Was It Gold What Shone? Platelet-Rich Plasma Applications, Outcomes and Security Considerations

  • Lucía JáñezEmail author
  • Paloma Tejero
  • Marina Battistella


Platelet-rich plasma (PRP) has been used for rapid healing and tissue regeneration in numerous and growing fields of Medicine, including in Aesthetic Medicine. PRP was the first revolution in the field of Regenerative Medicine applied to Aesthetic Medicine. Most studies are focused on cutaneous rejuvenation, while a limited number of publications are relative to other indications, such as dyschromia, scars, alopecia, striae distensae, and cellulite. Facial biostimulation with platelet-rich plasma is a simple method to improve skin, with a low complication rate. PRP may be combined with many other medical aesthetic treatments. PRP seems to be a promising therapeutic modality but the level of evidence from the available published data is low. Well designed, larger population-based trials are required to validate PRP use and to reaffirm its efficacy and safety.


  1. 1.
    Trujillo Perez M, Acebal Blanco F, Labrot-Moreno Moleón I, Carrero GA. Platelet gel. Update of its use in regeneration techniques. Seminario Médico. 2008;60(1):25–42.Google Scholar
  2. 2.
    Yuksel EP, Sahin G, Aydin F, Senturk N, Turanli AY. Evaluation of effects of platelet-rich plasma on human facial skin. J Cosmet Laser Ther. 2014;16(5):206–8. Scholar
  3. 3.
    Alcaraz-Rubio J, Oliver-Iguacel A, Sanchez-Lopez JM. Platelet-rich plasma in growth factors. A new door to regenerative medicine. Rev Hematol Mex. 2015;16:128–42.Google Scholar
  4. 4.
    Anitua E, Sánchez M, Nurden AT, Nurden P, Orive G, Andía I. New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol. 2006;24(5):227–34.PubMedCrossRefGoogle Scholar
  5. 5.
    Modarressi A. Platelet rich plasma (PRP) improves fat grafting outcomes. World J Plast Surg. 2013;2(1):6–13.PubMedPubMedCentralGoogle Scholar
  6. 6.
    Rodríguez-Flores J, Palomar-Gallego MA, Enguita-Valls AB, Rodríguez-Peralto JL, Torres J. Influence of platelet-rich plasma on the histologic characteristics of the autologous fat graft to the upper lip of rabbits. Aesthet Plast Surg. 2011;35:480–6. Scholar
  7. 7.
    Sclafani AP, Azzi J. Platelet preparations for use in facial rejuvenation and wound healing: a critical review of current literature. Aesthetic Plast Surg. 2015;39(4):495–505. Scholar
  8. 8.
    Arshdeep KMS. Platelet-rich plasma in dermatology: boon or a bane? Indian J Dermatol Venereol Leprol. 2014;80(1):5–14. Scholar
  9. 9.
    Díaz-Martínez MA, Ruiz-Villaverde R. Aplicaciones del plasma rico en plaquetas como terapia en dermatología. Más Dermatol. 2016;24:4–10. Scholar
  10. 10.
    Schwartz TA, Martínez SG, Re L. Factores de crecimiento derivados de plaquetas y sus aplicaciones en medicina regenerativa. Potencialidades del uso del ozono como activador. Revista Española de Ozonoterapia. 2011;1(1):54–73.Google Scholar
  11. 11.
    De Sola Semería L, Tejero P. Factores de crecimiento: Aplicaciones en Medicina Estética. In: Tresguerres JAF, Insua E, Castaño P, Tejero P. Medicina Estética y Antienvejecimiento. Editorial medica Panamericana 2ª ed, 2018:485-504.Google Scholar
  12. 12.
    Tam WL, Ang YS, Lim B. The molecular basis of ageing in stem cells. Mech Ageing Dev. 2007;128:137–48.PubMedCrossRefGoogle Scholar
  13. 13.
    Amini F, Abiri F, Ramasamy TS, Sing TES. Efficacy of platelet-rich plasma (PRP) on skin rejuvenation a systematic review. Iran J Dermatol. 2015;18(3):119–27.Google Scholar
  14. 14.
    Sclafani AP, McCormick SA. Induction of dermal collagenesis, angiogenesis, and adipogenesis in human skin by injection of platelet-rich fibrin matrix. Arch Facial Plast Surg. 2012;14(2):132–6.PubMedCrossRefGoogle Scholar
  15. 15.
    Shin MK, Lee JH, Lee SJ, Kim NI. Platelet-rich plasma combined with fractional laser therapy for skin rejuvenation. Dermatol Surg. 2012;38:623–30. Scholar
  16. 16.
    Cho JM, Lee YH, Baek RM, Lee SW. Effect of platelet rich plasma on ultraviolet b-induced skin wrinkles in nude mice. J Plast Reconstr Aesthet Surg. 2011;64(2):31–9. Scholar
  17. 17.
    Liu HY, Huang CF, Lin TC, Tsai CY, Tina Chen SY, Liu A, et al. Delayed animal aging through the recovery of stem cell senescence by platelet rich plasma. Biomaterials. 2014;35(37):9767–76. Scholar
  18. 18.
