Chronic pain afflicts many worldwide. Topical lidocaine has been known for its analgesic properties apart from its known role as a local anaesthetic in the management of both acute and chronic pain. Despite its widespread use, major concerns relating to its lack of efficacy arising from poor skin permeability persists. In this chapter, we explore the use of ultraviolet curing to fabricate a microneedle integrated transdermal patch (MITP) encapsulating lidocaine, allowing higher loading of the drug than previously reported methods. This integrated patch system is intended to provide a reservoir system with high drug loading, delivering the initial drug load rapidly and following that, a sustained release of the active ingredient. Therefore, this integrated patch could serve as an excellent drug delivery tool for paediatric applications and chronic care management, as well as in home care settings due to its ease of application.
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Koneti KK et al (2013) Management of acute pain. Surgery (UK) 31:77–83Google Scholar
Anonymous (2010) Practice guidelines for chronic pain management: an updated report by the American Society of Anesthesiologists Task Force on Chronic Pain Management and the American Society of Regional Anesthesia and Pain Medicine. Anesthesiology 112:810–833CrossRefGoogle Scholar
Reimer-Kent J (2004) Improving post-operative pain management by focusing on prevention. Nurs BC 36:20–24PubMedGoogle Scholar
Evans SR et al (2011) Peripheral neuropathy in HIV: prevalence and risk factors. AIDS 25:919–928CrossRefGoogle Scholar
Herberger K et al (2012) Local anesthetic effects of Lidocaine cream: randomized controlled trial using a standardized prick pain. J Dermatolog Treat 23:437–442CrossRefGoogle Scholar
Mick G et al (2012) Topical pain management with the 5% lidocaine medicated plaster—a review. Curr Med Res Opin 28:937–951CrossRefGoogle Scholar
Meier T et al (2003) Efficacy of lidocaine patch 5% in the treatment of focal peripheral neuropathic pain syndromes: a randomized, double-blind, placebo-controlled study. Pain 106:151–158CrossRefGoogle Scholar
Galer BS et al (1999) Topical lidocaine patch relieves postherpetic neuralgia more effectively than a vehicle topical patch: results of an enriched enrollment study. Pain 80:533–538CrossRefGoogle Scholar