Advertisement

Genetic Basis of Lichen Planus and Oral Cancer

  • Alexandre Rezende Vieira
Chapter

Abstract

Precancerous and cancerous lesions on the mouth, head, and neck are significant findings that can pose immediate threat to someone’s life. The occurrence of these conditions is influenced by multiple genes and modulated by the environment and can be defined as having a complex or multifactorial mode of inheritance. After years of developing strategies to fight cancer, patients are surviving longer and the need to deal with the consequences of head and neck cancer are also growing.

Keywords

Lichen planus Mouth Neoplasms Mucositis Dental caries Genetics Heredity 

References

  1. Abramoff MM, Lopes NN, Lopes LA, Dib LL, Guilherme A, Caran EM, Barreto AD, Lee ML, Petrilli AS. Low-level laser therapy in the prevention and treatment of chemotherapy-induced oral mucositis in young patients. Photomed Laser Surg. 2008;26:393–400.CrossRefGoogle Scholar
  2. Aghbari SMH, Abushouk AI, Attia A, Elmaraezy A, Menshawy A, Ahmed MS, Elsaadany BA. Malignant transformation of oral lichen planus and oral lichenoid lesions: a meta-analysis of 20095 patient data. Oral Oncol. 2017;68:92–102.CrossRefGoogle Scholar
  3. Ali J, Sabiha B, Jan HU, Haider SA, Khan AA, Ali SS. Genetic etiology of oral cancer. Oral Oncol. 2017;70:23–8.CrossRefGoogle Scholar
  4. Andrade Filho PA, Letra A, Cramer A, Prasad JL, Garlet GP, Vieira AR, Ferris RL, Menezes R. Insights from studies with oral clefts suggest associations between WNT-pathway genes and risk of oral cancer. J Dent Res. 2011;90:740–6.CrossRefGoogle Scholar
  5. Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tân PF, Westra WH, Chung CH, Jordan RC, Lu C, Kim H, Axelrod R, Silverman CC, Redmond KP, Gillison ML. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363(1):24–35.CrossRefGoogle Scholar
  6. Arbabi-Kalati F, Arbabi-Kalati F, Moridi T. Evaluation of the effect of low level laser on prevention of chemotherapy-induced mucositis. Acta Med Iran. 2013;51:157–62.PubMedGoogle Scholar
  7. Biddlestone J, Bandarra D, Rocha S. The role of hypoxia in inflammatory disease (review). Int J Mol Med. 2015;35(4):859–69.CrossRefGoogle Scholar
  8. Bombeccari GP, Guzzi G, Tettamanti M, Gianni AB, Baj A, Pallotti F, Spadari F. Oral lichen planus and malignant transformation: a longitudinal cohort study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(3):328–34.CrossRefGoogle Scholar
  9. Cauwels RG, Martens LC. Low level laser therapy in oral mucositis: a pilot study. Eur Arch Paediatr Dent. 2011;12:118–23.CrossRefGoogle Scholar
  10. Chen J, Xu R, Xia J, Huang J, Su B, Wang S. Aspirin inhibits hypoxia-mediated lung cancer cell stemness and exosome function. Pathol Res Pract. 2019;215(6):152379.CrossRefGoogle Scholar
  11. Chermetz M, Gobbo M, Ronfani L, Ottaviani G, Zanazzo GA, Verzegnassi F, Treister NS, Di Lenarda R, Biasotto M, Zacchigna S. Class IV laser therapy as treatment for chemotherapy-induced oral mucositis in onco-haematological paediatric patients: a prospective study. Int J Paediatr Dent. 2014;24:441–9.CrossRefGoogle Scholar
  12. Corti L, Chiarion-Sileni V, Aversa S, Ponzoni A, D’Arcais R, Paonutti S, Fiori D, Scotti G. Treatment of chemotherapy-induced oral mucositis with light-emitting diode. Photomed Laser Surg. 2006;24:207–13.CrossRefGoogle Scholar
