Role of Cardiac Imaging: Echocardiography
Echocardiography has crucial importance in the diagnosis of dilated cardiomyopathy (DCM). Echocardiographic features of DCM are left ventricular (LV) dilation and systolic dysfunction with impaired global contractility and normal LV wall thickness and LV diastolic dysfunction with elevation in LV filling pressure. Other frequent characteristics are LV dyssynchrony, right ventricular (RV) dysfunction, atrial dilation, functional mitral and tricuspid regurgitation, and secondary pulmonary hypertension. New echocardiographic technologies can be helpful, i.e., three-dimensional (3D) echocardiography for more accurate assessment of LV volumes and ejection fraction (EF) and speckle tracking for analysis of strain particularly for early diagnosis. Of note, many echocardiographic parameters have demonstrated important prognostic value in DCM.
Echocardiography is also useful in the differential diagnosis of other causes of LV dysfunction in patients with heart failure, as systemic hypertension; coronary, valvular, or congenital heart disease; supraventricular arrhythmias; myocarditis; alcohol abuse; systemic diseases; and cardiotoxicity secondary to antitumoral therapy.
Echocardiography plays also a pivotal role in the management and follow-up of patients with DCM. In fact, echocardiographic reassessment during follow-up under tailored medical therapy has not only important prognostic value but also helps the clinician in optimizing pharmacological treatment and confirming the indication for invasive procedures.
Finally, echocardiography is useful in familial screening for early diagnosis of DCM in asymptomatic patients.
KeywordsDilated cardiomyopathy Echocardiography Ejection fraction Restrictive filling 3D echocardiography Speckle tracking Global longitudinal strain Right ventricular dysfunction Functional mitral regurgitation
Abbreviations and Acronyms
Coronary flow reserve
Cardiac magnetic resonance
Cardiac resynchronization therapy
Dobutamine stress echocardiography
Effective regurgitant orifice area
Fractional area change
Global longitudinal strain
Implantable cardioverter defibrillator
Left bundle branch block
Late gadolinium enhancement
Left ventricular reverse remodeling
New York Heart Association
Proximal isovelocity surface area
Systolic dyssynchrony index
Tricuspid annular peak systolic excursion
Tissue Doppler imaging
Wall motion score index
7.1 Echocardiographic Features of Dilated Cardiomyopathy
Echocardiographic features of DCM
LV end-diastolic diameter >2.7 cm/m2 or >117% predicted value corrected for age and body surface area
Increased sphericity index is common
Not necessary for diagnosis (e.g., mildly dilated cardiomyopathy)
LV systolic dysfunction
EF < 45%
Impaired global contractility
LV wall motion abnormalities
Possible regional wall motion abnormalities mostly in LV septum and apex
LV wall thickness
Normal or only mildly increased
Common presence of LV eccentric hypertrophy
LV diastolic dysfunction
“Restrictive pattern” (E < 150 ms and E/A ratio > 2) is related to increased LV stiffness
Useful hallmark of advanced diastolic dysfunction and elevated LV filling pressure. Can vary during follow-up
Qualitative + quantitative polyparametric evaluation
Frequent if severe LV dysfunction and LBBB; not a selection criteria for CRT
RV dilation and dysfunction
TAPSE < 14 mm, RV FAC < 35%
Secondary of biventricular involvement and/or pulmonary hypertension
End-systolic LA volume index >34 ml/m2
Associated with diastolic dysfunction, MR, atrial fibrillation
EROA > 0.20 cm2 identifies a significant functional MR
Contributes to increase of LV filling pressure and decrease of forward stroke volume; increases LV adverse remodeling
Common in presence of RV dilation and dysfunction and pulmonary hypertension
Dobutamine or exercise stress echocardiographic test
Assessment of presence or absence of LV inotropic response; sustained improvement vs. biphasic response
LV dilation can usually be accompanied by LV eccentric hypertrophy, with normal or only mildly increased LV wall thickness and increased LV mass (due to LV dilation). This feature is important for differential diagnosis between idiopathic DCM and other causes of dysfunction, such as end-stage hypertrophic cardiomyopathy and infiltrative or hypertensive heart disease.
