• Santiago Mas-ComaEmail author
  • Mª Adela Valero
  • Mª Dolores Bargues
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1154)


Fascioliasis is a major parasitic disease caused by the digenetic trematodes Fasciola hepatica and Fasciola gigantica. The disease is a well-known veterinary problem of worldwide distribution. Fascioliasis is the vector-borne parasitic disease presenting the widest latitudinal, longitudinal, and altitudinal distribution known at present. In the last two decades, many surveys have shown it to be an important public health problem as well, including estimations of 2.4 million, up to 17 million people, or even higher depending on the hitherto unknown situations mainly in several regions of Asia and Africa. In recent years, the increasing number of human case reports in many countries of the five continents and the results of studies on pathogenicity and immunity, mainly regarding the chronic period of the disease, were the reasons why it was decided to no longer consider fascioliasis merely a secondary zoonotic disease but an important human parasitic disease. In this chapter, we review the most relevant features in relation to fascioliasis, including from the most traditional to the most innovative aspects.


Trematode Zoonoses Fascioliasis Fasciola hepatica Fasciola gigantica Food-borne trematode 



Reviews of fascioliasis carried out within Projects SAF2010-20805 of the Ministry of Economy and Competitiveness, Madrid, Spain; by Health Research Project No. PI16/00520, Subprograma Estatal de Generación de Conocimiento de la Acción Estratégica en Salud (AES), Plan Estatal de Investigación Científica y Técnica y de Innovación, ISCIII-MINECO, Madrid, Spain; by Project No. 2017/ACDE/001583 de Innovación para el Desarrollo of the Agencia Española de Cooperación Internacional para el Desarrollo (AECID), Ministry of Foreign Affairs and Cooperation, Madrid, Spain; by the Red de Investigación de Centros de Enfermedades Tropicales – RICET (Project No. RD16/0027/0023 of the PN de I + D + I, ISCIII-Subdirección General de Redes y Centros de Investigación Cooperativa RETICS), Ministry of Health and Consumption, Madrid; by Project No. 2016/099 of the PROMETEO Program, Programa of Ayudas para Grupos de Investigación de Excelencia, Generalitat Valenciana, Valencia, Spain.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Santiago Mas-Coma
    • 1
    Email author
  • Mª Adela Valero
    • 1
  • Mª Dolores Bargues
    • 1
  1. 1.Departamento de Farmacia y Tecnología Farmacéutica y Parasitología, Facultad de FarmaciaUniversidad de ValenciaValenciaSpain

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