Brain Tumors in Children

  • Enrico Ghizoni
  • Carolina Ribeiro Marques Naccarato
  • Roger Neves Mathias


Central nervous system (CNS) tumor has a high incidence during childhood and represents the second most common neoplasm in the pediatric population, only behind leukemias that are the most frequent tumors in children under 15 years old. The most frequent CNS tumors in the pediatric population are midline neoplasms (pontine and hypothalamic gliomas and craniopharyngiomas), posterior fossa tumors, and embrionary tumors. Approximately, 50–60% of these tumors have their initial growth in the posterior fossa. Many of the signs and symptoms are present in common pathologies like gastroenteritis, migraine, and behavioral disorders and can cause misdiagnoses. We describe the most common pediatric tumors and their treatment and prognosis.


Brain tumor Children Pediatric Treatment 

Suggested Readings and References

  1. 1.
    Karajannis M, Allen JC, Newcomb EW. Treatment of pediatric brain tumors. J Cell Physiol. 2008;217(3):584–9.CrossRefGoogle Scholar
  2. 2.
    Sala F, Cloarusso E, Mazza C, et al. Brain tumors in children under 3 years of age. Recent experience (1987–1997) in 39 patients. Pediatr Neurosurg. 1999;31:16–26.CrossRefGoogle Scholar
  3. 3.
    Wilne S, Collier J, Kennedy C, Koller K, Grundy R, Walker D. Presentation of childhood CNS tumours: a systematic review and meta-analysis. Lancet Oncol. 2007;8:685–95.CrossRefGoogle Scholar
  4. 4.
    Gajjar A, Chintagumpala M, Ashley D, et al. Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. Lancet Oncol. 2006;7:813–20.CrossRefGoogle Scholar
  5. 5.
    Dhall G, Grodman H, Ji L, et al. Outcome of children less than three years old at diagnosis with non-metastatic medulloblastoma treated with chemotherapy on the “Head Start” I and II protocols. Pediatr Blood Cancer. 2008;50:1169–75.CrossRefGoogle Scholar
  6. 6.
    Keating R, Goodrich J, Packer R. Tumors of the pediatric central nervous system. New York/Stuttgart: Thieme; 2001.CrossRefGoogle Scholar
  7. 7.
    Pollack IF, Jakacki R, Deutsch M, Hamilton RL. Current management of pediatric brain tumors. Semin Neurosurg. 2002;1:13.Google Scholar
  8. 8.
    Kaplan A, Albright A, Zimmerman R, et al. Brainstem gliomas in children. A Children’s Cancer Group review of 119 cases. Pediatr Neurosurg. 1996;24:185–92.CrossRefGoogle Scholar
  9. 9.
    Joaquim AF, Ghizoni E, Tedeschi H, Oliveira E. Ependimomas. In: Sebastião Eurico de Melo Souza (Org.). Tratamento das Doenças Neurológicas, vol. 1. 3ª ed. Rio de Janeiro: Guanabara Koogan; 2013. p. 368–71.Google Scholar
  10. 10.
    Echevarría ME, Fangusaro J, Goldman S. Pediatric central nervous system germ cell tumors: a review. Oncologist. 2008;13:690–9.CrossRefGoogle Scholar
  11. 11.
    Ghizoni E, Joaquim AF, Tedeschi H, Oliveira E. Tumores da Região Pineal. In: Sebastião Eurico de Melo Souza (Org.). Tratamento das Doenças Neurológicas, vol. 1. 3ª ed. Rio de Janeiro: Guanabara Koogan; 2013. p. 329–33.Google Scholar
  12. 12.
    Ghizoni E, Joaquim AF, Tedeschi H, Oliveira E. Craniofaringiomas. In: Sebastião Eurico de Melo Souza (Org.). Tratamento das Doenças Neurológicas, vol. 1. 3ª ed. Rio de Janeiro: Guanabara Koogan; 2013. p. 339–41.Google Scholar
  13. 13.
    Kassam A, Thomas AJ, Snyderman C, et al. Fully endoscopic expanded endonasal approach treating skull base lesions in pediatric patients. J Neurosurg Pediatr. 2007;106(2):75–86. Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Enrico Ghizoni
    • 1
  • Carolina Ribeiro Marques Naccarato
    • 2
  • Roger Neves Mathias
    • 3
  1. 1.Department of Neurology, Neurosurgery DivisionUniversity of Campinas (UNICAMP)CampinasBrazil
  2. 2.Department of RadiologyHospital BoldriniCampinasBrazil
  3. 3.Department of NeurologyUniversity of CampinasCampinasBrazil

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