Dicrocoeliidae Family: Major Species Causing Veterinary Diseases

  • M. Yolanda Manga-GonzálezEmail author
  • M. Carmen Ferreras
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1154)


This chapter analyses the taxonomic position of Dicrocoeliidae family and several of its genus and species. The biology of the major species causing veterinary diseases such Dicrocoelium dendriticum, Dicrocoelium hospes, Dicrocoelium chinensis, Eurytrema pancreaticum and Platynosomum fastosum, has been reviewed. All these species have an indirect life cycle, involving two intermediate hosts (molluscs as first and ants, grasshoppers and lizards as second). Dicrocoelium dendriticum is a very widespread hepatic trematode in the ruminants of many countries in Europe, Asia, North Africa and North America, even affecting humans. Dicrocoelium hospes is widely distributed in the savanna areas of Africa south of the Sahara, whilst D. chinensis has mainly been found in ruminants in East Asia and some European countries (probably imported from Asia). Eurytrema pancreaticum is a common parasite whose adults live in ruminant bile ducts, gall bladder, pancreatic ducts and intestines in Europe, Madagascar, Asia and South America. Adult P. fastosum live in the liver, gall bladder and pancreas of birds and mammals in Europe, Africa, Asia, North, Central and South America. Information about the epidemiology, pathology, clinical aspect, diagnosis, treatment, control, prevention and economic impact mainly of Dicrocoeliosis produced by D. dendriticum, as well as of Eurytrematodosis and Platynosomiosis, has been included.


Dicrocoeliidae Dicrocoelium dendriticum Dicrocoelium hospes Dicrocoelium chinensis Dicrocoeliosis Eurytrema cladorchis Eurytrema pancreaticum Platynosomum fastosum Eurytrematodosis Platynosomiosis 


  1. Afzal M, Shafique M, Hussain A, Saeed M (1981) A study of helminths of cattle and buffaloes in Lahore. Pakistan J Sci 33:14–20Google Scholar
  2. Agrawal SC, Sharma SK (1990) On a new trematode: neodicrocoeliinae subf. n., Neodicrocoelium gayaparsadai gen. n. et sp. n. (Trematoda, Dicrocoeliidae) from the airbreathing fish, Channa marulius (Ham.) from Jhansi (India). Helminthologia 27:91–98Google Scholar
  3. Al-Khalidi NW, Al-Bayati MMA (1989) The epidemiology of dicrocoeliasis in sheep in Mosul (Iraq). J Vet Parasitol 3:21–23Google Scholar
  4. Alunda JM, Manga-González MY (1982) Susceptibility of some species of the genus Helicella Férussac, 1821 (Gastropoda, Helicidae) to the infection by Dicrocoelium dendriticum (Trematoda). Malacologia 22:51–54Google Scholar
  5. Alunda JM, Rojo-Vázquez FA (1982) Susceptibility of some populations of Cernuella (Xeromagna) cespitum arigonis (Schmidt, 1875) (Gastropoda, Helicidae) from the Douro basin (Iberian Peninsula) to the infection by Dicrocoelium dendriticum (Trematoda). Malacologia 22:39–43Google Scholar
  6. Alunda JM, Rojo-Vázquez FA (1983a) Survival and infectivity of Dicrocoelium dendriticum eggs under field conditions in NW Spain. Vet Parasitol 13:245–249PubMedCrossRefPubMedCentralGoogle Scholar
  7. Alunda JM, Rojo-Vázquez FA (1983b) Effect of infection rate and host age on the intramolluscan development of Dicrocoelium dendriticum. Helminthologia 20:251–258Google Scholar
  8. Alunda JM, Rojo-Vázquez FA (1984) Some new molluscan hosts of Dicrocoelium dendriticum in Spain. Ann Parasitol Hum Comp 59:57–62PubMedCrossRefPubMedCentralGoogle Scholar
  9. Álvarez-Nogal R, Manga-González MY, González-Lanza C, Del Pozo Carnero P (1992) Preliminary study on Dicrocoelium dendriticum (Trematoda) first larval stages in experimentally infected Cernuella (Xeromagna) cespitum arigonis (Mollusca). In: Abstracts of the VIth European Multicolloquium of Parasitology, The HagueGoogle Scholar
  10. Alzieu JP, Ducos De Lahitte J (1991) La dicrocoeliose chez les bovins. Bull GTV 6:135–146Google Scholar
  11. Ambrosi M (1989) Efficacia del tiofanato a dose normale contro Dicrocoelium dendriticum. Il Nuovo Prog Vet 15–16:1–7Google Scholar
  12. Ambrosi M, Grenolli V (1991) Prove di campo sull’uso del mebendazole nel poliparassitismo ovino. Ob Doc Vet 12:89–91Google Scholar
  13. Ambrosi M, Principato M (1981) Dicroceliosi ovina: variazioni stagionali della positività coproscopica in animali spontaneamente parassitati. Ob Doc Vet 2:55–56Google Scholar
  14. Ambrosi M, Morettini B, Ranucci S, Tesei B (1986) Efficacia della somministrazione orale di tiofanato (1-bis(3-etossicarbonil-2-tioureido)benzene) per la terapia dell’infestione da Dicrocoelium dendriticum negli ovini. Riv Zootec Vet 14:25–31Google Scholar
  15. Andrade RIFS, Dantas AFM, Pimentel LA, Galiza GJN, Carvalho FKL (2012) Platynosomum fastosum-induced cholangiocarcinomas in cats. Vet Parasitol 190:277–280PubMedCrossRefPubMedCentralGoogle Scholar
  16. Angelovski T, Iliev A, Madzirov Z (1970) Nasi noviji rezultati istrazivanja epizootiologije dikrocelioze u ovaca. Vet Glasnik 24:995–999. En: Helm. Abstr, 42, 1126Google Scholar
  17. Badie A (1978) La dicroceliose ovine: incidence des facteurs climatiques et contribution à la mise au point d’une méthode de prévision. Ann Parasitol Hum Comp 53:373–385PubMedCrossRefPubMedCentralGoogle Scholar
  18. Badie A, Hourdin P, Rondelaud D (1992) L’infestation de Cochlicopa lubrica Müller par Dicrocoelium lanceolatum Rudolphi. A propos de quelques observations histophatologiques. Bull Soc Fr Parasitol 10:51–57Google Scholar
  19. Bahrami S, Jalali MHR, Jafari A (2015) Evaluation of hepatic antioxidant changes in ovine dicrocoeliasis. J Parasit Dis 39:766–769PubMedCrossRefPubMedCentralGoogle Scholar
  20. Bailenger J, Tribouley J, Amyot B, Duret J (1965) Importance des Léporides comme réservoirs sauvages dans l’épidemiologie des distomatoses a Fasciola hepatica et Dicrocoelium dendriticum. Ann Parasitol Hum Comp 40:51PubMedCrossRefPubMedCentralGoogle Scholar
  21. Baldelli B, Piergili-Fioretti D, Ambrosi M, Polidori GA, Grelloni V, Moretti A (1981) Dicroceliosi ovina: studio degli anticorpi verso Dicrocoelium dendriticum in agnelli nati da pecore spontaneamente infertte. Riv Parassitol 42:23–30Google Scholar
  22. Bari S, Arbabi M, Gill P, Sharif M, Hezarjaribi HZ, Dodangeh S, Alizadeh A, Hedayati Z, Sarvi S (2018) Morphological and molecular (28s RDNA) characterization of Dicrocoelium dendriticum isolates from sheep, goat and cattle in Marzandaran province, Iran. J Mazandaran Univ Med Sci 27:38–45Google Scholar
  23. Bártíková A, Vokřál I, Forstová-Křížová V, Skálová L, Lamka J, Szotákova B (2011) The transport of albendazole and albendazole sulphoxide in the lancet fluke (Dicrocoelium dendriticum). Vet Parasitol 176:27–33PubMedCrossRefPubMedCentralGoogle Scholar
  24. Bassani CA, Sangioni LA, Saut JPE, Yamamura MH, Headley SA (2006) Epidemiology of eurytrematosis (Eurytrema spp. Trematoda: Dicrocoeliidae) in slaughtered beef cattle from the central-west region of the State of Paraná, Brazil. Vet Parasitol 141:356–361PubMedCrossRefPubMedCentralGoogle Scholar
  25. Basu AK, Charles RA (2014) A review of the cat liver fluke Platynosomum fastosum Kossack, 1910 (Trematoda: Dicrocoeliidae). Vet Parasitol 200:1–7PubMedCrossRefPubMedCentralGoogle Scholar
  26. Batelli G, Poglayen G, Martini M (1987) Indagine sulla diffusione della fascioliasi bovina in provincia di Firenze. Summa 4:45–49Google Scholar
  27. Bazsalovicsová E, Králová-Hromadová I, Spakulová M, Reblánová M, Oberhauserová K (2010) Determination of ribosomal internal transcribed spacer 2 (ITS-2) interspecific markers in Fasciola hepatica, Fascioloides magna, Dicrocoelium dendriticum and Paramphistomum cervi (Trematoda), parasites of wild and domestic ruminants. Helminthologia 47:76–82CrossRefGoogle Scholar
