Breast Cancer in Men

  • BBSG – Brazilian Breast Study Group


Breast cancer in men is rare, with about 2600 cases/year in the United States, accounting for approximately 1% of all cases. About 11% of the cases involve in situ disease. The mean age at diagnosis is 67 years, and that is higher when compared to women. Few specific prospective studies are available to better characterize biology and treatment, despite the increasing numbers of survivors.


Male breast cancer Endocrine therapy Conservative surgery Sentinel node biopsy 

Recommended Reading

  1. 1.
    Dietz JR, Partridge AH, Gemignani ML, Javid SH, Kuerer HM. Breast cancer management updates: young and older, pregnant, or male. Ann Surg Oncol. 2015;22(10):3219–24. Review study on breast cancer in men: mastectomy is the most used surgical approach, although conservative surgery associated with radiotherapy is acceptable in selected cases. CrossRefGoogle Scholar
  2. 2.
    Flynn LW, Park J, Patil SM, Cody HS, Port ER. Sentinel lymph node biopsy is successful and accurate in male breast carcinoma. J Am Coll Surg. 2008;206:616–21. The sentinel lymph node in breast cancer in men had a 97% and identification rate and false-negative rate at 8%, similar to that found in women.Google Scholar
  3. 3.
    Freedman RA, Partridge AH. Emerging data and current challenges for young, old, obese, or male patients with breast cancer. Clin Cancer Res. 2017;23(11):2647–54. Review that highlights risks for breast cancer in men, as well as the differences between male and female cancer. At the moment, there is an effort of the scientific community to conduct studies that can improve the understanding of cancer in men. CrossRefGoogle Scholar
  4. 4.
    Shak S, Palmer G, Baehner FL, Millward C, Watson D, Sledge GW. Molecular characterization of male breast cancer by standardized quantitative RTPCR analysis: first large genomic study of 347 male breast cancers compared to 82,434 female breast cancers. J Clin Oncol. 2009;27:15s. The use of Oncotype Dx in men, although showing some similarities, evidenced a greater expression of estrogen receptor and progesterone, compared to women, as well as greater expression of Ki67. CrossRefGoogle Scholar
  5. 5.
    Zaenger D, Rabatic BM, Dasher B, Mourad WF. Is breast conserving therapy a safe modality for early-stage male breast cancer? Clin Breast Cancer. 2016;16:101–4. A study that demonstrated survival after conservative breast cancer therapy in men comparable to mastectomy in cases of initial breast cancer (T1-T2, N0).CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • BBSG – Brazilian Breast Study Group
    • 1
  1. 1.BBSGSao PauloBrazil

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