Antidepressants and anticonvulsants are widely used to treat a wide variety of pain disorders.
These medications have significant utility not only in the treatment of neuropathic pain but also in the management of nociceptive and mixed pain types, as well. Caution must be exercised when prescribing these compounds, as many have significant side effects and drug interactions, to which the elderly are particularly susceptible.
KeywordsAntidepressants Anticonvulsants Gabapentinoids Tricyclic Serotonin reuptake inhibitor Norepinephrine reuptake inhibitor Antiepileptic drug (AED)
- 1.DeBattista C. Antidepressant agents. In: Katzung BG, Trevor AJ, editors. Basic & clinical pharmacology. 13th ed. New York: McGraw-Hill; 2015.Google Scholar
- 4.Shelton R. Serotonin norepinephrine reuptake inhibitors: similarities and differences. Prim Psychiatry. 2009;15:5(Suppl 4):25–35.Google Scholar
- 6.Derry S, Gill D, Phillips T, Moore RA. Milnacipran for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2012;(3):Art. No.: CD008244. https://doi.org/10.1002/14651858.CD008244.pub2.
- 10.Aronoff GM, Gallagher RM, Patel JG. Pharmacological management of chronic pain: a review. In: Tollison CD, et al., editors. Practical pain management. 3rd ed. Philadelphia: Lippincott Williams and Wilkins; 2002.Google Scholar
- 15.Dinakar P. Principles in pain management. In: Daroff RB, Jankovic J, et al., editors. Bradley’s neurology in clinical practice. 7th ed. Philadelphia: Elsevier Health Sciences; 2015.Google Scholar