The comparative refractive index analysis for two systems, Au sol synthesized into solution of dextran-graft-polyacrylamide (D-g-PAA) starlike copolymer and solution of D-g-PAA under laser illumination, has been carried out. It was established that Au nanoparticles (AuNPs) are 1.5–6 nm in size. The size of individual polymer molecule in solution was equal to 50–60 nm. Au/D-g-PAA nanosystem was successfully used as nanocarrier for photodynamic anticancer therapy.
To understand the effect of laser illumination on Au sol, the method of holographic interferometry in real time was proposed and experimentally applied. The method is tested using the equipment kit to determine the refractive index (n) and its change (Δn) of liquid and gaseous media. The necessity of such research is determined by the problems existing in practical medicine.
To explain the experimental results, a phenomenological model is proposed which takes into account the features of the molecular structure of starlike dextran-graft-polyacrylamide copolymer with incorporated Au nanoparticles. Since under illumination with light with λirr = 650 nm the variation of n is observed mainly in the small volume of the cell near the laser beam transmission region, and thermal diffusion into the non-illuminated volume is practically absent, these nanosystems could be effective in target photothermal therapy.
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With the support of the Military and Research Directorate of the General Staff of the Armed Forces of Ukraine.
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