Retinopathy of Prematurity (ROP)



This chapter is only about retinopathy of prematurity (ROP). It contains a historical introduction about ROP and a short section about pathophysiology of ROP. Next follows a detailed classification of ROP illustrated with many pictures and finally the most recent screening recommendations.


Retinopathy of prematurity ROP Pathophysiology Classification Screening recommendations 


  1. 1.
    Silverman WA. Chapter 8: The consequences of oxygen restriction. In: Retrolental fibroplasia: a modern parable. New York: Grune & Stratton; 1980. Retrieved 21 September 2013.Google Scholar
  2. 2.
    Pierce EA, Avery RL, Foley ED, Aiello LP, Smith LE. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci U S A. 1995;92(3):905–9.CrossRefGoogle Scholar
  3. 3.
    Alon T, Hemo I, Itin A, Pe’er J, Stone J, Keshet E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med. 1995;1(10):1024–8.CrossRefGoogle Scholar
  4. 4.
    An International Classification of retinopathy of Prematurity. The committee for the classification of retinopathy of prematurity. Arch Ophthalmol. 1984;102:1130–4.CrossRefGoogle Scholar
  5. 5.
    An International Classification of Retinopathy of Prematurity. II. The classification of retinal detachment. The International Committee for the Classification of the late stages of retinopathy of prematurity. Arch Ophthalmol. 1987;105:906–12.CrossRefGoogle Scholar
  6. 6.
    International Committee for the Classification of Retinopathy of Prematurity. The international classification of retinopathy of prematurity revisited. Arch Ophthalmol. 2005;123:991–9.CrossRefGoogle Scholar
  7. 7.
    Fierson WM, American Academy of Pediatrics section on ophthalmology; American Academy of ophthalmology; American Association for Pediatric Ophthalmology and Strabismus; American Association of Certified Orthoptists. Screening examination of premature infants for retinopathy of prematurity. Pediatrics. 2013;131:189–95.CrossRefGoogle Scholar
  8. 8.
    Wilkinson AR, Haines L, Head K, Fielder AR. UK retinopathy of prematurity guideline. Early Hum Dev. 2008;84:71–4.CrossRefGoogle Scholar
  9. 9.
    Dai S, Austin N, Darlow B, New Zealand Paediatric Ophthalmology Interest Group; Newborn Network; Fetus and Newborn Special Interest Group; Paediatric Society of New Zealand. Retinopathy of prematurity: New Zealand recommendations for case detection and treatment. J Paediatr Child Health. 2015;51:955–9.CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.OphthalmologyUniversity of Uppsala OphthalmologyUppsalaSweden
  2. 2.Department of OphthalmologySamsung Medical Center, Sungkyunkwan UniversitySeoulSouth Korea

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