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Asymmetric Dimethylation on Arginine (ADMA) of Histones in Development, Differentiation and Disease

  • Amit K. Behera
  • Tapas K. KunduEmail author
Chapter
Part of the RNA Technologies book series (RNATECHN)

Abstract

Among myriads of histone modifications known today, asymmetric dimethylation of arginines (ADMA) have been found to have important implications in transcriptional regulation of gene expression. These modifications influence organismal development, regulate cellular differentiation of multiple lineages and modulate pathogenesis of various disease forms such as cancer, metabolic disorders and drug addiction. In this chapter, we discuss roles of ADMA of histones mediated by different type I PRMTs in above mentioned physiological contexts and shed light on prospective therapeutic developments.

Keywords

Asymmetric dimethylation on arginine (ADMA) PRMTs Histones Transcription Development Cellular differentiation 

Abbreviations

ADMA

Asymmetric dimethyl arginine

AMI

Arginine methyltransferase inhibitor

AML

Acute Myeloblastic Leukemia

AR

Androgen receptor

BRG1

Brahma-related gene-1

CaMKII

Ca2+/calmodulin-dependent protein kinase II

CNC

Cranial neural crest

CVD

Cardiovascular diseases

DDAH

Dimethylarginine dimethylaminohydrolase

DM1

Type I Diabetes mellitus

E2

Estradiol

EGFR

Epidermal growth factor receptor

ER

Estrogen receptor

GST-P

Glutathione S-transferase placental form

HCC

Hepatocellular carcinoma

MEF

Mouse embryonic fibroblast

MEF2C

Myocyte enhancer factor-2C

MMA

Monomethyl arginine

MTA

Methylthioadenosine

NAc

Nucleus accumbens

NOS

Nitric oxide synthase

Nrf2

Nuclear factor erythroid 2-related factor 2

NS/PC

Neural stem/precursor cells

OIS

Oncogene induced senescence

PAD4

Protein arginine deiminase 4

PAF1c

Polymerase-Associated Factor 1 complex

PPAR-gamma

Peroxisome proliferator activated receptor-gamma

PRMT

Protein arginine methyltransferase

PSA

Prostate specific antigen

SAM

S-Adenosyl-l-Methionine

SDMA

Symmetric dimethylarginine

SRC

Steroid receptor coactivator

YY1

Ying Yang 1

Notes

Acknowledgement

TKK is recipient of JC Bose fellowship from Dept. of Science and technology, Govt. of India (SR/S2/JCB-28/2010). This work was supported by funding from Dept. of Biotechnology, Govt. of India (BT/01/CEIB/10/III/01) and JNCASR, India.

Conflict of Interest

Authors declare that they have no conflict of interest.

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific ResearchBangaloreIndia
  2. 2.CSIR-Central Drug Research InstituteLucknowIndia

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