Development of Nano-Bioformulations of Nutrients for Sustainable Agriculture

  • Tanveer Bilal Pirzadah
  • Bisma Malik
  • Tariq Maqbool
  • Reiaz Ul Rehman
Part of the Nanotechnology in the Life Sciences book series (NALIS)


Nanobiotechnology is being utilized for crop improvement programs around the world. It is being felt that the solution for increasing the yield of crops by efficient utilization of fertilizers lies in nanotechnology. Although the green revolution was a boon to the world economy by increasing the crop productivity, the exhaustive usage of chemical fertilizers, herbicides, pesticides, and insecticides resulted in the loss of biodiversity and the development of resistance by the pathogens causing depletion of soil and variable crop losses over time. The delivery of agrochemicals by nanoparticles increases the efficiency for precision farming. The conventional/nonconventional fertilizers can be nano-encapsulated which results in their slow/precise release for aiding in sustainable agriculture. In the current article, the potential of nanotechnology for mitigating problems associated with conventional agriculture will be discussed.


Nano-biofertilizer Precision farming Biofertilizer 


  1. Anjali CH, Sharma Y, Mukherjee A, Chandrasekaran N (2012) Neem oil (Azadirachta indica) nanoemulsion-a potent larvicidal agent against Culex quinquefasciatus. Pest Manag Sci 68:158–163PubMedCrossRefGoogle Scholar
  2. Auffan M, Rose J, Bottero JY, Lowry GV, Jolivet JP, Wiesner MR (2009) Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective. Nat Nanotechnol 4:634–641. Scholar
  3. Baruah S, Dutta J (2009) Nanotechnology applications in sensing and pollution degradation in agriculture. Environ Chem Lett J 7:191–204CrossRefGoogle Scholar
  4. Bharde A, Rautray D, Bansal V, Ahmad A, Sarkar I, Yusuf SM, Sanyal M, Sastry M (2006) Extracellular biosynthesis of magnetite using fungi. Small 2(1):135–141PubMedCrossRefGoogle Scholar
  5. Bhattacharyya A, Duraisamy P, Govindarajan M, Buhroo AA, Prasad R (2016) Nano-biofungicides: emerging trend in insect pest control. In: Prasad R (ed) Advances and applications through fungal nanobiotechnology. Springer International Publishing, Cham, pp 307–319CrossRefGoogle Scholar
  6. Brady NR, Weil RR (1999) In: Brady NR, Weil RR (eds) The nature and properties of soils. Prentice Hall, New Jersey, pp 415–473Google Scholar
  7. Castro-Longoria E, Vilchis-Nestor AR, Avalos-Borja M (2011) Biosynthesis of silver, gold and bimetallic nanoparticles using the filamentous fungus Neurospora Crassa. Colloids Surf B Biointerfaces 83:42–48PubMedCrossRefGoogle Scholar
  8. Chen J (2006) The combined use of chemical and organic fertilizers for crop growth and soil fertility. Int. workshop on sustained management of the soil rhizosphere system for efficient crop production and fertilizer use. 16–20 October, ThailandGoogle Scholar
  9. Chinnamuthu CR, Boopathi PM (2009) Nanotechnology and agroecosystem. Madras Agric J 96:17–31Google Scholar
  10. Choi CW, Yoo SA, Oh IH, Park SH (1998) Characterization of an extracellular flocculating substance produced by a planktonic cyanobacterium, Anabaena sp. Biotechnol Lett 20:643–646CrossRefGoogle Scholar
  11. Cirigliano MC, Carman GM (1984) Isolation of a bioemulsifier from Candida lipolytica. Appl Environ Microbiol 48:747–750PubMedPubMedCentralGoogle Scholar