    Anitua E, Pino A, Orive G. Plasma rich in growth factors inhibits ultravioleta B induced photoageing of the skin in human dermal fibroblast culture. Curr Pharm Biotechnol. 2016;17(12):1068–78.PubMedCrossRefGoogle Scholar
  19. 19.
    Sclafani AP. Platelet-rich fibrin matrix for improvement of deep nasolabial folds. J Cosmet Dermatol. 2010;9:66–71. Scholar
  20. 20.
    Sclafani AP. Safety, efficacy, and utility of platelet-rich fibrin matrix in facial plastic surgery. Arch Facial Plast Surg. 2011;13(4):247–51. Scholar
  21. 21.
    Redaelli A, Romano D, Marcianó A. Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol. 2010;9(5):466–72.PubMedGoogle Scholar
  22. 22.
    Mehryan P, Zartab H, Rajabi A, Pazhoohi N, Firooz A. Assessment of efficacy of platelet-rich plasma (PRP) on infraorbital dark circles and crow’s feet wrinkles. J Cosmet Dermatol. 2014;13(1):72–8. Scholar
  23. 23.
    Moya REJ, Moya CY. Bioestimulación facial con PRP. Rev AMC. 2015;19(2):167–78.Google Scholar
  24. 24.
    Uysal CA, Ertas NM. Platelet-rich plasma increases pigmentation. J Craniofac Surg. 2017;28:e793. Scholar
  25. 25.
    Díaz-Ley B, Cuevast J, Alonso-Castro L, Calvo MI, Ríos-Buceta L, Orive G, Anitua E, Jaén P. Benefits of plasma rich in growth factors (PRGF) in skin photodamage: clinical response and histological assessment. Dermatol Ther. 2015;28(4):258–63. Scholar
  26. 26.
    Esquirol Caussa J, Herrero VE. Factor de crecimiento epidérmico, innovación y seguridad. Med Clin (Barc). 2015;145:305–12. Scholar
  27. 27.
    Dutoit D. Platelet-rich plasma (PRP) and ACR can ameliorate facial acne scarring: new role in biological rejuvenation. Aesthetic Medicine Congress, South Africa, October 5-6th 2007, Gallagher Estate, Gaugteng.Google Scholar
  28. 28.
    Lee JW, Kim BJ, Kim MN, Mun SK. The efficacy of autologous platelet rich plasma combined with ablative carbon dioxide fractional resurfacing for acne scars: a simultaneous split-face trial. Dermatol Surg. 2011;37:931–8. Scholar
  29. 29.
    Gawdat HI, Hegazy RA, Fawzy MM, Fathy M. Autologous platelet rich plasma: topical versus intradermal after fractional ablative carbon dioxide laser treatment of atrophic acne scars. Dermatol Surg. 2014;40(2):152–61. Scholar
  30. 30.
    Gentile P, De Angelis B, Pasin M, Cervelli G, Curcio CB, Floris M, et al. Adipose-derived stromal vascular fraction cells and platelet-rich plasma: basic and clinical evaluation for cell-based therapies in patients with scars on the face. J Craniofac Surg. 2014;25(1):267–72. Scholar
  31. 31.
    Ibrahim ZA, El-Tatawy RA, El-Samongy MA, Ali DA. Comparison between the efficacy and safety of platelet-rich plasma vs. microdermabrasion in the treatment of striae distensae: clinical and histopathological study. J Cosmet Dermatol. 2015;14(4):336–46. Scholar
  32. 32.
    Uebel CO, da Silva JB, Cantarelli D, Martins P. The role of platelet plasma growth factors in male pattern baldness surgery. Plast Reconstr Surg. 2006;118:1458–66. Scholar
  33. 33.
    Miao Y, Sun YB, Sun XJ, Du BJ, Jiang JD, Hu ZQ. Promotional effect of platelet-rich plasma on hair follicle reconstitution in vivo. Dermatol Surg. 2013;39(12):1868–76. Scholar
  34. 34.
    Takikawa M, Nakamura S, Nakamura S, Ishihara M, Kishimoto S, Sasaki K, et al. Enhanced effect of platelet-rich plasma containing a new carrier on hair growth. Dermatol Surg. 2011;37:1721–9. Scholar
  35. 35.
    Khatu SS, More YE, Gokhale NR, Chavhan DC, Bendsure N. Platelet-rich plasma in androgenic alopecia: myth or an effective tool. J Cutan Aesthet Surg. 2014;7(2):107–10. Scholar
  36. 36.
    Sclafani AP. Platelet-rich fibrin matrix (PRFM) for androgenetic alopecia. Facial Plast Surg. 2014;30(2):219–24. Scholar
  37. 37.
    Giordano S, Romeo M, Lankinen P. Platelet-rich plasma for androgenetic alopecia: Does it work? Evidence from meta analysis. J Cosmet Dermatol. 2017;16:374–81. Scholar
  38. 38.
    Li ZJ, Choi HI, Choi DK, Sohn KC, Im M, Seo YJ, et al. Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth. Dermatol Surg. 2012;38(7 Pt 1):1040–6. Scholar
  39. 39.
    Xiong Y, Liu Y, Song Z, Hao F, Yang X. Identification of Wnt/β-catenin signaling pathway in dermal papilla cells of human scalp hair follicles: TCF4 regulates the proliferation and secretory activity of dermal papilla cell. J Dermatol. 2014;41(1):84–91. Scholar
  40. 40.