  28. Beck MA, Goater CP, Colwell DD, van Paridon BJ (2014) Fluke abundance versus host age for an invasive trematode (Dicrocoelium dendriticum) of sympatric elk and beef cattle in southeastern Alberta, Canada. Int J Parasitol Parasites Wildlife 3:263–268CrossRefGoogle Scholar
  29. Beck MA, Goater CP, Colwell DD (2015) Comparative recruitment, morphology and reproduction of a generalist trematode, Dicrocoelium dendriticum, in three species of host. Parasitology 142:1297–1305PubMedPubMedCentralCrossRefGoogle Scholar
  30. Ben Amer KF, Ahmed Z (1980) Studies on the prevalence of liver flukes with special reference to Dicrocoelium dendriticum (Rudolphi, 1891) Looss 1899 in sheep and cattle from Tripoli region Libya. Riv Parassitol 41:15–18Google Scholar
  31. Bernal D, Trelis M, Montane S, Cantalapiedra F, Galiano A, Hackenberg M, Marcilla A (2014) Surface analysis of Dicrocoelium dendriticum. The molecular characterization of exosomes reveals the presence of miRNAs. J Proteomics 105:232–241PubMedPubMedCentralCrossRefGoogle Scholar
  32. Biant QQ, Zhao GH, Jia YQ, Fang YQ, Cheng WY, Du SZ, Ma XT, Lin Q (2015) Characterization of Dicrocoelium dendriticum isolates from small ruminants in Shaanxi Province, North-Westem China, using intemal transcribed spacers of nuclear ribosomal DNA. J Helminthol 89:124–129CrossRefGoogle Scholar
  33. Blasco S, Feliu C, Torres J, Casanova JC, Miguel J, Ruiz-Olmo J (1993) Oryctolagus cuniculus (Linnaeus, 1758) hospedador de Dicrocoelium dendriticum (Rudolphi, 1819) en Cataluña. Acta Parasitol Port 1(2):171Google Scholar
  34. Bocharova MM (1984) (Zonal distribution of foci of Dicrocoelium infection on the northern slopes of the Central Caucasus and the eastern pre-Caucasus region (USSR)). Materialy Nauchnoi Konferentsii Vsesoyuznogo Obshchestva Gel’mintologov (Biologiya y taksnomiya gel’mintov zhivotnykh y cheloveka) 34:97–105Google Scholar
  35. Bode L, Geyer E (1981) Experimental dicrocoeliasis: the humoral immune response of gladden hamsters and rabbits to primary infection with Dicrocoelium dendriticum. Z Parasitenkd 66:167–178PubMedCrossRefPubMedCentralGoogle Scholar
  36. Bolukbas CS, Gurler AT, Beyhan YE, Acici M, Umur S (2012) Helminths of roe deer (Capreolus capreolus) in the Middle Black Sea Region of Turkey. Parasitol Int 61:729–730PubMedCrossRefPubMedCentralGoogle Scholar
  37. Boray JC (1982) Molluscan hosts and trematodes. In: Symons LEA, Donald AD, Dineen JK (eds) Biology and control of endoparasites. Academic Press, SydneyGoogle Scholar
  38. Boray JC (1985) Flukes of domestic animals. In: Gaafar SM, Howard WE, Marsh RE (eds) Parasites, pests and predators. World Animal Science. B Disciplinary approach. Elsevier Science Publishers B.V, AmsterdamGoogle Scholar
  39. Botnevik CF, Malagocka J, Jensen B, Fredensborg BL (2016) Relative effect of temperature, light, and humidity on clinging behaviour of metacercariae infected ants. J Parasitol 102:495–500PubMedCrossRefPubMedCentralGoogle Scholar
  40. Bourgat R, Séguin D, Bayssade-Dufour C (1976) Données nouvelles sur Dicrocoelium hospes Looss, 1907: Anatomie de l’adulte et cycle évolutif. Ann Parasitol Hum Comp 50:701–714CrossRefGoogle Scholar
  41. Braga RR, Teixeira AC, Oliveira JAA, Cavalcanti LPG (2016) Prevalence of Platynosomum fastosum infection in free roaming cats in northeastern Brazil: fluke burden and grading of lesions. Vet Parasitol 227:20–25PubMedCrossRefPubMedCentralGoogle Scholar
  42. Braun U, Wolfensberger R, Hertzbrg H (1995) Diagnosis of liver flukes in cows—a comparison of the findings in the liver, in the faeces, and in the bile. Schweiz Arch Tierheilkd 137:438–444PubMedPubMedCentralGoogle Scholar
  43. Brugêre-Picoux J, Tafani JP, Chirol C, Morand M (1986) Efficacité du thiophanate sur Dicrocoelium lanceolatum chez le mouton. Rec Méd Vét 162:973–978Google Scholar
  44. Calamel M (1976) La dicrocoeliose ovine et caprine dans le Sud-Est de la France. Rev Med Vet 127:1529–1536Google Scholar
  45. Camara L, Pfister J, Aeschlimann A (1996) Analyse histopathologique de foie de bovin infesté par Dicrocoelium dendriticum. Vet Res 27:87–92PubMedPubMedCentralGoogle Scholar
  46. Campo R, Manga-González MY, González-Lanza C (1998) Characterization of adult Dicrocoelium dendriticum by isoelectric focusing. J Helminthol 72:109–116PubMedCrossRefPubMedCentralGoogle Scholar
  47. Campo R, Manga-González MY, González-Lanza C (2000) Relationship between egg output and parasitic burden in lambs experimentally infected with different doses of Dicrocoelium dendriticum (Digenea). Vet Parasitol 87:139–149PubMedCrossRefPubMedCentralGoogle Scholar
  48. Cavani C, Losi G, Manfredini M, Pavoncelli RM, Pietrobelli M, Restani R (1982) Ricerche sull’influenza della dicroceliasi sulle caratteristiche quantitative e qualitative della produzione di latte in pecore. Ob Doc Vet 3:59–63Google Scholar
  49. Cengiz ZT, Yilmaz H, Dulger AC, Cicek M (2010) Human infection with Dicrocoelium dendriticum in Turkey. Ann Saudi Med 30:59–161CrossRefGoogle Scholar
  50. Chandra G (1973) First detection of Dicrocoelium eggs in the faeces of experimentally infected lambs, Guinea pigs and pigs. HAU J Res 3:31–34Google Scholar
  51. Chang QC, Liu GH, Gao JF, Zheng X, Zhang Y, Duan H, Yue D-M, Fu X, Su X, Gao Y, Wang C-R (2016) Sequencing and characterization of the complete mitochondrial genome from the pancreatic fluke Eurytrema pancreaticum (Trematoda: Dicrocoeliidae). Gene 576:160–165PubMedCrossRefPubMedCentralGoogle Scholar
  52. Colwell DD, Goater CP (2010) Dicrocoelium dendriticum in cattle from Cypress Hills, Canada: humoral response and preliminary evaluation of an ELISA. Vet Parasitol 174:162–165PubMedCrossRefPubMedCentralGoogle Scholar
  53. Corba J, Krupicer I (1992) Efficacy of intraruminal albendazole boluses against Dicrocoelium dendriticum in sheep. Parasiol Res 78:640–642CrossRefGoogle Scholar
  54. Corba J, Hovorka J, Spaldonova R, Stoffa P, Legeny J, Andrasko H (1987) Efficacy of luxabendazole (hoe 216 V) sup. 5% in sheep naturally infected with the most important helminths. Helminthologia 24:227–235Google Scholar
  55. Corba JA, Krupicer L, Petko B, Varady M (1993) Efficacy of netobimin against liver flukes, gastrointesinal and lungworms in naturally infected sheep. Helminthologia 30:57–61Google Scholar
  56. Cordero-del-Campillo M, Rojo-Vázquez FA, Díez-Baños P, Chaton-Schaffner M (1982) Efficacité de l’albendazole contre une infestation naturelle a Dicrocoelium dendriticum chez le mouton. Rev Med Vet 133:41–49Google Scholar
  57. Cullen JM, Stalker MJ (2016) Liver and biliary system. In: Maxie MG (ed) Jubb, Kennedy, and Palmer’s pathology of domestic animals, 6th edn. Elsevier, St. LouisGoogle Scholar
  58. D’Ovidio D, Rinaldi L, Ianniello D, Donnelly TM, Pepe P, Capasso M, Cringoli G (2014) FLOTAC for diagnosis of endo-parasites in pet squirrels in southern Italy. Vet Parasitol 200:221–224PubMedCrossRefPubMedCentralGoogle Scholar
  59. Dadak AM, Wiesera C, Joachimb A, Franz S (2013) Efficacy and safety of oral praziquantel against Dicrocoelium dendriticum in llamas. Vet Parasitol 197:122–125PubMedCrossRefPubMedCentralGoogle Scholar
  60. Dawes B (1968) The Trematoda. Cambridge University Press, CambridgeGoogle Scholar
  61. Del-Rio J (1967) Epizootiología de la dicroceliosis en la provincia de León. An Fac Vet León 13:211–253Google Scholar
  62. Dementev IS, Karabaev DK (1968) (Infection of terrestrial molluscs and ant by Dicrocoelium dendriticum larvae in southeastern Kazakhstan). Vestik sel’-skokhozyaistvennoi Nauki, Alma-Ata 122:51–55Google Scholar
  63. Denev I, Savova S, Stoimenov K, Tahirov B, Donev A, Kassabov R, Petrov P (1970a) [An investigation into the dicrocoeliosis in north-eastern Bulgaria. II. On the intermediary and additional hosts of Dicrocoelium lanceatum (Stiles et Hassal, 1896)]. Vet Med Nauki 7:23–31Google Scholar
