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Sporadic Ovarian and Fallopian Tube Cancer in Postmenopausal Women

  • Faustino R. Pérez-LópezEmail author
Chapter

Abstract

Sporadic (non-hereditary) ovarian cancer is highly prevalent during the second half of life. Unfortunately, to date there are no useful strategies for its early diagnosis, and it is the most lethal gynecological malignancy. In many cases, the disease may start in the fallopian tubes and malignant cells migrate to implant in the ovary. This fact has determined the recommendation to carry out opportunistic salpingectomy as a general preventive measure in women who have completed their childbearing. Other modifiable ovarian cancer risk factors include (1) maintaining a normal body mass index and avoid gaining>5 kg/m2; (2) avoiding cigarette consumption; (3) appropriate treatment and follow-up of endometriosis, pelvic inflammatory disease, and previous ovarian borderline tumors; and (4) the maintaining of physical activity. Other recommendations include (1) encouraging breastfeeding for at least 1 year; (2) the use of combined oral contraceptives; (3) performing salpingectomy instead of just tubal ligation; (4) using low-fat diets for at least 4 years; and (5) consuming moderate amounts of red wine and the use of nonsteroidal anti-inflammatories.

Keywords

Assisted reproductive technology Breastfeeding Endometriosis Epithelial ovarian cancer Fallopian tube cancer Menopause hormonal therapy Nonsteroidal anti-inflammatory drugs Oral contraceptives Ovarian cancer Pelvic inflammatory disease Peritoneal cancer Salpingectomy Talc powder Tubal ligation 

Abbreviations

AMH

Anti-Müllerian hormone

BMI

Body mass index

COCs

Combined oral contraceptives

EOCs

Epithelial ovarian carcinomas

EPIC

European Prospective Investigation into Cancer and Nutrition

HR

Hazard ratio

IGF

Insulin growth factor

IGFBP

Insulin growth factor binding protein

MHT

Menopausal hormone therapy

MRI

Magnetic resonance imaging

NSAIDs

Nonsteroidal anti-inflammatory drugs

OC3

Ovarian Cancer Cohort Consortium

OCs

Oral contraceptives

PCOS

Polycystic ovary syndrome

Notes

Competing Interest

None to declare.

Funding: None.

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyUniversity of Zaragoza Facultad de MedicinaZaragozaSpain

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