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Maternal Use of Anticoagulants or Hemostatic Drugs and Infant Congenital Malformations

  • Bengt Källén
Chapter

Abstract

Coumarin derivatives have a known teratogenic effect but are relatively seldom used in early pregnancy nowadays. An association exists between maternal use of either anticoagulants or hemostatic drugs and a relatively severe malformation, notably a cardiovascular defect, in the offspring. This association is probably the result of a confounding by indication: a coagulopathy or a bleeding disorder.

References

  1. Cotrufo M, De Feo M, De Santo LS, Romano G, Della Corte A, Renzulli A, Gallo C. Risk of warfarin during pregnancy with mechanical valve prostheses. Obstet Gynecol. 2002;100:1040–1.Google Scholar
  2. Deruelle P, Denervaud M, Hachulla E, Ducloy-Bouthors AS, Valast AS, Pueach F, Trillot N, Hatron PY, Subtil D. Use of low-molecular-weight heparin from the first trimester of pregnancy: a retrospective study of 111 consecutive pregnancies. Eur J Obstet Gynecol Reprod Biol. 2006;127:73–8.CrossRefGoogle Scholar
  3. DiSaia P. Pregnancy and delivery of a patient with a Starr-Edwards mitral valve prosthesis. Obstet Gynecol. 1966;28:469–72.Google Scholar
  4. Ginsberg JS, Kowalchuk G, Hirsch J, Brill-Edwards P, Burrows R. Heparin therapy during pregnancy. Risks to the fetus and mother. Arch Intern Med. 1989;149:2233–6.CrossRefGoogle Scholar
  5. Hall JG, Pauli RM, Wilson KM. Maternal and fetal sequelae of anticoagulation during pregnancy. Am J Med. 1980;68:122–40.CrossRefGoogle Scholar
  6. Hoyer AC, Henrich W, Schaefer C, Spors B, Czernik C. Coumarin-Embryopathie nach intrauteriner Vitamin-K-Antagonisten-Exposition innerhalb der ersten 10 postmentstruellen Wochen. Ultraschall Med. 2010;31:411–3.CrossRefGoogle Scholar
  7. Iturbe-Alessio I, del Carmen-Fonseca M, Mutchinik O, Santos MA, Zajarías A, Salazar E. Risks of anticoagulant therapy in pregnant women with artificial heart valves. N Engl J Med. 1986;315:1390–3.CrossRefGoogle Scholar
  8. Kleppa M-J, Erlenwein S-V, Darashchonak N, von Kaisenberg CS, von Versen-Höynck F. Hypoxia and the anticoagulant dalteparin and acetyl salicylic acid affect human placental amino acid transport. PLoS One. 2014;9:e99217.  https://doi.org/10.1371/journal.pone.0099217.CrossRefPubMedPubMedCentralGoogle Scholar
  9. Schaefer C, Hannermann D, Meister R, Eléfant E, Paulus W, Vial T, Reuvers M, Robert-Gnansia E, Arnon J, De Santis M, Clementi M, Rodriguez-Pinilla E, Dolivo A, Merlob P. Vitamin K antagonists and pregnancy outcome. Thromb Haemost. 2006;95:949–57.CrossRefGoogle Scholar
  10. Vitale N, De Feo M, De Santo LS, Pollice A, Tedesco N, Cotrufo M. Dose-dependent fetal complications in pregnant women with mechanical heart valves. J Am Coll Cardiol. 1999;33:1637–41.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Bengt Källén
    • 1
  1. 1.Tornblad Institute for Comparative EmbryologyLund UniversityLundSweden

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