  64. Denev I, Stoimenov K, Donev A, Petrov P, Kasabov R (1970b) Dicrocoeliasis in North-Eastern Bulgaria. I. Geographical and seasonal incidence. Vet Med Nauki Sofia 7:21–29Google Scholar
  65. Dhar DN, Shing KS (1963) Histochemical studies on liver in dicrocoeliasis. Indian J Vet Sci 33:142–151Google Scholar
  66. Diakou A, Sokos C, Papadopoulos E (2014) Endoparasites found in European brown hares (Lepus europaeus) hunted in Macedonia, Greece. Helminthologia 51:345–351CrossRefGoogle Scholar
  67. Ekstam B, Johansson B, Dinnétz P, Ellström P (2011) Predicting rik habitats for the transmission of the small liver fluke, Dicrocoelium dendriticum to grazing ruminants. Geospat Health 6:125–131PubMedCrossRefPubMedCentralGoogle Scholar
  68. Ershov VS (1964) Textbook of veterinary helminthology. Izdatelstvo Kolos, MoscowGoogle Scholar
  69. Ezatpour B, Hasanvand A, Azami M, Anbari K, Ahmadpour F (2015) Prevalence of liver fluke infections in slaughtered animals in Lorestan, Iran. J Parasit Dis 39:725–729PubMedCrossRefPubMedCentralGoogle Scholar
  70. Fagbemi BO, Obarisiagbon IO (1991) Common antigens of Fasciola gigantica, Dicrocoelium hospes and Schistosoma bovis and their relevante to serology. Vet Q 13:81–87PubMedCrossRefPubMedCentralGoogle Scholar
  71. Fashuyi SA, Adeoye GO (1986) The possible snail intermediate hosts of Dicrocoelium hospes in Nigeria. Acta Vet Brno 55:85–88CrossRefGoogle Scholar
  72. Fauna Europaea (2012) Fauna Europaea version 2.5 web service available on line at
  73. Fávero JF, Schwertz CL, Doleski PH, Leal DBR, Machado G, Manzoni AG, de Silva ES, Gabriel ME, Stedilleb FA, Christ R, Stefanía LM, Mendes RE, da Silva AS (2016) NTPDase and 5′-nucleotidase as inflammatory markers in cattle naturally infected by Eurytrema coelomaticum. Comp Immunol Microbiol Infect Dis 48:48–53PubMedCrossRefPubMedCentralGoogle Scholar
  74. Ferreira AMR, Almeida ECP, Labarthe NV (1999) Liver fluke infection (Platynosomum concinnum) in Brazilian cats: prevalence and pathology. Feline Pract 27:19–22Google Scholar
  75. Ferreras MC, Campo R, González-Lanza C, Pérez V, García-Marín JF, Manga-González MY (2007) Immunohistochemical study of the local immune response in lambs experimentally infected with Dicrocoelium dendriticum (Digenea). Parasitol Res 101:547–555CrossRefGoogle Scholar
  76. Fuertes M, Pérez V, Benavides J, González-Lanza MC, Mezo M, González-Warleta M, Giráldez FJ, Fernandez M, Manga-González MY, Ferreras MC (2015, l209) Pathological changes in cattle naturally infected by Calicophoron daubneyi adult flukes. Vet Parasitol:188–196PubMedCrossRefPubMedCentralGoogle Scholar
  77. Goater CP, Colwell DD (2007) Epidemiological characteristics of an invading parasite: Dicrocoelium dendriticum in sympatric wapiti and beef cattle in southern Alberta, Canada. J Parasitol 93:491–494PubMedCrossRefPubMedCentralGoogle Scholar
  78. Godara R, Katoch R, Anish Y, Borah MK (2014) Dicrocoeliosis in goats in Jammu, India. J Parasit Dis 38:201–204PubMedCrossRefPubMedCentralGoogle Scholar
  79. Gómez BJ, Manga-González MY, Angulo E, González-Lanza C (1996) Alteraciones histológicas producidas por Dicrocoelium dendriticum (Trematoda) en dos especies de Cernuella (Mollusca) sacrificadas a los tres meses post-infestación. Iberus 14:189–195Google Scholar
  80. González-Lanza C, Manga-González MY, Del-Pozo P (1993) Coprological study of the Dicrocoelium dendriticum (Digenea) egg elimination by cattle in highland areas in León Province, Northwest Spain. Parasitol Res 79:488–491PubMedCrossRefPubMedCentralGoogle Scholar
  81. González-Lanza C, Manga-González MY, Campo R, Del-Pozo MP (1997) Larval development of Dicrocoelium dendriticum in Cernuella (Xeromagna) cespitum arigonis under controlled laboratory conditions. J Helminthol 71:311–317PubMedCrossRefPubMedCentralGoogle Scholar
  82. González-Lanza C, Manga-González MY, Campo R, Del-Pozo MP, Sandoval H, Oleaga A, Ramajo V (2000) IgG antibody response to ES or somatic antigens of Dicrocoelium dendriticum (Trematoda) in experimentally infected sheep. Parasitol Res 86:472–479PubMedCrossRefPubMedCentralGoogle Scholar
  83. González-Lanza C, Manga-González MY, Revilla-Nuín B (2006) Preliminary protective capacity study of a Dicrocoelium dendriticum antigenic protein in hamsters. Parasitol Res 99:749–752PubMedCrossRefPubMedCentralGoogle Scholar
  84. Gorjipoor S, Moazeni M, Sharifiyazdi H (2015) Characterization of Dicrocoelium dendriticum haplotypes from sheep and cattle in Iran based on the internal transcribed spacer 2 (ITS-2) and NADH dehydrogenase gene (nad1). J Helminthol 89:158–164PubMedCrossRefPubMedCentralGoogle Scholar
  85. Graydon RJ, Carmichael IH, Sánchez MD, Weidosari E, Widjayanti S (1992) Mortalities and wasting in Indonesian sheep associated with the trematode Eurytrema pancreaticum. Vet Rec 131:443PubMedCrossRefPubMedCentralGoogle Scholar
  86. Grigoryan GA, Akopyan VD (1960) [Experimental data on the biology of Dicrocoelium lanceolatum Stiles & Hassall, 1896]. Trudi Armyanskogo Nauchno Issledovatelskogo Instituta Zhivotnovodstva i Veterinarii 4:247–254Google Scholar
  87. Groschaft J (1961) [Mravenci doplnkoví mezihostitelé motolice (Dicrocoelium dendriticum Rudolphi 1819)]. Česk Parasitol 8:151–165Google Scholar
  88. Grosskopf HM, Schwertz CL, Machado G, Bottari NB, da Silva ES, Gabriel ME, Lucca NJ, Alves MS, Schetinge MRC, Morsch VM, Mendes RE, da Silva AS (2017) Cattle naturally infected by Eurytrema coelomaticum: relation between adenosine deaminase activity and zinc levels. Res Vet Sci 110:79–84PubMedCrossRefPubMedCentralGoogle Scholar
  89. Gu JT, Liu RK, Li QF, Wang XM, Da LT, Tang CT, Tang ZZ (1990) Epidemiological survey on Eurytrema pancreaticum and Dicrocoelium chinensis in sheep in the southern area of Daxinganling Mountain of Inner Mongolia. Chin J Vet Sci Technol 3:15–16Google Scholar
  90. Gualdieri L, Rinaldi L, Petrullo L, Morgoglione ME, Maurelli MP, Musella V, Piemonte M, Caravano L, Coppola MG, Cringoli G (2011) Intestinal parasites in the city of Naples (southern Italy). Acta Trop 117:196–201PubMedCrossRefPubMedCentralGoogle Scholar
  91. Gürelli G (2017) Dicrocoeliosis Epidemiyolojisinde Kara Salyangozlarinin Önemi. Turk Parazitol Dernegi 41:169–172CrossRefGoogle Scholar
  92. Gutiérrez JF, Castellá J, Muñoz E, Lacasa MI, Ferrer J, Meya J (1993) Parásitos de rumiantes salvajes em Cataluña (NE de España). Acta Parasitol Port 1(2):196Google Scholar
  93. Hayashi K, Tang WQ, Ohari Y, Ohtori M, Mohanta UK, Matsuo K, Sato H, Itagaki T (2017) Phylogenetic relationships between Dicrocoelium chinensis populations in Japan and China based on mitochondrial nad1 gene sequences. Parasitol Res 116:2605–2609PubMedCrossRefPubMedCentralGoogle Scholar
  94. Headley SA, Gillen MA, Sanches AW (2012) Platynosomum fastosum-induced chronic intrahepatic cholangitis and Spirometra spp infections in feral cats from Grand Cayman. J Helminthol 86:209–214PubMedCrossRefPubMedCentralGoogle Scholar
  95. Henkel H (1931) Untersuchungen zur Ermittlung des Zwischenwirtes von Dicrocoelium lanceatum. Z Parasitenkd 3:664–712CrossRefGoogle Scholar
  96. Heussler V, Kaufmann H, Glaser I, Ducommun D, Müller C, Dobbelaere D (1998) A DNA probe for the detection of Dicrocoelium dendriticum in ants of Formica spp. and Lasius spp. Parasitol Res 84:505–508PubMedCrossRefPubMedCentralGoogle Scholar
  97. Hilbe M, Robert N, Pospischil A, Gerspach C (2015) Pulmonary arterial lesions in new world camelids in association with Dicrocoelium dendriticum and Fasciola hepatica infection. Vet Pathol 52:1202–1209PubMedCrossRefPubMedCentralGoogle Scholar
