisthorchiidae, Trematoda). Parasitol Res 106:293–297PubMedCrossRefGoogle Scholar
  246. Shekhovtsov SV, Katokhin AV, Kolchanov NA, Mordvinov VA (2010) The complete mitochondrial genomes of the liver flukes Opisthorchis felineus and Clonorchis sinensis (Trematoda). Parasitol Int 59:100–103PubMedCrossRefGoogle Scholar
  247. Shen C, Kim J, Lee JK, Bae YM, Choi MH, Oh JK, Lim MK, Shin HR, Hong ST (2007) Collection of Clonorchis sinensis adult worms from infected humans after praziquantel treatment. Korean J Parasitol 45:149–152PubMedCrossRefGoogle Scholar
  248. Shimalov VV, Shimalov VT (2003) Helminth fauna of the red fox (Vulpes vulpes Linnaeus, 1758) in southern Belarus. Parasitol Res 89:77–78PubMedGoogle Scholar
  249. Shin HR, Lee CU, Park HJ, Seol SY, Chung JM, Choi HC, Ahn YO, Shigemastu T (1996) Hepatitis B and C virus, Clonorchis sinensis for the risk of liver cancer: a case-control study in Pusan, Korea. Int J Epidemiol 25:933–940PubMedCrossRefGoogle Scholar
  250. Shin HR, Oh JK, Lim MK, Shin A, Kong HJ, Jung KW, Won YJ, Park S, Park SJ, Hong ST (2010) Descriptive epidemiology of cholangiocarcinoma and clonorchiasis in Korea. J Korean Med Sci 25:1011–1016PubMedCrossRefGoogle Scholar
  251. Sirisinha S, Sahassananda D, Bunnag D, Rim HJ (1990) Immunological analysis of Opisthorchis and Clonorchis antigens. J Helminthol 64:133–138PubMedCrossRefGoogle Scholar
  252. Sirisinha S, Chawengkirttikul R, Sermswan R, Amornpant S, Mongkolsuk S, Panyim S (1991) Detection of Opisthorchis viverrini by monoclonal antibody-based ELISA and DNA hybridization. Am J Trop Med Hyg 44:140–145PubMedCrossRefGoogle Scholar
  253. Sirisinha S, Chawengkirttikul R, Haswell-Elkins MR, Elkins DB, Kaewkes S, Sithithaworn P (1995) Evaluation of a monoclonal antibody-based enzyme linked immunosorbent assay for the diagnosis of Opisthorchis viverrini infection in an endemic area. Am J Trop Med Hyg 52:521–524PubMedCrossRefGoogle Scholar
  254. Sithithaworn P, Haswell-Elkins M (2003) Epidemiology of Opisthorchis viverrini. Acta Trop 88:187–194PubMedCrossRefPubMedCentralGoogle Scholar
  255. Sithithaworn P, Tesana S, Pipitgool V, Kaewkes S, Pairojkul C, Sripa B, Paupairoj A, Thaiklar K (1991) Relationship between faecal egg count and worm burden of Opisthorchis viverrini in human autopsy cases. Parasitology 102(Pt 2):277–281PubMedCrossRefGoogle Scholar
  256. Sithithaworn P, Pipitgool V, Srisawangwong T, Elkins DB, Haswell-Elkins MR (1997) Seasonal variation of Opisthorchis viverrini infection in cyprinoid fish in north-east Thailand: implications for parasite control and food safety. Bull World Health Organ 75:125–131PubMedPubMedCentralGoogle Scholar
  257. Sithithaworn P, Sukavat K, Vannachone B, Sophonphong K, Ben-Embarek P, Petney T, Andrews R (2006) Epidemiology of food-borne trematodes and other parasite infections in a fishing community on the Nam Ngum reservoir, Lao PDR. Southeast Asian J Trop Med Publ Health 37:1083–1090Google Scholar
  258. Sithithaworn P, Nuchjungreed C, Srisawangwong T, Ando K, Petney TN, Chilton NB, Andrews RH (2007a) Genetic variation in Opisthorchis viverrini (Trematoda: Opisthorchiidae) from northeast Thailand and Laos PDR based on random amplified polymorphic DNA analyses. Parasitol Res 100:613–617PubMedCrossRefGoogle Scholar
  259. Sithithaworn P, Yongvanit P, Tesana S, Pairojkul C (2007b) Liver flukes. In: Murrell KD, Bernard F (eds) Food-borne parasitic zoonoses. Springer, Berlin, pp 3–52CrossRefGoogle Scholar
