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Breast Disease pp 555-577 | Cite as

Neurological Metastases

  • Sule Karaman
  • Seden Kucucuk
Chapter

Abstract

Breast cancer is the second most common cause of central nervous system (CNS) metastases and the most common cause of leptomeningeal metastases. The brain, cranial nerves, spinal cord, leptomeninges, and eyes are the parts of the CNS that are at risk for breast cancer metastases. With the advancements in systematic treatment and radiotherapy (RT) techniques, longer overall survival and disease-free survival have been achieved in metastatic brain cancer. Therefore, CNS metastasis has become a clinical problem warranting more attention. Although CNS metastases are not as common as bone and visceral organ metastases, their progressiveness, poor prognosis, and lack of effective, systemic treatment options pose a difficult challenge for the clinician and the patient.

In this section, parenchymal brain metastases and epidural and leptomeningeal metastases of breast cancer and their treatment will be described, and a neurological injury that occurs in breast cancer patients called brachial plexopathy and its treatment will be discussed.

Keywords

Metastatic breast cancer  Brain metastases  Leptomeningeal metastases  Epidural metastases  Stereotactic radiation therapy (SRT)  Whole-brain radiotherapy (WBRT)  Radiosurgery  Brain irradiation  Adjuvant WBRT  Hippocampus-sparing radiotherapy 

References

  1. 1.
    Barnholtz-Sloan JS, Sloan AE, Davis FG, Vigneau FD, Lai P, Sawaya RE. Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol. 2004;22:2865–72.PubMedCrossRefPubMedCentralGoogle Scholar
  2. 2.
    Counsell C, Grant R. Incidence studies of primary and secondary intracranial tumors: a systematic review of their methodology and results. J Neuro-Oncol. 1998;37:241–50.CrossRefGoogle Scholar
  3. 3.
    Andrews DW, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet. 2004;363:1665–72.PubMedCrossRefPubMedCentralGoogle Scholar
  4. 4.
    Hasegawa T, Kondziolka D, Flickinger JC, Germanwala A, Lunsford LD. Brain metastases treated with radiosurgery alone: an alternative to whole brain radiotherapy? Neurosurgery. 2003;52:1318–25.PubMedCrossRefPubMedCentralGoogle Scholar
  5. 5.
    Chidel MA, Suh JH, Reddy CA, Chao ST, Lundbeck MF, Barnett GH. Application of recursive partitioning analysis and evaluation of the use of whole brain radiation among patients treated with stereotactic radiosurgery for newly diagnosed brain metastases. Int J Radiat Oncol Biol Phys. 2000;47:993–9.PubMedCrossRefPubMedCentralGoogle Scholar
  6. 6.
    Flickinger JC, Kondziolka D, Lunsford LD, Coffey RJ, Goodman ML, Shaw EG, et al. A multi-institutional experience with stereotactic radiosurgery for solitary brain metastases. Int J Radiat Oncol Biol Phys. 1994;28:797–802.PubMedCrossRefPubMedCentralGoogle Scholar
  7. 7.
    Zimm S, Wampler GL, Stablein D, Hazra D, Young HF. Intracerebral metastases in solid-tumor patients: natural history and results of treatment. Cancer. 1981;48:384–94.PubMedCrossRefPubMedCentralGoogle Scholar
  8. 8.
    Pirzkall A, Debus J, Lohr F, Fuss M, Rhein B, Engenhart-Cabillic R, et al. Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastases. J Clin Oncol. 1998;16:3563–9.PubMedCrossRefPubMedCentralGoogle Scholar
  9. 9.
    Tsukada Y, Fouad A, Pickren JW, Lane WW. Central nervous system metastasis from breast carcinoma. Autopsy study. Cancer. 1983;52(12):2349–54.PubMedCrossRefPubMedCentralGoogle Scholar
  10. 10.
    Sparrow GE, Rubens RD. Brain metastases from breast cancer: clinical course, prognosis and influence of treatment. Clin Oncol. 1982;7(4):291–301.Google Scholar
  11. 11.
    Regine WF, Rogozinska A, Kryscio RJ, Tibbs PA, Young AB, Patchell RA. Recursive partitioning analysis classification I and II: applicability evaluated in a randomized trial for resected single brain metastases. Am J Clin Oncol. 2002;12:417–25.Google Scholar
  12. 12.