  98. Hildebrand J, Sitko J, Zalesny G, Jezewski W, Laskowski Z (2016) Molecular characteristics of representatives of the genus Brachylecithum Shtrom, 1940 (Digenea, Dicrocoeliidae) with comments on life cycle and host specificity. Parasitol Res 115:1417–1425PubMedCrossRefPubMedCentralGoogle Scholar
  99. Himonas CA, Liakos V (1980) Efficacy of albendazole against Dicrocoelium dendriticum in sheep. Vet Rec 197:288–289CrossRefGoogle Scholar
  100. Hinaidy HK (1983) Dicrocoelium suppereri nomen novum (syn. D. orientalis Sudarikov et Ryjikov 1951), a new trematode for the parasite fauna of Austria. Zentralbl Veterinarmed B 30:576–589PubMedCrossRefPubMedCentralGoogle Scholar
  101. Hohorst W (1962) Die rolle der Ameisen im Entwicklungsgang des Lanzettegels (Dicrocoelium dendriticum). Z Tropenmed Parasitol 13:377–397PubMedPubMedCentralGoogle Scholar
  102. Hohorst W, Graefe G (1961) Ameisen-obligatorische Zwischenwirte des Lanzettegels (Dicrocoelium dendriticum). Naturwissenschaften 48:229–230CrossRefGoogle Scholar
  103. Hohorst W, Lämmler G (1962) Experimentelle Dicrocoeliose-Studien. Z Tropenmed Parasitol 3:377–397Google Scholar
  104. Ilha MRS, Loretti AP, Reis ACF (2005) Wasting and mortality in beef cattle parasitized by Eurytrema coelomaticum in the State of Paraná, southern Brazil. Vet Parasitol 133:49–60PubMedCrossRefPubMedCentralGoogle Scholar
  105. Iyaji FO, Yaro CA, Peter MF, Abutu AEQ (2018) Fasciola hepatica and associated parasite, Dicrocoelium dendriticum in slaughter houses in Anyigba, Kogi State, Nigeria. Adv Infect Dis 8:1–9CrossRefGoogle Scholar
  106. Jahed Khaniki GR, Kia EB, Raei M (2013) Liver condemnation and economic losses due to parasitic infections in slaughtered animals in Iran. J Parasit Dis 37:240–244PubMedCrossRefPubMedCentralGoogle Scholar
  107. Jeandron A, Rinaldi L, Abdyldaieva G, Usubalieva J, Steinmann P, Cringoli G, Utzinger J (2011) Human infections with Dicrocoelium dendriticum in Kyrgyzstan: the tip of the iceberg? J Parasitol 97:1170–1172PubMedCrossRefPubMedCentralGoogle Scholar
  108. Jithendran KP, Bhat TK (1996) Prevalence of dicrocoeliosis in sheep and goats in Himachal Pradesh, India. Vet Parasitol 61:265–271PubMedCrossRefPubMedCentralGoogle Scholar
  109. Jonlija R, Cankovic M, Rozman M (1972) Examination of ants the second intermediary hosts of Dicrocoelium lanceatum in Bosnia and Hercegovina, I. Veterinaria 21:317–322Google Scholar
  110. Jonlija R, Milka R, Cankovic M (1973) Ispitivanje infestiranosti puzeva y mrava razvojnim oblicima Dicrocoelium lanceatum u Bosni y Hercegovini. l. Veterinaria 22:449–470Google Scholar
  111. Jubb KVF, Stent AW (2016) Pancreas. In: Maxie GM (ed) Jubb, Kennedy and Palmer’ Pathology of domestic animals, 6th edn. Elsevier, St. LouisGoogle Scholar
  112. Kajubiri V, Hohorst W (1977) Increasing incidence of Dicrocoelium hospes (LOOSS, 1907) (Trematoda: Digenea) in Uganda. J Helminthol 51:212–214PubMedCrossRefPubMedCentralGoogle Scholar
  113. Kalkan A (1971) Dicrocoelium dendriticum (Rudolphi, 1819) Looss, 1899 in Turkey. l. Field studies of intermediate and final hosts in the South Marmara region, 1968. Br Vet J 127:67–75PubMedCrossRefPubMedCentralGoogle Scholar
  114. Kalkan A (1976) Dicrocoelium dendriticum in Turkey. 2. Observations on second intermediate hosts (ants) in the South Marmara region. Etlik Veteriner Bakteriyoloji Enstitüsü Dergisi 4:11–37Google Scholar
  115. Karanfilovski G (1983) Economic losses caused by fascioliasis and dicrocoeliasis to livestock production in Pljevlja and surrounding area. Veterinaria Yugoslavica 32:253–260Google Scholar
  116. Kassai T, Takats C, Fok E, Redl P (1988) Activity of luxabendazole against liver flukes gastrointestinal roundworm and lungworm in naturally infected sheep. Parasitol Res 75:14–18PubMedCrossRefPubMedCentralGoogle Scholar
  117. Katayama F (1996) Alterations of the mucin components in bile duct epithelium associated with proliferating cholangitis. An experimental study. Hokkaido Igaky Zasshi 71:585–598Google Scholar
  118. Katsoulos PD, Christodoulopoulos G, Karatzia M, Pourliotis K, Minas A (2011) Liver flukes promote cholelithiasis in sheep. Vet Parasitol 179:262–265PubMedCrossRefPubMedCentralGoogle Scholar
  119. Kazacos KR, Dhillon AS, Winterfield RW, Thacker HL (1980) Fatal hepatic trematodiasis in cockatoos due to Platynosomum proxillicens. Avian Dis 24:788–793PubMedCrossRefPubMedCentralGoogle Scholar
  120. Kopp H (1975) Untersuchungen über die Eiausscheidung von Fasciola hepatica und Dicrocoelium dendriticum bei Schaf und Rind im Verlauf eines Jahres. Inaugural-Disertation zur Erlangung der tiermedizinischen Doktorwürde des Fachbereichs Tiermedizin der Ludwig- Maxinillians-Universität, MünchenGoogle Scholar
  121. Krull WH (1958) The migratory route of the metacercaria of Dicrocoelium dendriticum (Rudolphi, 1819) Looss, 1899 in the definitive host: Dicrocoeliidae. Cornell Vet 48:17–24PubMedPubMedCentralGoogle Scholar
  122. Krull WH, Mapes CR (1952a) Studies on the biology of Dicrocoelium dendriticum (Rudolphi, 1819) Looss, 1899 (Trematoda: Dicrocoeliidae), including its relation to the intermediate host, Cionella lubrica (Müller). VII. The second intermediate host of Dicrocoelium dendriticum. Cornell Vet 42:603–604PubMedPubMedCentralGoogle Scholar
  123. Krull WH, Mapes CR (1952b) Studies on the biology of Dicrocoelium dendriticum (Rudolphi, 1819) Looss, 1899 (Trematoda: Dicrocoeliidae), including its relation to the intermediate host, Cionella lubrica (Müller). III. Observations on the slimeballs of Dicrocoelium dendriticum. Cornell Vet 42:253–276PubMedPubMedCentralGoogle Scholar
  124. Krull WH, Mapes CR (1952c) Studies on the biology of Dicrocoelium dendriticum (Rudolphi, 1819) Looss, 1899 (Trematoda: Dicrocoeliidae), including its relation to the intermediate host, Cionella lubrica (Müller). IV. Infection experiments involving definitive hosts. Cornell Vet 42:277–285PubMedPubMedCentralGoogle Scholar
  125. Krull WH, Mapes CR (1953) Studies on the biology of Dicrocoelium dendriticum (Rudolphi, 1819) Looss, 1899 (Trematoda: Dicrocoeliidae), including its relation to the intermediate host, Cionella lubrica (Müller). IX. Notes on the cyst, metacercaria, and infection in the ant, Formica fusca. Cornell Vet 43:389–410PubMedPubMedCentralGoogle Scholar
  126. Kukolj V, Aleksic-Kovacevic S, Katic-Radivojevic S, Knezevic DJ, Jovanovic M (2015) The role and immunophenotypic characteristics of myofibroblasts in liver of sheep naturally infected with the lancet liver fluke (Dicrocoelium dendriticum). Vet Parasitol 208:181–189PubMedCrossRefPubMedCentralGoogle Scholar
  127. Lambacher B, Wittek T, Joachim A, Dadak A, Stanitzning A, Hinney B, Tichy A, Duscher G, Franz S (2016) From the New World to the Old Word: endoparasites of South American Camelids in Austria. Wien Tierarztl Monatsschr 103:33–42Google Scholar
  128. Lathroum CN, Shell L, Neuville K, Ketzis JK (2018) Efficacy of praziquantel in the treatment of Platynosomum fastosum in cats with natural infection. Vet Sci 5, 7 ppPubMedCentralCrossRefGoogle Scholar
  129. Leuckart R (1886-1901) Die Parasiten des Menschen und die von ihnen herrührenden Krankheiten, vol 2. C.F. Winter, Leipzig, pp 379–399Google Scholar
  130. Liakos DV (1985) Epidemiological survey of parasitoses of sheep and goats. Etlen Kteniat Hellen Vet Med 28:271–278Google Scholar
  131. Liu GH, Xu MJ, Song HK, Wang CR, Zhu XQ (2016) De novo assembly and characterization of the transcriptome of the pancreatic fluke Eurytrema pancreaticum (Trematoda: Dicrocoeliidae) using Illumina paired-end sequencing. Gene 576:333–338PubMedCrossRefPubMedCentralGoogle Scholar
