Advertisement

General Conclusions: The Current Status of the Regenerative Medicine in the Aesthetics Applications

  • Joan FontdevilaEmail author
  • Hernán Pinto
Chapter

Abstract

Regenerative medicine leads to new ways of treatment for many diseases, and this also spans to the procedures in the field of aesthetics where the focus is on the recovery of the youth’s features. Improvements and new technology in fat grafting, regenerative cells procurement, growth factors, and biological scaffolds can contribute to achieve these goals. Until the present time, the real indications of these techniques, fat grafting apart, are limited because we know their potential but restricted nowadays to clinical trials. Unluckily, technology now available at the point of care is less powerful than what the advertisements tell the patients. So we should be realistic when advising the patients about what can be achieved with a treatment based on regenerative medicine.

Keywords

Regeneration Stem cells Growth factors Scaffolds Lipofilling Fat grafting Fibrosis Reconstructive surgery Aesthetic surgery 

References

  1. 1.
    Nguyen A, Guo J, Banyard DA, Fadavi D, Toranto JD, Wirth GA, et al. Stromal vascular fraction: a regenerative reality? Part 1: Current concepts and review of the literature. J Plast Reconstr Aesthetic Surg. 2016;69(2):170–9.CrossRefGoogle Scholar
  2. 2.
    Marks PW, Witten CM, Califf RM. Clarifying stem-cell therapy’s benefits and risks. N Engl J Med. 2017;376(11):1007–9.CrossRefGoogle Scholar
  3. 3.
    Rachul CM, Percec I, Caulfield T. The fountain of stem cell-based youth? Online portrayals of anti-aging stem cell technologies. Aesthetic Surg J. 2015;35(6):730–6.CrossRefGoogle Scholar
  4. 4.
    Khunger N. Regenerative medicine in aesthetic surgery: hope or hype? J Cutan Aesthet Surg. 2014;7(4):187–8.CrossRefGoogle Scholar
  5. 5.
    McArdle A, Senarath-Yapa K, Walmsley GG, Hu M, Atashroo DA, Tevlin R, et al. The role of stem cells in aesthetic surgery: fact or fiction? Plast Reconstr Surg. 2014;134(2):193–200.CrossRefGoogle Scholar
  6. 6.
    Atiyeh BS, Ibrahim AE, Saad DA. Stem cell facelift: between reality and fiction. Aesthetic Surg J. 2013;33(3):334–8.CrossRefGoogle Scholar
  7. 7.
    Rubin JP. Commentary on: stem cell facelift: between reality and fiction. Aesthetic Surg J. 2013;33(3):339–40.CrossRefGoogle Scholar
  8. 8.
    Rigotti G, Charles-De-Sa L, Gontijo-De-Amorim NF, Takiya CM, Amable PR, Borojevic R, et al. Expanded stem cells, Stromal-vascular fraction, and platelet-rich plasma enriched fat: comparing results of different facial rejuvenation approaches in a clinical trial. Aesthetic Surg J. 2016;36(3):261–70.CrossRefGoogle Scholar
  9. 9.
    Fontdevila J, Guisantes E, Martínez E, Prades E, Berenguer J. Double-blind clinical trial to compare autologous fat grafts versus autologous fat grafts with PDGF: no effect of PDGF. Plast Reconstr Surg. 2014;134(2):219e–30e.CrossRefGoogle Scholar
  10. 10.
    Derby BM, Dai H, Reichensperger J, Cox L, Harrison C, Cosenza N, et al. Adipose-derived stem cell to epithelial stem cell transdifferentiation: a mechanism to potentially improve understanding of fat grafting’s impact on skin rejuvenation. Aesthetic Surg J. 2014;34(1):142–53.CrossRefGoogle Scholar
  11. 11.
    Pérez-Cano R, Vranckx JJ, Lasso JM, Calabrese C, Merck B, Milstein AM, et al. Prospective trial of adipose-derived regenerative cell (ADRC)-enriched fat grafting for partial mastectomy defects: the RESTORE-2 trial. Eur J Surg Oncol. 2012;38(5):382–9.CrossRefGoogle Scholar
  12. 12.
    James IB, Coleman SR, Rubin JP. Fat, stem cells, and platelet-rich plasma. Clin Plast Surg. 2016;43(3):473–88.CrossRefGoogle Scholar
  13. 13.
    Llull R, Dos-Anjos S. Comment to: “the role of stem cells in aesthetic surgery: fact or fiction?”. Plast Reconstr Surg. 2015;135(3):1.CrossRefGoogle Scholar
  14. 14.
    El Atat O, Antonios D, Hilal G, Hokayem N, Abou-Ghoch J, Hashim H, et al. An evaluation of the stemness, paracrine, and tumorigenic characteristics of highly expanded, minimally passaged adipose-derived stem cells. PLoS One. 2016;11(9):1–22.Google Scholar
  15. 15.
    Daley GQ. Polar extremes in the clinical use of stem cells. N Engl J Med. 2017;376(11):1075–7.CrossRefGoogle Scholar
  16. 16.
    Costello BJ, Shah G, Kumta P, Sfeir CS. Regenerative medicine for craniomaxillofacial surgery. Oral Maxillofac Surg Clin North Am. 2010;22(1):33–42.CrossRefGoogle Scholar
  17. 17.
    Markeson D, Pleat JM, Sharpe JR, Harris AL, Seifalian AM, Watt SM. Scarring, stem cells, scaffolds and skin repair. J Tissue Eng Regen Med. 2015;9(6):649–68.CrossRefGoogle Scholar
  18. 18.
    Park BS, Jang KA, Sung JH, Park JS, Kwon YH, Kim KJ, et al. Adipose-derived stem cells and their secretory factors as a promising therapy for skin aging. Dermatologic Surg. 2008;34(10):1323–6.Google Scholar
  19. 19.
    Jeon B-J, Kim D-W, Kim M-S, Park S-H, Dhong E-S, Yoon E-S, et al. Protective effects of adipose-derived stem cells against UVB-induced skin pigmentation. J Plast Surg Hand Surg. 2016;50(6)CrossRefGoogle Scholar
  20. 20.
    Mosahebi A. Commentary on: the fountain of stem cell-based youth? Online portrayals of anti-aging stem cell technologies. Aesthetic Surg J. 2015;35(6):737–8.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Plastic and Maxillofacial Surgery DepartmentHospital ClinicBarcelonaSpain
  2. 2.Surgical Specialties DepartmentUniversity of BarcelonaBarcelonaSpain
  3. 3.Spanish Society of Fat Tissue Transplantation (SETGRA)BarcelonaSpain
  4. 4.i2e3 Biomedical Research InstituteBarcelonaSpain

Personalised recommendations