Diffuse hypokinesis is typically seen in DCM, although regional wall motion abnormalities with akinesis or dyskinesis may be noticed, mostly at LV septum or apex, while better contractility is more common in the posterior and lateral walls. The presence of a coronary artery distribution of wall motion abnormalities raises the suspicion of coronary artery disease. “Idiopathic LV aneurysms” are rarely seen in DCM and should be distinguished from cases of myocarditis, sarcoidosis, or left-dominant arrhythmogenic cardiomyopathy (AC) .
LV mechanical dyssynchrony is another important aspect that can be evaluated with echocardiography in DCM patients with heart failure, LV systolic dysfunction, and left bundle branch block (LBBB). Echocardiography provides a multiparametric qualitative and quantitative approach for assessment of LV mechanical dyssynchrony . The “apical rocking” motion of the LV yields a first qualitative diagnostic hint, which should be confirmed by other indices, as “septal flash,” septal to posterior wall motion delay at M-mode, and TDI-derived indices (intervals from QRS to peak systolic velocities of wall motion of different LV segments, assessing the delay between opposite LV walls). Also the presence of significant interventricular dyssynchrony, demonstrated by the time delay between the LV and RV ejections at pulsed-wave (PW) Doppler, was proven to be associated with higher probability of favorable response to CRT in DCM patients . However, echo-Doppler indexes of dyssynchrony are scarcely reliable [13, 14], and therefore, current guidelines do not recommend echocardiography as selection criteria for CRT .
Echocardiography is pivotal to assess MV morphology, quantify mitral annulus dilation, and rule out the presence of structural leaflet disease. Furthermore, it is important to evaluate MR severity with a multiparametric approach . To increase sensitivity and specificity in detecting the severity of MR, transesophageal echocardiography provides the best accuracy. Indeed, transesophageal echocardiograms are capable of providing a more accurate estimation of morphological (MV annulus dilation, quantification of systolic leaflet retraction, coaptation depth, and tenting area) and functional (EROA calculated with proximal isovelocity surface area [PISA], regurgitant volume [RVol]) parameters.
In the presence of RV dilation and dysfunction, functional tricuspid regurgitation (TR) and pulmonary hypertension are quite common in DCM. Pulmonary hypertension is more frequently associated with the severity of functional MR and LV diastolic dysfunction than with the degree of LV systolic dysfunction . In particular, patients with “restrictive” or pseudonormal mitral inflow patterns have a higher pulmonary artery systolic pressure, and the improvement to an impaired relaxation pattern appears to be followed by a significant reduction of pulmonary artery pressure .
Stress echocardiography can be useful in DCM to assess the myocardial contractile reserve and the presence of inducible ischemia and to evaluate the coronary flow reserve (CFR) . However, to date there is no standardized protocol for stress echocardiography in patients with LV dysfunction, and the preferred stress technique (dobutamine, dipyridamole, or exercise) is chosen depending on the indication of the test, the exercise ability of each patient, image quality, and expertise of the center.
Exercise is the most physiological stress test, which should be used if the patient is able to exercise. However, the most used test in DCM patients is dobutamine stress echocardiography (DSE) . Low-dose dobutamine is the method of choice for assessment of myocardial contractile reserve. Also dipyridamole is a feasible test that can be used to assess the contractile response; it is less arrhythmogenic and better tolerated . A LV EF increase >20% or a wall motion score index (WMSI) >0.44 from baseline recognizes patients with preserved contractile reserve. A biphasic response in at least two segments and/or extensive ischemic response during high-dose dobutamine or exercise stress can help to identify ischemic cardiomyopathy, whereas idiopathic DCM is characterized by sustained improvement of LV function. Absence of inotropic response identifies patients with severe cardiomyopathy .
Dipyridamole stress test allows a combined assessment of contractile reserve and CFR on left anterior descending artery (defined by the ratio of hyperemic to rest peak diastolic flow velocity, normal value >2.5). CFR is often reduced in DCM, and it is associated with the functional class and the oxygen consumption.
DSE can also be useful to unmask a significant LV intraventricular dyssynchrony  and helps to identify potential responders to CRT (together with the presence of contractile reserve). Furthermore, it can be used to discriminate between true aortic valve stenosis and pseudo-stenosis combined with DCM . However, to date, indications for stress echocardiography in the setting of functional MR in idiopathic DCM are controversial .