  260. Sithithaworn P, Andrews RH, Nguyen VD, Wongsaroj T, Sinuon M, Odermatt P, Nawa Y, Liang S, Brindley PJ, Sripa B (2012a) The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. Parasitol Int 61:10–16PubMedCrossRefGoogle Scholar
  261. Sithithaworn P, Andrews RH, Petney TN, Saijuntha W, Laoprom N (2012b) The systematics and population genetics of Opisthorchis viverrini sensu lato: implications in parasite epidemiology and bile duct cancer. Parasitol Int 61:32–37PubMedCrossRefGoogle Scholar
  262. Sithithaworn P, Yongvanit P, Duenngai K, Kiatsopit N, Pairojkul C (2014) Roles of liver fluke infection as risk factor for cholangiocarcinoma. J Hepatobiliary Pancreat Sci 21:301–308PubMedCrossRefGoogle Scholar
  263. Smout MJ, Laha T, Mulvenna J, Sripa B, Suttiprapa S, Jones A, Brindley PJ, Loukas A (2009) A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cells. PLoS Pathog 5:e1000611PubMedPubMedCentralCrossRefGoogle Scholar
  264. Sohn WM, Yong TS, Eom KS, Pyo KH, Lee MY, Lim H, Choe S, Jeong HG, Sinuon M, Socheat D, Chai JY (2012) Prevalence of Opisthorchis viverrini infection in humans and fish in Kratie Province, Cambodia. Acta Trop 124:215–220PubMedCrossRefPubMedCentralGoogle Scholar
  265. Song L, Xu Z, Yu X (2007) Molecular cloning and characterization of a phosphoglycerate mutase gene from Clonorchis sinensis. Parasitol Res 101:709–714PubMedCrossRefGoogle Scholar
  266. Sornmani S, Schelp FP, Vivatanasesth P, Patihatakorn W, Impand P, Sitabutra P, Worasan P, Preuksaraj S (1984) A pilot project for controlling O. viverrini infection in Nong Wai, Northeast Thailand, by applying praziquantel and other measures. Arzneimittelforschung 34:1231–1234PubMedGoogle Scholar
  267. Sri-Aroon P, Butraporn P, Limsomboon J, Kerdpuech Y, Kaewpoolsri M, Kiatsiri S (2005) Freshwater mollusks of medical importance in Kalasin Province, northeast Thailand. Southeast Asian J Trop Med Publ Health 36:653–657Google Scholar
  268. Sri-Aroon P, Intapan PM, Lohachit C, Phongsasakulchoti P, Thanchomnang T, Lulitanond V, Hiscox A, Phompida S, Sananikhom P, Maleewong W, Brey PT (2011) Molecular evidence of Opisthorchis viverrini in infected bithyniid snails in the Lao People's Democratic Republic by specific hybridization probe-based real-time fluorescence resonance energy transfer PCR method. Parasitol Res 108:973–978PubMedCrossRefGoogle Scholar
  269. Sripa B (2003) Pathobiology of opisthorchiasis: an update. Acta Trop 88:209–220PubMedCrossRefGoogle Scholar
  270. Sripa B, Kaewkes S, Sithithaworn P, Mairiang E, Laha T, Smout M, Pairojkul C, Bhudhisawasdi V, Tesana S, Thinkamrop B, Bethony JM, Loukas A, Brindley PJ (2007) Liver fluke induces cholangiocarcinoma. PLoS Med 4:e201PubMedPubMedCentralCrossRefGoogle Scholar
  271. Sripa B, Mairiang E, Thinkhamrop B, Laha T, Kaewkes S, Sithithaworn P, Tessana S, Loukas A, Brindley PJ, Bethony JM (2009) Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of interleukin-6. Hepatology 50:1273–1281PubMedPubMedCentralCrossRefGoogle Scholar
  272. Sripa B, Brindley PJ, Mulvenna J, Laha T, Smout MJ, Mairiang E, Bethony JM, Loukas A (2012) The tumorigenic liver fluke Opisthorchis viverrini-multiple pathways to cancer. Trends Parasitol 28:395–407PubMedPubMedCentralCrossRefGoogle Scholar
  273. Stensvold CR, Saijuntha W, Sithithaworn P, Wongratanacheewin S, Strandgaard H, Ornbjerg N, Johansen MV (2006) Evaluation of PCR based coprodiagnosis of human opisthorchiasis. Acta Trop 97:26–30PubMedCrossRefPubMedCentralGoogle Scholar