    Stemmler HJ, Schmitt M, Willems A, Bernhard H, Harbeck N, Heinemann V. Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood–brain barrier. Anti-Cancer Drugs. 2007;18:23–8.PubMedCrossRefPubMedCentralGoogle Scholar
  13. 13.
    Lin NU, Winer EP. Brain metastases: the HER2 paradigm. Clin Cancer Res. 2007;13:1648–55.PubMedCrossRefPubMedCentralGoogle Scholar
  14. 14.
    Lin NU, Claus E, Sohl J, Razzak AR, Arnaout A, Winer EP. Sites of distant relapse and clinical outcomes in patients with metastatic triple-negative breast cancer: high incidence of central nervous system metastases. Cancer. 2008;113(10):2638–45.PubMedPubMedCentralCrossRefGoogle Scholar
  15. 15.
    Sperduto PW, Kased N, Roberge D, Xu Z, Shanley R, Luo X, Sneed PK, et al. Effect of tumor subtype on survival and the graded prognostic assessment for patients with breast cancer and brain metastases. Int J Radiat Oncol Biol Phys. 2012;82(5):2111–7.PubMedCrossRefPubMedCentralGoogle Scholar
  16. 16.
    Anders CK, Carey LA. Biology, metastatic patterns, and treatment of patients with triple-negative breast cancer. Clin Breast Cancer. 2009;9(2):73–81.CrossRefGoogle Scholar
  17. 17.
    Saip P, Cicin I, Eralp Y, Karagol H, Kucucuk S, Cosar AR, et al. Identification of patients who may benefit from the prophylactic cranial radiotherapy among breast cancer patients with brain metastasis. J Neuro-Oncol. 2009;93(2):243–51.CrossRefGoogle Scholar
  18. 18.
    Nussbaum ES, Djalilian HR, Cho KH, Hall WA. Brain metastases. Histology, multiplicity, surgery, and survival. Cancer. 1996;78(8):1781–8.PubMedCrossRefPubMedCentralGoogle Scholar
  19. 19.
    Schaefer PW, Budzik RF Jr, Gonzalez RG. Imaging of cerebral metastases. Neurosurg Clin N Am. 1996;7(3):393–423.PubMedCrossRefPubMedCentralGoogle Scholar
  20. 20.
    Vecht CJ, Hovestadt A, Verbiest HB, van Vliet JJ, van Putten WL. Dose-effect relationship of dexamethasone on Karnofsky performance in metastatic brain tumors. Neurology. 1994;44(4):675–80.PubMedCrossRefPubMedCentralGoogle Scholar
  21. 21.
    Soffietti R, Rudā R, Mutani R. Management of brain metastases. J Neurol. 2002;249(10):1357–69.PubMedCrossRefPubMedCentralGoogle Scholar
  22. 22.
    Niwinska A, Murawska M, Pogoda K. Breast cancer brain metastases: differences in survival depending on biological subtype, RPA RTOG prognostic class and systemic treatment after whole-brain radiotherapy. Ann Oncol. 2010;21:942–8.PubMedCrossRefPubMedCentralGoogle Scholar
  23. 23.
    Bonito D, Giarelli L, Falconieri G, Bonifacio-Gori D, Tomasic G, Vielh P. Association of breast cancer and meningioma. Report of 12 new cases and review of the literature. Pathol Res Pract. 1993;189(4):399–404.PubMedCrossRefPubMedCentralGoogle Scholar
  24. 24.
    Frisk G, Tinge B, Ekberg S, Eloranta S, Bäcklund LM, Lidbrink E, et al. Survival and level of care among breast cancer patients with brain metastases treated with whole brain radiotherapy. Breast Cancer Res Treat. 2017;166:887–96.PubMedPubMedCentralCrossRefGoogle Scholar
  25. 25.
    Aoyama H. Radiation therapy for brain metastases in breast cancer patients. Breast Cancer. 2011;18:244–51.PubMedCrossRefPubMedCentralGoogle Scholar
  26. 26.
