Outstanding Efficacy of Essential Oils Against Oral Pathogens

  • Jelena Marinković
  • Tatjana Marković
  • Biljana Miličić
  • Marina SokovićEmail author
  • Ana Ćirić
  • Dejan Marković


The essential oils (EOs), 30 tested on Streptococcus sanguinis and 21 on Streptococcus salivarius, expressed satisfactory antimicrobial activity (MIC ≤ 250 μL mL−1) on clinical isolates or corresponding referent strains (ATCC 10556 and ATCC 9222). S. sanguinis was more sensitive than S. salivarius on cineole-rich lacking thymol oils, while S. salivarius was more sensitive than S. sanguinis on thymol-rich lacking cineole oils. Analysis of the MIC values within the groups (MIC-strong or MIC-good) revealed that the clinical isolates of both Streptococcus species generally show lower sensitivity to EOs than their corresponding referent strains. Analysis of data for MIC-strong EOs tested on both ATCC Streptococcus strains revealed that in the class of monoterpene hydrocarbons, one should look for the presence of myrcene, α-thujone, α-phellandrene, and o-cymene, while in the class of oxygenated monoterpenes, the desired constituents should be camphor, 1,8-cineole, carvacrol, eugenol, and linalyl acetate.

The aim of this chapter is to present EOs with the most significant in vitro activity against Streptococcus sanguinis and Streptococcus salivarius, major human oral pathogens, and to estimate which of their constituents might contribute to desired activity, as “markers compounds.”


Streptococcus sanguinis Streptococcus salivarius Essential oil Antimicrobials ATCC strain Clinical isolate 



The authors appreciate financial support of the Ministry of Education, Science and Technological Development of Republic of Serbia (Grants № 172026 and 173032).


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Jelena Marinković
    • 1
  • Tatjana Marković
    • 2
  • Biljana Miličić
    • 3
  • Marina Soković
    • 4
    Email author
  • Ana Ćirić
    • 4
  • Dejan Marković
    • 5
  1. 1.“Vinča” Institute of Nuclear Sciences, Mike Petrovića Alasa 12University of BelgradeBelgradeSerbia
  2. 2.Institute for Medicinal Plant Research “Dr. Josif Pančić”, Tadeuša Koščuška 1BelgradeSerbia
  3. 3.Department for Medical Statistics and Informatics, School of Dental Medicine, Dr. Subotića 1University of BelgradeBelgradeSerbia
  4. 4.Institute for Biological Research “Siniša Stanković”, Bulevar Despota Stefana 142University of BelgradeBelgradeSerbia
  5. 5.Department of Pediatric and Preventive Dentistry, School of Dental Medicine, Dr. Subotića 11University of BelgradeBelgradeSerbia

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