  274. Sukontason K, Piangjai S, Muangyimpong Y, Sukontason K, Methanitikorn R, Chaithong U (1999) Prevalence of trematode metacercariae in cyprinoid fish of Ban Pao district, Chiang Mai Province, northern Thailand. Southeast Asian J Trop Med Publ Health 30:365–370Google Scholar
  275. Sun J, Xu J, Liang P, Mao Q, Huang Y, Lv X, Deng C, Liang C, de Hoog GS, Yu X (2011) Molecular identification of Clonorchis sinensis and discrimination with other opisthorchid liver fluke species using multiple Ligation-depended Probe Amplification (MLPA). Parasit Vectors 4:98PubMedPubMedCentralCrossRefGoogle Scholar
  276. Suttiprapa S, Sotillo J, Smout M, Suyapoh W, Chaiyadet S, Tripathi T, Laha T, Loukas A (2018) Opisthorchis viverrini proteome and host-parasite interactions. Adv Parasitol 102:45–72PubMedCrossRefPubMedCentralGoogle Scholar
  277. Suwannahitatorn P, Klomjit S, Naaglor T, Taamasri P, Rangsin R, Leelayoova S, Mungthin M (2013) A follow-up study of Opisthorchis viverrini infection after the implementation of control program in a rural community, central Thailand. Parasit Vectors 6:188PubMedPubMedCentralCrossRefGoogle Scholar
  278. Suwannatrai A, Suwannatrai K, Haruay S, Piratae S, Thammasiri C, Khampoosa P, Kulsantiwong J, Prasopdee S, Tarbsripair P, Suwanwerakamtorn R, Sukchan S, Boonmars T, Malone JB, Kearney MT, Tesana S (2011) Effect of soil surface salt on the density and distribution of the snail Bithynia siamensis goniomphalos in northeast Thailand. Geospat Health 5:183–190PubMedCrossRefGoogle Scholar
  279. Suwannatrai A, Pratumchart K, Suwannatrai K, Thinkhamrop K, Chaiyos J, Kim CS, Suwanweerakamtorn R, Boonmars T, Wongsaroj T, Sripa B (2017) Modeling impacts of climate change on the potential distribution of the carcinogenic liver fluke, Opisthorchis viverrini, in Thailand. Parasitol Res 116:243–250PubMedCrossRefGoogle Scholar
  280. Tang Y, Cho PY, Kim BS, Hong SJ (2005) Molecular cloning and characterization of vitelline precursor protein B1 from Clonorchis sinensis. J Parasitol 91:1374–1378PubMedCrossRefGoogle Scholar
  281. Tatonova YV, Chelomina GN, Besprosvannykh VV (2012) Genetic diversity of nuclear ITS1-5.8S-ITS2 rDNA sequence in Clonorchis sinensis Cobbold, 1875 (Trematoda: Opisthorchidae) from the Russian Far East. Parasitol Int 61:664–674PubMedCrossRefGoogle Scholar
  282. Tatonova YV, Chelomina GN, Besprozvannykh VV (2013) Genetic diversity of Clonorchis sinensis (Trematoda: Opisthorchiidae) in the Russian southern Far East based on mtDNA cox1 sequence variation. Folia Parasitol 60:155–162PubMedCrossRefGoogle Scholar
  283. Tesana S, Srisawangwonk T, Kaewkes S, Sithithaworn P, Kanla P, Arunyanart C (1991) Eggshell morphology of the small eggs of human trematodes in Thailand. Southeast Asian J Trop Med Publ Health 22:631–636Google Scholar
  284. Tesana S, Thapsripair P, Thammasiri C, Prasopdee S, Suwannatrai A, Harauy S, Piratae S, Khampoosa P, Kulsantiwong J, Donthaisong C, Chalokepanrat P, Viyanant V, Malone JB (2012) Effects of Bayluscide on Bithynia siamensis goniomphalos, the first intermediate host of the human liver fluke, Opisthorchis viverrini, in laboratory and field trials. Parasitol Int 61:52–55PubMedCrossRefGoogle Scholar
  285. Thaenkham U, Nuamtanong S, Vonghachack Y, Yoonuan T, Sanguankiat S, Dekumyoy P, Prommasack B, Kobayashi J, Waikagul J (2011) Discovery of Opisthorchis lobatus (Trematoda: Opisthorchiidae): a new record of small liver flukes in the Greater Mekong Sub-region. J Parasitol 97:1152–1158PubMedCrossRefGoogle Scholar