    Nieder C, Berberich W, Schnabel K. Tumor-related prognostic factors for remission of brain metastases after radiotherapy. Int J Radiat Oncol Biol Phys. 1997;39:25–30.PubMedCrossRefPubMedCentralGoogle Scholar
  27. 27.
    Ogura M, Mitsumori M, Okumura S, Yamauchi C, Kawamura S, Oya N, Nagata Y, Hiraoka M. Radiation therapy for brain metastases from breast cancer. Breast Cancer. 2003;10:349–55.PubMedCrossRefPubMedCentralGoogle Scholar
  28. 28.
    Mahmoud-Ahmed AS, Suh JH, Lee SY, Crownover RL, Barnett GH. Results of whole brain radiotherapy in patients with brain metastases from breast cancer: a retrospective study. Int J Radiat Oncol Biol Phys. 2002;54:810–7.PubMedCrossRefPubMedCentralGoogle Scholar
  29. 29.
    Le Scodan R, Massard C, Mouret-Fourme E, Guinebretierre JM, Cohen-Solal C, De Lalande B, et al. Brain metastases from breast carcinoma: validation of the radiation therapy oncology group recursive partitioning analysis classification and proposition of a new prognostic score. Int J Radiat Oncol Biol Phys. 2007;69:839–45.PubMedCrossRefPubMedCentralGoogle Scholar
  30. 30.
    Tsao MN, Xu W, Wong RK, Lloyd N, Laperriere N, Sahgal A, et al. Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases. Cochrane Database Syst Rev. 2018;25:1.Google Scholar
  31. 31.
    Borgelt B, Gelber R, Larson M, Hendrickson F, Griffin T, Roth R. Ultra-rapid high dose irradiation schedules for the palliation of brain metastases: final results of the first two studies by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys. 1981;7(12):1633–8.PubMedCrossRefPubMedCentralGoogle Scholar
  32. 32.
    Haie-Meder C, Pellae-Cosset B, Laplanche A, Lagrange JL, Tuchais C, Nogues C, et al. Results of a randomized clinical trial comparing two radiation schedules in the palliative treatment of brain metastases. Radiother Oncol. 1993;26(2):111–6.PubMedCrossRefPubMedCentralGoogle Scholar
  33. 33.
    Priestman TJ, Dunn J, Brada M, Rampling R, Baker PG. Final results of the Royal College of Radiologists’ trial comparing two different radiotherapy schedules in the treatment of cerebral metastases. Clin Oncol (R Coll Radiol). 1996;8(5):308–15.CrossRefGoogle Scholar
  34. 34.
    Murray KJ, Scott C, Greenberg HM, Emami B, Seider M, Vora NL, et al. A randomized phase III study of accelerated hyperfractionation versus standard in patients with unresected brain metastases: a report of the Radiation Therapy Oncology Group (RTOG) 9104. Int J Radiat Oncol Biol Phys. 1997;39(3):571–4.PubMedCrossRefPubMedCentralGoogle Scholar
  35. 35.
    Graham PH, Bucci J, Browne L. Randomized comparison of whole brain radiotherapy, 20 Gy in four daily fractions versus 40 Gy in 20 twice-daily fractions, for brain metastases. Int J Radiat Oncol Biol Phys. 2010;77(3):648–54.PubMedCrossRefPubMedCentralGoogle Scholar
  36. 36.
    Komarnicky LT, Phillips TL, Martz K, Asbell S, Isaacson S, Urtasun R. A randomized phase III protocol for the evaluation of misonidazole combined with radiation in the treatment of patients with brain metastases (RTOG-7916). Int J Radiat Oncol Biol Phys. 1991;20:53–8.PubMedCrossRefPubMedCentralGoogle Scholar
  37. 37.
    Mehta MP, Rodrigus P, Terhaard CH, Rao A, Suh J, Roa W, et al. Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases. J Clin Oncol. 2003;21:2529–36.PubMedCrossRefPubMedCentralGoogle Scholar
  38. 38.
    Knisely JP, Berkey B, Chakravarti A. A phase III study of conventional radiation therapy plus thalidomide vs. conventional radiation therapy for multiple brain metastases (RTOG 0118). Int J Radiat Oncol Biol Phys. 2008;71:79–86.PubMedCrossRefPubMedCentralGoogle Scholar
  39. 39.
