Disseminated Neoplasms

  • Venerino Poletti
  • Angelo Carloni
  • Marco Chilosi


Disseminated lung tumors are a large heterogenous group of disorders that may mimic more common interstitial lung disorders. Although CT scan feature may be characteristic and may suggest the diagnosis, histology is required for a definitive diagnosis. The need of lung tissue is now even more urgent for the possibility to identify targetable mutations/translocations/overexpressions of genes in the neoplastic cells and of the immune-checkpoint status. Transbronchial cryobiopsy may provide material for morphological and molecular investigations.


Disseminated lung tumors Metastases Angiosarcoma Lymphoproliferative disorders Transbronchial cryobiopsy 


  1. 1.
    Murer B, Chilosi M, Hasleton P, Flieder DB. Metastases involving the lungs. In: Hasleton P, Flieder DB, editors. Spencer’s pathology of the lung, vol. 2. Cambridge: Cambridge University Press; 2013. p. 1375–407.CrossRefGoogle Scholar
  2. 2.
    Allen TC, Cagle PT, Flieder DB. Mesenchymal and miscellaneous neoplasms. In: Hasleton P, Flieder DB, editors. Spencer’s pathology of the lung, vol. 2. Cambridge: Cambridge University Press; 2013. p. 1224–315.CrossRefGoogle Scholar
  3. 3.
    Poletti V, Ravaglia C, Tomassetti S, et al. Lymphoproliferative lung disorders: clinicopathological aspects. Eur Respir Rev. 2013;22:427–36.CrossRefGoogle Scholar
  4. 4.
    Milne P, Bigley V, Bacon CM, et al. Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults. Blood. 2017;130:167–75.CrossRefGoogle Scholar
  5. 5.
    Ozkaya N, Rosenblum MK, Durham DH, et al. The histopathology of Erdheim Chester disease: a comprehensive review of a molecularly characterized cohort. Mod Pathol. 2018;31:581–97.CrossRefGoogle Scholar
  6. 6.
    Weissferdt A, Tang X, Suster S, Wistuba II, Moran C. Pleuroparenchymal meningothelial proliferations: evidence for a common histogenesis. Am J Surg Pathol. 2015;39:1673–8.CrossRefGoogle Scholar
  7. 7.
    Mengoli MC, Rossi G, Cavazza A, et al. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) syndrome and carcinoid tumors with or without NECH: a clinicopathologic, radiologic and immunomolecular comparison study. Am J Surg Pathol. 2018;42:646–55.PubMedGoogle Scholar
  8. 8.
    Vargas-Madueno F, Gould E, Valor R, Ngo N, Zhang L, Villalona-Calero MA. EML4-ALK rearrangement and its therapeutic implications in inflammatory myofibroblastic tumors. Oncologist. 2018;23(10):1127–32.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Venerino Poletti
    • 1
    • 2
  • Angelo Carloni
    • 3
  • Marco Chilosi
    • 4
    • 5
  1. 1.Department of Diseases of the ThoraxOspedale Morgagni-PierantoniForlìItaly
  2. 2.Department of Respiratory Diseases and AllergyAarhus University HospitalAarhusDenmark
  3. 3.Department of RadiologyOspedale di TerniTerniItaly
  4. 4.Verona UniversityVeronaItaly
  5. 5.Department of PathologyP. Pederzoli HospitalPeschiera del GardaItaly

Personalised recommendations