  12. Corradini E, De Moura MR, Mattoso LHC (2010) A preliminary study of the incorporation of NPK fertilizer into chitosan nanoparticles. Express Polym Lett 4:509–515CrossRefGoogle Scholar
  13. Cui HX, Sun CJ, Liu Q, Jiang J, Gu W (2010) Applications of nanotechnology in agrochemical formulation, perspectives, challenges and strategies. In: International conference on Nanoagri, Sao Pedro, Brazil, pp 28–33Google Scholar
  14. DeRosa MC, Monreal C, Schnitzer M, Walsh R, Sultan Y (2010) Nanotechnology in fertilizers. Nat Nanotechnol 5:91PubMedCrossRefGoogle Scholar
  15. Ding Z, Bourven I, Guibaud G, van Hullebusch ED, Panico A, Pirozzi F, Esposito G (2015) Role of extracellular polymeric substances (EPS) production in bioaggregation: application to wastewater treatment. Appl Microb Biotechnol 99(23):9883–9905CrossRefGoogle Scholar
  16. Duhan JS, Kumar R, Kumar N, Kaur P, Nehra K, Duhan S (2017) Nanotechnology: the new perspective in precision agriculture. Biotechnol Rep 15:11–23CrossRefGoogle Scholar
  17. FAO (2017) The future of food and agriculture – trends and challenges. FAQ, RomeGoogle Scholar
  18. Fayaz M, Balaji K, Girilal M, Yadav R, Kalaichelvan PT, Venketesan R (2010) Biogenic synthesis of silver nanoparticles and their synergistic effect with antibiotics: a study against gram-positive and gram-negative bacteria. Nanomed Nanotechnol Biol Med 6:103–109CrossRefGoogle Scholar
  19. Gade A, Bonde PP, Ingle AP, Marcato P, Duran N, Rai MK (2008) Exploitation of Aspergillus niger for synthesis of silver nanoparticles. J Biobaased Mater Bioenergy 2(3):1–5Google Scholar
  20. Gajbhiye M, Kesharwani J, Ingle A, Gade A, Rai M (2009) Fungus mediated synthesis of silver nanoparticles and their activity against pathogenic fungi in combination with fluconazole. Nanomed Nanotechnol Biol Med 5:382–386CrossRefGoogle Scholar
  21. Gericke M, Pinches A (2006) Biological synthesis of metal nanoparticles. Hydrometallurgy 83:132–140CrossRefGoogle Scholar
  22. Godfray CHJ, Crute IR, Haddad L, Lawrence D, Muir JF, Nisbett N, Pretty J, Robinson S, Toulmin C, Whiteley R (2010) The future of the global food system. Philos Trans R Soc B 365:2769–2777. (Accessed 20 Oct 2016)CrossRefGoogle Scholar
  23. Jia LR, Xia J, Zhou N, Chen WY (2008) Preservation of fruits by hydrolyzed collagen/sodium alginate nanoparticles latex. Food Mach 1:46–50Google Scholar
  24. Knell M (2010) Nanotechnology and the sixth technological revolution. In: Cozzens SE, Wetmore JM (eds) Nanotechnology and the challenges of equity, equality and development. Springer, Dordrecht, pp 127–143. Scholar
  25. Kottegoda N, Munaweera I, Madusanka N, Karunaratne V (2011) A green slow-release fertilizer composition based on urea-modified hydroxyapatite nanoparticles encapsulated wood. Curr Sci 101:73–78Google Scholar
  26. Kumar S, Chauhan N, Gopal M, Kumar R, Dilbaghi N (2015) Development and evaluation of alginate-chitosan nanocapsules for controlled release of acetamiprid. Int J Biol Macromol 81:631–637PubMedCrossRefGoogle Scholar
  27. McBratney A, Whelan B, Ancev T, Bouma J (2005) Future directions of precision agriculture. Precis Agric 6:7–23CrossRefGoogle Scholar