    Rastegar H, Ahmadi Ashtiani H, Aghaei M, Ehsani A, Barikbin B. Combination of herbal extracts and platelet-rich plasma induced dermal papilla cell proliferation: involvement of ERK and Akt pathways. J Cosmet Dermatol. 2013;12(2):116–22. Scholar
  41. 41.
    Schiavone G, Raskovic D, Greco J, Abeni D. Platelet-rich plasma for androgenetic alopecia: a pilot study. Dermatol Surg. 2014;40(9):1010–9. Scholar
  42. 42.
    Cervelli V, Garcovich S, Bielli A, Cervelli G, Curcio B, Scioli MG. The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation. Biomed Res Int. 2014;2014:760709. Scholar
  43. 43.
    Trink A, Sorbellini E, Bezzola P, Rodella L, Rezzani R, Ramot Y, et al. A randomized, double-blind, placebo- and active-controlled, half-head study to evaluate the effects of platelet-rich plasma on alopecia areata. Br J Dermatol. 2013;169(3):690–4. Scholar
  44. 44.
    Leibaschoff G. Cellulite: Is it a fat problem? Prime (Int J Aesthetic Anti-ageing Med). 2014:22.Google Scholar
  45. 45.
    Hernández I, Rossani G, Dávila M. Plasma rico en plaquetas como inductor de reparación en la paniculopatía edematofibroesclerótica. Reingeniería de Tejidos. 2005;7(2):18–24.Google Scholar
  46. 46.
    Lazzeri D, Agostini T, Figus M, Nardi M, Pantaloni M, Lazzeri S. Blindness following cosmetic injections of the face. Plast Reconstr Surg. 2012;129:995–1012. Scholar
  47. 47.
    Tansatit T, Moon HJ, Apinuntrum P, Phetudom T. Verification of embolic channel causing blindness following filler injection. Aesthet Plast Surg. 2015;39:154–61. Scholar
  48. 48.
    Glaich AS, Cohen JL, Goldberg LH. Injection necrosis of the glabella: protocol for prevention and treatment after use of dermal fillers. Dermatol Surg. 2006;32:276–81.PubMedGoogle Scholar
  49. 49.
    Liao J, Ehrlich M, Woodward JA. Soft tissue fillers: avoiding and treating complications. EyeNet Magazine 2013 Feb.
  50. 50.
    Sclafani AP, Fagien S. Treatment of injectable soft tissue filler complications. Dermatol Surg. 2009;35(Suppl 2):1672–80. Scholar
  51. 51.
    Kalyam K, Kavoussi SC, Ehrlich M, Teng CC, Chadha N, Khodadadeh S, Liu J. Irreversible blindness following periocular autologous platelet-rich plasma skin rejuvenation treatment. Ophthalmic Plast Reconstr Surg. 2017;33(3S Suppl 1):S12–6. Scholar
  52. 52.
    Gómez-Font R, De Miguel-Márquez M, Padierna-Gangas AI. Revitalización facial con PRP. Resultados clínicos en una serie de 6 pacientes consecutivos. Magazine de los títulos propios de la UCM. Medicina Estética y Antienvejecimiento. 2012;6:19–26.Google Scholar
  53. 53.
    García JV, González JA, Albandea N. Tratamiento del envejecimiento cutáneo mediante bioestimulación con factores de crecimiento autógenos. Rejuvenecimiento cutáneo. 2005;7(2):8–14.Google Scholar
  54. 54.
    Na JI, Choi JW, Choi HR, Jeong JB, Park KC, Youn SW, et al. Rapid healing and reduced erythema after ablative fractional carbon dioxide laser resurfacing combined with the application of autologous platelet-rich plasma. Dermatol Surg. 2011;37(4):463–8. Scholar
  55. 55.
    Hui Q, Chang P, Guo B, Zhang Y, Tao K. The clinical efficacy of autologous platelet-rich plasma combined with ultra-pulsed fractional CO2 laser therapy for facial rejuvenation. Rejuvenation Res. 2017;20(1):25–31. Scholar
  56. 56.
    Del Ojo CD. Plasma rico en plaquetas, ¿es útil en dermatología? Med Cutan Iber Lat Am. 2015;43(2):87–9.Google Scholar
  57. 57.
    Kim H, Gallo J. Evaluation of the effect of platelet-rich plasma on recovery after ablative fractional photothermolysis. JAMA Facial Plast Surg. 2015;17(2):97–102. Scholar
  58. 58.
    Bocci V, Valacchi G, Rossi R, Giustarini D, Paccagnini E, Pucci AM, et al. Studies on the biological effects of ozone: 9. Effects of ozone on human platelets. Platelets. 1999;10:110–6. Scholar
  59. 59.
    Re L, Sanchez GM, Mawsouf N. Clinical evidence of ozone interaction with pain mediators. Saudi Med J. 2010;31:1363–7.PubMedGoogle Scholar
  60. 60.
    Bulam H, Ayhan S, Sezgin B, Zinnuroglu M, Konac E, Varol N, et al. The inhibitory effect of platelet-rich plasma on botulinum toxin type-A: an experimental study in rabbits. Aesthet Plast Surg. 2015;39:134–40. Scholar
  61. 61.