Importantly, many of the aforementioned echocardiographic parameters, evaluated at baseline and at follow-up, are crucial for the prognostic stratification of DCM patients (see paragraph on prognostic role of echocardiography in DCM) and are useful to evaluate the progression of the disease and the response to therapy.
7.2 Role of New Echocardiographic Techniques
Technological advances in the field of cardiac ultrasound have led to new noninvasive techniques, such as 3D echocardiography, TDI, and speckle-tracking echocardiography (STE). These techniques have demonstrated a significant incremental value over basic echocardiography [2, 27, 28, 29].
Technological advances in the field of cardiac ultrasound have led to further new noninvasive techniques, such as TDI and STE, for assessing cardiac mechanics and segmental and global LV function. The peak systolic myocardial velocity S′, a simple TDI index of systolic longitudinal function, is a marker of impaired subendocardial fiber contraction and correlates with myocardial fibrosis . STE has emerged as a novel technology to detect myocardial abnormalities. Strain analysis allows discrimination between active and passive movement of myocardial segments and permits separate assessment of distinct components of myocardial deformation (longitudinal and circumferential shortening, radial thickening, rotation, and twisting). Patients with DCM have an increased LV mass and volume and typically decreased contractility of the LV walls . These changes lead to impaired strain in all direction (longitudinal, radial, and circumferential) [42, 43, 44, 45].
Strain echocardiography is important for the arrhythmic risk stratification of patients with DCM since global longitudinal strain (GLS) is a promising marker of arrhythmias. Mechanical dispersion predicted arrhythmic events in patients with DCM independently of LV EF . Speckle-tracking longitudinal deformation has also a potential role in assessing fibrosis as detected by contrast CMR late gadolinium enhancement (LGE), but the relationship between myocardial fibrosis and segmental strain is still not well established, especially in setting of DCM. In a small prospective study, abnormal 3D speckle-tracking GLS could detect LGE-determinant myocardial fibrosis with a sensitivity of 85%, a specificity of 85%, a positive predictive value of 69%, and a negative predictive value of 93%, considering an optimal GLS cutoff value of −15.25% .
LV twist and torsion have been investigated with different measurement methods during the past two decades, using tagged CMR as the gold standard . Many studies using different echocardiographic techniques, like TDI, STE, velocity vector imaging, and 3D STE, showed that LV torsion (twisting and untwisting) represents an important mechanism for both ejection and filling. LV twist/torsion indexes are significantly impaired in patients with DCM correlating with worse functional capacity and LV function [42, 49, 50]. Reduced LV torsion in patients with DCM was found to be a predictor of response to CRT and increased after 8 months of therapy .
Advanced indices of LV intraventricular mechanical dyssynchrony are based on TDI, speckle-tracking imaging, and 3D echocardiography . As stated in the previous paragraph, the role of echocardiography in assessing LV mechanic dyssynchrony in DCM patients remains controversial to date. The Predictors of Response to Cardiac Resynchronization Therapy (PROSPECT) trial examined the predictive value of 12 echocardiographic parameters of dyssynchrony, including both conventional- and TDI-based methods, showing only a modest sensitivity and specificity of these markers . Three-dimensional echocardiography has been used as a technique for dyssynchrony quantification. The systolic dyssynchrony index (SDI) is calculated as the standard deviation of regional ejection time (time to reach minimal volume). Three-dimensional echocardiography allows evaluating all LV segments simultaneously, displaying a “bull’s eye” map, which demonstrates the time required to each segment to reach minimal volume. Three-dimensional echocardiography-derived LV SDI was described as highly predictive of response to CRT at 48 h , 6 months [56, 57], and 1 year of follow-up . Benefits from CRT have been defined as a ≥15% reduction in LV ESV at follow-up [56, 57, 58], which can also readily be measured by 3D echocardiography.