  286. Thaewnongiew K, Singthong S, Kutchamart S, Tangsawad S, Promthet S, Sailugkum S, Wongba N (2014) Prevalence and risk factors for Opisthorchis viverrini infections in upper Northeast Thailand. Asian Pac J Cancer Prev 15:6609–6612PubMedCrossRefGoogle Scholar
  287. Toledo R, Bernal MD, Marcilla A (2011) Proteomics of foodborne trematodes. J Proteomics 74:1485–1503PubMedCrossRefGoogle Scholar
  288. Touch S, Komalamisra C, Radomyos P, Waikagul J (2009) Discovery of Opisthorchis viverrini metacercariae in freshwater fish in southern Cambodia. Acta Trop 111:108–113PubMedCrossRefGoogle Scholar
  289. Touch S, Yoonuan T, Nuamtanong S, Homsuwan N, Phuphisut O, Thaenkham U, Waikagul J (2013) Seasonal variation of Opisthorchis viverrini metacercarial infection in cyprinid fish from Southern Cambodia. J Trop Med Parasitol 36:1–7Google Scholar
  290. Traub RJ, Macaranas J, Mungthin M, Leelayoova S, Cribb T, Murrell KD, Thompson RC (2009) A new PCR-based approach indicates the range of Clonorchis sinensis now extends to Central Thailand. PLoS Negl Trop Dis 3:e367PubMedPubMedCentralCrossRefGoogle Scholar
  291. Traverso A, Repetto E, Magnani S, Meloni T, Natrella M, Marchisio P, Giacomazzi C, Bernardi P, Gatti S, Gomez Morales MA, Pozio E (2012) A large outbreak of Opisthorchis felineus in Italy suggests that opisthorchiasis develops as a febrile eosinophilic syndrome with cholestasis rather than a hepatitis-like syndrome. Eur J Clin Microbiol Infect Dis 31:1089–1093PubMedCrossRefGoogle Scholar
  292. Tyson GL, El-Serag HB (2011) Risk factors for cholangiocarcinoma. Hepatology 54:173–184PubMedPubMedCentralCrossRefGoogle Scholar
  293. Upatham ES, Sukhapanth N (1980) Field studies on the bionomics of Bithynia siamensis siamensis and the transmission of Opisthorchis viverrini in Bangna, Bangkok, Thailand. Southeast Asian J Trop Med Publ Health 11:355–358Google Scholar
  294. Upatham ES, Viyanant V, Kurathong S, Brockelman WY, Menaruchi A, Saowakontha S, Intarakhao C, Vajrasthira S, Warren KS (1982) Morbidity in relation to intensity of infection in Opisthorchiasis viverrini: study of a community in Khon Kaen, Thailand. Am J Trop Med Hyg 31:1156–1163PubMedCrossRefGoogle Scholar
  295. Upatham ES, Viyanant V, Kurathong S, Rojborwonwitaya J, Brockelman WY, Ardsungnoen S, Lee P, Vajrasthira S (1984) Relationship between prevalence and intensity of Opisthorchis viverrini infection, and clinical symptoms and signs in a rural community in north-east Thailand. Bull World Health Organ 62:451–461PubMedPubMedCentralGoogle Scholar
  296. Upatham ES, Brockelman WY, Viyanant V, Lee P, Kaengraeng R, Prayoonwiwat B (1985) Incidence of endemic Opisthorchis viverrini infection in a village in northeast Thailand. Am J Trop Med Hyg 34:903–906PubMedCrossRefPubMedCentralGoogle Scholar
  297. Upatham ES, Viyanant V, Brockelman WY, Kurathong S, Lee P, Kraengraeng R (1988) Rate of re-infection by Opisthorchis viverrini in an endemic northeast Thai community after chemotherapy. Int J Parasitol 18:643–649PubMedCrossRefPubMedCentralGoogle Scholar
  298. Van Hellemond JJ, Retra K, Brouwers JF, van Balkom BW, Yazdanbakhsh M, Shoemaker CB, Tielens AG (2006) Functions of the tegument of schistosomes: clues from the proteome and lipidome. Int J Parasitol 36:691–699PubMedCrossRefPubMedCentralGoogle Scholar