    Boss WK. Methods for the repair and rejuvenation of tissues using platelet-rich plasma composition. US Patent Aplication. 2015;14:597–704.Google Scholar
  62. 62.
    Chawla S. Split face comparative study of microneedling with PRP versus microneedling with vitamin C in treating atrophic post acne scars. J Cutan Aesthet Surg. 2014;7(4):209–12. Scholar
  63. 63.
    Conde Montero E, Fernández Santos ME, Suárez Fernández R. Platelet-rich plasma: applications in dermatology. Actas Dermosifiliogr. 2015;106(2):104–11. Scholar
  64. 64.
    Aguilar G, Fernández S. Comparación del uso de peeling de ácido salicílico y carboxiterapia alternando con JALUPRO y PRP en el tratamiento de cicatrices post acné. Rev Cient Soc Esp Med Est. 2014;40:36–45.Google Scholar
  65. 65.
    Tantari SHW, Murlistyarini S. Combination treatment of skin needling, platelet-rich plasma and glycolic acid 70% chemical peeling for atrophic acne scars in Fitzpatrick’s skin type IV–VI. J Clin Exp Dermatol Res. 2016;7:364. Scholar
  66. 66.
    Ulusal BG. Platelet-rich plasma and hyaluronic acid - an efficient biostimulation method for face rejuvenation. J Cosmet Dermatol. 2016;16:112–9. Scholar
  67. 67.
    Aguilar P, Hersant B, SidAhmed-Mezi M, Bosc R, Vidal L, Meningaud JP. Novel technique of vulvo-vaginal rejuvenation by lipofilling and injection of combined platelet-rich-plasma and hyaluronic acid: a case report. Springerplus. 2016;5(1):1184. Scholar
  68. 68.
    Kim IS, Park KY, Kim BJ, Kim MN, Kim CW, Kim SE. Efficacy of intradermal radiofrequency combined with autologous platelet-rich plasma in striae distensae: a pilot study. Int J Dermatol. 2012;51(10):1253–8. Scholar
  69. 69.
    Manuskiatti W, Boonthaweeyuwat E, Varothai S. Treatment of striae distensae with a TriPollar radiofrequency device: a pilot study. J Dermatolog Treat. 2009;20(6):359–64. Scholar
  70. 70.
    Nikolidakis D, Jansen JA. The biology of platelet-rich plasma and its application in oral surgery: literature review. Tissue Eng Part B Rev. 2008;14:249–58. Scholar
  71. 71.
    Bashutski JD, Wang HL. Role of platelet-rich plasma in soft tissue root-coverage: a review. Quintessence Int. 2008;39:473–83.PubMedGoogle Scholar
  72. 72.
    Arora NS, Ramanayake T, Ren YF, Romanos GE. Platelet-rich plasma: a literature review. Implant Dent. 2009;18:303–10. Scholar
  73. 73.
    Hom DB, Linzie BM, Huang TC. The healing effects of autologous platelet gel on acute human skin wounds. Arch Facial Plast Surg. 2007;9:174–83. Scholar
  74. 74.
    Chignon-Sicard B, Georgiou CA, Fontas E, et al. Efficacy of leukocyte- and platelet-rich fibrin in wound healing: a randomized controlled clinical trial. Plast Reconstr Surg. 2012;130(6):819e–29e. Scholar
  75. 75.
    Knighton DR, Ciresi K, Fiegel VD, Schumerth S, Butler E, Cerra F. Stimulation of repair in chronic, nonhealing, cutaneous ulcers using platelet-derived wound healing formula. Surg Gynecol Obstet. 1990;170:56–60.PubMedGoogle Scholar
  76. 76.
    Notodihardjo PV, Morimoto N, Kakudo N, Matsui M, Sakamoto M, Liem PH, et al. Gelatin hydrogel impregnated with platelet-rich plasma releasate promotes angiogenesis and wound healing in murine model. J Artif Organs. 2015;18(1):64–71. Scholar
  77. 77.
    Kakudo N, Morimoto N, Kushida S, Ogawa T, Kusumoto K. Platelet-rich plasma releasate promotes angiogenesis in vitro and in vivo. Med Mol Morphol. 2014;47(2):83–9. Scholar
  78. 78.
    Whitman DH, Berry RL, Green DM. Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg. 1997;55:1294–9.PubMedCrossRefGoogle Scholar
  79. 79.
    Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost. 2004;91:4–15. Scholar
  80. 80.
    Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85:638–46.PubMedCrossRefGoogle Scholar
  81. 81.
    Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg. 2004;62:489–96.PubMedCrossRefGoogle Scholar
  82. 82.
    Fennis JP, Stoelinga PJ, Jansen JA. Mandibular reconstruction: a clinical and radiographic animal study on the use of autogenous scaffolds and platelet rich plasma. Int J Oral Maxillofac Surg. 2002;31:281–6. Scholar
  83. 83.
    Froum SJ, Wallace SS, Tarnow DP, Cho SC. Effect of platelet-rich plasma on bone growth and osseointegration in human maxillary sinus grafts: three bilateral case reports. Int J Periodontics Restorative Dent. 2002;22(1):45–53.PubMedGoogle Scholar
  84. 84.
