Bisphosphonate Infusion Therapy

  • Todd H. Ruth
  • Veena Graff


Bisphosphonates (e.g., pamidronate, clodronate, alendronate) are pyrophosphate analogs, traditionally used in the treatment of pathologic conditions associated with abnormal bone metabolism, such as osteoporosis, Paget’s disease, and cancer-related bone pain. Recent research shows encouraging results regarding efficacy in often difficult to treat chronic pain syndromes including complex regional pain syndrome and osteoarthritic low back pain. These results combined with a benign safety profile makes bisphosphonate infusion an intriguing modality for physicians to consider for patients suffering from these conditions.


Bisphosphonates Bisphosphonate infusions Complex regional pain syndrome Reflex sympathetic dystrophy syndrome CRPS CRPS-1 Reflex sympathetic dystrophy Chronic pain Chronic low back pain CLBP Alendronate Clodronate Pamidronate Neridronate 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Todd H. Ruth
    • 1
  • Veena Graff
    • 2
  1. 1.University of Pennsylvania Perelman School of Medicine, Department of Interventional Pain MedicinePhiladelphiaUSA
  2. 2.Department of Anesthesiology and Critical CareUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaUSA

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