Several groups have addressed analysis of LV strain of opposite walls by STE as the ideal technique for the assessment of LV intraventricular dyssynchrony [14, 59, 60]. Radial strain values were demonstrated to be reliable indexes of LV mechanical dyssynchrony useful to identify potential responders to CRT . The Speckle Tracking and Resynchronization (STAR) study demonstrated that radial and transverse LV strain values were significantly related to LV EF response and long-term outcome after CRT . On the other hand, absence of radial or transverse dyssynchrony (≥130 ms time difference in peak strain values between opposing segments) at baseline was an adverse prognostic factor after CRT . In one study pacing at the site of the latest mechanical activation, as determined by speckle-tracking radial strain analysis, resulted in superior echocardiographic response after 6 months of CRT and better prognosis during long-term follow-up. Moreover, the demonstration of scar tissue by speckle-tracking GLS was found to be an independent predictor of lack of response to CRT and was related to the total scar burden assessed with CMR . Furthermore, 3D speckle-tracking strain indices have been studied to quantify dyssynchrony before and after CRT .
For the echocardiographic assessment of LV diastolic dysfunction in patients with DCM, the ratio of early diastolic transmitral flow velocity to early diastolic annular velocity (E/E′) is frequently used to predict an increase in LV filling pressure. This approach, however, has several limitations, and its accuracy is questionable, particularly in patients with advanced DCM and severe heart failure. A study with invasive hemodynamic assessment as gold standard showed that E/E′ ratio had a weak correlation with LV filling pressure in DCM, particularly those with severe LV dilatation and after CRT . Other new indices for LV diastolic dysfunction evaluation obtained by speckle-tracking techniques analysis are promising. Circumferential strain and strain rate during late diastolic LV filling, E/circumferential strain rate at early diastolic LV filling, and E/circumferential strain at the time of peak E wave had greater area under the curve than the E/E′ ratio for the prediction of pulmonary capillary wedge pressure >12 mmHg .
Importantly, 2D LA strain assessment with speckle-tracking technique demonstrated a better correlation than other Doppler indices, such as E/E′ ratio, with LV filling pressure as measured by right catheterization, in patients with advanced systolic heart failure . In particular, the peak atrial longitudinal strain that corresponds to LA expansion during the reservoir phase is reduced in the presence of an increased LA pressure, and this parameter could be useful in the multiparametric assessment of LV filling pressure. In addition, LA strain represents a promising noninvasive technique to assess left atrial pump function in patients with DCM. Two-dimensional STE-based LA function is impaired in patients with nonischemic DCM . In a study with 134 patients with either idiopathic or ischemic DCM, LA systolic deformation was more depressed in idiopathic compared with ischemic DCM and was closely associated with functional capacity during effort. LA lateral wall systolic strain and LA volume were powerful independent predictors of peak oxygen consumption during cardiopulmonary exercise testing .
Quantification of MR is challenging and should be performed by using 2D or 3D vena contracta and PISA method [17, 68]. It is well known that the 2D vena contracta and PISA method have several limitations. These methods assume the EROA is nearly circular, and the exact shape and size might not be accurately assessed due to the limited scan plane orientation of 2D echocardiography. Real-time 3D echocardiography is now available to overcome this limitation, which is particularly relevant in patients with functional MR, in whom EROA geometry is usually complex and asymmetric [69, 70, 71]. The direct measurement of the regurgitation orifice area with 3D echocardiography avoids the underestimation of its size, independently from the eccentricity of the MR jet or from cardiac rhythm [72, 73]. Quantification of RVol of functional MR with 3D echocardiography showed excellent correlation with RVol measured by CMR (r = 0.94), without a significant difference between these techniques (mean difference = −0.08 mL/beat). Conversely, 2D echocardiography approach from the four-chamber view significantly underestimated RVol (r = 0.006) as compared with CMR (mean difference = 2.9 mL/beat) . Currently, dedicated MV analysis softwares allow a fast, complete, and reproducible evaluation of MV anatomy and function (MV annulus dimensions, MV annulus displacement, MV leaflet surface, tenting volume, aortomitral angle, and papillary muscle geometry) [74, 75, 76]. Furthermore, 3D transesophageal echocardiography plays an important role in the selection of patients for MitraClip, in the echocardiographic guidance of the procedure and in the pre- and post-procedural MR quantification .
