In this chapter, various methodological aspects and the most common sources of information in the literature are briefly discussed. Different methods of ascertainment of congenital malformations and of drug exposure are described, the problem of confounding and of mass significance. A detailed description of the system used when analyzing the Swedish health registers with its positive and negative aspects is given.
- Heinonen OP, Slone D, Shapiro S. Birth defects and drugs in pregnancy. Littleton, MA: Publishing Sciences Group Inc.; 1977.Google Scholar
- Källén B. Drugs during pregnancy. New York: Nova Biomedical Books; 2009.Google Scholar
- Robert E, Vollset SE, Botto L, Lancaster PA, Merlob P, Mastroiacovo P. Malformation surveillance and maternal drug exposure. Int J Risk Saf Med. 1994;6:75–118.Google Scholar