  132. Loos-Frank B (1978) Zum Verhalten von Ameisen der Gattung Formica (Hymenoptera: Formicidae) gegenüber Schleimballen des Kleinen Leberegels Dicrocoelium dendriticum (Digenea: Dicrocoeliidae) und über infektionsbedingte Veränderungen ihrer Hämolymphe. Entomol Germ 4:12–23Google Scholar
  133. Lucius, R (1981) Untersuchungen zur Biologie, Pathologie und Ökologie von Dicrocoelium hospes Looss, 1907 (Trematode, Dicrocoeliidae). Dissertation zur Erlangung des Grades eines Doktors der Naturwissenschaften vorgelegt der Fakultät II (Biologie) der Universität HohenheimGoogle Scholar
  134. Lucius R, Frank W (1978) Beitrag zur Biologie von Dicrocoelium hospes Looss, 1907 (Trematodes, Dicrocoeliidae). Acta Trop 35:161–181PubMedPubMedCentralGoogle Scholar
  135. Lukin AK (1980) The prevalence and economic loss due to dicrocoeliasis in ruminants. Trudy Saratovskoi Nauchno-Issledovatel’skoi veterinamoi Stantsii 14:76–79Google Scholar
  136. Macko JK, Pacenovsky J (1987) On the variability of Dicrocoelium dendriticum (Rudolphi, 1819) in domestic and free-living animals. II. On individual variability of the cattle (Bos taurus -race locale) dicrocoeliids in Algeria. Helminthologia 24:111–118Google Scholar
  137. Malek EA (1980a) Ocurrence of Dicrocoelium hospes in Mali and Senegal, West Africa. J Helminthol 54:45–46PubMedCrossRefPubMedCentralGoogle Scholar
  138. Malek EA (1980b) Snail-transmitted parasitic diseases, vol I & II. CRC Press, New YorkGoogle Scholar
  139. Mañas I, Gómez V, Lozano J, Rodríguez M, Campos M (1978) Estudio de la frecuencia de la dicroceliosis en el ganado de la provincia de Granada. Rev Iber Parasitol 38:751–773Google Scholar
  140. Manga-González, MY (1983) Los Helicidae (Gastropoda, Pulmonata) de la Provincia de León. Institución “Fray Bernardino de Sahagún”, Excma. Diputación Provincial de León, Consejo Superior de Investigaciones Científicas (CECEL), León, SpainGoogle Scholar
  141. Manga-González MY (1987) Some aspects of the biology and helminthofaune of Helicella (Helicella) itala (Linnaeus, 1758) (Mollusca). Natural infection by Dicrocoeliidae (Trematoda). Rev Iber Parasitol 1987:131–148Google Scholar
  142. Manga-González MY (1999) Trematodos. In: Cordero del Campillo MC, Rojo-Vázquez FA, Martínez-Fernández AR, Sánchez-Acedo C, Hernández-Rodríguez S, Navarrete I, Díez-Baños P, Quiroz-Romero H, Carvalho-Varela M (eds) Parasitología Veterinaria. McGraw-Hill. Interamericana, Madrid, pp 79–104Google Scholar
  143. Manga-González MY, González-Lanza C (2005) Field and experimental studies on Dicrocoelium dendriticum and dicrocoeliosis in northern Spain. J Helminthol 79:291–302PubMedCrossRefPubMedCentralGoogle Scholar
  144. Manga-González MY, Quiroz-Romero H (1999) Dicroceliosis. In: Cordero del Campillo MC, Rojo-Vázquez FA, Martínez-Fernández AR, Sánchez-Acedo C, Hernández-Rodríguez S, Navarrete I, Díez-Baños P, Quiroz-Romero H, Carvalho-Varela M (eds) Parasitología Veterinaria. McGraw-Hill. Interamericana, Madrid, pp 260–283Google Scholar
  145. Manga-González MY, González-Lanza C, Del-Pozo-Carnero P (1991) Dynamics of the elimination of Dicrocoelium dendriticum (Trematoda, Digenea) eggs in the faeces of lambs and ewes in the Porma Basin (León, NW Spain). Ann Parasitol Hum Comp 66:57–61PubMedCrossRefPubMedCentralGoogle Scholar
  146. Manga-González MY, González-Lanza C, Del-Pozo-Carnero MP & Campo R (1995) Studies on experimental infection by Dicrocoelium dendriticum (Trematoda) of Cernuella (Xeromagna) cespitum arigonis (Mollusca) specimens in natural environmnet. In: Abstracts of 12th internacional malacological congress, Vigo, SpainGoogle Scholar
  147. Manga-González MY, González-Lanza C, Cabanas E, Campo R (2001) Contributions to and review of dicrocoeliosis, with special reference to the intermediate hosts of Dicrocoelium dendriticum. Parasitology 123:S91–S114PubMedCrossRefPubMedCentralGoogle Scholar
  148. Manga-González MY, Ferreras MC, Campo R, González-Lanza C, Perez V, García-Marín JF (2004) Hepatic marker enzymes, biochemical parameters and pathological effects in lambs experimentally infected with Dicrocoelium dendriticum. Parasitol Res 93:344–355PubMedCrossRefPubMedCentralGoogle Scholar
  149. Manga-González MY, González-Lanza C, Cabanas E (2007) Dicrocoelium dendriticum primoinfection and kinetic egg elimination in marked lambs and ewes from León mountains (Spain). Rev Iber Parasitol 67:15–25Google Scholar
  150. Manga-González MY, Quiroz-Romero H, González-Lanza C, Miñambres B, Ochoa P (2010) Strategic control of Dicrocoelium dendriticum (Digenea) egg excretion by naturally infected sheep. Vet Med 55:19–29CrossRefGoogle Scholar
  151. Mapes CR (1951) Studies on the biology of Dicrocoelium dendriticum (Rudolphi, 1819) Loos, 1899 (Trematoda, Dicrocoeliidae), including its relation to the intermediate host, Cionella lubrica (Müller). I. A study of Dicrocoelium dendriticum and Dicrocoelium infection. Cornell Vet 41:382–432PubMedPubMedCentralGoogle Scholar
  152. Martínez-Ibeas, AM (2013) Nuevos enfoques para el diagnóstico y el control de la Dicrocoeliosis, importante parasitosis hepática de los rumiantes. Tesis Doctoral, Universidad de León (España), 267 PagesGoogle Scholar
  153. Martínez-Ibeas AM, Martínez-Valladares M, González-Lanza C, Miñambres B, Manga-González MY (2011) Detection of Dicrocoelium dendriticum larval stages in mollusc and ant, intermediate hosts by PCR, using mitochondrial and ribosomal internal transcribed spacer (ITS-2) sequences. Parasitology 138:1916–1923PubMedCrossRefPubMedCentralGoogle Scholar
  154. Martinez-Ibeas AM, González-Lanza C, Manga-González MY (2013a) Proteomic analysis of the tegument and excretory-secretory products of Dicrocoelium dendriticum (Digenea) adult worms. Exp Parasitol 133:411–420PubMedCrossRefPubMedCentralGoogle Scholar
  155. Martínez-Ibeas AM, Perteguer MJ, González-Lanza C, Garate T, Manga-González MY (2013b) Analysis of an expressed sequence tag library from Dicrocoelium dentriticum. Exp Parasitol 135:287–296PubMedCrossRefPubMedCentralGoogle Scholar
  156. Martín-Vega D, Garbout A, Ahmed F, Wicklein M, Goater CP, Colwell DD, Hall MJR (2018) 3D virtual histology at the host/parasite interface: visualization of the master manipulator, Dicrocoelium dendriticum, in the brain of its ant host. Sci Rep 8:8587PubMedPubMedCentralCrossRefGoogle Scholar
  157. Mattes O (1936) Der Entwicklungsgang des Lanzettegels Dicrocoelium lanceolatum. Z Parasitenkd 8:371–430CrossRefGoogle Scholar
  158. Mattioli MP, Batista JS, Ferrari M, Paludo GR, Dias CA, Hoppe EG, da Rocha GC, Monteiro RV (2016) Clinical, hematological, biochemical, and ultrasonographic aspects of Platynosomum sp. (Trematoda: Dicrocoeliidae) infection of captive Callithrix penicillata. Primates 57:279–287PubMedCrossRefPubMedCentralGoogle Scholar
  159. Mattioli MP, dos Santos Batista J, Ferrari M, Paludo GR, Dias CA, Hoppe EGL, Chaves da Rocha G, Monteiro RV (2016) Clinical, hematological, biochemical, and ultrasonographic aspects of Platynosomum sp. (Trematoda: Dicrocoeliidae) infection of captive Callithrix penicillata. Primates 57:279–287PubMedCrossRefPubMedCentralGoogle Scholar
  160. Maurelli MP, Rinaldi L, Capuano F, Perugini AG, Veneziano G, Cringoli G (2007) Characterization of the 28S and the second internal transcribed spacer of ribosomal DNA of Dicrocoelium dendriticum and Dicrocoelium hospes. Parasitol Res 101:1251–1255PubMedCrossRefPubMedCentralGoogle Scholar
  161. Mederacke I (2013) Liver fibrosis-mouse models and relevance in human liver. Z Gastroenterol 51:55–62PubMedCrossRefPubMedCentralGoogle Scholar
  162. Mehlhorn, H & Walldorf, V (1988) Life cycles. In: Parasitology in focus: facts and trends. Springer, BerlinGoogle Scholar