    Scott C, Suh J, Stea B, Nabid A, Hackman J. Improved survival, quality of life, and quality-adjusted survival in breast cancer patients treated with efaproxiral (Efaproxyn) plus whole-brain radiation therapy for brain metastases. Am J Clin Oncol. 2007;30:580–7.PubMedCrossRefPubMedCentralGoogle Scholar
  40. 40.
    Antonadou D, Paraskevaidis M, Sarris G, Coliarakis N, Economou I, Karageorgis P, Throuvalas N. Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases. J Clin Oncol. 2002;20:3644–50.PubMedCrossRefPubMedCentralGoogle Scholar
  41. 41.
    Verger E, Gil M, Yaya R, Viñolas N, Villà S, Pujol T, Quintó L, Graus F. Temozolomide and concomitant whole brain radiotherapy in patients with brain metastases: a phase II randomized trial. Int J Radiat Oncol Biol Phys. 2005;61:185–91.PubMedCrossRefPubMedCentralGoogle Scholar
  42. 42.
    Cao KI, Lebas N, Gerber S, Levy C, Le Scodan R, Bourgier C. Phase II randomized study of whole-brain radiation therapy with or without concurrent temozolomide for brain metastases from breast cancer. Ann Oncol. 2015;26(1):89–94.PubMedCrossRefPubMedCentralGoogle Scholar
  43. 43.
    Chargari C, Idrissi HR, Pierga JY, Bollet MA, Diéras V, Campana F, et al. Preliminary results of whole brain radiotherapy with concurrent trastuzumab for treatment of brain metastases in breast cancer patients. Int J Radiat Oncol Biol Phys. 2011;88:631–6.CrossRefGoogle Scholar
  44. 44.
    Lin NU, Freedman RA, Ramakrishna N, Younger J, Storniolo AM, Bellon JR, et al. A phase I study of lapatinib with whole brain radiotherapy in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer brain metastases. Breast Cancer Res Treat. 2013;142:405–14.PubMedCrossRefPubMedCentralGoogle Scholar
  45. 45.
    Christodoulou C, Kalogera-Fountzila A, Karavasilis V, Kouvatseas G, Papandreou CN. Samantas et al. Lapatinib with whole brain radiotherapy in patients with brain metastases from breast and non-small cell lung cancer: a phase II study of the Hellenic Cooperative Oncology Group (HeCOG). J Neuro-Oncol. 2017;134(2):443–51.CrossRefGoogle Scholar
  46. 46.
    Duchnowska R, Jassem J, Goswami CP, Gokem-Polar Y, Thorat MA, Flores N, et al. 13-gene signature to predict rapid development of brain metastases in patients with HER-2-positive advanced breast cancer. J Clin Oncol. 2012;30(15):505.Google Scholar
  47. 47.
    Miller JA, Kotecha R, Ahluwalia MS, Mohammadi AM, Chao ST, Barnett GH. Overall survival and the response to radiotherapy among molecular subtypes of breast cancer brain metastases treated with targeted therapies. Cancer. 2017;123(12):2283–93.PubMedCrossRefPubMedCentralGoogle Scholar
  48. 48.
    Patchell RA, Tibbs PA, Walsh JW, Dempsey RJ, Maruyama Y, Kryscio RJ, et al. A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med. 1990;322:494–500.PubMedCrossRefPubMedCentralGoogle Scholar
  49. 49.
    Vecht CJ, Haaxma-Reiche H, Noordijk EM, Padberg GW, Voormolen JH, Hoekstra FH, et al. Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery. Ann Neurol. 1993;33:583–90.PubMedCrossRefPubMedCentralGoogle Scholar
  50. 50.
    Mintz AH, Kestle J, Rathbone MP, Gaspar L, Hugenholtz H, Fisher B, et al. A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis. Cancer. 1996;78:1470–6.PubMedCrossRefPubMedCentralGoogle Scholar
  51. 51.
    Soon YY, Tham IW, Lim KH, Koh WY, Lu JJ. Surgery or radiosurgery plus whole brain radiotherapy versus surgery or radiosurgery alone for brain metastases. Cochrane Database Syst Rev. 2014;3:CD009454.Google Scholar
  52. 52.
