Maternal Use of Mild Analgesics and Infant Congenital Malformations
Prospective studies have generally showed no teratogenicity of mild analgesics which agrees with the new data presented here for most common analgesics. An exception is an observed association between use of acetaminophen and pyloric stenosis in the infant but this has to be verified in new studies. Furthermore, a significant increase in malformation rate after maternal use of phenazone was found which also needs verification. There have been some discussions in the literature if mild analgesics (and NSAIDs) could affect the androgenic regulation of the descent of the testes or the development of hypospadias. The former phenomenon cannot be effectively studied in the present Swedish material, but there are no signs of an increased risk for hypospadias.
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