    Wiltfang J, Schlegel KA, Schultze-Mosgau S, Nkenke E, Zimmermann R, Kessler P. Sinus floor augmentation with beta-tricalciumphosphate (beta-TCP): does platelet-rich plasma promote its osseous integration and degradation? Clin Oral Implants Res. 2003;14(2):213–8.PubMedCrossRefGoogle Scholar
  85. 85.
    Simman R, Hoffmann A, Bohinc RJ, Peterson WC, Russ AJ. Role of platelet-rich plasma in acceleration of bone fracture healing. Ann Plast Surg. 2008;61:337–44. Scholar
  86. 86.
    Tajima S, Tobita M, Orbay H, Hyakusoku H, Mizuno H. Direct and indirect effects on bone regeneration of a combination of adipose-derived stem cells and platelet-rich plasma. Tissue Eng Part A. 2015;21(5–6):895–905. Scholar
  87. 87.
    Taylor DW, Petrera M, Hendry M, Theodoropoulos JS. A systematic review of the use of platelet-rich plasma in sports medicine as a new treatment for tendon and ligament injuries. Clin J Sport Med. 2011;21:344–52. Scholar
  88. 88.
    Peerbooms JC, van Laar W, Faber F, Schuller HM, van der Hoeven H, Gosens T. Use of platelet rich plasma to treat plantar fasciitis: design of a multi centre randomized controlled trial. BMC Musculoskelet Disord. 2010;11:69. Scholar
  89. 89.
    Silva A, Sampaio R. Anatomic ACL reconstruction: does the platelet-rich plasma accelerate tendon healing? Knee Surg Sports Traumatol Arthrosc. 2009;17(6):676–82. Scholar
  90. 90.
    Paoloni J, De Vos RJ, Hamilton B, Murrell GA, Orchard J. Platelet-rich plasma treatment for ligament and tendon injuries. Clin J Sport Med. 2011;21:37–45. Scholar
  91. 91.
    Chen TM, Tsai JC, Burnouf T. A novel technique combining platelet gel, skin graft, and fibrin glue for healing recalcitrant lower extremity ulcers. Dermatol Surg. 2010;36:453–60. Scholar
  92. 92.
    Savarino L, Cenni E, Tarabusi C, Dallari D, Stagni C, Cenacchi A, et al. Evaluation of bone healing enhancement by lyophilized bone grafts supplemented with platelet gel: a standardized methodology in patients with tibial osteotomy for genu varus. J Biomed Mater Res B Appl Biomater. 2006;76:364–72. Scholar
  93. 93.
    Riestra AC, Alonso-Herreros JM, Merayo-Lloves J. Platelet rich plasma in ocular surface. Arch Soc Esp Oftalmol. 2016;91(10):475–90. Scholar
  94. 94.
    Tanidir ST, Yuksel N, Altintas O, Yildiz DK, Sener E, Caglar Y. The effect of subconjunctival platelet-rich plasma on corneal epithelial wound healing. Cornea. 2010;29(6):664–9. Scholar
  95. 95.
    Alio JL, Abad M, Artola A, Rodriguez-Prats JL, Pastor S, Ruiz-Colecha J. Use of autologous platelet-rich plasma in the treatment of dormant corneal ulcers. Ophthalmology. 2007;114(7):1286–93. Scholar
  96. 96.
    Ortuño-Prados VJ, Alio JL. Tratamiento de úlcera corneal neurotrófica con plasma rico en plaquetas y Tutopatch®. Arch Soc Esp Oftalmol. 2011;86(4):121–3. Epub 2011 Feb 20.PubMedCrossRefGoogle Scholar
  97. 97.
    Márquez-de-Aracena R, Montero-de-Espinosa I, Muñoz M, Pereira G. Subconjunctival application of plasma platelet concentrate in the treatment of ocular burns. Preliminary results. Arch Soc Esp Oftalmol. 2007;82(8):475–81.PubMedCrossRefGoogle Scholar
  98. 98.
    Gehring S, Hoerauf H, Laqua H, Kirchner H, Klüter H. Preparation of autologous platelets for the ophthalmologic treatment of macular holes. Transfusion. 1999;39:144–8.PubMedCrossRefGoogle Scholar
  99. 99.
    Limoli PG, Limoli C, Vingolo EM, Scalinci SZ, Nebbioso M. Cell surgery and growth factors in dry age-related macular degeneration: visual prognosis and morphological study. Oncotarget. 2016;7:46913–23. Scholar
  100. 100.
    Figueroa MS, Govetto A, Arriba-Palomero PD. Short-term results of platelet-rich plasma as adjuvant to 23-G vitrectomy in the treament of high myopic macular holes. Eur J Ophthalmol. 2016;26:491–6. Scholar
  101. 101.
    Navarrete Álvaro ML, Ortiz N, Rodriguez L, Boemo R, Fuentes JF, Mateo A, et al. Pilot study on the efficiency of the biostimulation with autologous plasma rich in platelet growth factors in otorhinolaryngology: otologic surgery (tympanoplasty type I). ISRN Surg. 2011;2011:451020. Scholar
  102. 102.
    Yoo J, Roth K, Hughes B, Fung K, Franklin J, Lampe H, et al. Evaluation of postoperative drainage with application of platelet-rich and platelet-poor plasma following hemithyroidectomy: a randomized controlled clinical trial. Head Neck. 2008;30(12):1552–8. Scholar
  103. 103.