  299. Van CD, Doungchawee G, Suttiprapa S, Arimatsu Y, Kaewkes S, Sripa B (2017) Association between Opisthorchis viverrini and Leptospira spp. infection in endemic Northeast Thailand. Parasitol Int 66:503–509PubMedCrossRefPubMedCentralGoogle Scholar
  300. Vichasri S, Viyanant V, Upatham ES (1982) Opisthorchis viverrini: intensity and rates of infection in cyprinoid fish from an endemic focus in Northeast Thailand. Southeast Asian J Trop Med Publ Health 13:138–141Google Scholar
  301. Vinogradoff K (1892) On a new species of distomum (Distomum sibericum) in the human liver (in Russian). Zentralblatt für allgemeine Pathologie u pathologische Anatomie 3:910–911Google Scholar
  302. Viyanant V, Brockelman WY, Lee P, Ardsungnoen S, Upatham ES (1983) A comparison of a modified quick-Kato technique and the Stoll dilution method for field examination for Opisthorchis viverrini eggs. J Helminthol 57:191–195PubMedCrossRefPubMedCentralGoogle Scholar
  303. Waikagul J (1998) Opisthorchis viverrini metacercaria in Thai freshwater fish. Southeast Asian J Trop Med Publ Health 29:324–326Google Scholar
  304. Waikagul J, Dekumyoy P, Chaichana K, Thairungroje Anantapruti M, Komalamisra C, Kitikoon V (2002) Serodiagnosis of human opisthorchiasis using cocktail and electroeluted Bithynia snail antigens. Parasitol Int 51:237–247PubMedCrossRefPubMedCentralGoogle Scholar
  305. Wang X, Chen W, Huang Y, Sun J, Men J, Liu H, Luo F, Guo L, Lv X, Deng C, Zhou C, Fan Y, Li X, Huang L, Hu Y, Liang C, Hu X, Xu J, Yu X (2011) The draft genome of the carcinogenic human liver fluke Clonorchis sinensis. Genome Biol 12:R107PubMedPubMedCentralCrossRefGoogle Scholar
  306. Wang YC, Feng CC, Sithithaworn P (2013) Environmental determinants of Opisthorchis viverrini prevalence in northeast Thailand. Geospat Health 8:111–123PubMedCrossRefPubMedCentralGoogle Scholar
  307. Wang D, Young ND, Korhonen PK, Gasser RB (2018) Clonorchis sinensis and Clonorchiasis: the relevance of exploring genetic variation. Adv Parasitol 100:155–208PubMedCrossRefPubMedCentralGoogle Scholar
  308. Watthanakulpanich D, Waikagul J, Dekumyoy P, Anantaphruti MT (2003) Studies on concomitant antigens of Bithynia funiculata for detection of antibody to Opisthorchis viverrini: effect of different centrifugal speeds on antigen preparation. Southeast Asian J Trop Med Publ Health 34(Suppl 2):114–120Google Scholar
  309. Watwiengkam N, Sithithaworn J, Duenngai K, Sripa B, Laha T, Johansen MV, Sithithaworn P (2013) Improved performance and quantitative detection of copro-antigens by a monoclonal antibody based ELISA to diagnose human opisthorchiasis. Acta Trop 128:659–665PubMedCrossRefPubMedCentralGoogle Scholar
  310. Wegner DH (1984) The profile of the trematodicidal compound praziquantel. Arzneimittelforschung 34:1132–1136PubMedPubMedCentralGoogle Scholar
  311. WHO (1995) Control of foodborne trematode infections. World Health Organization, GenevaGoogle Scholar
  312. Wongratanacheewin S, Pumidonming W, Sermswan RW, Maleewong W (2001) Development of a PCR-based method for the detection of Opisthorchis viverrini in experimentally infected hamsters. Parasitology 122:175–180PubMedCrossRefPubMedCentralGoogle Scholar
  313. Wongratanacheewin S, Pumidonming W, Sermswan RW, Pipitgool V, Maleewong W (2002) Detection of Opisthorchis viverrini in human stool specimens by PCR. J Clin Microbiol 40:3879–3880PubMedPubMedCentralCrossRefGoogle Scholar