  28. Milani N, McLaughlin MJ, Stacey SP, Kirkby JK, Hettiarachchi GM, Beak DG, Cornelis G (2012) Dissolution kinetics of macronutrient fertilizers coated with manufactured zinc oxide nanoparticles. J Agric Food Chem 60:3991–3998PubMedCrossRefGoogle Scholar
  29. Milani N, Hettiarachchi GM, Kirby JK, Beak DG, Stacey SP, McLaughlin MJ (2015) Fate of zinc oxide nanoparticles coated onto macronutrient fertilizers in an alkaline calcareous soil. PLoS One:10. Scholar
  30. Mirzaei A, Vazan S, Naseri R (2010) Response of yield components of safflower (Carthamus tinctorius L.) to seed inoculation with Azotobacter and Azosprilium and different nitrogen levels under dry land condition. World Appl Sci J 11(10):1287–1291Google Scholar
  31. Mishra S, Singh A, Keswani C, Singh HB (2014) Nanotechnology: exploring potential application in agriculture and its opportunities and constraints. Biotech Today 4:9–14. Scholar
  32. Mishra S, Singh A, Keswani C, Saxena A, Sarma BK, Singh HB (2015) Harnessing plant-microbe interactions for enhanced protection against phytopathogens. In: Arora NK (ed) Plant microbes symbiosis: applied facets. Springer, New Delhi, pp 111–125Google Scholar
  33. Moharrer S, Mohammad B, Gharamohammad RA, Yargol M (2012) Biological synthesis of silver nanoparticles by Aspergillus flavus, isolated from soil of Ahar copper mine. Indian J Sci Technol 5:2443–24447Google Scholar
  34. Narayanan KB, Sakthivel N (2010) Facile green synthesis of gold nanostructures by NADPH-dependent enzyme from the extract of Sclerotium rolfsii. Colloids Surf A Physicochem Eng Asp 380:156–161CrossRefGoogle Scholar
  35. Nithya R, Ragunathan R (2009) Synthesis of silver nanoparticle using pleurotus Pleurotus sajor caju and its antimicrobial study. Dig J Nanomater Bios 4:623–629Google Scholar
  36. Ojaghloo F, Farahvash F, Hassanzadeh A, Pouryusef M (2007) Effect of inoculation with azotobacter and phosphate biofertilizers on yield of safflower (Carthamus tinctorius L.). J Agric Sci, Islamic Azad University, Tabriz Branch 3:25–30Google Scholar
  37. Ombodi A, Saigusa M (2000) Broadcast application versus band application of polyolefin coated fertilizer on green peppers grown on anisole. J Plant Nutr 23:1485–1493CrossRefGoogle Scholar
  38. Park HM, Li X, Jin CZ, Park CY, Cho WJ, Ha CS (2002) Preparation and properties of biodegradable thermoplastic starch/clay hybrids. Macromol Mater Eng 287:553–558CrossRefGoogle Scholar
  39. Prasad R, Kumar V, Prasad KS (2014) Nanotechnology in sustainable agriculture: present concerns and future aspects. Afr J Biotechnol 13:705–713CrossRefGoogle Scholar
  40. Prasad R, Kumar M, Varma A (2015) Role of PGPR in soil fertility and plant health. In: Egamberdieva D, Shrivastava S and Varma A (eds.), Plant Growth-Promoting Rhizobacteria (PGPR) and Medicinal Plants Springer International Publishing Switzerland, pp. 247–260Google Scholar
  41. Prasad R (2016) Advances and applications through fungal nanobiotechnology. Springer, International Publishing, Cham. (978-3-319-42989-2)CrossRefGoogle Scholar
  42. Prasad R, Pandey R, Barman I (2016) Engineering tailored nanoparticles with microbes: quo vadis. WIREs Nanomed Nanobiotechnol 8:316–330. Scholar
  43. Prasad R, Bhattacharyya A, Nguyen QD (2017a) Nanotechnology in sustainable agriculture: Recent developments, challenges, and perspectives. Front Microbiol 8:1014.