  163. Mitchell G, Cuthill G, Haine A, Zadoks R, Chaudhry U, Skuce P, Sargison N (2017) Evaluation of molecular methods for the field study of the natural history of Dicrocoelium dendriticum. Vet Parasitol 235:100–105PubMedCrossRefPubMedCentralGoogle Scholar
  164. Mitterer KE (1975) Untersuchungen zum Schlüpfen der Miracidien des Kleinen Leberegels Dicrocoelium dendriticum. Z Parasitenkd 48:35–45PubMedCrossRefPubMedCentralGoogle Scholar
  165. Mohamed ARE, Mummery V (1990) Human dicrocoeliosis. Report on 208 cases from Saudi Arabia. Trop Geogr Med 42:1–7Google Scholar
  166. Mohanta UK, Ichikawa-Seki M, Hayashi K, Itagaki T (2016) Morphological and molecular characterization of Eurytrema cladorchis parasitizing cattle (Bos indicus) in Bangladesh. Parasitol Res 114:2099–2105CrossRefGoogle Scholar
  167. Morozova EV, Ryskov AP, Semyenova SK (2002) RAPD variation in two trematode species (Fasciola hepatica and Dicrocoelium dendriticum) from a single cattle population. Russ J Genet 38:977–983CrossRefGoogle Scholar
  168. Moulinié JJ (1856) De la reproduction chez les trématodes endoparasites. Mémoires de l'Institut de Genève 3:31–44Google Scholar
  169. Nali RC, Zamudio KR, Prado CPA (2014) Microsatellite markers for Bokermannohyla species (Anura, Hylidae) from the Brazilian cerrado and Atlantic forest domains. Amphibia-Reptilia 35:355–360CrossRefGoogle Scholar
  170. Nascimento Ramos RA, Santana Lima VF, Melo Monteiro MF, de Andrade SM, Lepold R, da Gloria Faustino MA, Rinaldi L, Cringoli G, Camara Alves L (2016) New insights into diagnosis of Platynosomum fastosum (Trematoda: Dicrocoeliidae) in cats. Parasitol Res 115:479–482CrossRefGoogle Scholar
  171. Neuhaus W (1936) Untersuchungen über bau und entwicklung der Lanzettegel-Cercarie (Cercaria vitrina) und Klarstellung des infektionsvorganges beim endwirt. Z Parasitenkd 8:431–473CrossRefGoogle Scholar
  172. Neuhaus W (1938) Die Invasiosnswege der Lanzettegelcercarie bei der Infektion des Endwirtes und ihre Entwicklung zum Dicrocoelium lanceatum. Z Parasitenkd 10:476–512CrossRefGoogle Scholar
  173. Nguyen HM, Hoang HV, Ho LT (2017) Platynosomum fastosum (Trematoda: Dicrocoeliidae) from cats in Vietnam: morphological redescription and molecular phylogenetics. Korean J Parasitol 55:39–45PubMedPubMedCentralCrossRefGoogle Scholar
  174. Nöller W (1929) Befunde bei Schnecken von Thüringer Schafweiden in einem Lanzettegelgebiete. Tierärztliche Rundschau 35:485–489Google Scholar
  175. Nöller W (1932) Über die Rolle der Wildkaninchen als Lanzettegelträger in einem Thüringer Lanzettegelbiete. Tierärztliche Rundschau 38:190–191Google Scholar
  176. Odhner T (1910) Dicrocoelium dendriticum (Rud.) der “richtige” Name des kleinen Leberegels. Zool Anz 35:317–318Google Scholar
  177. Otranto D, Traversa D (2002) A review of dicrocoeliosis of ruminants including recent advances in the diagnosis and treatment. Vet Parasitol 107:317–335PubMedCrossRefPubMedCentralGoogle Scholar
  178. Otranto D, Traversa D (2003) Dicrocoeliosis of ruminants: a little known fluke disease. Trends Parasitol 19:12–15PubMedCrossRefPubMedCentralGoogle Scholar
  179. Otranto D, Rehbein S, Weigl S, Castacessi C, Parisi A, Lia RP, Olson PD (2007) Morphological and molecular differentiation between Dicrocoelium dendriticum (Rudolphi, 1819) and Dicrocoelium chinensis (Sudarikov and Ryjikov, 1951) Tang and Tang, 1978 (Platyhelminthes: Digenea). Acta Trop 104:91–98PubMedCrossRefPubMedCentralGoogle Scholar
  180. Panin, VY (1971) (A new trematode Suborder, Dicrocoeliata n. suborder). Izvestiya Akademii Nauk Kazakhskoi SSR 6:60–66. En: Helminthological Abstract (1974) 44:270Google Scholar
  181. Panin, VY (1981) (Principles of the taxonomy and the system of trematodes of the family Dicrocoeliidae Odhner, 1911). Parazity komponenty vodnykh i nazemnykh biotsenozov Kazakhstana 123–133Google Scholar
  182. Paraschivescu, D (1978) Dynamics of formicids (Hym., Formicidae) in tetany of some meadows with dicrocelioza in Romania. Travaux du Museúm d’Histoire Naturell “Grigore Antipa” 19:321–323Google Scholar
  183. Paraschivescu D (1981) Etho-ökologische Untersuchungen an einigen Formiciden-Arten als Zwischenwirte von Dicrocoelium dendriticum. Waldhygiene 14:65–72Google Scholar
  184. Paraschivescu D (1983) Untersuchungen zur Temperaturabhangigkeit der Tetaniephase von Formica pratensis bei einer Infektion mit Stadien des Kleinen Leberegels Dicrocoelium dendriticum. Waldhygiene 15:21–24Google Scholar
  185. Paraschivescu D, Hurghisiu I, Popescu S (1976) Bioecologic and biochemical research upon Formicidae complementary hosts of the Dicrocoelium lanceatum fluke (Stiles and Hassall, 1896). Arch Vet 11(12):159–178Google Scholar
  186. Pavlov P, Popov A, Bankov D, Bratanov V, Dimitrov G (1965) Untersuchungen über die Wirksamkeit von Hetolin® bei der Infektion der Schafe mit Dicrocoelium lanceolatum. Tierarztl Umsch 20:574–575Google Scholar
  187. Pegreffi G (1957) La distomatosi epatica da Dicrocoelium dendriticum. Vet Ital 8:123–135Google Scholar
  188. Pepe P, Castellano M, Alfano S, Della Pepa ME, Tirino V, Piemonte M, Desiderio V, Zappavigna S, Galdiero M, Caraglia M, Cringoli G, Rinaldi L, Galdiero M (2015) Dicrocoelium dendriticum induces autophagic vacuoles accumulation in human hepatocarcinoma cells. Vet Parasitol 212:175–180PubMedCrossRefPubMedCentralGoogle Scholar
  189. Piana P (1882) Le cercarie nei molluschi studiate in rapporto colla presenza del Distoma epatico e del Distoma lanceolato nel fegato del ruminanti domestici. Clin Vet (Milan) 5:306–314Google Scholar
  190. Pinto HA, Mati VLT, de Melo AL (2014) New insights into the life cycle of Platynosomum (Trematoda: Dicrocoeliidae). Parasitol Res 113:2701–2707PubMedCrossRefPubMedCentralGoogle Scholar
  191. Pinto HA, Mati VLT, de Melo AL (2016) Can the same species of Platynosomum (Trematoda: Dicrocoeliidae) infect both mammalian and avian hosts? J Helminthol 90:372–376PubMedCrossRefPubMedCentralGoogle Scholar
  192. Pinto HA, Pulido-Murillo EA, Braga RR, Mati VLT, Melo AL, Tkach VV (2018) DNA sequences confirm low specificity to definitive host and wide distribution of the cat pathogen Platynosomum illiciens (=P. fastosum) (Trematoda: Dicrocoeliidae). Parasitol Res 117:1975–1978PubMedCrossRefPubMedCentralGoogle Scholar
  193. Poglayen G, Roda R, Tona A, Mulciri A, Venturi G (1996) Endoparasites of the muflon (Ovis ammon musimon) from the Belluno province, Italy. Ricerche di Biologia della Selvaggina 4:73–77Google Scholar
  194. Pojmanska T (2008) Family Dicrocoeliidae Looss, 1899. In: Bray RA, Gibson DI, Jones A (eds) Keys to the Trematoda, vol 3. CAB, LondonGoogle Scholar
  195. Polozhentseva AA (1968) (Observations of Dicrocoelium in the hepatic veins of sheep). Veterinariya, Moscow 45:59–60Google Scholar
  196. Prunescu C, Prunescu P, Fromunda V, Paraschivescu D, Popescu S (1979) Histopathological changes of the liver in hamsters with experimental dicroceliasis. Arch Vet 14:83–90Google Scholar
  197. Quesada A, Russillo A, Rosa P, Cringoli G (1991) Diffusione di F. hepatica e D. dendriticum in greggi ovini allevati in un distretto alto-collinare delle Basilicata. Acta Med Vet 37:295–304Google Scholar
  198. Ractliffe LH (1968) Hatching of Dicrocoelium lanceolatum eggs. Exp Parasitol 23:67–78PubMedCrossRefPubMedCentralGoogle Scholar
  199. Rahko T (1972a) Studies on the pathology of dicrocoeliasis and fascioliasis in the goat. I. The histopathology of the liver and bile ducts. Acta Vet Scand 13:554–562PubMedPubMedCentralGoogle Scholar
  200. Rahko T (1972b) Studies on the pathology of dicrocoeliasis and fascioliasis in the goat. II. The histochemistry of bile-duct mucosubstances. Acta Vet Scand 13:563–574PubMedPubMedCentralGoogle Scholar
