Approach and Management of Cervical Cancer

  • Alvaro Henrique Ingles Garces
  • Andreia Cristina de Melo
  • Eduardo Paulino
  • Angélica Nogueira-Rodrigues
  • Rachele Grazziotin
  • Márcio Lemberg Reisner
  • Mariane Sousa Fontes Dias
  • Gustavo Guitmann
  • Gustavo Iglesias
  • Carlos Gil Ferreira


Cervical cancer (CC) represents the third most commonly diagnosed cancer and the fourth cause of cancer death in women worldwide [GLOBOCAN: Estimated cancer incidence, mortality and prevalence worldwide in 2012 international agency for research on cancer; 2012. Available at: Accessed 27 Dec 2017, 2012]. In 2012, across the world, 528,000 new cases were diagnosed with 266,000 deaths, with 85% of the cases occurring in developing countries (GLOBOCAN: Estimated cancer incidence, mortality and prevalence worldwide in 2012 international agency for research on cancer; 2012. Available at: Accessed 27 Dec 2017, 2012; Mathers C, Boerma T, Ma Fat D: The global burden of disease: 2004 update. World Health Organization, Geneva, Available at: Accessed 27 Dec 2017, 2008; Kamangar F, Dores GM, Anderson WF: J Clin Oncol 24:2137–2150, 2006). In the United States, it is the third most common gynaecologic cancer diagnosed and cause of death among gynaecologic cancers (Siegel R, Naishadham D, Jemal A: CA Cancer J Clin 63:11, 2013). Human papillomavirus (HPV) is central to the development of cervical neoplasia and can be detected in 99.7% of CCs.


Cervical cancer Chemotherapy Radiotherapy 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Alvaro Henrique Ingles Garces
    • 1
  • Andreia Cristina de Melo
    • 2
    • 3
    • 4
  • Eduardo Paulino
    • 5
    • 4
  • Angélica Nogueira-Rodrigues
    • 6
    • 7
    • 4
  • Rachele Grazziotin
    • 8
  • Márcio Lemberg Reisner
    • 8
  • Mariane Sousa Fontes Dias
    • 3
  • Gustavo Guitmann
    • 8
    • 9
    • 10
  • Gustavo Iglesias
    • 8
  • Carlos Gil Ferreira
    • 11
  1. 1.Drug Development Unit and West Wing Clinical Research Centre, The Royal Marsden Foundation TrustSuttonUK
  2. 2.INCA (Brazilian National Cancer Institute)Rio de JaneiroBrazil
  3. 3.Grupo Oncoclínicas do BrasilSão PauloBrazil
  4. 4.Brazilian Group of Gynecologic Oncology, EVA GroupRio de JaneiroBrazil
  5. 5.Department of Gynaecology OncologyBrazilian National Cancer InstituteRio de JaneiroBrazil
  6. 6.Federal University of Minas GeraisBelo HorizonteBrazil
  7. 7.Dom OncologiaDivinópolisBrazil
  8. 8.Brazilian National Cancer InstituteRio de JaneiroBrazil
  9. 9.Department of Gynaecology Oncology, Americas Medical CityRio de JaneiroBrazil
  10. 10.Society Gynecologic OncologyChicagoUSA
  11. 11.President Oncoclínicas InstituteRio de JaneiroBrazil

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