7.3 Clinical Echocardiography in DCM: Advantages and Limitations in Clinical Practice
Echocardiographic clues in differential diagnosis of DCM
Possible differential diagnosis vs. DCM
Associated significant LV hypertrophy
1. Advanced hypertrophic cardiomyopathy
2. Advanced infiltrative/storage cardiomyopathy
3. Advanced hypertensive heart disease
Segmental wall motion abnormalities with coronary artery distribution
Biphasic response in at least two LV segments and/or extensive ischemic response during high-dose dobutamine or exercise stress
Wall motion abnormalities with non-coronary distribution/idiopathic LV aneurysms
1. Left-dominant or biventricular AC
3. Cardiac sarcoidosis
Prevalent RV dilation and dysfunction
1. Arrhythmogenic RV cardiomyopathy with biventricular involvement
2. Congenital heart disease
3. Pulmonary hypertension
Presence of RV/LV aneurysms
Low-gradient aortic valve stenosis + LV dysfunction
True severe aortic valve stenosis vs. pseudo-severe aortic stenosis + DCM > differentiation by response to DSE
Significant MR + LV dysfunction
Functional MR+DCM vs. organic MR + secondary LV dysfunction > through transthoracic + transesophageal echocardiography assessment of MV
LV dysfunction without severe dilation, LV hypertrophy, non-coronary wall motion abnormalities, LV thrombi
Reversibility of pathological echocardiographic parameters once the causal factors are removed
Other cardiomyopathies: inflammatory, alcoholic, tachycardia-induced, stress-induced, chemotherapy-induced, peripartum
Mild/moderate LV systolic dysfunction without significant dilation + severe diastolic dysfunction
Mildly dilated cardiomyopathy vs. restrictive cardiomyopathy
“Red flags” echocardiographic clues can raise the suspicion of a diagnosis but are however not totally specific for a definitive etiology. For example, documentation of LV dysfunction, not necessarily associated with LV hypertrophy, in patients with history of systemic hypertension may clarify the cause of LV dysfunction as end-stage dilated and hypokinetic phase of hypertensive heart disease that may mimic a DCM . Also multivessel coronary heart disease can be indistinguishable by echocardiography from DCM, and sometimes only coronary angiography clarifies the diagnosis. In some cases, a diagnostic hint originates from the evidence of segmental wall motion abnormalities with coronary distribution, as well as the proof of an ischemic “biphasic” response at DSE. Other noninvasive imaging techniques, as CMR which evaluates the LGE pattern, single-photon emission computed tomography (CT) which assesses perfusion abnormalities, and CT which depicts the coronary anatomy, are useful to differentiate ischemic from nonischemic DCM.
Regarding the differential diagnosis in the case of DCM associated with valve disease, low-dose dobutamine stress test is particularly valuable in the differentiation between a true severe aortic valve stenosis with consequent LV dysfunction and a pseudo-aortic valve stenosis in the presence of DCM. Also a severe MR can lead to advanced LV dysfunction: in this case transthoracic and transesophageal echocardiographic assessment of MV apparatus is valuable in excluding organic MV disease.
Several other cardiomyopathies can mimic the morphological features of DCM. Echocardiography can give diagnostic hints but remains often limited in defining DCM etiology, thus suggesting the use of second-level imaging investigations, primarily CMR which can recognize distinct LGE distribution in different cardiomyopathies. Myocarditis is echocardiographically characterized by LV dysfunction frequently without severe dilation, sometimes LV hypertrophy due to interstitial edema, wall motion abnormalities with non-coronary distribution, and possible presence of LV thrombi . CMR in these cases facilitates the diagnosis detecting myocardial edema, but the diagnostic gold standard remains endomyocardial biopsy. AC with biventricular or “left-dominant” involvement can be suspected by echocardiography in presence of biventricular dysfunction and in presence of RV/LV aneurysms . Again, the diagnostic imaging tool of choice in suspected AC is CMR . Also advanced hypertrophic cardiomyopathy in hypokinetic-dilated end-stage has echocardiographic features similar to DCM with LV spherical remodeling and apparent regression of LV hypertrophy . The presence of previous echocardiographic exams with documentation of severe LV hypertrophy typical of hypertrophic cardiomyopathy may help the diagnosis in these extreme cases. Of note, evidence of significant LV hypertrophy may also suggest advanced stages of infiltrative/storage cardiomyopathy . Hemochromatosis causes a restrictive cardiomyopathy which progresses to an end-stage DCM with echocardiographic features undistinguishable from idiopathic DCM. Therefore, CMR is the imaging modality of choice to detect the iron overload in the myocardium. Also the differential diagnosis between LV non-compaction and DCM with conspicuous trabeculations secondary to LV remodeling is often possible only with CMR. Finally, other cardiomyopathies (inflammatory, alcoholic, tachycardia-induced , stress-induced, chemotherapy-induced, peripartum) usually show a reversibility of pathological echocardiographic parameters once the causal factors have resolved; therefore echocardiography is extremely valuable in follow-up of these patients.
