Heterogeneity of Small Cell Lung Cancer Stem Cells

  • D. Prabavathy
  • Niveditha Ramadoss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1139)


Small cell lung cancer, a subtype of lung cancer is an extremely malignant disease due to its metastases and recurrence. Patients with SCLC develop resistance to chemotherapy and the disease relapses. This relapse and resistance are attributed to the heterogeneity of SCLC. Various factors such as recurrent mutations in key regulatory genes such as TP53, RB1, and myc, epigenetic changes, and cancer stem cells contribute to the observed heterogeneity. Cancer stem cell models predict neuroendocrine origin of SCLC. Though an unambiguous established CSC marker has not been assigned, markers CD133, CD44 have been found associated with SCLC. Genetically engineered mouse models (GEMMs) allow the validation of driver mutations and are necessary for design of targeted therapy. This chapter outlines the factors contributing to SCLC heterogeneity, detection methods, and the current therapy trials.


SCLC Neuroendocrine markers CD133 CD44 Side population cells Intratumor heterogeneity TP53 RB1 Clonal evolution CSC model Lysine demethylase 1 Notch pathway Genetically engineered mouse model 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • D. Prabavathy
    • 1
  • Niveditha Ramadoss
    • 2
  1. 1.Department of Biotechnology, School of Bio and Chemical EngineeringSathyabama Institute of Science and TechnologyChennaiIndia
  2. 2.Department of BiologyCalifornia State University NorthridgeNorthridgeUSA

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