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Breast Disease pp 495-503 | Cite as

End-of-Life Considerations in Patients with Breast Cancer

  • Nazim Serdar TurhalEmail author
  • Faysal Dane
Chapter

Abstract

Cancer is a leading cause of death worldwide. Terminally ill cancer patients and their families often have some exceptional physical, psychosocial, and spiritual symptoms. Experts who provide care to these patients and their families should widen their assessments to guarantee physical and psychosocial comfort and to detect objectives of care and social and spiritual causes of suffering. Here, some problems frequently faced in dying cancer patients in the last days or weeks of life will be discussed.

Keywords

Breast cancer Terminal illness Prognosis End of life Hospice Suffering Nutrition Palliation Bereavement Grief 

References

  1. 1.
    Lamont EB, Christakis NA. Complexities in prognostication in advanced cancer: “to help them live their lives the way they want to”. JAMA. 2003;290:98.CrossRefGoogle Scholar
  2. 2.
    Yourman LC, Lee SJ, Schonberg MA, Widera EW, Smith AK. Prognostic indices for older adults: a systematic review. JAMA. 2012;307:182.CrossRefGoogle Scholar
  3. 3.
    Ahalt C, Walter LC, Yourman L, Eng C, Pérez-Stable EJ, Smith AK. “Knowing is better”: preferences of diverse older adults for discussing prognosis. J Gen Intern Med. 2012;27:568.CrossRefGoogle Scholar
  4. 4.
    Moulton B, King JS. Aligning ethics with medical decision-making: the quest for informed patient choice. J Law Med Ethics. 2010;38:85.CrossRefGoogle Scholar
  5. 5.
    Smith AK, Williams BA, Lo B. Discussing overall prognosis with the very elderly. N Engl J Med. 2011;365:2149.CrossRefGoogle Scholar
  6. 6.
    Bousquet G, Orri M, Winterman S, Brugiere C, Verneuil L, Revah-Levy A. In: breaking bad news in oncology: a metasynthesis. J Clin Oncol. 2015;33(22):2437–43.CrossRefGoogle Scholar
  7. 7.
    Butow P, Tattersall MHN, Stockler M. Discussing prognosis and communicating risk. In: Kissane D, Bultz B, Butow P, Finlay I, editors. Handbook of communication in oncology and palliative care. New York: Oxford University Press; 2010.Google Scholar
  8. 8.
    Cheung WY, Neville BA, Cameron DB, Cook EF, Earle CC. Comparisons of patient and physician expectations for cancer survivorship care. J Clin Oncol. 2009;27:2489.CrossRefGoogle Scholar
  9. 9.
    Foley E, Baillie A, Huxter M, Price M, Sinclair E. Mindfulness-based cognitive therapy for individuals whose lives have been affected by cancer: a randomized controlled trial. J Consult Clin Psychol. 2010;78(1):72.CrossRefGoogle Scholar
  10. 10.
    Ernst E, Pittler MH, Wider B, Boddy K. Complementary/alternative medicine for supportive cancer care: development of the evidence-base. Support Care Cancer. 2007;15(5):565.CrossRefGoogle Scholar
  11. 11.
    Muriel AC, Rauch PK. Talking with families and children about the death of a parent. In: Hanks G, Cherny NI, Christakis NA, et al., editors. The Oxford textbook of palliative medicine. 4th ed. Oxford: Oxford University Press; 2009.Google Scholar
  12. 12.
    Danis M. The roles of ethnicity, race, religion, and socioeconomic status in end-of-life care in the ICU. In: Curtis JR, Rubenfeld GD, editors. Managing death in the intensive care unit. Oxford: Oxford University Press; 2001. p. 215.Google Scholar
  13. 13.
    Crawley LM, Marshall PA, Lo B, Koenig BA. Strategies for culturally effective end-of-life. Ann Intern Med. 2002;27(136):673.CrossRefGoogle Scholar
  14. 14.
    Periyakoil VS, Neri E, Kraemer H. No easy talk: a mixed methods study of doctor reported barriers to conducting effective end-of-life conversations with diverse patients. PLoS One. 2015;10(4):e0122321.CrossRefGoogle Scholar
  15. 15.
    Harrington SE, Smith TJ. The role of chemotherapy at the end of life: “when is enough, enough?”. JAMA. 2008;299:2667.CrossRefGoogle Scholar
  16. 16.
    Searight HR, Gafford J. Cultural diversity at the end of life: issues and guidelines for family physicians. Am Fam Physician. 2005;71:515.PubMedGoogle Scholar
  17. 17.
    Saunders C. The founding philosophy. In: Saunders C, Summers DH, Teller N, editors. Hospice the living idea. Philadelphia: WB Saunders; 1981. p. 4.Google Scholar
  18. 18.
