• Pooja Raibagkar
  • Nagagopal Venna


Amyloidosis refers to a group of hereditary and acquired disorders characterized by accumulation and extracellular deposition of insoluble higher-order oligomers of misfolded proteins in a beta-pleated sheet configuration that specifically bind with Congo red dye and demonstrate green, yellow, or orange birefringence under polarized microscopy. These deposits are found in central and peripheral nervous system in addition to kidneys, heart, liver, skin, musculoskeletal system, lungs, cornea, etc. There are currently 36 different amyloid fibrils identified in humans.


Amyloids Amyloidosis Peripheral nervous system Central nervous system Hereditary amyloidosis Acquired amyloidosis Liver transplantation Amyloidogenic oligomers TTR tetramer stabilizing agents Stem cell transplant Alzheimer’s disease Cerebral amyloid angiopathy 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Pooja Raibagkar
    • 1
  • Nagagopal Venna
    • 2
  1. 1.Department of NeurologyLahey Hospital & Medical Center, Tufts University School of MedicineBurlingtonUSA
  2. 2.Division of Neuroimmunology and Neuroinfectious Diseases, Advanced General and Autoimmune NeurologyMassachusetts General HospitalBostonUSA

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