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Pericytes in Metastasis

  • Zalitha Pieterse
  • Devbarna Sinha
  • Pritinder KaurEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1147)

Abstract

Pericytes have long been known to contribute indirectly to tumour growth by regulating angiogenesis. Thus, remodelling tumour blood vessels to maintain blood supply is critical for continued tumour growth. A role for pericytes in restricting leakage of tumour cells through blood vessels has also become evident given that adequate pericyte coverage of these blood vessels is critical for maintaining vascular permeability. Interestingly, the relocation of pericytes from blood vessels to the tumour microenvironment results in the emergence of different properties in these cells that actively promote tumour growth and metastasis—functions not associated with their well-studied role in vascular stability and permeability. These form the focus of this review.

Keywords

Cancer Cancer cell invasion Cancer stem cells Epithelial-mesenchymal interactions Mesenchymal stem cells Metastasis Ovarian cancer Pericytes Tumour microenvironment Vascular permeability Tumour vasculature 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Zalitha Pieterse
    • 1
  • Devbarna Sinha
    • 2
  • Pritinder Kaur
    • 1
    Email author
  1. 1.Curtin Health Innovation Research InstituteCurtin UniversityPerthAustralia
  2. 2.Peter MacCallum Cancer CentreMelbourneAustralia

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