    Bindal RK, Sawaya R, Leavens ME, Lee JJ. Surgical treatment of multiple brain metastases. J Neurosurg. 1993;79(2):210–6.PubMedCrossRefPubMedCentralGoogle Scholar
  53. 53.
    Patchell RA, Tibbs PA, Regine W, Dempsey R, Mohiuddin M, Kryscio R, et al. Postoperative radiotherapy in the treatment of single metastases to the brain. J Am Med Assoc. 1998;280(17):1485–9.CrossRefGoogle Scholar
  54. 54.
    Kocher M, Soffietti R, Abacioglu U, Villa S, Fauchon F, Baumert B, et al. Adjuvant whole-brain radiotherapy versus -observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952–26001 Study. J Clin Oncol. 2011;29(2):134–41.PubMedCrossRefPubMedCentralGoogle Scholar
  55. 55.
    Kelly PJ, Lin YB, Yu AY, Alexander BM, Hacker F, Marcus KJ, Weiss SE. Stereotactic irradiation of the postoperative resection cavity for brain metastasis: a frameless linear accelerator-based case series and review of the technique. Int J Radiat Oncol Biol Phys. 2012;82(1):95–101.PubMedCrossRefPubMedCentralGoogle Scholar
  56. 56.
    Choi CY, Chang SD, Gibbs IC, Adler JR, Harsh GR, Lieberson RE, et al. Stereotactic radiosurgery of the postoperative resection cavity for brain metastases: prospective evaluation of target margin on tumor control. Int J Radiat Oncol Biol Phys. 2012;84(2):336–42.PubMedCrossRefPubMedCentralGoogle Scholar
  57. 57.
    Brown PD, Ballman KV, Cerhan JH, Anderson SK, Carrero XW, Whitton AC, et al. Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicenter, randomized, controlled, phase 3 trial. Lancet Oncol. 2017;18(8):1049.PubMedPubMedCentralCrossRefGoogle Scholar
  58. 58.
    Sneed PK, Lamborn KR, Forstner JM, McDermott MW, Chang S, Park E, Gutin PH, Phillips TL, Wara WM, Larson DA. Radiosurgery for brain metastases: is whole brain radiotherapy necessary? Int J Radiat Oncol Biol Phys. 1999;43(3):549–58.PubMedCrossRefPubMedCentralGoogle Scholar
  59. 59.
    Atkins KM, Pashtan IM, Bussière MR, Kang KH, Niemierko A, Daly JE, Botticello TM, et al. Proton stereotactic radiosurgery for brain metastases: a single-institution analysis of 370 patients. Int J Radiat Oncol Biol Phys. 2018;101(4):820.PubMedCrossRefPubMedCentralGoogle Scholar
  60. 60.
    Yamamoto M, Serizawa T, Shuto T, Akabane A, Higuchi Y, Kawagishi J, et al. Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study. Lancet Oncol. 2014;15(4):387–95.PubMedCrossRefPubMedCentralGoogle Scholar
  61. 61.
    Bindal AK, Bindal RK, Hess KR, Shiu A, Hassenbusch SJ, Shi WM, Sawaya R. Surgery versus radiosurgery in the treatment of brain metastasis. J Neurosurg. 1996;84(5):748–54.PubMedCrossRefPubMedCentralGoogle Scholar
  62. 62.
    O’Neill BP, Iturria NJ, Link MJ, Pollock BE, Ballman KV, O’Fallon JR. A comparison of surgical resection and stereotactic radiosurgery in the treatment of solitary brain metastases. Int J Radiat Oncol Biol Phys. 2003;55(5):1169–76.PubMedCrossRefPubMedCentralGoogle Scholar
  63. 63.
    Auchter RM, Lamond JP, Alexander E, Buatti JM, Chappell R, Friedman WA, et al. A multiinstitutional outcome and prognostic factor analysis of radiosurgery for resectable single brain metastasis. Int J Radiat Oncol Biol Phys. 1996;35(1):27–35.PubMedCrossRefPubMedCentralGoogle Scholar
  64. 64.
    Kondziolka D, Patel A, Lunsford LD, Kassam A, Flickinger JC. Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. Int J Radiat Oncol Biol Phys. 1999;45(2):427–34.PubMedCrossRefPubMedCentralGoogle Scholar
  65. 65.
