Zeolite Microneedles: Recent Advancements and Implications in the Delivery of Collagen

  • Amar Ramović
  • Zerina ZorlakEmail author
  • Đenana Husić
  • Samir Ramić
Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 73)


Zeolites are one of the most interesting areas of nanotechnology. They have wide application because of their properties, so they are also used for microneedles for delivery of various drugs. Until now, they have been used for the delivery of insulin, diclofenac and ketoprofen and our work will reveal collagen delivery capabilities and thus the application of zeolite microgels in the application of anti-age preparations based on the comparison of insulin molecule characteristics and collagen molecules. Since it is a preparation that is increasingly used in cosmetology and dermatology, we also find out how the best microneedles made of zeolite are applied for delivery of collagen and explain the application of dermaroller and dermapen with this microneedles.


Zeolites Microneedles Collagen Dermaroller Dermapen Skin 


Conflict of Interest

Authors have no conflicts of interest to disclose.


  1. 1.
    Iliescu, S.F., Ionescu, D., Petrescu, M., Iliescu, C.: A review on transdermal drug delivery using microneedles: current research and perspective. Ann. Acad. Rom. Sci. Series Sci. Technol. Inf. 7(1), 734 (2014)Google Scholar
  2. 2.
    Tucak, A.: Mikroiglama posredovana dostava lijekova kroz kožu – Formulacijski aspekti. Unpublished Master Thesis, University of Sarajevo, Sarajevo (2017)Google Scholar
  3. 3.
    Jha, B., Singh, D.: Basics of zeolites. In: Advanced Structured Materials, pp. 5–31 (2016)Google Scholar
  4. 4.
    Wong, L., Sun, W., Chan, N., Lai, W., Leung, W., Tsang, J., et al.: Zeolite microneedles for transdermal drug delivery. In: Zeolites to Porous MOF Materials—The 40th Anniversary of International Zeolite Conference, Proceedings of the 15th International Zeolite Conference, pp. 525–530 (2007)CrossRefGoogle Scholar
  5. 5.
    Pina, M.P., Mallada, R., Arruebo, M., Urbiztondo, M., Navascués, N., de la Iglesia, O., Santamaria, J.: Zeolite films and membranes. Emerging applications nanoscience. Institute of Aragon, University of Zaragoza, 50009 Zaragoza, SpainGoogle Scholar
  6. 6.
    Defect-free zeolite membrane. Membr. Technol. 1998(104), 13 (1998)Google Scholar
  7. 7.
    Hovhannisyan, V., Dong, C., Lai, F., Chang, N., Chen, S.: Natural zeolite for adsorbing and release of functional materials. J. Biomed. Opt. 23(09), 1 (2018)CrossRefGoogle Scholar
  8. 8.
    Andronikashvili, T., Pagava, K., Kurashvili, T., Eprikashvili, L.: Possibility of application of natural zeolites for medicinal purposes. Bull. Georgian Nat. Acad. Sci. 3(2), 158–167 (2009)Google Scholar
  9. 9.
    Jacobs, P., Martens, J.: Synthesis of High-Silica Aluminosilicate Zeolites, 1st edn. Elsevier, Amsterdam (1987)Google Scholar
  10. 10.
    Cerri, G., Farina, M., Brundu, A., Daković, A., Giunchedi, P., Gavini, E., et al.: Natural zeolites for pharmaceutical formulations: preparation and evaluation of a clinoptilolite-based material. Microporous Mesoporous Mater. 223, 58–67 (2016)CrossRefGoogle Scholar
  11. 11.
    Poon, T.: Zeolite microneedles: fabrication, mechanics and transdermal drug delivery. M. Phil Thesis, Hong Kong University of Science and Technology (2013)Google Scholar
