Collagenase Model of Intracerebral Hemorrhage in Rats

  • Anatol Manaenko
  • Derek Nowrangi
  • Reis Cesar
  • Jiping Tang
  • John H. ZhangEmail author
Part of the Springer Series in Translational Stroke Research book series (SSTSR)


Intracerebral hemorrhage is the most devastating stroke subtype with a high mortality rate. Currently there are no clinically approved therapeutic strategies decreasing mortality and improving quality of life for the ICH patients. Preclinical models mimicking human pathophysiology of intracerebral hemorrhage are necessary to evaluate the potential effectiveness of new therapeutic approaches. Rodents are the most commonly used species for modeling stroke, including hemorrhagic stroke. This chapter focuses on describing the “collagenase” model of intracerebral hemorrhage on rats.


Intracerebral hemorrhage Stroke Animal model Rat Collagenase 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Anatol Manaenko
    • 1
  • Derek Nowrangi
    • 1
  • Reis Cesar
    • 2
  • Jiping Tang
    • 1
  • John H. Zhang
    • 1
    Email author
  1. 1.Department of Physiology and PharmacologyLoma Linda University School of MedicineLoma LindaUSA
  2. 2.Departments of Anesthesiology and NeurosurgeryLoma Linda University School of MedicineLoma LindaUSA

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