  13. Freitas AC, Campos L, Brandão TB, Cristófaro M, Eduardo FP, Luiz AC, Marques MM, Eduardo CP, Simões A. Chemotherapy-induced oral mucositis: effect of LED and laser phototherapy treatment protocols. Photomed Laser Surg. 2014;32:81–7.CrossRefGoogle Scholar
  14. Hou J, Gu Y, Hou W, Wu S, Lou Y, Yang W, Zhu L, Hu Y, Sun M, Xue H. p53 codon 72 polymorphism, human papillomavirus infection, and their interaction to oral carcinoma susceptibility. BMC Genet. 2015;16:72.CrossRefGoogle Scholar
  15. Jafari A, Najafi SH, Moradi F, Kharazifard MJ, Khami MR. Delay in the diagnosis and treatment of oral cancer. J Dent (Shiraz). 2013;14(3):146–50.Google Scholar
  16. Kaidar-Person O, Gil Z, Billan S. Precision medicine in head and neck cancer. Drug Resist Updat. 2018;40:13–6.CrossRefGoogle Scholar
  17. Kuhn A, Porto FA, Miraglia P, Brunetto AL. Low-level infrared laser therapy in chemotherapy-induced oral mucositis: a randomized placebo-controlled trial in children. J Pediatri Hematol Oncol. 2009;31:33–7.CrossRefGoogle Scholar
  18. Mallick S, Benson R, Rath GK. Radiation induced oral mucositis: a review of current literature on prevention and management. Eur Arch Otorhinolaryngol. 2016;273(9):2285–93.CrossRefGoogle Scholar
  19. Mignogna MD, Lo Muzio L, Lo Russo L, Fedele S, Ruoppo E, Bucci E. Clinical guidelines in early detection of oral squamous cell carcinoma arising in oral lichen planus: a 5-year experience. Oral Oncol. 2001;37(3):262–7.CrossRefGoogle Scholar
  20. Modesto A, Vieira AR. Oral soft tissue alterations. Part 1. Vesicle-bubble diseases, ulcerative conditions, and papilloma-verrucous lesions. J Bras Med. 1994;67:101–6.Google Scholar
  21. Mougeot JC, Stevens CB, Almon KG, Paster BJ, Lalla RV, Brennan MT, Mougeot FB. Caries-associated oral microbiome in head and neck câncer radiation patients: a longitudinal study. J Oral Microbiol. 2019;11(1):1586421.CrossRefGoogle Scholar
  22. Muñoz AA, Haddad RI, Woo SB, Bhattacharyya N. Behavior of oral squamous cell carcinoma in subjects with prior lichen planus. Otolaryngol Head Neck Surg. 2016;136(3):401–4.CrossRefGoogle Scholar
  23. Nes AG, Posso MB. Patients with moderate chemotherapy-induced mucositis: pain therapy using low intensity lasers. Int Nurs Rev. 2005;52:68–72.CrossRefGoogle Scholar
  24. Pérez MÁ, Gandolfo MS, Masquijo Bisio P, Paparella ML, Itoiz ME. Different expression. Patterns of carbonic anhydrase IX in oral lichen planus and leukoplakia. Acta Odontol Latinoam. 2018;31(2):77–81.PubMedGoogle Scholar
  25. Rigby N, Kulathinal RJ. Genetic architecture of sexual dimorphism in humans. J Cell Physiol. 2015;230(10):2304–10.CrossRefGoogle Scholar
  26. Shaw L, Ribeiro AL, Levine AP, Pontikos N, Balloux F, Segal AS, Roberts AP, Smith AM. The human salivar microbiome is shaped by shared environment rather than genetics: evidence from a large family of closely related individuals. MBio. 2017;8(5):e011237–17.CrossRefGoogle Scholar
  27. Wong SF, Wilder-Smith P. Pilot study of laser effects on oral mucositis in patients receiving chemotherapy. Cancer J. 2002;8:247–54.CrossRefGoogle Scholar
  28. Wood S Jr, Hilgard P. Aspirin and tumor metastasis. Lancet. 1972;3(7783):932–3.Google Scholar
  29. Zhou Y, Vieira AR. Association between TNFα −308 G/A polymorphism and oral lichen planus (OLP): a meta-analysis. J Appl Oral Sci. 2018;26:e20170184.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Alexandre Rezende Vieira
    • 1
  1. 1.Oral BiologyUniversity of PittsburghPittsburghUSA

Personalised recommendations