  314. Wongratanacheewin S, Sermswan RW, Sirisinha S (2003) Immunology and molecular biology of Opisthorchis viverrini infection. Acta Trop 88:195–207PubMedCrossRefPubMedCentralGoogle Scholar
  315. Wongsaroj T, Sakolvaree Y, Chaicumpa W, Maleewong W, Kitikoon V, Tapchaisri P, Chongsa-nguan M, Cross JH (2001) Affinity purified oval antigen for diagnosis of Opisthorchiasis viverrini. Asian Pac J Allergy Immunol 19:245–258PubMedPubMedCentralGoogle Scholar
  316. Wongsawad C, Wongsawad P, Anuntalabhochai S, Chai JY, Sukontason K (2013) Occurrence and molecular identification of liver and minute intestinal flukes metacercariae in freshwater fish from Fang-Mae Ai Agricultural Basin, Chiang Mai province, Thailand. Asian Biomed 7:97–104Google Scholar
  317. Worasith C, Kamamia C, Yakovleva A, Duenngai K, Wangboon C, Sithithaworn J, Watwiengkam N, Namwat N, Techasen A, Loilome W, Yongvanit P, Loukas A, Sithithaworn P, Bethony JM (2015) Advances in the diagnosis of human opisthorchiasis: development of Opisthorchis viverrini antigen detection in urine. PLoS Negl Trop Dis 9:e0004157PubMedPubMedCentralCrossRefGoogle Scholar
  318. Wykoff DE, Harinasuta C, Juttijudata P, Winn MM (1965) Opisthorchis viverrini in Thailand-the life cycle and comparison with O. felineus. J Parasitol 51:207–214PubMedCrossRefPubMedCentralGoogle Scholar
  319. Xiao JY, Gao JF, Cai LS, Dai Y, Yang CJ, Luo L, Agatsuma T, Wang CR (2013) Genetic variation among Clonorchis sinensis isolates from different hosts and geographical locations revealed by sequence analysis of mitochondrial and ribosomal DNA regions. Mitochondrial DNA 24:559–564PubMedCrossRefPubMedCentralGoogle Scholar
  320. Xu M, Jiang Z, Huang W, Yin J, Ou S, Jiang Y, Meng L, Cao S, Yu A, Cao J, Shen Y (2018) Altered gut microbiota composition in subjects infected with Clonorchis sinensis. Front Microbiol 9:2292PubMedPubMedCentralCrossRefGoogle Scholar
  321. Yang G, Jing C, Zhu P, Hu X, Xu J, Wu Z, Yu X (2006) Molecular cloning and characterization of a novel lactate dehydrogenase gene from Clonorchis sinensis. Parasitol Res 99:55–64PubMedCrossRefPubMedCentralGoogle Scholar
  322. Yongvanit P, Pinlaor S, Bartsch H (2012) Oxidative and nitrative DNA damage: key events in opisthorchiasis-induced carcinogenesis. Parasitol Int 61:130–135PubMedCrossRefPubMedCentralGoogle Scholar
  323. Yossepowitch O, Gotesman T, Assous M, Marva E, Zimlichman R, Dan M (2004) Opisthorchiasis from imported raw fish. Emerg Infect Dis 10:2122–2126PubMedPubMedCentralCrossRefGoogle Scholar
  324. Young ND, Campbell BE, Hall RS, Jex AR, Cantacessi C, Laha T, Sohn WM, Sripa B, Loukas A, Brindley PJ, Gasser RB (2010) Unlocking the transcriptomes of two carcinogenic parasites, Clonorchis sinensis and Opisthorchis viverrini. PLoS Negl Trop Dis 4:e719PubMedPubMedCentralCrossRefGoogle Scholar
  325. Zadesenets KS, Karamysheva TV, Katokhin AV, Mordvinov VA, Rubtsov NB (2012a) Distribution of repetitive DNA sequences in chromosomes of five opisthorchid species (Trematoda, Opisthorchiidae). Parasitol Int 61:84–86PubMedCrossRefPubMedCentralGoogle Scholar
  326. Zadesenets KS, Katokhin AV, Mordvinov VA, Rubtsov NB (2012b) Comparative cytogenetics of opisthorchid species (Trematoda, Opisthorchiidae). Parasitol Int 61:87–89PubMedCrossRefPubMedCentralGoogle Scholar
  327. Zadesenets KS, Katokhin AV, Mordvinov VA, Rubtsov NB (2012c) Telomeric DNA in chromosomes of five opisthorchid species. Parasitol Int 61:81–83PubMedCrossRefPubMedCentralGoogle Scholar