  201. Rahko T (1972c) Studies on the pathology of dicrocoeliasis and fascioliasis in the goat. III. The histochemistry of mast cells and globule leucocytes. Acta Vet Scand 13:575–584PubMedPubMedCentralGoogle Scholar
  202. Ranucci S, Mughetti L, Ambrosi M, Grelloni V (1981) Rilievi ematochimici, anatomo-istopatologici e parassitologici in ovini infetti da dicroceliosi. Riv Zoot Vet 9:173–175Google Scholar
  203. Rehbein S, Kokott S, Lindner T (1999) Evaluation of thecniques for the enumeration of Dicrocoelium eggs in sheep faeces. Zentralbl Veterinarmed 46:133–139CrossRefGoogle Scholar
  204. Revilla-Nuín B, Manga-González MY, Miñambres B, González-Lanza C (2005) Partial characterization and isolation of 130kDa antigenic protein of Dicrocoelium dendriticum adults. Vet Parasitol 134:229–240PubMedCrossRefPubMedCentralGoogle Scholar
  205. Robinson N, Piedrafita D, Snibson K, Harrison P, Meeusen E (2010) Immune cell kinetics in the ovine abomasal mucosa following hyperimmunization and challenge with Haemonchus contortus. Vet Res 41:37PubMedPubMedCentralCrossRefGoogle Scholar
  206. Rojo-Vázquez FA, Cordero-del-Campillo M, Díez-Baños P, Chaton-Schaffner M (1981) Relation existant entre le nombre d’oeufs dans les feces et la charge parasitaire lors des infestations naturelles a Dicrocoelium dendriticum chez les ovins. Rev Med Vet 132:601–607Google Scholar
  207. Rojo-Vázquez FA, Meana A, Tarazona JM, Duncan JL (1989) The efficacy of netobimin, 15 mg/kg, against Dicrocoelium dendriticum in sheep. Vet Rec 124:512–513PubMedCrossRefPubMedCentralGoogle Scholar
  208. Rojo-Vázquez FA, Meana A, Valcárcel F, Martínez-Valladares M (2012) Update on trematode infections in sheep. Vet Parsitol 189:15–38CrossRefGoogle Scholar
  209. Roming T, Lucius R, Frank W (1980) Cerebral larvae in the second intermediate host of Dicrocoelium dendriticum (Rudolphi, 1819) and Dicrocoelium hospes Looss, 1907 (Trematodes, Dicrocoeliidae). Z Parasitenkd 63:277–286CrossRefGoogle Scholar
  210. Rozman S, Gradjanin M, Cankovic M (1974) The transitory hosts of Dicrocoelium dendriticum in the mountain area of Bosnia and Herzegovina. In: Proceedings of the third international congress of parasitology, Munich, 1974Google Scholar
  211. Sadykhov IA, Melikov YuF (1980) (Features of the distribution of Fasciola and Dicrocoelium in farming complexes in the Sheki-Zakataly area of the Azerbaidzhan SSR). Izvestiya Akademii Nauk Azerbaidzhan SSR, Biol Nauki 3:75–79. En: Helminthological Abstract (1981) 50:5810Google Scholar
  212. Salimova M (1972) (Experimental dicrocoeliasis of Karakul lambs). Trudy VII Vsesoyuznoi Konferentsii po Prirodnoi Ochagovosti Boleznei i Obshchim Voprosam Parazitologii Zhivotnykn, 14–18 Oktyabrya 1969, Samarkand, 6. Tashkent, USSR: Izdatel’stvo “FAN” Uzbekskoi SSR:155–157Google Scholar
  213. Samadieh H, Mohammadi G-R, Malaki M, Borji H, Azizzadeh M, Heidarpour M (2017) Relationships between oxidative stress, liver, and erythrocyte injury, trace elements and parasite burden in sheep naturally infected with Dicrocoelium dendriticum. Iran J Parasitol 12:46–55PubMedPubMedCentralGoogle Scholar
  214. Sánchez-Andrade R, Paz-Silva A, Suárez JL, Arias M, López C, Morrondo P, Scala A (2003) Serum antibodies to Dicrocoelium dendriticum in sheep from Sardinia (Italy). Prev Vet Med 57:1–5PubMedCrossRefPubMedCentralGoogle Scholar
  215. Sánchez-Campos S, Tuñón MJ, González P, Campo R, Ferreras MC, Manga-González MY, González-Gallego J (1996) Effects of experimental dicrocoeliosis on oxidative drug metabolism in hamster liver. Comp Biochem Physiol 115C:55–60Google Scholar
  216. Sánchez-Campos S, Tuñón MJ, González P, Marín JJG, González-Gallego J (1998) Enhanced bile formation induced by experimental dicrocoeliosis in the hamster. Life Sci 63:1963–1974PubMedCrossRefPubMedCentralGoogle Scholar
  217. Sánchez-Campos S, Tuñón MJ, González P, González-Gallego J (1999) Oxidative stress and changes in liver antioxidant enzymes induced by experimental dicrocoeliosis in hamsters. Parasitol Res 85:468–474PubMedCrossRefPubMedCentralGoogle Scholar
  218. Sánchez-Campos S, González P, Ferreras MC, García-Iglesias MJ, González-Gallego J, Tuñón MJ (2000) Morphologic and biochemical changes caused by experimentally induced dicrocoeliosis in hamsters (Mesocricetus auratus). Comp Med 50:147–152PubMedPubMedCentralGoogle Scholar
  219. Sandoval H, Manga-González MY, Campo R, Garcia P, Castro JM, Pérez de la Vega M (1999) Preliminary study on genetic variability of Dicrocoelium dendriticum determined by random amplified polymorphic DNA. Parasitol Int 48:21–26PubMedCrossRefPubMedCentralGoogle Scholar
  220. Sandoval H, Manga-González MY, Castro JM (2013) A tool for diagnosis of Dicrocoelium dendriticum infection: hatching eggs and molecular identification of the miracidium. Parasitol Res 112:1589–1595PubMedCrossRefPubMedCentralGoogle Scholar
  221. Sanz F, Tarazona JM, Jurado R, Frías J, Tarazona JV, Duncan JL (1987) An evaluation of the efficacy of netobimin against Dicrocoelium dendriticum in sheep. Vet Rec 17:57–58CrossRefGoogle Scholar
  222. Sargison ND, Baird GJ, Sotiraki S, Gilleard JS, Busin V (2012) Hepatogenous photosensitisation in Scottish sheep caused by Dicrocoelium dendriticum. Vet Parasitol 189:233–237PubMedCrossRefPubMedCentralGoogle Scholar
  223. Scala A, Coda S, Ximenes LA, Cavedagna G (1991) Dicroceliasi ovina in Sardegna: Tassi di prevalenza, lesioni anatomo-istopatologiche e tests ematochimici. Atti Federazione Mediterranea Sanità e Produzione Ruminanti 1:209–214Google Scholar
  224. Schneider, J (1971) Die Wanderung der Metacercarien von Dicrocoelium dendriticum (Rud. 1819), Looss, 1899 (Digenea, Trematoda) im Ameisen Zwischen wirt und ihre Steuerung durch physiologisch-ökologische Faktoren. Inaügural Dissertation Naturwiss. Fakultat der Johaim Wolfgang for the Universita, Frankfurt/MGoogle Scholar
  225. Schneider G, Hohorst W (1971) Wanderung der Metacercarien des Lanzett-Egels in Ameisen. Naturwissenschaften 58:327–328PubMedCrossRefPubMedCentralGoogle Scholar
  226. Schuster R (1987) Ein geschichtlicher Überblick zur Namensgebung des Lanzettegels Dicrocoelium dendriticum. Angew Parasitol 28:205–206PubMedPubMedCentralGoogle Scholar
  227. Schuster R (1991) Factors influencing the metacercarial intensity in ants and the size of Dicrocoelium dendriticum metacercarial cyst. J Helminthol 65:275–279PubMedCrossRefPubMedCentralGoogle Scholar
  228. Schuster R (1992) Zur Beeinflussung von Helicella obvia durch Dicrocoelium Parthenitae. Angew Parasitol 33:61–64PubMedPubMedCentralGoogle Scholar
  229. Schuster R (1993) Infection patterns in the first intermediate host of Dicrocoelium dendriticum. Vet Parasitol 47:235–243PubMedCrossRefPubMedCentralGoogle Scholar
  230. Schuster R, Hiepe T (1993) Bekämpfung der Dicrocoeliose beim Schaf. Monatsh Veterinarmed 48:657–661Google Scholar
  231. Schwertz CI, Gabriel ME, Henker LC, Bottari NB, do Carmo G, Guarda Ndos S, Moresco RN, Machado G, Morsch VM, Schetinger MRC, Stedille FA, Baska P, Mattei V, da Silva AS, Mendes RE (2016) Oxidative stress associated with pathological changes in the pancreasof cattle naturally infected by Eurytrema coelomaticum. Vet Parasitol 223:102–110PubMedCrossRefPubMedCentralGoogle Scholar
  232. Senlik B, Cirak VY, Muz M, Tinar R (2006) Changes in faecal egg counts at different hours of the day and relationship between faecal egg count and parasite burden in sheep naturally infected with Dicrocoelium dendriticum. Turk J Vet Anim Sci 30:107–111Google Scholar
  233. Senlik B, Cirak VY, Tinar R (2008) Field efficacy of two netobimin oral suspensions (5% and 15%) in sheep naturally infected with Dicrocoelium dendriticum. Small Rumin Res 80:104–106CrossRefGoogle Scholar