    Scala M, Mereu P, Spagnolo F, Massa M, Barla A, Mosci S, Forno G, Ingenito A, Strada P. The use of platelet-rich plasma gel in patients with mixed tumour undergoing superficial parotidectomy: a randomized study. In Vivo. 2014;28(1):121–4.PubMedGoogle Scholar
  104. 104.
    Caloprisco G, Borean A. Chronic skin ulcers: a regenerative simulation by topical hemotherapy. Int J Artif Organs. 2004;27(9):816–7.PubMedCrossRefGoogle Scholar
  105. 105.
    Frykberg RG, Driver VR, Carman D, Lucero B, Borris-Hale C, Fylling CP, et al. Chronic wounds treated with a physiologically relevant concentration of platelet-rich plasma gel: a prospective case series. Ostomy Wound Manage. 2010;56:36–44.PubMedGoogle Scholar
  106. 106.
    Villela DL, Santos VL. Evidence on the use of platelet-rich plasma for diabetic ulcer: a systematic review. Growth Factors. 2010;28(2):111–6. Scholar
  107. 107.
    Dougherty EJ. An evidence-based model comparing the cost-effectiveness of platelet-rich plasma gel to alternative therapies for patients with nonhealing diabetic foot ulcers. Adv Skin Wound Care. 2008;21:568–75. Scholar
  108. 108.
    Driver VR, Hanft J, Fylling CP, Beriou JM. A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. Ostomy Wound Manage. 2006;52:68–74.PubMedGoogle Scholar
  109. 109.
    Salazar-Álvarez AE, Riera-del-Moral LF, García-Arranz M, Álvarez-García J, Concepción-Rodríguez NA, Riera-de-Cubas L. Use of platelet-rich plasma in the healing of chronic ulcers of the lower extremity. Actas Dermosifiliogr. 2014;105(6):597–604. Scholar
  110. 110.
    Josifova D, Gatt G, Aquilina A, Serafimov V, Vella A, Felice A. Treatment of leg ulcers with platelet-derived wound healing factor (PDWHFS) in a patient with beta thalassaemia intermedia. Br J Haematol. 2001;112:527–9.PubMedCrossRefGoogle Scholar
  111. 111.
    Gilsanz F, Escalante F, Auray C, Olbés AG. Treatment of leg ulcers in beta-thalassaemia intermedia: use of platelet-derived wound healing factors from the patient’s own platelets. Br J Haematol. 2001;115(3):710.PubMedCrossRefGoogle Scholar
  112. 112.
    Anitua E, Sánchez M, Nurden AT, Zalduendo MM, de la Fuente M, Azofra J, et al. Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients. Rheumatology (Oxford). 2007;46:1769–72. Scholar
  113. 113.
    Sánchez M, Anitua E, Azofra J, Aguirre JJ, Andia I. Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study. Clin Exp Rheumatol. 2008;26:910–3.PubMedGoogle Scholar
  114. 114.
    Farrag TY, Lehar M, Verhaegen P, Carson KA, Byrne PJ. Effect of platelet rich plasma and fibrin sealant on facial nerve regeneration in a rat model. Laryngoscope. 2007;117(1):157–65. Scholar
  115. 115.
    Zheng C, Zhu Q, Liu X, Huang X, He C, Jiang L, et al. Improved peripheral nerve regeneration using acellular nerve allografts loaded with platelet-rich plasma. Tissue Eng Part A. 2014;20(23–24):3228–40. Scholar
  116. 116.
    Cho HH, Jang S, Lee SC, Jeong HS, Park JS, Han JY, et al. Effect of neural-induced mesenchymal stem cells and platelet-rich plasma on facial nerve regeneration in an acute nerve injury model. Laryngoscope. 2010;120:907–13. Scholar
  117. 117.
    Sariguney Y, Yavuzer R, Elmas C, Yenicesu I, Bolay H, Atabay K. Effect of platelet-rich plasma on peripheral nerve regeneration. J Reconstr Microsurg. 2008;24(3):159–67. Scholar
  118. 118.
    Carrillo-Mora P, González-Villalva A, Macías-Hernández SI, Pineda-Villaseñor C. Platelet-rich plasma: versatile tool of regenerative medicine? Cir Cir. 2013;81:74–82.PubMedGoogle Scholar
  119. 119.
    Hegewald AA, Ringe J, Sittinger M, Thome C. Regenerative treatment strategies in spinal surgery. Front Biosci. 2008;13:1507–25.PubMedCrossRefGoogle Scholar
  120. 120.
    Masuda K, Oegema TR Jr, An HS. Growth factors and treatment of intervertebral disc degeneration. Spine (Phila Pa 1976). 2004;29:2757–69.CrossRefGoogle Scholar
  121. 121.
    Fanning J, Murrain L, Flora R, Hutchings T, Johnson JM, Fenton BW. Phase I/II prospective trial of autologous platelet tissue graft in gynecologic surgery. J Minim Invasive Gynecol. 2007;14:633–7. Scholar
  122. 122.
    Sipurzynski-Budrass S, Macher S, Haeusler M, Lanzer G. Successful treatment of premature rupture of membranes after genetic amniocentesis by intra-amniotic injection of platelets and cryoprecipitate (amniopatch): a case report. Vox Sang. 2006;91(1):88–90. Scholar
  123. 123.
