Non-neoplastic Diseases of Anus

  • Sejal Subhash Shah


Non-neoplastic diseases of the anus encompass a variety of lesions which include inflammatory processes such as anorectal infections and involvement by inflammatory bowel disease. The most common causes of anorectal infections are sexually transmitted infections with pathogens such as herpes simplex virus and Treponema pallidum (syphilis). An increase in proportion of these infections has been observed in recent years. This chapter highlights the pathognomonic features of these infections which will be useful to the pathologist for accurate diagnosis and hence early treatment and prevention of further transmission. Anal canal is involved in a significant proportion of patients with Crohn’s disease. In a small subset of patients, anal canal is the only site involved at presentation. Various chronic and debilitating manifestations of Crohn’s disease are discussed which include anal fissures, strictures, and fistulas. Pathological features of other benign lesions such as fibroepithelial polyps, inflammatory cloacogenic polyp, hemorrhoids, and anal abscesses are also discussed.


Herpes simplex virus Syphilis Chlamydia Crohn’s disease Hemorrhoids Fibroepithelial polyp Inflammatory cloacogenic polyp Fistula Fissure 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Sejal Subhash Shah
    • 1
  1. 1.Department of PathologyKaiser Permanente Southern CaliforniaIrvineUSA

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