Dexmedetomidine Infusion Therapy

  • Simon Zec
  • Antony Tharian
  • Kenneth D. Candido
  • Nebojsa Nick KnezevicEmail author


Dexmedetomidine (4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, is a highly potent, selective α2-adrenergic receptor agonist with sedative, analgesic and anxiolytic properties. Although primarily used for sedation in adult intensive care unit patients, novel applications have emerged in the literature, with favorable results in the prevention of delirium, acute postoperative pain, and opioid induced hyperalgesia, amongst others. Dexmedetomidine exerts its action by binding to α2A-, α2B-, and α2C-adrenoceptors, producing plasma concentration-dependent hypotension and bradycardia without respiratory depression.


Dexmedetomidine Infusion Acute postoperative pain Complex regional pain syndrome Opioid-induced hyperalgesia Sedation in the ICU Delirium in ICU Drug withdrawal and weaning Awake fiberoptic intubation Procedural sedation Awake fiberoptic intubation 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Simon Zec
    • 1
  • Antony Tharian
    • 1
    • 2
  • Kenneth D. Candido
    • 1
    • 2
    • 3
  • Nebojsa Nick Knezevic
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of AnesthesiologyAdvocate Illinois Masonic Medical CenterChicagoUSA
  2. 2.Department of AnesthesiologyUniversity of IllinoisChicagoUSA
  3. 3.Department of SurgeryUniversity of IllinoisChicagoUSA

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