Experimental Laceration Spinal Cord Injury Model in Rodents

  • Yi Ping Zhang
  • Lisa B. E. ShieldsEmail author
  • Christopher B. Shields
Part of the Springer Series in Translational Stroke Research book series (SSTSR)


Experimental laceration spinal cord injury (l-SCI) is an important in vivo model to investigate mechanisms of axonal regeneration and neurite plasticity following SCI. l-SCI is customarily performed freehand under visual guidance that results in variable lesion depths and shapes. In this chapter, a precise l- SCI model will be described for rodents using the Louisville Injury System Apparatus (LISA). This method incorporates: (1) reliable vertebral stabilization and spinal cord exposure and (2) accurate tissue laceration without contusion.


Spinal cord injury Laceration SCI model Louisville Injury System Apparatus (LISA) Axonal regeneration 



We acknowledge Norton Healthcare for their continued support.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Yi Ping Zhang
    • 1
  • Lisa B. E. Shields
    • 1
    Email author
  • Christopher B. Shields
    • 1
    • 2
  1. 1.Norton Neuroscience Institute, Norton HealthcareLouisvilleUSA
  2. 2.Department of Anatomical Sciences and NeurobiologyUniversity of Louisville School of MedicineLouisvilleUSA

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