    Chougule PB, Burton-Williams M, Saris S, Zheng Z, Ponte B, Noren G, et al. Randomized treatment of brain metastasis with gamma knife radiosurgery, whole brain radiotherapy or both. Int J Radiat Oncol Biol Phys. 2000;48(3S):114.CrossRefGoogle Scholar
  66. 66.
    Patil CG, Pricola K, Sarmiento JM, Garg SK, Bryant A, Black KL. Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases. Cochrane Database Syst Rev. 2012;9:CD006121.Google Scholar
  67. 67.
    Chang E, Wefel J, Hess K, Allen P, Lang F, Kornguth D, et al. Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol. 2009;10(11):1037–44.PubMedCrossRefPubMedCentralGoogle Scholar
  68. 68.
    Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K, et al. Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases. J Am Med Assoc. 2006;295(21):2483–90.CrossRefGoogle Scholar
  69. 69.
    Tsao MN, Lloyd N, Wong RKS, Chow E, Rakovitch E, Laperriere N, et al. Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases. Cochrane Database Syst Rev. 2012;4:58–60.Google Scholar
  70. 70.
    Brown PD, Jaeckle K, Balmain KV, Farace E, Cerhan JH, Anderson SK, et al. Effect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: a randomized clinical trial. JAMA. 2016;316(4):401–9.PubMedPubMedCentralCrossRefGoogle Scholar
  71. 71.
    Roos D, Writh A, Burmeister B, Spry N, Drummond K, Beresford J, et al. Whole brain irradiation following surgery or radiosurgery for solitary brain metastases: mature results of a prematurely closed randomized Trans- Tasman Radiation Oncology Group trial (TROG 98.05). Radiother Oncol. 2006;80(3):318–22.PubMedCrossRefPubMedCentralGoogle Scholar
  72. 72.
    Soffietti R, Kocher M, Abacioglu U, Villa S, Fauchon F, Baumert B, et al. A European Organization for Research and Treatment of Cancer phase III trial of adjuvant whole brain radiotherapy versus observation in patients with one to three brain metastases from solid tumors after surgical resection or radiosurgery: quality of life results. J Clin Oncol. 2013;31:65–72.PubMedCrossRefPubMedCentralGoogle Scholar
  73. 73.
    Rogers LR, Rock JP, Sills AK, Vogelbaum MA, Suh JH, Ellis TL, et al. Results of a phase II trial of the GliaSite radiation therapy system for the treatment of newly diagnosed, resected single brain metastases. J Neurosurg. 2006;105(3):375–84.PubMedCrossRefPubMedCentralGoogle Scholar
  74. 74.
    Cosgrove GR, Hochberg FH, Zervas NT, Pardo FS, Valenzuela RF, Chapman P. Interstitial irradiation of brain tumors, using a miniature radiosurgery device: initial experience. Neurosurgery. 1997;40(3):518–23.PubMedPubMedCentralGoogle Scholar
  75. 75.
    Wong WW, Schild SE, Sawyer TE, Shaw EG. Analysis of outcome in patients reirradiated for brain metastases. Int J Radiat Oncol Biol Phys. 1996;34(3):585–90.PubMedCrossRefPubMedCentralGoogle Scholar
  76. 76.
    Shaw E, Scott C, Souhami L, Dinapoli R, Kline R, Loeffler J, et al. Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05. Int J Radiat Oncol Biol Phys. 2000;47(2):291–8.PubMedCrossRefPubMedCentralGoogle Scholar
  77. 77.
    Lin NU, Bellon JR, Winer EP. CNS metastases in breast cancer. J Clin Oncol. 2004;22(17):3608–17.PubMedCrossRefPubMedCentralGoogle Scholar
  78. 78.
    Rosner D, Nemoto T, Lane WW. Chemotherapy induces regression of brain metastases in breast carcinoma. Cancer. 1986;58(4):832–9.PubMedCrossRefPubMedCentralGoogle Scholar
  79. 79.
    Lange OF, Scheef W, Haase KD. Palliative radio-chemotherapy with ifosfamide and BCNU for breast cancer patients with cerebral metastases. Cancer Chemother Pharmacol. 1990;26(1):78–80.CrossRefGoogle Scholar
  80. 80.