  44. Prasad R, Kumar M, Kumar V (2017b) Nanotechnology: An Agriculture paradigm. Springer Nature Singapore Pte Ltd. (ISBN: 978-981-10-4573-8)Google Scholar
  45. Prasad R (2017) Fungal nanotechnology: applications in agriculture, industry, and medicine. Springer Nature Singapore Pte Ltd., Singapore. (ISBN 978-3-319-68423-9)CrossRefGoogle Scholar
  46. Prasad R, Bhattacharyya A, Nguyen QD (2017) Nanotechnology in sustainable agriculture: recent developments, challenges and perspectives. Front Microbiol 8:1014. Scholar
  47. Prasad R, Kumar V, Kumar M, Wang S (2018a) Fungal Nanobionics: Principles and Applications. Springer Nature Singapore Pte Ltd. (ISBN 978-981-10-8666-3)
  48. Prasad R, Gill SS, Tuteja N (2018b) Crop Improvement Through Microbial Biotechnology. ElsevierGoogle Scholar
  49. Rai M, Yadav A, Bridge P, Gade A (2009) Myconanotechnology: a new and emerging science. In: Rai MK, Bridge PD (eds) Applied mycology. CAB International, New York, pp 258–267CrossRefGoogle Scholar
  50. Raliya R, Tarafdar JC, Gulecha K, Choudhary K, Ram R, Mal P, Saran RP (2013) Review article; Scope of nanoscience and nanotechnology in agriculture. J Appl Biol Biotech 1(03):041–044Google Scholar
  51. Raliya R, Nair R, Chavalmane S, Wang WN, Biswas P (2015) Mechanistic evaluation of translocation and physiological impact of titanium dioxide and zinc oxide nanoparticles on the tomato (Solanum lycopersicum L.) plant. Metallomics 12:1584–1594CrossRefGoogle Scholar
  52. Sabourin V, Ayande A (2015) Commercial opportunities and market demand for nanotechnologies in agribusiness sector. J Technol Manag Innov 10:40–51CrossRefGoogle Scholar
  53. Sangeetha J, Thangadurai D, Hospet R, Purushotham P, Karekalammanavar G, Mundaragi AC, David M, Shinge MR, Thimmappa SC, Prasad R, Harish ER (2017a) Agricultural nanotechnology: Concepts, benefits, and risks. In: Prasad R, Kumar M, Kumar V (eds.). Nanotechnology, Springer Nature Singapore Pte Ltd, pp. 1–17Google Scholar
  54. Sangeetha J, Thangadurai D, Hospet R, Harish ER, Purushotham P, Mujeeb MA, Shrinivas J, David M, Mundaragi AC, Thimmappa AC, Arakera SB, Prasad R (2017b) Nanoagrotechnology for soil quality, crop performance and environmental management. In: Prasad R, Kumar M, Kumar V (eds.). Nanotechnology, Springer Nature Singapore Pte Ltd, pp. 73–97Google Scholar
  55. Sadowski Z, Maliszewska GB, Polowczyk I, Kozlecki T (2008) Synthesis of silver nanoparticles using microorganisms. Mater Sci Pol 26:419–425Google Scholar
  56. Sahin F, Cakmakci R, Kantar F (2004) Sugar beet and barley yields relation to inoculation with N2-fixing and phosphate solubilizing bacteria. Plant Soil 265:123–129CrossRefGoogle Scholar
  57. Salantur A, Ozturk A, Akten S, Sahin F, Donmez F (2005) Effect of inoculation with nonindigenous and indigenous rhizobacteria of Erzurum (Turkey) origin on growth and yield of spring barley. Plant Soil 275:147–156CrossRefGoogle Scholar
  58. Salunkhe RB, Patil SV, Salunke BK, Patil CD, Sonawane AM (2011) Studies on silver accumulation and nanoparticle synthesis by Cochliobolus lunatus. Appl Biochem Biotechnol 165:221–234PubMedCrossRefGoogle Scholar
  59. Sarkar J, Chattopadhyay D, Patra S, Deo SS, Sinha S, Ghosh M, Mukherjee A, Acharya K (2011) Alternaria alternata mediated synthesis of protein capped silver nanoparticles and their genotoxic activity. Dig J Nanomater Biostruct 6:563–573Google Scholar
