How should Alice in Wonderland syndrome be diagnosed? How should it be treated? For numerous other medical conditions, diagnostic criteria are available from scientific organisations such as the World Health Organization, the American Psychiatric Association, the International League Against Epilepsy and so on. In addition, these organisations may issue evidence-based guidelines which stipulate how disorders should preferably be treated. However, for Alice in Wonderland syndrome, no such diagnostic criteria and therapeutic algorithms are available. As you probably have guessed, that is because the syndrome has until now hardly been investigated. As a consequence, Alice in Wonderland syndrome is perhaps the poster child for orphan diseases: a condition ‘forgotten’ by the powers that be and, therefore, playing no role whatsoever in the canon of medicine.
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