    National Hospice and Palliative Care Organization. Facts and figures: hospice care in America. World Wide Web URL: http://www.nhpco.org/i4a/pages/Index.cfm?pageid=3274, 2007.
  19. 19.
    Casarett DJ, Quill TE. “I’m not ready for hospice”: strategies for timely and effective hospice discussions. Ann Intern Med. 2007;146:443.CrossRefGoogle Scholar
  20. 20.
    Lynn J. Serving patients who may die soon and their families: the role of hospice and other services. JAMA. 2001;85:925.CrossRefGoogle Scholar
  21. 21.
    Piper BF, Cella D. Cancer-related fatigue: definitions and clinical subtypes. J Natl Compr Cancer Netw. 2010;8:958.CrossRefGoogle Scholar
  22. 22.
    Kutner JS, Kassner CT, Nowels DE. Symptom burden at the end of life: hospice providers’ perceptions. J Pain Symptom Manag. 2001;21:473.CrossRefGoogle Scholar
  23. 23.
    Stone P, Richards M, A’Hern R, Hardy J. A study to investigate the prevalence, severity and correlates of fatigue among patients with cancer in comparison with a control group of volunteers without cancer. Ann Oncol. 2000;11:561.CrossRefGoogle Scholar
  24. 24.
    Hwang SS, Chang VT, Rue M, Kasimis B. Multidimensional independent predictors of cancer-related fatigue. J Pain Symptom Manag. 2003;26:604.CrossRefGoogle Scholar
  25. 25.
    Peuckmann V, Elsner F, Krumm N, Trottenberg P, Radbruch L. Pharmacological treatments for fatigue associated with palliative care. Cochrane Database Syst Rev. 2010;10(11):CD006788.Google Scholar
  26. 26.
    Hugel H, Ellershaw JE, Cook L, Skinner J, Irvine C. The prevalence, key causes and management of insomnia in palliative care patients. J Pain Symptom Manag. 2004;27:316.CrossRefGoogle Scholar
  27. 27.
    Bruera E, Fainsinger RL, Schoeller T, Ripamonti C. Rapid discontinuation of hypnotics in terminal cancer patients: a prospective study. Ann Oncol. 1996;7:855.CrossRefGoogle Scholar
  28. 28.
    Holbrook AM, Crowther R, Lotter A, Cheng C, King D. Meta-analysis of benzodiazepine use in the treatment of insomnia. CMAJ. 2000;162:225.PubMedPubMedCentralGoogle Scholar
  29. 29.
    Nowell PD, Mazumdar S, Buysse DJ, Dew MA, Reynolds CF 3rd, Kupfer DJ. Benzodiazepines and zolpidem for chronic insomnia: a meta-analysis of treatment efficacy. JAMA. 1997;278:2170.CrossRefGoogle Scholar
  30. 30.
    Davis MP, Hallerberg G, Palliative Medicine Study Group of the Multinational Association of Supportive Care in Cancer. A systematic review of the treatment of nausea and/or vomiting in cancer unrelated to chemotherapy or radiation. J Pain Symptom Manag. 2010;39:756.CrossRefGoogle Scholar
  31. 31.
    Bruera E, Seifert L, Watanabe S, Babul N, Darke A, Harsanyi Z, et al. Chronic nausea in advanced cancer patients: a retrospective assessment of a metoclopramide-based antiemetic regimen. J Pain Symptom Manag. 1996;11:147.CrossRefGoogle Scholar
  32. 32.
    Huang ZB, Ahronheim JC. Nutrition and hydration in terminally ill patients: an update. Clin Geriatr Med. 2000;16:313.CrossRefGoogle Scholar
  33. 33.
    Good P, Cavenagh J, Mather M, Ravenscroft P. Medically assisted hydration for palliative care patients. Cochrane Database Syst Rev. 2008;16(2):CD006273.Google Scholar
  34. 34.
    Bruera E, Hui D, Dalal S, Torres-Vigil I, Trumble J, Roosth J, et al. Parenteral hydration in patients with advanced cancer: a multicenter, double-blind, placebo-controlled randomized trial. J Clin Oncol. 2013;31:111.CrossRefGoogle Scholar
  35. 35.
    Wee B, Hillier R. Interventions for noisy breathing in patients near to death. Cochrane Database Syst Rev. 2008;23(1):CD005177.Google Scholar
  36. 36.
    Ripamonti C, Fulfaro F, Bruera E. Dyspnoea in patients with advanced cancer: incidence, causes and treatments. Cancer Treat Rev. 1998;24:69.CrossRefGoogle Scholar
  37. 37.
    Gysels M, Bausewein C, Higginson IJ. Experiences of breathlessness: a systematic review of the qualitative literature. Palliat Support Care. 2007;5:281.CrossRefGoogle Scholar
  38. 38.
    Trajkovic-Vidakovic M, de Graeff A, Voest EE, Teunissen SC. Symptoms tell it all: a systematic review of the value of symptom assessment to predict survival in advanced cancer patients. Crit Rev Oncol Hematol. 2012;84:130.CrossRefGoogle Scholar
  39. 39.
