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Hybrid Nanocomposites Synthesized into Stimuli Responsible Polymer Matrices: Synthesis and Application Prospects

  • Nataliya Kutsevol
  • Iuliia Harahuts
  • Oksana Nadtoka
  • Antonina Naumenko
  • Oleg Yeshchenko
Conference paper
Part of the Springer Proceedings in Physics book series (SPPHY, volume 221)

Abstract

Poly-N-isopropylacrylamide (PNIPAAm) is a biocompatible thermosensitive polymer that is promising for use in nanobiotechnology applications since this polymer has a phase transition temperature (LCST) in the physiological temperature range. LCST can be regulated by changing the hydrophilic-hydrophobic balance of the PNIPAAm-containing macromolecule or by changing its structure. The radical copolymerization method was used for the synthesis of the starlike copolymers with dextran core of various molecular weights and with various amounts of grafted dextran-poly-N-isopropylacrylamide (D-PNIPAAm) chains. It was shown that reducing the distance between PNIPAAm grafts affects the conformational transition characteristics of the polymer.

The incorporation of gold nanoparticles into poly(N-isopropylacrylamide) (PNIPAAm) polymer-nanocarrier is one of the modern approaches for the creation of new generation of drugs for photodynamic and photothermal antitumor therapy. The gold nanoparticles were synthesized in situ into D-PNIPAAm copolymers. Transmission electron microscopy has shown that gold nanoparticles had a spherical shape and a size of 5–10 nm. Dynamic light scattering was used to study the D-PNIPAAm/Au nanosystem in the region of the conformational transition of a polymer matrix. It was established that nanosystem D-PNIPAAm/Au contained free nanoparticles of metals, as well as aggregates of polymer macromolecules with incorporated Au nanoparticles. The size of gold nanoparticles did not change in the studied temperature region.

Keywords

Nanocomposite Starlike copolymer Gold nanoparticle Photosensitizer Photodynamic activity 

Notes

Acknowledgments

This research was supported in part by the grant of the Ukrainian State Fund for Fundamental Research, project Ф76/64-2017 “New hybrid nanocomposites for photodynamic chemotherapy of tumor cells.”

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nataliya Kutsevol
    • 1
  • Iuliia Harahuts
    • 1
  • Oksana Nadtoka
    • 1
  • Antonina Naumenko
    • 2
  • Oleg Yeshchenko
    • 2
  1. 1.Faculty of ChemistryTaras Shevchenko National University of KyivKyivUkraine
  2. 2.Faculty of PhysicsTaras Shevchenko National University of KyivKyivUkraine

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