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Penile Cancer

  • Nikolaos Tsoukalas
  • Konstantinos Tsapakidis
  • George Kyrgias
  • Maria Tolia
Chapter

Abstract

Penile cancer is a rare tumor. The annual incidence is estimated to be 1 in 100,000 males, accounting for less than 1% of all cancers in men. Regarding histology it consists of squamous cells in 95% of cases. Treatment modalities include surgery, radiotherapy and chemotherapy. Early diagnosis is important since advanced disease is related not only with worse prognosis but also with impaired quality of life.

Keywords

Penile cancer HPV Penis Cancer Squamous cell carcinoma 

References

  1. 1.
    Mansur D (2013) Cancer of the penis and male urethra. In: Perez and Brady’s principles and practice of radiation oncology, 6th edn. Lippincott Williams & Wilkins, Philadelphia, pp 1345–1354Google Scholar
  2. 2.
    Schoen EJ, Oehrli M, Colby CJ et al (2000) The highly protective effect of newborn circumcision against invasive penile cancer. Pediatrics 105:E36CrossRefGoogle Scholar
  3. 3.
    Miralles-Guri C, Bruni L, Cubilla AL et al (2009) Human papillomavirus prevalence and type distribution in penile carcinoma. J Clin Pathol 62:870–878CrossRefGoogle Scholar
  4. 4.
    Barroso LF, Wilkins T (2011) Human papillomavirus vaccination in males: the state of the science. Curr Infect Dis Rep 13:175–181CrossRefGoogle Scholar
  5. 5.
    Kumar S, Ananthakrishnan N, Prema V (1998) Predicting regional lymph node metastasis in carcinoma of the penis: a comparison between fine-needle aspiration cytology, sentinel lymph node biopsy and medial inguinal lymph node biopsy. Br J Urol 81:453–457CrossRefGoogle Scholar
  6. 6.
    Schlenker B, Scher B, Tiling R et al (2012) Detection of inguinal lymph node involvement in penile squamous cell carcinoma by 18F-florodeoxyglucose PET/CT: a prospective single-center study. Urol Oncol 30(1):55–59CrossRefGoogle Scholar
  7. 7.
    Graafland NM, Leijte JAP, Valdes Olmos RA et al (2009) Scanning with 18F-FDG-PET/ CT for detection of pelvic nodal involvement in inguinal node- positive penile carcinoma. Eur Urol 56:339–345CrossRefGoogle Scholar
  8. 8.
    Villavicencio H, Rubio-Briones J, Regalado R et al (1997) Grade, local stage and growth pattern as prognostic factors in carcinoma of the penis. Eur Urol 32:442–447CrossRefGoogle Scholar
  9. 9.
    Shapiro D, Shasha D, Tareen M et al (2011) Contemporary management of localized penile cancer. Expert Rev Anticancer Ther 11(1):29–36CrossRefGoogle Scholar
  10. 10.
    Solsana E, Bahl A, Brandes SB et al (2010) New developments in the treatment of localized penile cancer. Urology 76(2, Suppl 1):S36–S42CrossRefGoogle Scholar
  11. 11.
    Colberg JW, Andriole GL, Catalona WJ (1997) Long-term follow-up of men undergoing modified inguinal lymphadenectomy for carcinoma of the penis. Br J Urol 79:54–57CrossRefGoogle Scholar
  12. 12.
    Solsona E, Iborra I, Rubio J et al (2001) Prospective validation of the association of local tumor stage and grade as a predictive factor for occult lymph node micrometastasis in patients with penile carcinoma and clinically negative inguinal lymph nodes. J Urol 165:1506–1509CrossRefGoogle Scholar
  13. 13.
    Perinetti E, Crane DB, Catalona WJ (1980) Unreliability of sentinel lymph node biopsy for staging penile carcinoma. J Urol 124:734–735CrossRefGoogle Scholar
  14. 14.
    Protzel C, Seitz AK, Hakenberg OW et al (2013) Neoadjuvant, adjuvant and palliative chemotherapy of penile cancer. Urologe A 52(11):1556–1560CrossRefGoogle Scholar
  15. 15.
    Zanetta G, Lissoni A, Pellegrino A et al (1998) Neoadjuvant chemotherapy with cisplatin, ifosfamide and paclitaxel for locally advanced squamous-cell cervical cancer. Ann Oncol 9(9):977–980CrossRefGoogle Scholar
  16. 16.
    Sonpavde G, Pagliaro LC, Buonerba C et al (2013) Penile cancer: current therapy and future directions. Ann Oncol 24(5):1179–1189CrossRefGoogle Scholar
  17. 17.
    Pagliaro LC, Williams DL, Daliani D et al (2010) Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. J Clin Oncol 28(24):3851–3857CrossRefGoogle Scholar
  18. 18.
    Langsenlehner T, Mayer R, Quehenberger F, Prettenhofer U, Langsenlehner U, Pummer K, Kapp KS (2008) The role of radiation therapy after incomplete resection of penile cancer. Strahlenther Onkol 184(7):359–363CrossRefGoogle Scholar
  19. 19.
    Johnson TV, Hsiao W, Delman KA, Jani AB, Brawley OW, Master VA (2010) Extensive inguinal lymphadenectomy improves overall 5-year survival in penile cancer patients: results from the Surveillance, Epidemiology, and End Results program. Cancer 116(12):2960–2966CrossRefGoogle Scholar
  20. 20.
    Wood DP (2011) Re: extensive inguinal lymphadenectomy improves overall 5-year survival in penile cancerpatients: results from the surveillance, epidemiology, and end results program. J Urol 185(4):1282CrossRefGoogle Scholar
  21. 21.
    Burt LM, Shrieve DC, Tward JD (2014) Stage presentation, care patterns, and treatment outcomes for squamous cell carcinoma of the penis. Int J Radiat Oncol Biol Phys 88(1):94–100CrossRefGoogle Scholar
  22. 22.
    Crook J, Mazeron JJ (2012) Penile Cancer. In: Gunderson L, Tepper J (eds) Clinical radiation oncology, 3rd edn. Elsevier Saunders, Philadelphia, pp 1167–1176CrossRefGoogle Scholar
  23. 23.
    De Crevoisier R, Slimane K, Sanfilippo N et al (2009) Long-term results of brachytherapy for carcinoma of the penis confined to the glans (N- or NX). Int J Radiat Oncol Biol Phys 74:1150–1156CrossRefGoogle Scholar
  24. 24.
    Delaunay B, Soh PN, Delannes M et al (2014) Brachytherapy for penile cancer: efficacy and impact on sexual function. Brachytherapy 13(4):380–387CrossRefGoogle Scholar
  25. 25.
    Hasan S, Francis A, Hagenauer A, Hirsh A, Kaminsky D, Traughber B, Abouassaly R, Ellis R (2015) The role of brachytherapy in organ preservation for penile cancer: a meta-analysis and review of the literature. Brachytherapy 1538–4721(15):00456Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nikolaos Tsoukalas
    • 1
  • Konstantinos Tsapakidis
    • 2
  • George Kyrgias
    • 3
  • Maria Tolia
    • 3
  1. 1.Oncology Clinic, 401 General Military HospitalAthensGreece
  2. 2.Oncology DepartmentUniversity HospitalLarissaGreece
  3. 3.Department of RadiotherapyUniversity of Thessaly, School of Health Sciences, Faculty of MedicineBiopolisGreece

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