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Microneedle Patch for Fast Onset and Long-Lasting Delivery of Painkillers

  • Jaspreet Singh Kochhar
  • Justin J. Y. Tan
  • Yee Chin Kwang
  • Lifeng Kang
Chapter

Abstract

Chronic pain afflicts many worldwide. Topical lidocaine has been known for its analgesic properties apart from its known role as a local anaesthetic in the management of both acute and chronic pain. Despite its widespread use, major concerns relating to its lack of efficacy arising from poor skin permeability persists. In this chapter, we explore the use of ultraviolet curing to fabricate a microneedle integrated transdermal patch (MITP) encapsulating lidocaine, allowing higher loading of the drug than previously reported methods. This integrated patch system is intended to provide a reservoir system with high drug loading, delivering the initial drug load rapidly and following that, a sustained release of the active ingredient. Therefore, this integrated patch could serve as an excellent drug delivery tool for paediatric applications and chronic care management, as well as in home care settings due to its ease of application.

Keywords

Chronic pain Painkiller Lidocaine Microneedle integrated transdermal patch 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Jaspreet Singh Kochhar
    • 1
  • Justin J. Y. Tan
    • 2
  • Yee Chin Kwang
    • 3
  • Lifeng Kang
    • 3
  1. 1.Procter & GambleSingaporeSingapore
  2. 2.Department of PharmacyNational University of SingaporeSingaporeSingapore
  3. 3.School of PharmacyUniversity of SydneySydneyAustralia

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