  234. Shahbazi Y, Hashemnia M, Safavi EAA (2016) A retrospective survery of liver flukes in livestock based on abattoir data in Kermanshah, west of Iran. J Parasit Dis 40:948–953PubMedCrossRefPubMedCentralGoogle Scholar
  235. Şimşek S, Köroğlu E, Ütük AE (2006) Application of Western blotting and enzyme linked immunosorbent assay (ELISA) for the diagnosis of Dicrocoelium dendriticum in sheep using excretory secretory (E/S) antigens. Turk J Vet Anim Sci 30:113–119Google Scholar
  236. Skálová L, Forstová-Křížová V, Civilink V, Szotáková B, Storkánová L, Velík J, Lamka J (2007) Mouflon (Ovis musimon) dicrocoeliosis: effects of parasitosis on the activities of biotransformation enzymes and albendazole metabolism in liver. Vet Parasitol 146:254–262PubMedCrossRefPubMedCentralGoogle Scholar
  237. Soulsby EJL (1982) Helminths, arthropods and protozoa of domesticated animals, 7th edn. Baillère Tindal, LondonGoogle Scholar
  238. Spindler EM, Zhaler M, Loos-Frank B (1986) Behavioural aspects of ants as second intermediate hosts of Dicrocoelium dendriticum. Z Parasitenkd 72:689–692CrossRefGoogle Scholar
  239. Srivastava GC (1975) The intensity of infection in naturally infected Formica pratensis with the metacercariae of Dicrocoelium dendriticum in relation to their size. J Helminthol 49:57–64Google Scholar
  240. Srivastava GC, Kolev G, Georgiev M (1978) A surgical approach to trace the route of migration of Dicrocoelium dendriticum in the laboratory animals. Riv Parassitol 39:131–137Google Scholar
  241. Stratan NM (1986) Efficacy of Acemidophen against Dicrocoelium dendriticum in sheep. Byulleten’ Vsesoyuznogo Instituta Gel’mintologii im. K.I Skryabina 42:64–66Google Scholar
  242. Su X, Zhang Y, Zheng X, Wang XX, Li Y, Li Q, Wang CR (2018) Characterization of the complete nuclear ribosomal DNA sequences of Eurytrema pancreaticum. J Helminthol 92:484–490PubMedCrossRefPubMedCentralGoogle Scholar
  243. Sudarikov VE, Ryjikov KM (1951) On the helminth fauna of ungulates of the Baikal region. Trudy Gelmintologicheskoi- Laboratorii Akaemiya Nauk SSSR 5:53–58Google Scholar
  244. Svadzhyan PK (1951) [Contribution to the study of the snails serving as intermediate hosts of Dicrocoelium lanceatum]. Izvestiya Akademii Nauk Armyanskoi SSR 4:649–656Google Scholar
  245. Svadzhyan PK (1959) Puti migracii metacerkarii Dicrocoelium lanceatum Stiles et Hassall, 1896 v organizme okonchatel’nogo joziaina. Veterinariya 36:45–48Google Scholar
  246. Svadzhyan PK (1960) [The development of metacercariae of Dicrocoelium dendriticum in the second intermediate host- the ant]. Zool Zhurnal 39:1568–1571Google Scholar
  247. Taira K, Shirasaka S, Taira N, Ando Y, Adachi Y (2006) Morphometry on lancet flukes found in Japanese sika deer (Cervus nippon centralis) captured in Iwate Prefecture, Japan. J Vet Med Sci 68:375–377PubMedCrossRefPubMedCentralGoogle Scholar
  248. Tang C, Tang Z, Qi P, Duo C, Li Q, Cao H, Pan C (1981) Studies on the biology of Dicrocoelium lanceatum in Xin Jiang Automonous Region. Acta Zool Sin 27:265–273Google Scholar
  249. Tang C, Tang Z, Tang L, Cui Q, Lu H, Qian Y (1983) Studies on the biology and epizooties of Dicrocoelium chinensis in the eastern Inner Mongol Autonomous region. Acta Zool Sin 29:340–349Google Scholar
  250. Tang C, Tang L, Wang F, Shi H, Sai Q, Wen Z, Luo Y (1985) Investigations on the biology of a few Dicrocoelium species of sheep on Qinghai Plateau. Acta Zool Sin 31:245–262Google Scholar
  251. Tarry DW (1969) Dicrocoelium dendriticum: the life cycle in Britain. J Helminthol 43:403–416CrossRefGoogle Scholar
  252. Timon-David J (1962) Fourmis et “Petite Douve”. Nouvelle découvertes et progrès de la question. L’Entomologiste 18:69–72Google Scholar
  253. Timon-David J (1965) Infestation expérimentale d’une hélicelle par huit espèces de trématodes digénétiques appartenant à quatre familles différentes. Ann Parasitol Hum Comp 40:149–154PubMedCrossRefPubMedCentralGoogle Scholar
  254. Travassos L (1944) Revisao da Familia Dicrocoeliidae Odhner, 1910. Monografías do Instituto Oswaldo Cruz 2: vii+357 ppGoogle Scholar
  255. Uriarte J, Cabaret J, Tanco JA (1985) The distribution and abundance of parasitic infections in sheep grazing on irrigated or non-irrigated pastures in north-eastern Spain. Ann Rech Vet 16:321–325PubMedPubMedCentralGoogle Scholar
  256. van Paridon BJ, Goater CP, Gilleard JS, Criscione CD (2016) Characterization of nine microsatellite loci for Dicrocoelium dendriticum, an emerging liver fluke of ungulates in North America, and their use to detect clonemates and random mating. Mol Biochem Parasitol 207:19–22PubMedCrossRefPubMedCentralGoogle Scholar
  257. van Paridon BJ, Guilleard JS, Colwell DD, Goater CP (2017a) Life cycle, host utilization, and ecological fitting for invasive lanced liver fluke, Dicrocoelium dendriticum, emerging in southern Alberta, Canada. J Parasitol 103:207–212PubMedCrossRefPubMedCentralGoogle Scholar
  258. van Paridon BJ, Colwell DD, Goater CP, Gilleard JS (2017b) Population genetic analysis informs the invasion history of the emerging trematode Dicrocoelium dendriticum into Canada. Int J Parasitol 47:845–856PubMedCrossRefPubMedCentralGoogle Scholar
  259. Vershinin II (1957) (Epizootiology of Dicrocoelium infections of sheep and its biology in the Kaluga region). Trudy Moskovskoy Veterinarnoi Akademii 19:3–15Google Scholar
  260. Vogel H (1929) Beobachtungen über Cercaria vitrina und deren Beziehung zum Lanzettegelproblem. Arch Schiffs Tropen Hyg 33:474–489Google Scholar
  261. Vogel H, Falcao J (1954) Über den Lebenszyklus des Lanzettegels, Dicrocoelium dendriticum, in Deutschland. Z Tropenmed Parasitol 5:275–296PubMedPubMedCentralGoogle Scholar
  262. Von Linstow D (1887) Helminthologische Untersuchungen, Cercaria vitrina n.sp. Zoologische Jahrbücher. Abteil Syst Oekolgie Geograph Tiere (Jena) 3:105–106Google Scholar
  263. Von Willemoes-Suhm R (1871) Zur Entwicklungsgeschichte des kleinen Leberegels. Z Wiss Zool 21:175–179Google Scholar
  264. Warren KS, Swan RA, Hobbs RP, Heriyanto, Kuhn EM, Heeney JL (1998) Platynosomum fastosum in ex-captive orangutans from Indonesia. J Wildl Dis 34:644–646PubMedCrossRefPubMedCentralGoogle Scholar
  265. Wedrychowicz H, Ducommun D, Górski P, Pefister K (1995) Somatic antigens of adult Dicrocoelium dendriticum recognized by bile antibodies of naturally infected cattle. Vet Parasitol 56:47–56PubMedCrossRefPubMedCentralGoogle Scholar
  266. Wedrychowicz H, Ducommun D, Bambara OD, Pefister K (1997) Local and systematic antibody response against surface, somatic and ES antigens of Dicrocoelium dendriticum in sheep naturally infected with the trematode. Acta Parasitol 42:248–253Google Scholar
  267. Wolff K, Hauser B, Wild P (1984) Dicrocoeliose des Schafes: Untersuchungen zur Pathogenese und zur Regeneration des Leber nach Therapie. Berl Munch Tierarztl Wochenschr 97:378–387PubMedPubMedCentralGoogle Scholar
  268. Yamaguti S (1958) Systema Helminthum. I. Digenetic Trematodes of Vertebrates. Interscience, New YorkGoogle Scholar
  269. Zarnik B (1910) Über den Entwicklungszyklus von Dicrocoelium lanceatum (Distomum lanceolatum). Sitzungsberichte der Physikalisch-medizinischen Gesellschaf zu Würzburg 2:27–31Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • M. Yolanda Manga-González
    • 1
    Email author
  • M. Carmen Ferreras
    • 2
  1. 1.Departamento de Sanidad Animal, Instituto de Ganadería de MontañaConsejo Superior de Investigaciones Científicas (CSIC-ULE)LeónSpain
  2. 2.Departamento de Sanidad Animal, Facultad de Veterinaria, Instituto de Ganadería de Montaña (CSIC-ULE)Universidad de LeónLeónSpain

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