Echocardiography is also important in the early diagnosis of DCM in patients with positive familiar history and/or in presence of a positive genetic mutation [4, 89, 90]. The diagnosis of DCM is obtained in presence of two or more affected family members or in presence of a first-degree relative of a DCM patient with unexplained sudden death at <35 years . Familiar screening including history, physical examination, ECG, and echocardiography is indicated in probands and first-degree relatives. LV dilation and reduced fractional shortening are common in asymptomatic relatives of patients with DCM and are associated with a significant risk for disease progression . Advanced echocardiographic techniques as myocardial deformation imaging might permit the detection of latent DCM (with reduced strain) earlier than LV enlargement and depression of EF . In controversial cases other imaging techniques as CMR, as well as follow-up reassessment, are indicated.
In addition, several echocardiographic parameters, assessed at baseline and at follow-up, are relevant for prognostic stratification of DCM patients (see paragraph about prognostic role of echocardiography in DCM) and help the clinician in assessing the progression of the disease and the response to treatment. They also guide in taking decisions not only about pharmacological therapy but also indication for invasive treatments as implantable device therapy (implantable cardioverter defibrillators (ICD), CRT, and correction of valvulopathy [92, 93, 94, 95]). Documentation of LV EF < 30%, severe LV dilatation, and LV thrombosis suggests the indication for anticoagulation therapy in order to lower the risk of thromboembolism. Echocardiographic LV EF measurement is an important parameter for determining the appropriateness of ICD and CRT implantation. LV EF ≤ 35% in association with advanced New York Heart Association (NYHA) class despite optimal medical therapy for at least 3 months is considered in the indication for ICD and, if prolonged QRS is present, is an echo criterion for the selection of patients for CRT. Accurate MV echocardiographic evaluation is becoming increasingly more relevant due to the emerging role of percutaneous procedures to treat functional MR. In particular, the percutaneous mitral valve edge-to-edge repair with MitraClip implantation in heart failure patients with severe functional MR and high risk for surgery is a new therapeutic possibility. Echocardiography is fundamental not only in the selection of patients  but also in guiding the procedure and in the follow-up. Echocardiography can also provide assistance in the implantation of ventricular assist devices and the evaluation for heart transplantation in end-stage heart failure patients.
In conclusion, echocardiography is the first-line imaging exam in patients with DCM, and it has a pivotal role in assessing its morphological and functional features and in piloting treatment options. However, sometimes echocardiographic data are not sufficient, and they should guide further and more specific cardiac diagnostic investigations. General advantages of echocardiography over other imaging techniques in clinical everyday practice are its extensive availability, accessibility, and low cost. Furthermore, it is noninvasive, safe, and free from radiations and can be performed in patients with heart devices who cannot undergo magnetic fields. Limitations of echocardiography include inadequate image quality and unfeasibility for tissue characterization. Moreover, as other imaging techniques, the operators require a learning curve and adequate expertise and familiarity with the disease.
7.4 Prognostic Role of Echocardiographic Data in DCM
The natural history of DCM has dramatically improved in the last 20 years as a result of the introduction in clinical practice of beta-blockers, ACE inhibitors, and mineralocorticoid receptor antagonists which showed not only a reduction in mortality and morbidity but also significant improvements in terms of LV reverse remodeling (LVRR) [27, 28, 97, 98]. Therefore, studies on the prognostic role of echocardiography should be contextualized in their historical phase of conception, keeping in mind that during the last three decades, the gradual optimization of medical therapy has paralleled a significant improvement in survival .