  60. Sastry M, Ahmad A, Khan MI, Kumar R (2003) Biosynthesis of metal nanoparticles using fungi and actinomycete. Curr Sci 85(2):162–170Google Scholar
  61. Sawle BD, Salimath B, Deshpande R, Bedre MD, Prabhakar KB, Venkataraman A (2008) Biosynthesis and stabilization of Au and Au–Ag alloy nanoparticles by fungus, Fusarium semitectum. Sci Technol Adv Mater 9:9035012Google Scholar
  62. Singh P, Balaji R (2011) Biological synthesis and characterization of silver nanoparticles using the fungus Trichoderma harzianum. Asian J Exp Biol Sci 2:600–605Google Scholar
  63. Sutherland IW (1998) Novel and established applications of microbial polysaccharides. Trends Biotechnol 16(1):41–46PubMedCrossRefGoogle Scholar
  64. Tilman D, Cassman KG, Matson PA, Naylor R, Polasky S (2002) Agricultural sustainability and intensive production practices. Nature 418:671–677PubMedCrossRefGoogle Scholar
  65. Torney F, Trewyn BG, Lin VS-Y, Wang K (2007) Mesoporous silica nanoparticles deliver DNA and chemicals into plants. Nat Nanotechnol 2:295–300PubMedCrossRefGoogle Scholar
  66. Vahabi K, Ali Mansoori G, Karimi S (2011) Biosynthesis of silver nanoparticles by fungus Trichoderma reesei (a route for largescale production of AgNPs). Insci J 1:65–79CrossRefGoogle Scholar
  67. Vamvakaki V, Chaniotakis NA (2007) Pesticide detection with a liposome-based nano-biosensor. Biosens Bioelectron 22:2848–2853PubMedCrossRefGoogle Scholar
  68. Verma VC, Kharwar RN, Gange AC (2010) Biosynthesis of antimicrobial silver nanoparticles by the endophytic fungus Aspergillus clavatus. Nanomedicine 5:33–40PubMedCrossRefGoogle Scholar
  69. Verma VC, Singh SK, Solanki R, Prakash, S (2011) Biofabrication of anisotropic gold nanotriangles using extract of endophytic Aspergillus clavatus as a dual functional reductant and stabilizer. Nanoscale Res Lett 6:16–22Google Scholar
  70. Wanyika H, Gatebe E, Kioni P, Tang Z, Gao Y (2012) Mesoporous silica nanoparticles carrier for urea: potential applications in agrochemical delivery systems. J Nanosci Nanotechnol 12:2221–2228PubMedCrossRefGoogle Scholar
  71. Xia T, Li N, Nel AE (2009) Potential health impact of nanoparticles. Annu Rev Public Health 30:137–150PubMedCrossRefGoogle Scholar
  72. Yasari E, Patwardhan AM (2007) Effects of (Azotobacter and Azospirillum) inoculants and chemical fertilizers on growth and productivity of canola (Brassica napus L.).Asian J. Plant Sci 6(1):77–82Google Scholar
  73. Yosefi K, Galavi M, Ramrodi M, Mousavi SR (2011) Effect of bio-phosphate and chemical phosphorus fertilizer accompanied with micronutrient foliar application on growth, yield and yield components of maize (Single Cross 704). Aust J Crop Sci 5(2):175–180Google Scholar
  74. Zahir A, Arshad ZM, Frankenberger WF (2004) Plant growth promoting rhizobacteria: applications and perspectives in agriculture. Adv Agron 81:97–168CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Tanveer Bilal Pirzadah
    • 1
  • Bisma Malik
    • 1
  • Tariq Maqbool
    • 2
  • Reiaz Ul Rehman
    • 1
  1. 1.Department of BioresourcesUniversity of KashmirSrinagarIndia
  2. 2.Department of NanotechnologyUniversity of KashmirSrinagarIndia

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