A Rat Model of Cerebellar Hemorrhage Using Bacterial Collagenase Injection

  • Devin W. McBride
  • Tim Lekic
  • Jiping Tang
  • John H. ZhangEmail author
Part of the Springer Series in Translational Stroke Research book series (SSTSR)


Cerebellar hemorrhage causes unique functional deficits, including ataxic, sensorimotor, and memory deficiencies. Despite the occurrence of CH, most studies have focused on intracerebral hemorrhage. Yet, the unique behavioral deficits of CH necessitates attention for the development of treatments. This chapter details the bacterial collagenase injection model for creating cerebellar hemorrhage. This model is unique in that it leads to reproducible postural deficits caused by a well-defined hemorrhage within the cerebellum. Cerebellar hemorrhage leads to acute increases in brain water content and acute sensorimotor and postural deficits, as well as long-term sensorimotor and memory deficits due to cerebellar tissue atrophy. Herein, the surgical procedures, evaluation of outcomes, caveats, limitations, and alternatives are described.


Cerebellum Collagenase Stroke Cerebellar hemorrhage CH Rat 

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Devin W. McBride
    • 1
  • Tim Lekic
    • 1
  • Jiping Tang
    • 1
  • John H. Zhang
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of Physiology and PharmacologyLoma Linda University School of MedicineLoma LindaUSA
  2. 2.Department of NeurosurgeryLoma Linda University School of MedicineLoma LindaUSA
  3. 3.Department of AnesthesiologyLoma Linda University School of MedicineLoma LindaUSA

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