Main echocardiographic parameters clinically useful to assess prognosis in patients with DCM
At first assessment
Larger indexed LV ESV is predictor of early arrhythmic events
Independent predictor of outcome
LV diastolic dysfunction
Independent prognostic indicator of poor outcome or heart transplantation
Independently associated with a poor prognosis
Correlates with worse functional status, more advanced LV failure, and has prognostic importance. Biventricular dilation is associated with a worse prognosis as compared to isolated LV dilation
Correlates with ↓exercise tolerance and ↑pro-BNP
Pulmonary artery pressure
Peak TR velocity >2.5 m/s is associated with increased mortality, increased hospitalization, and higher incidence of heart failure
Independent predictor of arrhythmogenic events in DCM
Contractile reserve at DSE
Characterized by a decrease in LV dimensions and normalization of LV shape associated with a significant improvement of systolic function. It is one of the main determinants of prognosis
Persistent vs. reversible LV restrictive filling pattern
Associated with subsequent mortality and transplantation rate
Improvement of functional MR
Early improvement is a favorable independent prognostic factor
Regression vs. persistence or new development of RV systolic dysfunction
Independent risk factor of subsequent outcome
LV dilatation and systolic dysfunction are the hallmarks of the disease and markers of adverse outcome [2, 18, 27, 28, 100]. Remodeling in DCM includes other features as dyssynchronous ventricular contraction, functional MR, dilatation of other chambers, and myocardial fibrosis. Conversely, LVRR, characterized by a decrease in LV dimensions and the normalization of shape associated with a significant improvement of systolic function, is a therapeutic goal (nowadays achieved in almost 40% of patients in optimal medical and device treatment) and adds prognostic value for the stratification of long-term risk . Therefore, although baseline LV EF is an independent predictor or outcome both in adults and children with idiopathic DCM , a serial thorough assessment of LV size and systolic function, especially after medical treatment optimization, is pivotal in the management of these patients. At approximately 24 months after diagnosis and establishment of optimal medical therapy, LVRR is considered completed; nonetheless, possible disease progression indicates the need for continuous follow-up, lifelong therapy, and evaluation of potential negative prognostic factors (including atrial fibrillation, LV restrictive filling, RV dysfunction, LBBB, functional MR) .
Severe LV diastolic dysfunction, characterized by restrictive filling pattern, has been demonstrated a powerful adverse prognostic sign specifically in patients with DCM, as in other patients with heart failure . Furthermore, persistence of LV restrictive filling pattern is associated with high mortality and transplantation rate, while patients with reversible restrictive filling have a high probability of improvement and excellent survival . Early diastolic mitral filling E/early diastolic mitral annular velocity E′ at TDI (E/E′ ratio) is associated with exercise capacity in DCM . E/E′ ratio was also demonstrated to be a powerful predictor of clinical outcome in DCM patients . Furthermore, baseline lateral E/E′ ratio was an independent predictor for cardiac events in patients with heart failure treated with CRT .
LA enlargement is often observed in DCM as a consequence of LV diastolic dysfunction, functional MR, and atrial fibrillation. LA volume has incremental prognostic value in patients with DCM and correlates with exercise tolerance and pro-BNP .
Functional MR is independently associated with a poor prognosis in patients with LV dysfunction [16, 92, 106]. Improvement of functional MR in response to pharmacological therapy and CRT has been previously demonstrated . Stolfo et al.  showed that in patients with DCM receiving optimal medical treatment, early improvement of functional MR is frequent (more than half of the cases) and is a favorable independent prognostic factor. Furthermore, early improvement of functional MR is frequently documented after CRT implantation in DCM and is associated with improved transplant-free survival . With the emergence of percutaneous transcatheter MV procedures for the treatment of MR (MitraClip repair), the prognostic importance of correction of functional MR in DCM is likely to increase .
Concomitant RV dysfunction, in particular TAPSE < 14 mm, represents an adverse prognostic marker in DCM .
