Maternal Use of Other Psychoactive Drugs and Infant Congenital Malformations
The use of methylphenidate for ADHD appears to carry little risk for congenital malformations but more adequate studies are needed. There seems to be little concern about a teratogenic effect of drugs for Parkinsonism, parasymphathomimetic drugs, or drugs for vertigo. Practically no information exists on drugs for dementia or ALS. Nicotine replacement therapy (NRT) may not cause malformations but more data are needed. Other drugs used for smoking cessations have so far not demonstrated teratogenicity. Only little information is available on the use of disulfiram and other drugs for alcohol abuse. Methadone used for opioid addiction may increase the malformation risk while buprenorphine seems to be less risky even though findings vary. Further information is needed but a possible risk must be weighed against the risk of untreated drug abuse.
- Glaxo/SmithKline. The bupropion pregnancy registry. Final report. 2008. http://pregnancyregistry.gsk.com/documents/bup_report_final_2008.pdf.
- Harrison-Woolrych M, Paterson H, Tan M. Exposure to the smoking cessation medicine varenicline during pregnancy: a prospective nationwide cohort study. Pharmacoepidemiol Drug Saf. 2013;2013(22):1086–92.Google Scholar
- Heinonen OP, Slone D, Shapiro S. Birth defects and drugs in pregnancy. Littleton, MA: Publishing Sciences Group; 1977.Google Scholar
- Hyubrechts KF, Bröms G, Christensen LB, Einarsdotter K, Engeland A, Furu K, Gissler M, Hernandez-Diaz S, Karlsson P, Karlstad Ø, Kieler H, Lahesmaa-Korpinen AM, Mogun H, Nørgaard M, Reutfors J, Sørensen HT, Zoega H, Baterman BT. Association between methylphenidate and amphetamine use in pregnancy and risk of congenital malformations: a cohort study from the International Pregnancy Safety Study Consortium. JAMA Psychiat. 2018;75:167–75.CrossRefGoogle Scholar
- Litta R, Rainone R, Zingaviello L. A case of incomplete amelia. Pediatria (Napoli). 1983;91:287–93.Google Scholar
- Nørgaard M, Nielsson MS, Heide-Jørgensen U. Birth and neonatal outcomes following opioid use in pregnancy: a Danish population-based study. Subst Abus. 2015;9:5–11.Google Scholar
- Richardson JL, Stephens S, Yates LM, Diav-Citrin O, Amon J, Beghin O, Kayser A, Kennedy D, Cupitt D, Te Winkel B, Peltonen M, Kaplan YC, Thomas SH. Pregnancy outcomes after maternal varenicline use: analysis of surveillance data collected by the European Network of Teratology Information Services. Reprod Toxicol. 2017;67:26–34.CrossRefGoogle Scholar
- Wurst KE, Zedler BK, Joyce AR, Sasinowski M, Murrelle EL. A Swedish population-based study of adverse birth outcomes among pregnant women treated with buprenorphine or methadone: preliminary findings. Subst Abus. 2016;10:89–97.Google Scholar