Clonidine Infusion Therapy

  • Nam K. Ly
  • Jon Livelsberger
  • Rany T. AbdallahEmail author


Clonidine, an ⍺-adrenergic imidazoline derivative, was developed in the 1960’s to treat nasal congestion (Stähle, Best Pract Res Clin Anaesthesiol. 14:237–46, 2000). Researchers quickly discovered its decongestant properties was accompanied with significant hypotension and bradycardia (Stähle, Best Pract Res Clin Anaesthesiol. 14:237–46, 2000). Clonidine has been used extensively as an antihypertensive medication. More research on sympathetic ⍺2 receptor agonsim resulted in FDA to approval of clonidine for many other indications ranging from pain syndromes to sedation.


Clonidine Infusion Acute postoperative pain ICU sedation and analgesia Neonatal abstinence syndrome Opioid induced myoclonus 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nam K. Ly
    • 1
  • Jon Livelsberger
    • 1
  • Rany T. Abdallah
    • 1
    • 2
    Email author
  1. 1.AnesthesiologyTemple University Health SystemPhiladelphiaUSA
  2. 2.Lewis Katz School of Medicine, Temple University, Department of Anesthesiology and Perioperative CarePhiladelphiaUSA

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