    Englert SJ, Estep TH, Ellis-Stoll CC. Postoperative surgical chest and leg incision sites using platelet gel: a retrospective study. J Extra Corpor Technol. 2008;40(4):225–8.PubMedPubMedCentralGoogle Scholar
  124. 124.
    de Hingh IH, Nienhuijs SW, Overdevest EP, Scheele K, Everts PA. Mesh fixation with autologous platelet-rich fibrin sealant in inguinal hernia repair. Eur Surg Res. 2009;43(3):306–9. Scholar
  125. 125.
    Gómez-Caro A, Ausin P, Boada M. Platelet rich plasma improves the healing process after airway anastomosis. Interact Cardiovasc Thorac Surg. 2011;13(6):552–6. Scholar
  126. 126.
    Sommeling CE, Heyneman A, Hoeksema H, Verbelen J, Stillaert FB, Monstrey S. The use of platelet-rich plasma in plastic surgery: a systematic review. J Plast Reconstr Aesthet Surg. 2013;66(3):301–11. Scholar
  127. 127.
    Clevens RA. Autologous platelet rich plasma in facial plastic surgery. Proceedings from the 8th International symposium of facial plastic surgery. New York, May, 2002.Google Scholar
  128. 128.
    Bhanot S, Alex JC. Current applications of platelet gels in facial plastic surgery. Facial Plast Surg. 2002;18(1):27–33. Scholar
  129. 129.
    Vick VL, Holds JB, Hartstein ME, Rich RM, Davidson BR. Use of autologous platelet concentrate in blepharoplasty surgery. Ophthal Plast Reconstr Surg. 2006;22(2):102–4. Scholar
  130. 130.
    Shinichiro N, Masayuki I, Megumi T, Kaoru M, Satoko K, Shingo N, et al. Platelet-rich plasma (PRP) promotes survival of fat-grafts in rats. Ann Plast Surg. 2010;65:101–6. Scholar
  131. 131.
    Nakamura S, Ishihara M, Takikawa M, Murakami K, Kishimoto S, Nakamura S, et al. Platelet-rich plasma (PRP) promotes survival of fat-grafts in rats. Ann Plast Surg. 2010;65(1):101–6. Scholar
  132. 132.
    Por YC, Yeow VK, Louri N, Lim TK, Kee I, Song IC, et al. Platelet-rich plasma has no effect on increasing free fat graft survival in the nude mouse. J Plast Reconstr Aesthet Surg. 2009;62(8):1030–4. Scholar
  133. 133.
    Natsuko K, Tatsuya M, Toshihito M, Satoshi K, Zefanya NF, Kenji K. Proliferation-promoting effect of platelet-rich plasma on human adipose-derived stem cells and human dermal fibroblasts. Plast Reconstr Surg. 2008;122:1352–60. Scholar
  134. 134.
    Cervelli V, Palla L, Pascali M, De Angelis B, Curcio BC, Gentile P. Autologous platelet-rich plasma mixed with purified fat graft in aesthetic plastic surgery. Aesthet Plast Surg. 2009;33:716–21. Scholar
  135. 135.
    Pires Fraga MF, Nishio RT, Ishikawa RS, Perin LF, Helene A Jr, Malheiros CA. Increased survival of free fat grafts with platelet-rich plasma in rabbits. J Plast Reconstr Aesthet Surg. 2010;63(12):e818–22. Scholar
  136. 136.
    Oh DS, Cheon YW, Jeon YR, Lew DH. Activated platelet-rich plasma improves fat graft survival in nude mice: a pilot study. Dermatol Surg. 2011;37(5):619–25. Scholar
  137. 137.
    Li K, Li F, Li J, Wang H, Zheng X, Long J, et al. Increased survival of human free fat grafts with varying densities of human adipose-derived stem cells and platelet-rich plasma. J Tissue Eng Regen Med. 2017;11(1):209–19. Scholar
  138. 138.
    Cervelli V, Gentile P, Scioli MG, Grimaldi M, Casciani CU, Spagnioli LG, et al. Application of platelet-rich plasma to fat grafting during plastic surgical procedures: clinical and in vitro evaluation. Tissue Eng Part C Methods. 2009;15:625–34. Scholar
  139. 139.
    Willemsen JC, van der Lei B, Vermeulen KM, Stevens HP. The effects of platelet-rich plasma on recovery time and aesthetic outcome in facial rejuvenation: preliminary retrospective observations. Aesthet Plast Surg. 2014;38(5):1057–63. Scholar
  140. 140.
    Rigotti G, Charles-de-Sá L, Gontijo-de-Amorim NF, Takiya CM, Amable PR, Borojevic R, et al. Expanded stem cells, stromal-vascular fraction, and platelet-rich plasma enriched fat: comparing results of different facial rejuvenation approaches in a clinical trial. Aesthet Surg J. 2016;36(3):261–70. Scholar
  141. 141.
    Gentile P, Orlandi A, Scioli MG, Di Pasquali C, Bocchini I, Curcio CB, et al. A comparative translational study: the combined use of enhanced stromal vascular fraction and platelet-rich plasma improves fat grafting maintenance in breast reconstruction. Stem Cells Transl Med. 2012;1:341–51. Scholar
  142. 142.
