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Nanocosmetics pp 161-177 | Cite as

Nanocrystals for Dermal Application

  • Olga Pelikh
  • Steffen F. Hartmann
  • Abraham M. Abraham
  • Cornelia M. KeckEmail author
Chapter

Abstract

Dermal application of actives aims at delivering the active to the desired place of action, typically to the deeper layers of the skin. Passive diffusion is the main driving force of absorption into the skin, and a main prerequisite for effective passive diffusion is a sufficient amount of dissolved active within the formulation, because only dissolved molecules can be taken up. Many cosmetic and cosmeceutical actives possess poor solubility and can therefore not be delivered to the skin by classical formulation approaches. One of the modern and most powerful strategies to overcome poor solubility is the use of nanocrystals, which are addressed in this chapter.

Keywords

Nanocrystals Nanosuspensions Poor solublity Noyes-Whitney equation Kelvin equation Dissolution rate Solubility 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Olga Pelikh
    • 1
  • Steffen F. Hartmann
    • 1
  • Abraham M. Abraham
    • 1
  • Cornelia M. Keck
    • 1
    Email author
  1. 1.Department of Pharmaceutics and BiopharmaceuticsPhilipps-Universität MarburgMarburgGermany

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