  12. 12.
    Wong, L.: Molecular delivery system based on the nanoporous zeolite microstructures. M. Phil Thesis, Hong Kong University of Science and Technology (2006)Google Scholar
  13. 13.
    Bacakova, L., Vandrovcova, M., Kopova, I., Jirka, I.: Applications of zeolites in biotechnology and medicine—a review. Biomater. Sci. 6(5), 974–989 (2018)CrossRefGoogle Scholar
  14. 14.
    Sim, V., Poon, H.Y., Wong, W., Chau, L.Y.K., Han, W., Kwan, S.M., et al.: Zeolite microneedle: design for drug delivery. In: Proceedings of the AIChE Annual Meeting (2013)Google Scholar
  15. 15.
    Gelse, K.: Collagens—structure, function, and biosynthesis. Adv. Drug Deliv. Rev. 55(12), 1531–1546 (2003)CrossRefGoogle Scholar
  16. 16.
    Derewenda, U., Derewenda, Z., Dodson, G., Hubbard, R., Korber, F.: Molecular structure of insulin: the insulin monomer and its assembly. Br. Med. Bull. 45(1), 4–18 (1989)CrossRefGoogle Scholar
  17. 17.
    Shorten, P., McMahon, C., Soboleva, T.: Insulin transport within skeletal muscle transverse tubule networks. Biophys. J. 93(9), 3001–3007 (2007)CrossRefGoogle Scholar
  18. 18.
    Sun, W., Inayathullah, M., Manoukian, M., Malkovskiy, A., Manickam, S., Marinkovich, M., et al.: Transdermal delivery of functional collagen via Polyvinylpyrrolidone Microneedles. Ann. Biomed. Eng. 43(12), 2978–2990 (2015)CrossRefGoogle Scholar
  19. 19.
    Barbosa, G., Debone, H., Severino, P., Souto, E., da Silva, C.: Design and characterization of chitosan/zeolite composite films—effect of zeolite type and zeolite dose on the film properties. Mater. Sci. Eng. C. 60, 246–254 (2016)CrossRefGoogle Scholar
  20. 20.
    Tsioris, K., Raja, W., Pritchard, E., Panilaitis, B., Kaplan, D., Omenetto, F.: Fabrication of silk microneedles for controlled-release drug delivery. Adv. Funct. Mater. 22(2), 330–335 (2011)CrossRefGoogle Scholar
  21. 21.
    Faraji, D., Jahandideh, A., Asghari, A., Akbarzadeh, A., Hesaraki, S.: Effect of zeolite and zeolite/collagen nanocomposite scaffolds on healing of segmental femur bone defect in rabbits. Iran. J. Vet. Surg. 12(2), 63–69 (2017)Google Scholar
  22. 22.
    Kochhar, J., Anbalagan, P., Shelar, S., Neo, J., Iliescu, C., Kang, L.: Direct microneedle array fabrication off a photomask to deliver collagen through skin. Pharm. Res. 31(7), 1724–1734 (2014)CrossRefGoogle Scholar
  23. 23.
    McCrudden, M., McAlister, E., Courtenay, A., González-Vázquez, P., RajSingh, T., Donnelly, R.: Microneedle applications in improving skin appearance. Exp. Dermatol. 24(8), 561–566 (2015)CrossRefGoogle Scholar
  24. 24.
    Park, K., Kwon, H., Lee, C., Kim, D., Yoon, J., Kim, M., et al.: Efficacy and safety of a new microneedle patch for skin brightening: a Randomized, split-face, single-blind study. J. Cosmet. Dermatol. 16(3), 382–387 (2017)CrossRefGoogle Scholar
  25. 25.
    Jung, H.: Microneedle: the future of pharmaceutical and cosmeceutical delivery systems. J. Pharm. Drug Deliv. Res. 06(03), 1 (2017)CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Amar Ramović
    • 1
  • Zerina Zorlak
    • 1
    Email author
  • Đenana Husić
    • 1
  • Samir Ramić
    • 1
  1. 1.Faculty of PharmacyUniversity of SarajevoSarajevoBosnia and Herzegovina

Personalised recommendations