    Gennai A, Zambelli A, Repaci E, Quarto R, Baldelli I, Fraternali G, et al. Skin rejuvenation and volume enhancement with the micro superficial enhanced fluid fat injection (M-SEFFI) for skin aging of the periocular and perioral regions. Aesthet Surg J. 2017;37(1):14–23. Scholar
  143. 143.
    Findikcioglu F, Findikcioglu K, Yavuzer R, Lortlar N, Atabay K. Effect of preoperative subcutaneous platelet-rich plasma and fibrin glue application on skin flap survival. Aesthet Plast Surg. 2012;36:1246–53. Scholar
  144. 144.
    Man D, Plosker H, Winland-Brown JE. The use of autologous platelet-rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin glue) in cosmetic surgery. Plast Reconstr Surg. 2001;107(1):229–37.PubMedCrossRefGoogle Scholar
  145. 145.
    Powell DM, Chang E, Farrior EH. Recovery from deep plane rhytidectomy following unilateral wound treatment with autologous platelet gel: a pilot study. Arch Facial Plast Surg. 2001;3:245–50.PubMedCrossRefGoogle Scholar
  146. 146.
    Kakudo N, Kushida S, Minakata T, Suzuki K, Kusumoto K. Platelet-rich plasma promotes epithelialization and angiogenesis in a split thickness skin graft donor site. Med Mol Morphol. 2011;44(4):233–6. Scholar
  147. 147.
    Kim HY, Park JH, Han YS, Kim H. The effect of plateletrich plasma on flap survival in random extension of an axial pattern flap in rabbits. Plast Reconstr Surg. 2013;132(1):85–92. Scholar
  148. 148.
    Sevim KZ, Yazar M, Irmak F, Tekkesin MS, Yildiz K, Sirvan SS. Use of platelet-rich plasma solution applied with composite chondrocutaneous graft technique: an experimental study in rabbit model. J Oral Maxillofac Surg. 2014;72(7):1407–19. Scholar
  149. 149.
    Chandra RK, Handorf C, West M, Kruger EA, Jackson S. Histologic effects of autologous platelet gel in skin flap healing. Arch Facial Plast Surg. 2007;9(4):260–3. Scholar
  150. 150.
    Danielsen P, Jorgensen B, Karlsmark T, Jorgensen LN, Agren MS. Effect of topical autologous platelet-rich fibrin versus no intervention on epithelialization of donor sites and meshed split-thickness skin autografts: a randomized clinical trial. Plast Reconstr Surg. 2008;122:1431–40. Scholar
  151. 151.
    Henderson JL, Cupp CL, Ross EV, Shick PC, Keefe MA, Wester DC, et al. The effects of autologous platelet gel on wound healing. Ear Nose Throat J. 2003;82(8):598–602.PubMedCrossRefGoogle Scholar
  152. 152.
    Pallua N, Wolter T, Markowicz M. Platelet-rich plasma in burns. Burns. 2010;36(1):4–8. Scholar
  153. 153.
    Lavik E, Langer R. Tissue engineering: current state and perspectives. Appl Microbiol Biotechnol. 2004;65:1–8. Scholar
  154. 154.
    Fabi S, Sundaram H. The potential of topical and injectable growth factors and cytokines for skin rejuvenation. Facial Plast Surg. 2014;30(2):157–71. Scholar
  155. 155.
    Martinez-Gonzales JM, Cano-Sanchez J, Gonzalo-Lafuente JC, Campo-Trapero J, Esparza-Gomez G, Seoane J. Do ambulatory-use platelet-rich plasma (PRP) concentrates present risks? Med Oral. 2002;7(5):375–90.Google Scholar
  156. 156.
    Beca T, Hernandez G, Morantes S, Bascones A. Platelet-rich plasma. A bibliographic review. Av Periodon Implantol. 2007;19(1):39–52.Google Scholar
  157. 157.
    Albanese A, Licata ME, Polizzi B, Campisi G. Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. Immun Ageing. 2013;10:23. Scholar
  158. 158.
    Menter DG, Kopetz S, Hawk E, Sood AK, Loree JM, Gresele P, Honn KV. Platelet “First Responders” in wound response, cancer, and metastasis. Cancer Metastasis Rev. 2017;36(2):199–213. Scholar
  159. 159.
    Menter DG, Tucker SC, Kopetz S, Sood AK, Crissman JD, Honn KV. Platelets and cancer: a casual o causal relationship: revisited. Cancer Metastasis Rev. 2014;33(1):231–69. Scholar
  160. 160.
    Zenker S. Platelet rich plasma (PRP) for facial rejuvenation. J Med Esth et Chir Derm. 2010;148(37):179–83.Google Scholar
  161. 161.
    Di Matteo B, Filardo G, Lo Presti M, Kon E, Marcacci M. Chronic anti-platelet therapy: a contraindication for platelet-rich plasma intra-articular injections? Eur Rev Med Pharmacol Sci. 2014;18(1 Suppl):55–9.PubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Lucía Jáñez
    • 1
    Email author
  • Paloma Tejero
    • 2
  • Marina Battistella
    • 3
  1. 1.Institute of Knowledge Technology (Complutense University)MadridSpain
  2. 2.University of AlcaláMadridSpain
  3. 3.Mediestetic ClinicToledoSpain

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