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Urticaria and Facial Angioedema

  • Elena Camelia Berghea
Chapter

Practical Points

  • Chronic urticaria is less common in children than it is in adults [3]

  • The underlying cause of chronic urticaria in children do not appear to differ from those seen in adults [4]

  • The treatment algorithm recommended in children with chronic urticaria is the same like in adults

  • NSAIDs hypersensitivity is common in pediatric population and may precede the onset of chronic spontaneous urticaria by years [5]

  • Ibuprofen and paracetamol are among frequent causes of NSAID hypersensitivity in children

  • Oral drug provocation test is the gold standard for diagnosis of oral hypersensitivity reactions and allow identification of a safe alternative NSAID [6]

Keywords

Drug-provocation test Chronic spontaneous urticaria Chronic inducible urticaria NSAIDs-exacerbated cutaneous disease 

References

  1. 1.
    Maurer M, Church MK, Goncalo M, Sussman G, Sanchez-Borges M. Management and treatment of chronic urticaria (CU). J Eur Acad Dermatol Venereol. 2015;29(Suppl 3):16–32.CrossRefGoogle Scholar
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    Zuberbier T, Aberer W, Asero R, Bindslev-Jensen C, Brzoza Z, Canonica GW, Church MK, Ensina LF, Gimenez-Arnau A, Godse K, Goncalo M, Grattan C, Hebert J, Hide M, Kaplan A, Kapp A, Abdul Latiff AH, Mathelier-Fusade P, Metz M, Nast A, Saini SS, Sanchez-Borges M, Schmid-Grendelmeier P, Simons FE, Staubach P, Sussman G, Toubi E, Vena GA, Wedi B, Zhu XJ, Maurer M, European Academy of Allergy and Clinical Immunology; Global Allergy and Asthma European Network; European Dermatology Forum; World Allergy Organization. The EAACI/GA(2) LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update. Allergy. 2014;69(7):868–87.CrossRefGoogle Scholar
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    Sackesen C, Sekerel BE, Orhan F, Kocabas CN, Tuncer A, Adalioglu G. The etiology of different forms of urticaria in childhood. Pediatr Dermatol. 2004;21(2):102–8.CrossRefGoogle Scholar
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    Sanchez-Borges M, Capriles-Behrens E, Caballero-Fonseca F. Hypersensitivity to non-steroidal anti-inflammatory drugs in childhood. Pediatr Allergy Immunol. 2004;15(4):376–80.CrossRefGoogle Scholar
  5. 5.
    Asero R. Intolerance to nonsteroidal anti-inflammatory drugs might precede by years the onset of chronic urticaria. J Allergy Clin Immunol. 2003;111(5):1095–8.CrossRefGoogle Scholar
  6. 6.
    Zambonino MA, Torres MJ, Muñoz C, Requena G, Mayorga C, Posadas T, Urda A, Blanca M, Corzo JL. Drug provocation tests in the diagnosis of hypersensitivity reactions to non-steroidal anti-inflammatory drugs in children. Pediatr Allergy Immunol. 2013;24(2):151–9.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Elena Camelia Berghea
    • 1
    • 2
  1. 1.Emergency Clinical Hospital for Children M.S. CurieBucharestRomania
  2. 2.University of Medicine and Pharmacy Carol DavilaBucharestRomania

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