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Dihydroergotamine Infusion Therapy

  • Jay Karri
  • Alaa Abd-Elsayed
Chapter

Abstract

Intravenous dihydroergotamine (DHE) is a relatively underutilized medication with a plethora of supportive clinical evidence for its use in persons with numerous headache disorders. It has been found to be effective for acute migraines, status migranosus, chronic migraines, medication overuse headaches, and cluster headaches. Given the high prevalence of these conditions and their associations to disability and significant healthcare burdens, DHE may be an appropriate medication for many people with these ailments, if reasonable and clinically appropriate. Not only has it been found to be comparable or superior to many standard of care treatments, but also DHE is relatively well tolerated with generally a generally low prevalence of severe adverse risks. However, DHE is not fully innocuous; it has an adverse effect profile that includes myocardial, cerebral, or peripheral limb ischemic or infarction. Consequently, the appropriate clinical measures must be undertaken to appropriately risk stratify DHE candidates and monitor those receiving the medication.

Keywords

Dihydroergotamine Intravenous infusion Headache Migraine 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Jay Karri
    • 1
  • Alaa Abd-Elsayed
    • 2
  1. 1.Department of Physical Medicine and RehabilitationBaylor College of MedicineHoustonUSA
  2. 2.Department of AnesthesiologyUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA

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