Maternal Use of Other Drugs than NSAIDs for Musculoskeletal Diseases and Infant Congenital Malformations
Muscle relaxing drugs do not seem to increase the risk for major malformations and the increased risk of minor anomalies is probably not causal but due to uneven reporting. Among drugs used for gout, some uncertainty exists for allopurinol with a possible association with a pattern of malformations but further data are needed to evaluate this. If true, the absolute risk appears to be low. Data on bisphosphonates during pregnancy are few but indicate no or low teratogenic risk. Further data are needed.
- Heinonen OP, Slone D, Shapiro S. Birth defects and drugs in pregnancy. Littleton, MA: Publishing Sciences Group; 1977.Google Scholar
- Hoeltzenbein M, Stieler K, Panse M, Wacker E, Schaefer C. Allopurinol use during pregnancy—outcome of 31 prospectively ascertained cases and a phenotype possibly indicative for teratogenicity. PLoS One. 2013;8:e66637. https://doi.org/10.1371/journal.pone/0066637.CrossRefPubMedPubMedCentralGoogle Scholar