  328. Zavoikin VD, Zelia OP, Bronshtein AM, Sokerina OA, Iarotskii LS, Firsova RA, Mikhailov MM, Gerasimov IV (1994) The procedure for the wide use of praziquantel in a complex of measures to control opisthorchiasis. 1. The tolerance and efficacy of different doses of biltricide during outpatient use in foci. Med Parazitol 24–27Google Scholar
  329. Zhang HM, Jiang H, Xu B, Tan CP (2007) Preliminary survey on the infection status of freshwater fish with metacercariae of Metorchis orientalis in Guangxi province. In: The 1st International symposium on geospatial health, Lijiang, Yunnan, China, pp 39–41Google Scholar
  330. Zheng N, Xu J, Wu Z, Chen J, Hu X, Song L, Yang G, Ji C, Chen S, Gu S, Ying K, Yu X (2005) Clonorchis sinensis: molecular cloning and functional expression of novel cytosolic malate dehydrogenase. Exp Parasitol 109:220–227PubMedCrossRefPubMedCentralGoogle Scholar
  331. Zheng N, Huang B, Xu J, Huang S, Chen J, Hu X, Ying K, Yu X (2006) Enzymatic and physico-chemical characteristics of recombinant cMDH and mMDH of Clonorchis sinensis. Parasitol Res 99:174–180PubMedCrossRefGoogle Scholar
  332. Zheng N, Huang B, Xu J, Huang S, Chen J, Hu X, Ji C, Ying K, Yu X (2008) Cloning and expression of mitochondrial malate dehydrogenase of Clonorchis sinensis. Parasitol Res 102:989–995PubMedCrossRefPubMedCentralGoogle Scholar
  333. Zheng M, Hu K, Liu W, Hu X, Hu F, Huang L, Wang P, Hu Y, Huang Y, Li W, Liang C, Yin X, He Q, Yu X (2011) Proteomic analysis of excretory secretory products from Clonorchis sinensis adult worms: molecular characterization and serological reactivity of a excretory-secretory antigen-fructose-1,6-bisphosphatase. Parasitol Res 109:737–744PubMedCrossRefPubMedCentralGoogle Scholar
  334. Zhigileva ON, Zenovkina DV, Zamyatina TA (2013) Genetic variability and population differentiation of Opisthorchis felineus (Trematoda) in Western Siberian rivers. Russ J Genet Appl Res 3:371–377CrossRefGoogle Scholar
  335. Zhou Z, Hu X, Huang Y, Hu H, Ma C, Chen X, Hu F, Xu J, Lu F, Wu Z, Yu X (2007) Molecular cloning and identification of a novel Clonorchis sinensis gene encoding a tegumental protein. Parasitol Res 101:737–742PubMedCrossRefGoogle Scholar
  336. Zhou Z, Xia H, Hu X, Huang Y, Li Y, Li L, Ma C, Chen X, Hu F, Xu J, Lu F, Wu Z, Yu X (2008) Oral administration of a Bacillus subtilis spore-based vaccine expressing Clonorchis sinensis tegumental protein 22.3 kDa confers protection against Clonorchis sinensis. Vaccine 26:1817–1825PubMedCrossRefGoogle Scholar
  337. Ziegler AD, Andrews RH, Grundy-Warr C, Sithithaworn P, Petney TN (2011) Fighting liverflukes with food safety education. Science 331:282–283PubMedCrossRefPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Weerachai Saijuntha
    • 1
  • Paiboon Sithithaworn
    • 2
    Email author
  • Nadda Kiatsopit
    • 2
  • Ross H. Andrews
    • 3
    • 4
  • Trevor N. Petney
    • 3
    • 5
  1. 1.Walai Rukhavej Botanical Research InstituteMahasarakham UniversityMaha SarakhamThailand
  2. 2.Department of Parasitology, Faculty of MedicineCholangiocarcinoma Research Institute, Khon Kaen UniversityKhon KaenThailand
  3. 3.CASCAP, Faculty of MedicineCholangiocarcinoma Research Institute, Khon Kaen UniversityKhon KaenThailand
  4. 4.Faculty of MedicineSt Mary’s Campus, Imperial College LondonLondonUK
  5. 5.Department of Paleontology and EvolutionState Museum of Natural HistoryKarlsruheGermany

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