The serial assessment of RV function by echocardiography is useful, particularly after optimization of medical therapy or after CRT. A regression of RV dysfunction is associated with a favorable transplant-free survival, whereas the persistence or the new development of RV systolic dysfunction is an independent risk factor of adverse outcome [112, 113, 114].
Functional TR is often associated with RV dilatation, RV dysfunction, or pulmonary hypertension. Pulmonary artery pressure measured from TR velocity provides additional prognostic information as peak TR velocity of more than 2.5 m/s is associated with increased mortality, increased hospitalization, and higher incidence of heart failure .
A significant prolongation of QRS duration in the context of LBBB is the main marker of ventricular dyssynchrony used in trials of CRT . Echocardiographic techniques may also detect mechanical dyssynchrony in some patients without significant QRS prolongation. However, in a large series of patients with systolic heart failure, echocardiographic evidence of LV dyssynchrony and a QRS duration of less than 130 ms, CRT did not reduce the rate of death or hospitalization for heart failure and may increase mortality . Therefore, assessment of dyssynchrony should not be part of the routine echocardiographic evaluation for patients with DCM and should be used in selected cases only.
Recent data demonstrated that the reversion after CRT treatment of simple qualitative echocardiographic signs of LV intraventricular dyssynchrony (septal flash and apical rocking) is a favorable prognostic sign and is associated with frequent improvement of LV function .
Few data are presently available about prognostic value of evaluation of LV strain by STE in DCM. LV subendocardial longitudinal function is often early deranged in DCM, and LV GLS is markedly decreased in DCM when compared with healthy controls . As showed by Haugaa et al., LV GLS may be a valuable tool in the selection of candidates for CRT and independent predictor of arrhythmogenic events in DCM .
As previously stated, approximately one third of patients with DCM exhibit an improvement of LV function on optimal medical therapy. Merlo et al.  showed on a large cohort of patients with idiopathic DCM that LVRR (defined as a normalization or improvement of LV systolic function and a significant decrease in LV size) is related with more favorable outcomes in the long term. In this study, baseline independent predictors of LVRR were higher systolic blood pressure and the absence of LBBB. Notably, no baseline echocardiographic parameters were predictive of subsequent LVRR.
The implantation of an ICD in selected patients with DCM may prevent sudden cardiac death. Current international guidelines recommend ICD implantation in patients and previous cardiac arrest (secondary prevention) or in patients with severely reduced EF (≤35%) and NYHA II/III despite optimal medical therapy (primary prevention) with a life expectancy >1 year . It is recommended that patients should receive at least 3 months of optimal medical therapy before considering ICD implantation in primary prevention, as LVRR with recovery of systolic function may lead to unnecessary implantation. Patients that experience sudden death or major ventricular arrhythmias within the 6 months window after diagnosis are approximately 2%; larger indexed LV ESV and QRS duration are predictors of early arrhythmic events .
Assessment of contractile reserve by DSE may be a useful tool to predict outcome in patients with DCM . There is no general consensus on the definition of positive response to dobutamine in this specific context, but generally an increase in LVEF from rest to peak stress by ≥5 points or a percentage change from baseline of ≥20% indicates the presence of contractile reserve . Pinamonti et al.  investigated 51 patients with DCM with DSE and found that the addition of DSE-derived information added a moderate but significant improvement of sensitivity to a model based only on rest echocardiography, with a general low predictive power. In addition, a reduced CFR during dipyridamole vasodilator test together with absence of contractile reserve provides additional negative prognostic value in DCM patients. CFR on left anterior descending artery less than 2 yields the worse prognosis .
In conclusion, echocardiography remains an extremely useful tool for the prognostic stratification of patients with DCM. The approach to echocardiographic interpretation should be holistic and not focused only on the LV systolic function or the regional wall motion abnormalities but also on the possible coexistence of diastolic impairment, valvular defects as functional MR, and other chamber dilatation. A serial echocardiographic assessment is mandatory in patients with DCM in order to capture possible improvements due to medical treatment and adverse progression of the disease, to clarify the possible presence of specific etiologies often characterized by reversibility of the systolic function (as myocarditis or alcoholic cardiomyopathy), and finally to select patients that may benefit from device therapy.
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