    Boogerd W, Dalesio O, Bais EM, et al. Response of brain metastases from breast cancer to systemic chemotherapy. Cancer. 1992;69(4):972–80.PubMedCrossRefPubMedCentralGoogle Scholar
  81. 81.
    Rivera E, Meyers C, Groves M, et al. Phase I study of capecitabine in combination with temozolomide in the treatment of patients with brain metastases from breast carcinoma. Cancer. 2006;107(6):1348–54.PubMedCrossRefPubMedCentralGoogle Scholar
  82. 82.
    Kouvaris JR, Miliadou A, Kouloulias VE, Kolokouris D, Balafouta MJ, Papacharalampous XN, Vlahos LJ. Phase II study of temozolomide and concomitant whole-brain radiotherapy in patients with brain metastases from solid tumors. Onkologie. 2007;30(7):361–6.PubMedPubMedCentralGoogle Scholar
  83. 83.
    Kurt M, Aksoy S, Hayran M, Guler N. A retrospective review of breast cancer patients with central nervous system metastasis treated with capecitabine. J Clin Oncol. 2007;256:1098.Google Scholar
  84. 84.
    Cocconi G, Lottici R, Bisagni G, Bacchi M, Tonato M, Passalacqua R, et al. Combination therapy with platinum and etoposide of brain metastases from breast carcinoma. Cancer Investig. 1990;8:327–34.CrossRefGoogle Scholar
  85. 85.
    Lin NU, Diéras V, Paul D, Lossignol D, Christodoulou C, Stemmler HJ, et al. Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer. Clin Cancer Res. 2009;15(4):1452–9.PubMedCrossRefPubMedCentralGoogle Scholar
  86. 86.
    Yap HY, Yap BS, Rasmussen S, Levens ME, Hortobagyi GN, Blumenschein GR. Treatment for meningeal carcinomatosis in breast cancer. Cancer. 1982;50(2):219–22.PubMedCrossRefPubMedCentralGoogle Scholar
  87. 87.
    Chamberlain MC, Kormanik PR. Carcinomatous meningitis secondary to breast cancer: predictors of response to combined modality therapy. J Neuro-Oncol. 1997;35(1):55–64.CrossRefGoogle Scholar
  88. 88.
    Glantz MJ, Jaeckle KA, Chamberlain MC, Phuphanich S, Recht L, Swinnen LJ, et al. A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors. Clin Cancer Res. 1999;5(11):3394–402.PubMedPubMedCentralGoogle Scholar
  89. 89.
    Fornasier VL, Horne JG. Metastases to the vertebral column. Cancer. 1975;36(2):590–4.PubMedCrossRefPubMedCentralGoogle Scholar
  90. 90.
    Siemionow K, Lieberman IH. Surgical approaches to metastatic spine disease. Curr Opin Support Palliat Care. 2008;2(3):192–6.PubMedCrossRefPubMedCentralGoogle Scholar
  91. 91.
    Park HK, Chang JC. Review of stereotactic radiosurgery for intramedullary spinal lesions. Korean J Spine. 2013;10(1):1–6.PubMedPubMedCentralCrossRefGoogle Scholar
  92. 92.
    Wood JJ, Gawler J, Whittle RJ, Staunton MD. Brachial plexopathy in breast carcinoma-an unsolved problem. Eur J Surg Oncol. 1991;17:265–9.PubMedPubMedCentralGoogle Scholar
  93. 93.
    Pierce SM, Recht A, Lingos TI, Abner A, Viccini F, Silver B, et al. Long-term radiation complications following conservative surgery (CS) and radiation therapy (RT) in patients with early stage breast cancer. Int J Radiat Oncol Biol Phys. 1992;23(5):915–23.PubMedCrossRefPubMedCentralGoogle Scholar
  94. 94.
    Cherny NI, Foley KM. Brachial plexopathy in patients with breast cancer. In: Harris JR, Hellman S, Henderson IC, Kinne DW, editors. Breast diseases. 1st ed. Philadelphia: JB Lippincott; 1996. p. 722–39.Google Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Sule Karaman
    • 1
  • Seden Kucucuk
    • 1
  1. 1.Radiation Oncology DepartmentIstanbul University Institute of OncologyÇapa, IstanbulTurkey

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