Hormonally Related Headaches

  • Rossella E. NappiEmail author
  • Silvia Martella
  • Grazia Sances
  • Manuela Piccinino
  • Roberta Rossini
  • Lara Tiranini
  • Emanuela Brambilla
  • Alessandro Kunder Franco
  • Alessandra Inzoli
  • Cristina Tassorelli
Part of the ISGE Series book series (ISGE)


Hormonally related headaches relate to reproductive milestones and to prescription of hormonal compounds for contraception, treatment of reproductive conditions, and relief of climacteric symptoms. Counseling should take into account the risk-benefit profile of the individual woman, especially when menstrual-related migraine (MRM) is diagnosed. Indeed, before prescribing exogenous hormones, it is crucial to evaluate vascular risk factors and potential impact on head pain. In addition, it is important to identify the so-called estrogen-withdrawal headache, in which head pain occurs during the hormone-free interval of hormonal contraception containing estrogens or hormonal replacement therapy (HRT). Even though some hormonal strategies may help, we still need some research to improve the knowledge about the use of estrogens and progestogens in women with hormonally related headaches.


Migraine Headache Estrogen Progestins Combined hormonal contraception Progestogen-only contraception Vascular risk Extended regimen combined oral contraceptives Menopause Hormonal replacement therapy 


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Copyright information

© International Society of Gynecological Endocrinology 2019

Authors and Affiliations

  • Rossella E. Nappi
    • 1
    • 2
    Email author
  • Silvia Martella
    • 1
    • 2
  • Grazia Sances
    • 3
  • Manuela Piccinino
    • 1
  • Roberta Rossini
    • 1
  • Lara Tiranini
    • 1
    • 2
  • Emanuela Brambilla
    • 1
    • 2
  • Alessandro Kunder Franco
    • 1
    • 2
  • Alessandra Inzoli
    • 1
    • 2
  • Cristina Tassorelli
    • 3
    • 4
  1. 1.Research Center for Reproductive Medicine, Gynecological Endocrinology and MenopauseIRCCS San Matteo FoundationPaviaItaly
  2. 2.Department of Clinical, Surgical, Diagnostic and Pediatric SciencesUniversity of PaviaPaviaItaly
  3. 3.Headache Science CentreNational Neurological Institute C. MondinoPaviaItaly
  4. 4.Department of Brain and BehaviorUniversity of PaviaPaviaItaly

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