Maternal Use of NSAID Drugs and Infant Congenital Malformations
The literature on teratogenic effects of NSAID is large but inconsistent. Well-performed studies have indicated a moderately increased risk for cardiac defects after at least some NSAIDs and notably naproxen. There also seems to be an association between maternal use of the propionic acid derivatives ibuprofen and naproxen and infant cleft lip/palate, so far not seen for other NSAIDs. Avoidance of these drugs and notably naproxen in early pregnancy can be recommended but if exposure has occurred, the individual risk is low. Further data are needed on the use of coxibs in early pregnancy.
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