    Maltoni M, Pirovano M, Scarpi E, Marinari M, Indelli M, Arnoldi E, et al. Prediction of survival of patients terminally ill with cancer. Results of an Italian prospective multicentric study. Cancer. 1995;75:2613.CrossRefGoogle Scholar
  40. 40.
    Davidson PM, Johnson MJ. Update on the role of palliative oxygen. Curr Opin Support Palliat Care. 2011;5:87.CrossRefGoogle Scholar
  41. 41.
    Cranston JM, Crockett A, Currow D. Oxygen therapy for dyspnoea in adults. Cochrane Database Syst Rev. 2008;16(3):CD004769.Google Scholar
  42. 42.
    Abernethy AP, McDonald CF, Frith PA, Clark K, Herndon JE 2nd, Marcello J, et al. Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: a double-blind, randomised controlled trial. Lancet. 2010;376:784.CrossRefGoogle Scholar
  43. 43.
    Nava S, Ferrer M, Esquinas A, Scala R, Groff P, Cosentini R, et al. Palliative use of non-invasive ventilation in end-of-life patients with solid tumours: a randomised feasibility trial. Lancet Oncol. 2013;14:219.CrossRefGoogle Scholar
  44. 44.
    Abernethy AP, Currow DC, Frith P, Fazekas BS, McHugh A, Bui C. Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. BMJ. 2003;327:523.CrossRefGoogle Scholar
  45. 45.
    Viola R, Kiteley C, Lloyd NS, Mackay JA, Wilson J, Wong RK. The management of dyspnea in cancer patients: a systematic review. Support Care Cancer. 2008;16:329.CrossRefGoogle Scholar
  46. 46.
    Currow DC, McDonald C, Oaten S, Kenny B, Allcroft P, Frith P, et al. Once-daily opioids for chronic dyspnea: a dose increment and pharmacovigilance study. J Pain Symptom Manag. 2011;42:388.CrossRefGoogle Scholar
  47. 47.
    Simon ST, Higginson IJ, Booth S, Harding R, Bausewein C. Benzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adults. Cochrane Database Syst Rev. 2010;20(1):CD007354.Google Scholar
  48. 48.
    Massie MJ. Prevalence of depression in patients with cancer. J Natl Cancer Inst Monogr. 2004;32:57.CrossRefGoogle Scholar
  49. 49.
    Fernandez F, Adams F, Holmes VF, Levy JK, Neidhart M. Methylphenidate for depressive disorders in cancer patients. An alternative to standard antidepressants. Psychosomatics. 1987;28:455.CrossRefGoogle Scholar
  50. 50.
    Pereira J, Hanson J, Bruera E. The frequency and clinical course of cognitive impairment in patients with terminal cancer. Cancer. 1997;79:835.CrossRefGoogle Scholar
  51. 51.
    Massie MJ, Holland J, Glass E. Delirium in terminally ill cancer patients. Am J Psychiatry. 1983;140:1048.CrossRefGoogle Scholar
  52. 52.
    Breitbart W, Marotta R, Platt MM, Weisman H, Derevenco M, Grau C, et al. A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Am J Psychiatry. 1996;153:231.CrossRefGoogle Scholar
  53. 53.
    Yamagishi A, Morita T, Miyashita M, Sato K, Tsuneto S, Shima Y. The care strategy for families of terminally ill cancer patients who become unable to take nourishment orally: recommendations from a nationwide survey of bereaved family members’ experiences. J Pain Symptom Manag. 2010;40:671.CrossRefGoogle Scholar
  54. 54.
    Borum ML, Lynn J, Zhong Z, Roth K, Connors AF Jr, Desbiens NA, et al. The effect of nutritional supplementation on survival in seriously ill hospitalized adults: an evaluation of the SUPPORT data. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. J Am Geriatr Soc. 2000;48:S33.CrossRefGoogle Scholar
  55. 55.
    Dunlop RJ, Campbell CW. Cytokines and advanced cancer. J Pain Symptom Manag. 2000;20:214.CrossRefGoogle Scholar
  56. 56.
    Maltoni M, Scarpi E, Rosati M, Derni S, Fabbri L, Martini F, et al. Palliative sedation in end-of-life care and survival: a systematic review. J Clin Oncol. 2012;30:1378.CrossRefGoogle Scholar
  57. 57.
    Osterweis M. Bereavement: reactions, consequences, and care. Washington, DC: National Academy Press; 1984.Google Scholar
  58. 58.
    Maciejewski PK, Zhang B, Block SD, Prigerson HG. An empirical examination of the stage theory of grief. JAMA. 2007;297:716.CrossRefGoogle Scholar
  59. 59.
    Bradley EH, Prigerson H, Carlson MD, Cherlin E, Johnson-Hurzeler R, Kasl SV. Depression among surviving caregivers: does length of hospice enrollment matter? Am J Psychiatry. 2004;161:2257.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Medical OncologyMarmara University, School of MedicineIstanbulTurkey
  2. 2.Medical Oncology, Anadolu Medical CenterKocaeliTurkey

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